Restraint device for mouse studies

Abstract

The utility model discloses a fixing device for mouse research, including bottom plate, first fixed mechanism and second fixed mechanism, and first fixed mechanism includes head fixing spare and sets up the support assembly on the bottom plate, and head fixing spare is detachably connected with support assembly and is used for fixing the head of mouse, and second fixed mechanism sets up in bottom plate and includes accommodation cylinder, and accommodation cylinder has the inner chamber for accommodating mouse, and the wall portion of inner chamber can restrict the activity of mouse trunk, and accommodation cylinder is equipped with the observation window that communicates the inner chamber, and observation window can make mouse in inner chamber at least head expose, to be used for observing mouse. The utility model utilizes the trunk of accommodation cylinder to mouse and restricts its activity, and the operation of mouse trunk fixation is simplified, and the cylindrical design of accommodation cylinder makes mouse's four limbs difficult to find suitable fixed fulcrum or support surface, is favorable to reduce the interference of single force in its struggling process to the imaging, reduces the possibility of picture shaking in the imaging process.

Description

Technical Field

[0001] This utility model relates to the field of biological research auxiliary tools, and in particular to a fixation device for mouse research. Background Technology

[0002] With the development of two-photon microscopy, researchers can now investigate the relationship between neuronal function and multiple factors (such as specific behaviors and diseases) at in vivo single-cell resolution. Because the brain structure of mice is highly conserved compared to that of humans, and mice, as a mammalian model organism, have advantages such as low breeding difficulty and short experimental cycles, and because they can effectively mimic some human behavioral patterns, they are widely used in neuroscience. During research, mice need to be immobilized for observation. Some existing immobilization devices surgically fix the mouse's head with a head fixator, while the mouse's trunk is placed directly on a flat surface. This type of immobilization device is generally only suitable for anesthetized mice. For awake mice, some immobilization devices use a combination of a head fixator and straps: the head fixator is surgically fixed to the mouse's head, while the trunk is strapped to a fixation plate. However, this fixation method has obvious drawbacks: the operation is relatively complex and troublesome, and the mice are prone to strong struggles during the binding process, which increases the difficulty of the operation; in addition, during the observation process, the mice with their trunks bound are prone to struggle due to discomfort, which will cause shaking of the imaging image and affect the observation and research of the mouse brain structure. Utility Model Content

[0003] This invention aims to solve at least one of the technical problems existing in the prior art. To this end, this invention proposes a fixation device for mouse research, which uses a accommodating cylinder to contain the mouse's torso and restrict its movement. The structure is simple and simplifies the operation of fixing the mouse's torso. The cylindrical design of the accommodating cylinder makes it difficult for the mouse's limbs to find a suitable fixation point or support surface, which helps to reduce the interference of a single force on the imaging during the mouse's struggle, thereby reducing the possibility and degree of image shaking during the imaging process.

[0004] The fixation device for mouse research according to an embodiment of the present invention includes a base plate, a first fixation mechanism, and a second fixation mechanism. The first fixation mechanism includes a head fixation member and a support assembly disposed on the base plate. The head fixation member is detachably connected to the support assembly and is used to fix the head of the mouse. The second fixation mechanism is disposed on the base plate and includes a receiving cylinder. The receiving cylinder has an inner cavity for receiving the mouse. The wall of the inner cavity can restrict the movement of the mouse's trunk. The receiving cylinder is provided with an observation window communicating with the inner cavity. The observation window can expose at least the head of the mouse in the inner cavity for observation of the mouse.

[0005] The fixation device for mouse research according to the embodiments of this utility model has at least the following beneficial effects: In use, the head fixation component is surgically fixed to the mouse's head, and then the mouse is placed in the inner cavity of the accommodating cylinder. The head fixation component is fixed by connecting with the support assembly, thereby fixing the mouse's head. The size of the inner cavity is adapted to the size of the mouse's body, and the wall of the inner cavity restricts the movement of the mouse's torso, thereby fixing the mouse's torso. This utility model has a simple and reasonable structure. By using the accommodating cylinder to accommodate the mouse's torso and restrict its movement, it simplifies the operation of fixing the mouse's torso. Moreover, the cylindrical design of the accommodating cylinder makes it difficult for the mouse's limbs to find a suitable fixation point or support surface, which helps to reduce the interference of a single force on imaging during its struggle, thereby reducing the possibility and degree of image shaking during imaging.

