Drug experiment sample gradient dilution automation equipment

Abstract

The utility model discloses a medicine experiment sample gradient dilution automation equipment mainly relates to sample gradient dilution equipment. Including bottom plate and adjusting structure, the upper surface fixed connection of bottom plate has transverse adjusting mechanism, the surface mounting of transverse adjusting mechanism has main shaft, the surface mounting of main shaft has pipettor, the surface of pipettor is equipped with adjusting structure, adjusting structure includes electric push rod, electric push rod and pipettor fixed connection, the output fixed connection of electric push rod card frame, the inner wall of card frame is connected with adjusting frame, the surface sliding connection of adjusting frame and pipettor, the both sides of adjusting frame all are connected with adjusting arm rotation. The utility model has the beneficial effect that: automatic clamping and releasing are carried out to the suction tube, the electric push rod is driven to drive the clamping arm to open and close, the firmness of the connection of the suction head and the suction tube is ensured, the dilution operation accuracy and the automation efficiency are improved.

Description

Technical Field

[0001] This utility model relates to the field of sample gradient dilution equipment technology, and in particular to automated equipment for gradient dilution of drug experimental samples. Background Technology

[0002] Gradual dilution of samples is a device that continuously dilutes the original sample according to a certain ratio to obtain a series of solutions with different concentrations.

[0003] Existing technologies, such as the utility model patent with publication number CN221440750U, disclose a device for gradient dilution of bacterial solutions. This patent employs a base and a dilution assembly slidably connected to the base for rapid dilution of the bacterial solution. It also includes a coating assembly comprising a coating box and a culture medium tray slidably connected to the base. The coating box can be moved away from above the culture medium tray to facilitate the movement of the injection column above the culture medium tray, thereby facilitating the injection of the diluted bacterial solution into the culture dishes. After the bacterial solution is injected into the culture dishes, the coating box can slide again, positioning the culture medium tray below the coating box, allowing the coating rod inside the coating box to extend downwards into the culture dishes for coating. A first-step motor drives the culture medium tray to rotate. After injecting and coating one culture dish, another culture dish can be rotated to the same position for injection and coating.

[0004] The inventors discovered the following problems in their daily work when using gradient dilution equipment: the fixing method between pipettes and pipette tips mostly still relies on simple physical insertion and removal, that is, manually or mechanically forcibly putting the pipette on the tip. This method has obvious defects: First, in long-term, large-volume operations, the pipette may loosen due to vibration or collision with the container wall, resulting in insufficient airtightness, causing liquid leakage or inaccurate pipetting volume, which seriously affects the accuracy of gradient dilution; Second, for equipment that needs to be compatible with different sizes of pipettes, this simple connection method cannot guarantee that the connection is consistent every time. Utility Model Content

[0005] The purpose of this invention is to address the shortcomings of existing technologies, such as low stability in the connection between pipettes and liquid pipettes, which leads to low experimental efficiency.

[0006] To achieve the above objectives, this utility model adopts the following technical solution: an automated gradient dilution device for drug experimental samples, comprising a base plate and an adjustment structure. A lateral adjustment mechanism is fixedly connected to the upper surface of the base plate. A main shaft is mounted on the surface of the lateral adjustment mechanism. A pipette is mounted on the surface of the main shaft. Several pipette tips are provided at the lower end of the pipette. Pipettes are fixedly connected to the surfaces of the pipette tips via the adjustment structure. A fixing plate is fixedly connected to the upper surface of the base plate. Several containers are abutted against the upper surface of the fixing plate. An adjustment structure is provided on the surface of the pipette. The adjustment structure includes an electric push rod, which is fixedly connected to the pipette. A retaining frame is fixedly connected to the output end of the electric push rod. An adjustment frame is engaged with the inner wall of the retaining frame. The adjustment frame is slidably connected to the surface of the pipette. Adjustment arms are rotatably connected to both sides of the adjustment frame. Two support frames are fixedly connected to both sides of the pipette at positions corresponding to the adjustment arms. Clamping arms are rotatably connected to the inner walls of the support frames. The clamping arms are rotatably connected to the ends of the adjustment arms away from the adjustment frames. A clamping plate is fixedly connected to the ends of the clamping arms away from the support frames.

