A precision quantitative device for inoculating bacteria strains for vaccine production

Abstract

This invention provides a precise quantitative device for inoculating vaccine strains, including an inoculation tube with a needle inserted at its lower end. A rubber piston is slidably connected inside the inoculation tube, and a support cylinder is inserted in the middle of the rubber piston to push the piston and expel the strain. Two limiting plates are fixedly connected to the upper end of the rubber piston. The support cylinder has a connecting hole inside, and a squeezing column is threadedly connected to the middle of the upper end of the support cylinder. A rubber ball is placed inside the connecting hole, and the lower end of the squeezing column is fixedly connected to the rubber ball. When the squeezing column moves downward, it drives the rubber ball to move, increasing the pressure inside the inoculation tube to clear the strain from the needle. The rubber piston has a connecting cavity inside, and the lower end of the support cylinder is inserted into the connecting cavity. This invention ensures the accuracy of inoculation by pressurizing the inside of the connecting hole, and the pressurized gas cleans the residual strain from the needle, thus maintaining the same quality for different batches of vaccines.

Description

Technical Field

[0001] This utility model relates to the field of vaccine strain inoculation technology, and in particular to a precise quantitative device for inoculating vaccine strains. Background Technology

[0002] In the vaccine production process, bacterial inoculation is a crucial initial step. The commonly used method for inoculation is manual titration, where operators use a syringe. However, after inoculation, some bacteria remain in the needle. For vaccines with extremely strict requirements on bacterial quantity, this method's precision is far from sufficient, easily leading to inconsistencies in quality within the same batch and between different batches. Utility Model Content

[0003] The purpose of this invention is to provide a precise quantitative device for inoculating bacterial strains for vaccine production. It incorporates a secondary pressurization structure inside the traditional syringe plunger, using increased air pressure to empty the bacterial strains inside the needle, thereby solving the problems mentioned in the background art.

[0004] The technical solution adopted by this utility model to solve its technical problem is: a precise quantitative device for inoculating bacterial strains for vaccine production, including an inoculation tube, a needle inserted into the lower end of the inoculation tube, a rubber piston slidably connected inside the inoculation tube, a support cylinder inserted in the middle of the rubber piston for pushing the rubber piston to move and squeeze out the bacterial strain, and two limiting plates fixedly connected to the upper end of the rubber piston.

[0005] The support cylinder has a connecting hole inside, and a squeezing column is threadedly connected to the middle of the upper end of the support cylinder. A rubber ball is placed inside the connecting hole. The lower end of the squeezing column is fixedly connected to the rubber ball. When the squeezing column moves downward, it drives the rubber ball to move, increasing the pressure inside the inoculation tube to clear the bacteria inside the needle.

[0006] The rubber piston has a connecting cavity inside, and the lower end of the support cylinder is inserted into the connecting cavity. The rubber piston has a pressure hole in the middle to release the air pressure inside the support cylinder.

[0007] A limiting protrusion is fixedly connected in the middle of the connecting cavity. A connecting groove is provided in the middle of the limiting protrusion to connect the pressurizing hole and the connecting hole. A sealing platform is fixedly connected in the inner wall of the support cylinder.

[0008] Preferably, the limiting protrusion is a hemispherical structure, and the arc-shaped surface of the limiting protrusion is engaged with the connecting hole in the middle of the support cylinder to position and install the rubber piston and the support cylinder.

[0009] Preferably, the sealing platform has a semi-circular structure, and the side of the sealing platform facing the limiting protrusion has an arc-shaped concave surface. The connecting groove has an arc-shaped structure, and the sealing platform is used to seal the connecting groove.

[0010] Preferably, the limiting plate is a semi-circular structure, and two limiting plates are spliced ​​together to form a circular structure. The inner sidewall of the limiting plate is rotatably connected to the outer sidewall of the support cylinder, which is used to support and limit the support cylinder and allow the support cylinder to rotate between the two limiting plates.

[0011] Preferably, an elastic sheet is fixedly connected to the outer wall of the support cylinder. The elastic sheet has an arc-shaped structure, and a positioning protrusion is fixedly connected to the side of the elastic sheet facing the limiting plate. The side of the positioning protrusion is an arc-shaped surface, which is used to position the angle of the support cylinder.

[0012] Preferably, the side of the limiting plate is provided with two positioning grooves for positioning the angle of the support cylinder and the sealing platform.

[0013] Preferably, a pressure plate is fixedly connected to the upper end of the extrusion column, and a hanging plate is fixedly connected to the side of the inoculation tube. The hanging plate has an arc-shaped structure and is used to position and place the inoculation tube.