[0006] According to some embodiments of the present invention, the second fixing mechanism further includes a connecting component, the receiving cylinder is connected to the base plate through the connecting component, the receiving cylinder can be disassembled and replaced relative to the connecting component and / or the second fixing mechanism can be disassembled and replaced relative to the base plate.

[0007] According to some embodiments of the present invention, the connecting assembly includes connecting posts and connecting members. Multiple connecting posts are provided and spaced apart on the base plate. Multiple connecting members are provided corresponding to the connecting posts. One end of the connecting member is connected to the corresponding connecting post, and the other end of the connecting member is provided with a hook. The side of the receiving cylinder is provided with an ear plate, and the hook is detachably hooked onto the ear plate.

[0008] According to some embodiments of the present invention, an elastic portion is provided between the two ends of the connector, and when the two ends of the connector are respectively connected to the connecting post and the receiving cylinder, the elastic portion is in a stretched state.

[0009] According to some embodiments of the present invention, the base plate is provided with mounting holes, the connecting column can cooperate with the mounting holes, and the mounting holes are provided in a plurality of parallel arrays distributed on the base plate.

[0010] According to some embodiments of the present invention, the accommodating tube is provided with a cut structure parallel to the axis of the accommodating tube to form an observation window that exposes the head and torso of the mouse in the cavity.

[0011] According to some embodiments of the present invention, the accommodating tube is provided with a cut structure inclined to the axis of the accommodating tube to form an observation window that exposes the head of the mouse in the inner cavity.

[0012] According to some embodiments of the present invention, the accommodating tube is provided with a blocking part, which is located on the front side of the mouse's head in the inner cavity and has an avoidance notch corresponding to the breathing position of the mouse's head.

[0013] According to some embodiments of the present invention, the support assembly includes a support column and a connecting beam. Two support columns are provided and are respectively located on both sides of the receiving tube. The two ends of the connecting beam are respectively connected to the two support columns. The head fixing member is detachably connected to the middle of the connecting beam and is located on the upper side of the observation window.

[0014] According to some embodiments of the present invention, the longitudinal position of the head fixing member relative to the receiving cylinder is adjustable.

[0015] Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0016] The above and / or additional aspects and advantages of this utility model will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which:

[0017] Figure 1 This is a schematic diagram of the fixation device used in mouse research according to an embodiment of the present invention;

[0018] Figure 2 for Figure 1 A schematic diagram of the structure in which the fixing device is in another state;

[0019] Figure 3 for Figure 1 A schematic diagram of the structure after the fixing device is replaced with another type of receiving cylinder.

[0020] Figure label:

[0021] Base plate 100, mounting holes 101;

[0022] First fixing mechanism 200, opening slot 201, head fixing part 210, support column 220, connecting beam 230, mounting base 240, locking screw 250;

[0023] The second fixing mechanism 300, the inner cavity 301, the observation window 302, the accommodating tube 310, the ear plate 311, the blocking part 312, the connecting column 320, the connecting piece 330, the hook part 331, and the elastic part 332. Detailed Implementation

[0024] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this utility model, and should not be construed as limiting this utility model.

[0025] In the description of this utility model, it should be understood that if directional descriptions are involved, such as up, down, front, back, left, right, etc., indicating the directional or positional relationship based on the directional or positional relationship shown in the accompanying drawings, it is only for the convenience of describing this utility model and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0026] In the description of this utility model, if words such as several, greater than, less than, exceeding, above, below, or within appear, several means one or more, multiple means two or more, greater than, less than, exceeding, etc. are understood to exclude the number itself, and above, below, or within are understood to include the number itself.

[0027] If the terms "first" and "second" are used only to distinguish technical features, they should not be construed as indicating or implying relative importance, or implicitly indicating the number of technical features indicated, or implicitly indicating the order of the technical features indicated.

[0028] In the description of this utility model, unless otherwise explicitly defined, terms such as "setting," "installation," and "connection" should be interpreted broadly, and those skilled in the art can reasonably determine the specific meaning of the above terms in this utility model in conjunction with the specific content of the technical solution.

[0029] Reference Figure 1 , Figure 2 and Figure 3A fixation device for mouse research includes a base plate 100, a first fixation mechanism 200, and a second fixation mechanism 300. The first fixation mechanism 200 includes a head fixation member 210 and a support assembly disposed on the base plate 100. The head fixation member 210 is detachably connected to the support assembly and is used to fix the head of the mouse. The second fixation mechanism 300 is disposed on the base plate 100 and includes a receiving cylinder 310. The receiving cylinder 310 has an inner cavity 301 for receiving the mouse. The wall of the inner cavity 301 can restrict the movement of the mouse's torso. The receiving cylinder 310 is provided with an observation window 302 communicating with the inner cavity 301. The observation window 302 can expose at least the head of the mouse in the inner cavity 301 for observation of the mouse.