[0007] The aforementioned components achieve the following effects: automatically clamping and releasing the pipette, and driving the clamping arm to open and close via an electric actuator, ensuring a firm connection between the pipette tip and the pipette, preventing it from falling off during pipetting, and improving the accuracy and automation efficiency of dilution operations.

[0008] Preferably, a plurality of sliding rods are fixedly connected to both sides of the pipette, and the surfaces of the plurality of sliding rods are slidably connected to the adjustment frame.

[0009] The effect achieved by the above components is to guide the movement of the adjustment frame with the slide bar, making its movement more stable, preventing the adjustment frame from deviating, and improving the stability and reliability of the clamping structure.

[0010] Preferably, a plurality of reserved slots are provided on the side of the two clamping plates that are close to each other, corresponding to the position of the suction head, and the reserved slots are arc-shaped slots.

[0011] The effects achieved by the above components are: the arc design of the reserved slot better accommodates the suction head, avoids direct contact between the clamping plate and the suction head, reduces wear, and at the same time makes the clamping force evenly distributed, protecting the integrity of the suction head.

[0012] Preferably, anti-slip pads are fixedly connected to the sides of the two clamps that are close to each other, and the anti-slip pads are rubber pads.

[0013] The effects achieved by the above components are as follows: the anti-slip pad increases the friction between the clamp and the straw, preventing the straw from sliding or rotating during clamping, ensuring a firm connection, and improving operational safety.

[0014] Preferably, the upper surface of the fixed plate is provided with an auxiliary structure, the auxiliary structure including two sliding grooves, the two sliding grooves being formed on the fixed plate, and a plurality of sliders being slidably connected to the inner walls of the two sliding grooves, the plurality of sliders being grouped in pairs, an auxiliary frame being fixedly connected to the upper surface of the sliders in the same group, an auxiliary frame being fixedly connected to one side of the auxiliary frame, the inner wall of the auxiliary frame being slidably connected to the container, and an auxiliary rod being threaded into the upper surface of the auxiliary frame.

[0015] The effects achieved by the above components are: rapid positioning and fixation of containers, adaptation to containers of different sizes through the sliding auxiliary frame, restriction of container position by the auxiliary frame, and stability of the container after the auxiliary rod is locked, which facilitates pipetting operations and improves the adaptability and efficiency of experiments.

[0016] Preferably, the lower surface of the slider is rotatably connected to two pulleys, and the arc surface of the pulleys is slidably connected to the groove.

[0017] The effects achieved by the above components are as follows: the pulley reduces the friction between the slider and the groove, making the auxiliary frame move lightly and effortlessly, adjusting the position more smoothly, and improving the ease of operation.

[0018] Preferably, the upper surface of the fixing plate is provided with an auxiliary groove corresponding to the position of the auxiliary rod, and the inner wall of the auxiliary groove is fixedly connected with a number of anti-slip protrusions.

[0019] The effects achieved by the above components are as follows: the auxiliary groove cooperates with the auxiliary rod, the anti-slip protrusion increases the friction, prevents the auxiliary rod from loosening, ensures that the auxiliary frame is firmly fixed, and enhances the overall stability.

[0020] In summary, the beneficial effects of this utility model are as follows:

[0021] In this invention, an adjustment structure enables rapid, precise, and reliable automated clamping and disassembly of pipettes and pipette tips. This structure provides stable power via an electric actuator, driving a linkage mechanism composed of a clamping frame, an adjustment frame, an adjustment arm, and a clamping arm. This ultimately translates into the synchronous opening and closing of two clamping plates. This design replaces the traditional method of manually inserting and removing pipettes, resulting in: first, significantly improved operational efficiency, particularly suitable for gradient dilution processes requiring large volumes and multiple pipetting operations; second, mechanical clamping ensures the airtightness and consistency of each pipette and tip connection, effectively preventing loose connections or liquid leakage caused by uneven manual force, thus guaranteeing the accuracy and repeatability of gradient dilution; and third, reduced operator workload and skill dependence, enhancing the automation level and reliability of the entire drug experiment.