[0014] The beneficial effects of this invention are as follows: Through the cooperation of the rubber piston and the support cylinder, precise quantitative control of the bacterial strain is achieved during the inoculation process. A connecting hole is provided inside the support cylinder. A pressure plate drives the squeezing column to rotate. As the squeezing column changes height, it moves the rubber ball along with it. The rubber ball compresses the air inside the connecting hole, thereby increasing the air pressure inside the connecting hole. When the air pressure reaches a certain value, the pressurized gas cleans the residual bacterial strain inside the needle, ensuring the accuracy of the bacterial inoculation and maintaining the same quality across different batches of vaccine. Attached Figure Description

[0015] Figure 1 This is a three-dimensional connection diagram of the inoculation tube provided by this utility model.

[0016] Figure 2 This is a schematic diagram of the internal connection of the inoculation tube provided by this utility model.

[0017] Figure 3 This is a schematic diagram of the internal connection of the rubber piston provided by this utility model.

[0018] Figure 4 This is a schematic diagram of the internal connection of the support cylinder provided by this utility model.

[0019] In the diagram: 1. Inoculation tube, 2. Needle, 3. Hanging plate, 4. Support cylinder, 5. Extrusion column, 6. Pressure plate, 7. Rubber piston, 8. Limiting plate, 9. Positioning groove, 10. Elastic sheet, 11. Positioning protrusion, 12. Pressurization hole, 13. Connecting cavity, 14. Connecting hole, 15. Rubber ball, 16. Limiting protrusion, 17. Connecting groove, 18. Sealing platform. Detailed Implementation

[0020] To make the objectives, technical solutions, and advantages of this utility model clearer, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present utility model and are not intended to limit the present utility model.

[0021] See Figures 1-4 This invention provides a precise quantitative device for inoculating bacterial strains for vaccine production. It includes an inoculation tube 1, with a needle 2 inserted into its lower end. A rubber piston 7 is slidably connected inside the inoculation tube 1, and a support cylinder 4 is inserted into the middle of the rubber piston 7 to push it and expel the bacterial strain. Two limiting plates 8 are fixedly connected to the upper end of the rubber piston 7; the fixing method can also be welding, riveting, screwing, or gluing. A pressure plate 6 is fixedly connected to the upper end of an extrusion column 5, and a hanging plate 3 with an arc-shaped structure is fixedly connected to the side of the inoculation tube 1 for positioning the inoculation tube 1. Through the cooperation of the rubber piston 7 and the support cylinder 4, the bacterial strain inside the inoculation tube 1 is discharged through the needle 2, achieving precise quantitative control of the bacterial strain during inoculation. The limiting plates 8 ensure the stability of the support cylinder 4 when pushing the rubber piston 7, thereby improving the accuracy and reliability of inoculation and avoiding inoculation failure or experimental errors caused by inaccurate bacterial strain quantity.

[0022] The support cylinder 4 has a connecting hole 14 inside. A squeezing column 5 is threadedly connected to the middle of the upper end of the support cylinder 4. A rubber ball 15 is located inside the connecting hole 14. The lower end of the squeezing column 5 is fixedly connected to the rubber ball 15. When the squeezing column 5 moves downward, it drives the rubber ball 15 to move, increasing the pressure inside the inoculation tube 1 to clear the bacteria inside the needle 2. The rubber piston 7 has a connecting cavity 13 inside. The lower end of the support cylinder 4 is inserted into the connecting cavity 13. A pressure hole 12 is located in the middle of the rubber piston 7 to release the air pressure inside the support cylinder 4. After the bacteria inside the inoculation tube 1 are discharged, the squeezing column 5 is moved by rotating the pressure plate 6. The squeezing column 5 drives the rubber ball 15 to move in the connecting hole 14 and compresses and pressurizes the air inside the connecting hole 14. A limiting protrusion 16 is fixedly connected in the middle of the connecting cavity 13. A connecting groove 17 is located in the middle of the limiting protrusion 16 to connect the pressure hole 12 and the connecting hole 14. A sealing platform 18 is fixedly connected in the inner wall of the support cylinder 4. The pressurized air reaches the pressurization hole 12 through the connecting groove 17 in the middle of the limiting protrusion 16, and is discharged from the pressurization hole 12 to clean the bacteria remaining inside the needle.

[0023] The limiting protrusion 16 is a hemispherical structure. The arc-shaped surface of the limiting protrusion 16 engages with the connecting hole 14 in the middle of the support cylinder 4, and is used to position and install the rubber piston 7 and the support cylinder 4. The sealing platform 18 is a semi-circular structure. The side of the sealing platform 18 facing the limiting protrusion 16 has an arc-shaped concave surface. The connecting groove 17 is an arc-shaped structure. The sealing platform 18 is used to seal the connecting groove 17 and isolate the connecting groove 17 from the pressure hole 12. When the inoculation tube draws in the inoculum, the arc-shaped concave surface of the sealing platform 18 fits tightly with the limiting protrusion 16 to form a sealed environment, preventing the inoculum from being drawn into the connecting hole 14.