[0022] By setting up an auxiliary structure, experimental containers can be flexibly and stably positioned and fixed. This structure allows the auxiliary frame to be quickly adjusted according to the size of different containers by sliding the slider in the groove. Then, the threaded self-locking principle between the auxiliary rod and the fixed plate is used to firmly lock them, which greatly enhances the stability of the containers during the liquid transfer process, prevents them from tipping over or shifting due to contact, and ensures the accuracy of the sample addition operation. It also simplifies the steps of container replacement and layout adjustment, and provides strong support for the continuity and efficiency of the experimental process. Attached Figure Description

[0023] Appendix Figure 1 This is a three-dimensional structural schematic diagram of the present invention;

[0024] Appendix Figure 2 This is a schematic diagram of the adjustment structure of this utility model;

[0025] Appendix Figure 3 This is a partial structural schematic diagram of the adjustment structure of this utility model;

[0026] Appendix Figure 4 This is a partial structural diagram of the auxiliary structure of this utility model.

[0027] The following are the labels in the attached diagram: 1. Base plate; 2. Lateral adjustment mechanism; 3. Main shaft; 4. Pipette; 5. Pipette; 6. Adjustment structure; 601. Electric actuator; 602. Clip frame; 603. Adjustment frame; 604. Slide rod; 605. Adjustment arm; 606. Support frame; 607. Clamping arm; 608. Clamping plate; 609. Reserved groove; 610. Anti-slip pad; 7. Auxiliary structure; 71. Slide groove; 72. Slider; 73. Pulley; 74. Auxiliary frame; 75. Auxiliary frame; 76. Auxiliary rod; 77. Auxiliary groove; 8. Fixing plate; 9. Container. Detailed Implementation

[0028] The present invention will be further illustrated below with reference to specific embodiments. It should be understood that these embodiments are for illustrative purposes only and are not intended to limit the scope of the present invention. Furthermore, it should be understood that after reading the teachings of this invention, those skilled in the art can make various alterations or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims.

[0029] Reference Figure 1As shown, this utility model provides a technical solution: an automated gradient dilution device for drug experimental samples, including a base plate 1 and an adjustment structure 6. A transverse adjustment mechanism 2 is fixedly connected to the upper surface of the base plate 1. A main shaft 3 is mounted on the surface of the transverse adjustment mechanism 2. A pipette 4 is mounted on the surface of the main shaft 3. Several pipette tips are provided at the lower end of the pipette 4. Pipettes 5 are fixedly connected to the surfaces of the pipette tips via the adjustment structure 6. A fixing plate 8 is fixedly connected to the upper surface of the base plate 1. Several containers 9 are abutted against the upper surface of the fixing plate 8. The adjustment structure 6 is provided on the surface of the pipette 4, and an auxiliary structure 7 is provided on the upper surface of the fixing plate 8.

[0030] The specific settings and functions of its adjustment structure 6 and auxiliary structure 7 will be discussed below.

[0031] Reference Figure 2 and Figure 3 As shown in this embodiment: the adjustment structure 6 includes an electric actuator 601, which is fixedly connected to the pipette 4. The output end of the electric actuator 601 is fixedly connected to a retaining frame 602. An adjustment frame 603 is engaged with the inner wall of the retaining frame 602. The adjustment frame 603 is slidably connected to the surface of the pipette 4. Adjustment arms 605 are rotatably connected to both sides of the adjustment frame 603. Two support frames 606 are fixedly connected to the two sides of the pipette 4 at positions corresponding to the adjustment arms 605. Clamping arms 607 are rotatably connected to the inner walls of the support frames 606. The clamping arms 607 are rotatably connected to the end of the adjustment arm 605 away from the adjustment frame 603. A clamping plate 608 is fixedly connected to the end of the clamping arm 607 away from the support frame 606 to automatically clamp and release the pipette 5. The electric actuator 601 drives the clamping arms 607 to open and close, ensuring a firm connection between the pipette tip and the pipette 5, preventing it from falling off during pipetting, and improving the accuracy and automation efficiency of the dilution operation. Several sliding rods 604 are fixedly connected to both sides of the pipette 4. The surfaces of the sliding rods 604 are slidably connected to the adjustment frame 603. The sliding rods 604 guide the movement of the adjustment frame 603, making its movement more stable and preventing the adjustment frame 603 from deviating, thereby improving the stability and reliability of the clamping structure. Several reserved slots 609 are provided on the side of the two clamping plates 608 that are close to each other, corresponding to the position of the pipette tip. The reserved slots 609 are arc-shaped. The arc design of the reserved slots 609 better accommodates the pipette tip, avoids direct contact between the clamping plate 608 and the pipette tip, reduces wear, and at the same time makes the clamping force evenly distributed, protecting the integrity of the pipette tip. Anti-slip pads 610 are fixedly connected to the side of the two clamping plates 608 that are close to each other. The anti-slip pads 610 are rubber pads. The anti-slip pads 610 increase the friction between the clamping plate 608 and the pipette 5, preventing the pipette 5 from sliding or rotating during the clamping process, ensuring a firm connection, and improving operational safety.