[0024] The limiting plate 8 has a semi-circular structure. Two limiting plates 8 are spliced ​​together to form a circular structure. The inner wall of the limiting plate 8 is rotatably connected to the outer side of the support cylinder 4, which is used to support and limit the support cylinder 4 and allow the support cylinder 4 to rotate between the two limiting plates 8. An elastic sheet 10 is fixedly connected to the outer wall of the support cylinder 4. The elastic sheet 10 has an arc-shaped structure. A positioning protrusion 11 is fixedly connected to the side of the elastic sheet 10 facing the limiting plate 8. The side of the positioning protrusion 11 is an arc-shaped surface, which is used to position the angle of the support cylinder 4. The side of the limiting plate 8 is provided with two positioning grooves 9, which are used to position the angle between the support cylinder 4 and the sealing platform 18. By rotating the support cylinder 4, the angle of the support cylinder 4 is changed. At this time, the positioning protrusion 11 at the elastic sheet 10 moves from one positioning groove 9 to another positioning groove, positioning the angle of the support cylinder 4, thereby determining the position of the sealing platform 18 and ensuring that the sealing platform 18 can seal or open the communicating groove 17 of the limiting protrusion 16.

[0025] The above are merely preferred embodiments of the present utility model and are not intended to limit the present utility model. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A precise quantitative device for inoculating bacterial strains for vaccine production, comprising an inoculation tube (1), characterized in that: A needle (2) is inserted into the lower end of the inoculation tube (1). A rubber piston (7) is slidably connected inside the inoculation tube (1). A support cylinder (4) is inserted into the middle of the rubber piston (7) to push the rubber piston (7) to move and squeeze out the inoculum. Two limiting plates (8) are fixedly connected to the upper end of the rubber piston (7). The support cylinder (4) has a connecting hole (14) inside. The upper end of the support cylinder (4) is threaded with a squeezing column (5). The connecting hole (14) has a rubber ball (15) inside. The lower end of the squeezing column (5) is fixedly connected to the rubber ball (15). When the squeezing column (5) moves downward, it drives the rubber ball (15) to move and increase the pressure inside the inoculation tube (1) to clear the bacteria inside the needle (2). The rubber piston (7) has a connecting cavity (13) inside, and the lower end of the support cylinder (4) is inserted into the connecting cavity (13). The rubber piston (7) has a pressure hole (12) in the middle to release the air pressure inside the support cylinder (4). The connecting cavity (13) is fixedly connected to a limiting protrusion (16), and the limiting protrusion (16) is provided with a connecting groove (17) in the middle for connecting the pressurizing hole (12) and the connecting hole (14). A sealing platform (18) is fixedly connected to the inner wall of the support cylinder (4).

2. The precise quantitative device for inoculating bacterial strains for vaccine production according to claim 1, characterized in that: The limiting protrusion (16) is a hemispherical structure. The arc-shaped surface of the limiting protrusion (16) is engaged with the connecting hole (14) in the middle of the support cylinder (4) to position and install the rubber piston (7) and the support cylinder (4).

3. The precise quantitative device for inoculating vaccine production strains according to claim 1, characterized in that: The sealing platform (18) has a semi-circular structure. The side of the sealing platform (18) facing the limiting protrusion (16) has an arc-shaped concave surface. The connecting groove (17) has an arc-shaped structure. The sealing platform (18) is used to seal the connecting groove (17).

4. The precise quantitative device for inoculating bacterial strains for vaccine production according to claim 1, characterized in that: The limiting plate (8) is a semi-circular structure. The two limiting plates (8) are spliced ​​together to form a circular structure. The inner sidewall of the limiting plate (8) is rotatably connected to the outer sidewall of the support cylinder (4) to support and limit the support cylinder (4) and to allow the support cylinder (4) to rotate between the two limiting plates (8).

5. The precise quantitative device for inoculating bacterial strains for vaccine production according to claim 1, characterized in that: An elastic sheet (10) is fixedly connected to the outer wall of the support cylinder (4). The elastic sheet (10) has an arc-shaped structure. A positioning protrusion (11) is fixedly connected to the side of the elastic sheet (10) facing the limiting plate (8). The side of the positioning protrusion (11) is an arc-shaped surface, which is used to position the angle of the support cylinder (4).

6. The precise quantitative device for inoculating bacterial strains for vaccine production according to claim 1, characterized in that: The side of the limiting plate (8) is provided with two positioning grooves (9) for positioning the angle of the support cylinder (4) and the sealing platform (18).

7. The precise quantitative device for inoculating bacterial strains for vaccine production according to claim 1, characterized in that: The upper end of the extrusion column (5) is fixedly connected to a pressure plate (6), and the side of the inoculation tube (1) is fixedly connected to a hanging plate (3). The hanging plate (3) is an arc-shaped structure used to position and place the inoculation tube (1).

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