[0032] Reference Figure 4As shown in this embodiment: the auxiliary structure 7 includes two slide grooves 71, which are formed on the fixed plate 8. Several sliders 72 are slidably connected to the inner walls of the two slide grooves 71, with each pair of sliders 72 forming a group. An auxiliary frame 74 is fixedly connected to the upper surface of the sliders 72 in the same group. An auxiliary frame 75 is fixedly connected to one side of the auxiliary frame 74. The inner wall of the auxiliary frame 75 is slidably connected to the container 9. An auxiliary rod 76 is threaded into the upper surface of the auxiliary frame 74 for quick positioning and fixing of the container 9. The sliding auxiliary frame 74 adapts to containers 9 of different sizes, the auxiliary frame 75 restricts the position of the container 9, and the locking of the auxiliary rod 76 ensures the stability of the container 9. To facilitate pipetting operations and improve the adaptability and efficiency of experiments, two pulleys 73 are rotatably connected to the lower surface of the slider 72. The arc surface of the pulleys 73 is slidably connected to the slide groove 71. The pulleys 73 reduce the friction between the slider 72 and the slide groove 71, making the auxiliary frame 74 easy to move and effortless, and smoother when adjusting its position, thus improving the convenience of operation. An auxiliary groove 77 is provided on the upper surface of the fixing plate 8 at the position corresponding to the auxiliary rod 76. Several anti-slip protrusions are fixedly connected to the inner wall of the auxiliary groove 77. The auxiliary groove 77 cooperates with the auxiliary rod 76, and the anti-slip protrusions increase the friction, prevent the auxiliary rod 76 from loosening, ensure that the auxiliary frame 74 is firmly fixed, and enhance the overall stability.

[0033] Detailed Instructions for Use: By setting the adjustment structure 6, first activate the electric actuator 601, controlling the output end of the electric actuator 601 to retract. The electric actuator 601 drives the clamping frame 602 to move upward, and the clamping frame 602 in turn drives the adjustment frame 603 to move upward along the pipette 4. During this process, the adjustment frame 603 drives the adjustment arms 605 on both sides to move. The end of the adjustment arm 605 away from the adjustment frame 603 drives the clamping arm 607 to move, causing the clamping arm 607 to rotate along the inner wall of the support frame 606. At this time, the clamping arm 607 drives the clamping plate 608 away from the pipette tip at the lower end of the pipette 4. After the two clamping plates 608 open a certain distance away from each other, the horizontal adjustment mechanism 2 and the main shaft 3 control the pipette 4 to approach the pipette 5 container 9, so that the pipette tip at the lower end of the pipette 4 is inserted into the pipette 5. Then, control the output end of the electric actuator 601. Extending, the electric actuator 601 drives the adjusting frame 603 downward through the clamping frame 602. The adjusting frame 603 drives the clamping arm 607 to rotate and close along the support frame 606 through the adjusting arm 605. The clamping arms 607 on both sides of the pipette 4 drive the clamping plate 608 to fix the pipette 5 to the pipette tip. The sliding rod 604 guides the movement of the adjusting frame 603, making its movement more stable and preventing the adjusting frame 603 from deviating, thus improving the stability and reliability of the clamping structure. The arc design of the reserved groove 609 better accommodates the pipette tip, avoids direct contact between the clamping plate 608 and the pipette tip, reduces wear, and at the same time makes the clamping force evenly distributed, protecting the integrity of the pipette tip. The anti-slip pad 610 increases the friction between the clamping plate 608 and the pipette 5, preventing the pipette 5 from sliding or rotating during clamping, ensuring a firm connection and improving operational safety.

[0034] By setting up auxiliary structure 7, first rotate auxiliary rod 76. Auxiliary rod 76 moves upward along auxiliary frame 74 away from fixed plate 8 via threads, releasing the limitation on auxiliary frame 74. At this time, auxiliary frame 74 can be moved along fixed plate 8. The sliders 72 at both ends of auxiliary frame 74 always move along slide groove 71. The two auxiliary frames 74 limit the two sides of container 9 and make the auxiliary frame 75 on auxiliary frame 74 fit tightly against the surface of container 9. Then rotate auxiliary rod 76 in the opposite direction. Auxiliary rod 76 moves downward along auxiliary frame 74 via threads. Auxiliary rod 76 presses fixed plate 8 to fix the position of auxiliary frame 74, thereby fixing the position of container 9. Among them, pulley 73 reduces the friction between slider 72 and slide groove 71, making auxiliary frame 74 move lightly and effortlessly, and making position adjustment smoother, improving the convenience of operation. Auxiliary groove 77 cooperates with auxiliary rod 76, and anti-slip protrusions increase friction to prevent auxiliary rod 76 from loosening, ensuring that auxiliary frame 74 is firmly fixed and enhancing overall stability.

Claims

1. An automated device for gradient dilution of drug test samples, comprising a base plate (1) and an adjustment structure (6), characterized in that: A lateral adjustment mechanism (2) is fixedly connected to the upper surface of the base plate (1). A main shaft (3) is mounted on the surface of the lateral adjustment mechanism (2). A pipette (4) is mounted on the surface of the main shaft (3). Several pipette tips are provided at the lower end of the pipette (4). Pipettes (5) are fixedly connected to the surfaces of the pipette tips via an adjustment structure (6). A fixing plate (8) is fixedly connected to the upper surface of the base plate (1). Several containers (9) are abutted against the upper surface of the fixing plate (8). An adjustment structure (6) is provided on the surface of the pipette (4). The adjustment structure (6) includes an electric push rod (601). The electric push rod (601) is fixedly connected to the pipette (4). The output end of (601) is fixedly connected to a frame (602). An adjustment frame (603) is snapped into the inner wall of the frame (602). The adjustment frame (603) is slidably connected to the surface of the pipette (4). Adjustment arms (605) are rotatably connected to both sides of the adjustment frame (603). Two support frames (606) are fixedly connected to both sides of the pipette (4) at positions corresponding to the adjustment arms (605). A clamping arm (607) is rotatably connected to the inner wall of the support frame (606). The clamping arm (607) is rotatably connected to the end of the adjustment arm (605) away from the adjustment frame (603). A clamping plate (608) is fixedly connected to the end of the clamping arm (607) away from the support frame (606).

2. The automated gradient dilution device for drug experimental samples according to claim 1, characterized in that: Several slide rods (604) are fixedly connected to both sides of the pipette (4), and the surfaces of the slide rods (604) are slidably connected to the adjustment frame (603).

3. The automated gradient dilution device for drug experimental samples according to claim 1, characterized in that: Several reserved slots (609) are provided on the side of the two clamping plates (608) that are close to each other, corresponding to the position of the suction head. The reserved slots (609) are arc-shaped slots.

4. The automated gradient dilution device for drug experimental samples according to claim 1, characterized in that: Each of the two clamping plates (608) is fixedly connected to an anti-slip pad (610) on the side closest to each other. The anti-slip pad (610) is a rubber pad.

5. The automated gradient dilution device for drug test samples according to claim 1, characterized in that: The upper surface of the fixed plate (8) is provided with an auxiliary structure (7). The auxiliary structure (7) includes two slide grooves (71). The two slide grooves (71) are opened on the fixed plate (8). Several sliders (72) are slidably connected to the inner walls of the two slide grooves (71). The sliders (72) are grouped in pairs. An auxiliary frame (74) is fixedly connected to the upper surface of the sliders (72) in the same group. An auxiliary frame (75) is fixedly connected to one side of the auxiliary frame (74). The inner wall of the auxiliary frame (75) is slidably connected to the container (9). An auxiliary rod (76) is threaded into the upper surface of the auxiliary frame (74).

6. The automated gradient dilution device for drug test samples according to claim 5, characterized in that: The lower surface of the slider (72) is rotatably connected to two pulleys (73), and the arc surface of the pulleys (73) is slidably connected to the groove (71).

7. The automated gradient dilution device for drug test samples according to claim 5, characterized in that: An auxiliary groove (77) is provided on the upper surface of the fixed plate (8) at the position corresponding to the auxiliary rod (76), and a number of anti-slip protrusions are fixedly connected to the inner wall of the auxiliary groove (77).

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