[0030] Understandably, such as Figure 1 , Figure 2 and Figure 3 As shown, both the first fixing mechanism 200 and the second fixing mechanism 300 are connected to the base plate 100. The head fixing member 210 is located on the upper side of the observation window 302 through its connection with the support assembly. In use, the head fixing member 210 is first disassembled from the support assembly. The head fixing member 210 is surgically fixed to the mouse's head. Then, the mouse is placed in the inner cavity 301 of the accommodating tube 310, with its head exposed outside the inner cavity 301 through the observation window 302 of the accommodating tube 310. The head fixing member 210 on the mouse's head is connected to the support assembly to fix it on the upper side of the observation window 302, thereby fixing the mouse's head. The size of the inner cavity 301 is adapted to the size of the mouse's body. The walls of the inner cavity 301 restrict the movement of the mouse's trunk, thereby fixing the mouse's trunk. This invention has a simple and reasonable structure. It uses the container 310 to contain the mouse's torso and restrict its movement, which simplifies the operation of fixing the mouse's torso. The cylindrical design of the container 310 makes it difficult for the mouse's limbs to find a suitable fixed fulcrum or support surface, which helps to reduce the interference of a single force on the imaging during its struggle, thereby reducing the possibility and degree of image shaking during the imaging process.

[0031] In practical applications, the specific structures of the base plate 100, the first fixing mechanism 200, and the second fixing mechanism 300 can be set according to actual usage needs. They will not be described in detail here, but will be explained in detail below.

[0032] In some embodiments, the second fixing mechanism 300 further includes a connecting component, the receiving cylinder 310 is connected to the base plate 100 through the connecting component, the receiving cylinder 310 can be disassembled and replaced relative to the connecting component and / or the second fixing mechanism 300 can be disassembled and replaced relative to the base plate 100.

[0033] Understandably, by making the receiving tube 310 detachable and / or the second fixation mechanism 300 entirely detachable and replaceable, the body size of mice of different ages can vary. Therefore, by replacing the receiving tube 310 with a different size or replacing the second fixation mechanism 300 entirely, the body fixation needs of mice of different ages can be met, thus improving adaptability. In practical applications, when replacing different receiving tubes 310 or different second fixation mechanisms 300, the head fixation component 210 can also be replaced accordingly as needed, and the specific configuration can be set according to actual usage requirements.

[0034] In some embodiments, the connecting assembly includes connecting posts 320 and connecting members 330. Multiple connecting posts 320 are provided and spaced apart on the base plate 100. Multiple connecting members 330 are provided corresponding to the connecting posts 320. One end of the connecting member 330 is connected to the corresponding connecting post 320, and the other end of the connecting member 330 is provided with a hook 331. The side of the receiving cylinder 310 is provided with an ear plate 311, and the hook 331 is detachably hooked onto the ear plate 311.

[0035] Understandably, such as Figure 1 , Figure 2 and Figure 3 As shown, four connecting posts 320 are arranged in a rectangular array around the accommodating cylinder 310, and four corresponding connecting pieces 330 are provided. Similarly, four corresponding ear plates 311 are also provided. One end of the connecting piece 330 is connected to the corresponding connecting post 320, and the other end is hooked to the ear plate 311 via a hook 331, thereby achieving a detachable connection between the accommodating cylinder 310 and the connecting assembly. The structure is simple and easy to disassemble and replace. In practical applications, the connecting posts 320 and the connecting pieces 330 can also be connected by hooking, or by bonding, welding, sleeve, etc. In addition to the above methods, the connecting assembly and the accommodating cylinder 310 can also be detachably connected by a threaded structure, or the connecting assembly and the base plate 100 can be detachably replaced by a threaded structure. The specific configuration can be set according to the usage requirements.

[0036] In some embodiments, an elastic portion 332 is provided between the two ends of the connector 330. When the two ends of the connector 330 are respectively connected to the connecting post 320 and the receiving cylinder 310, the elastic portion 332 is in a stretched state.

[0037] Understandably, such as Figure 1 , Figure 2 and Figure 3As shown, the two ends of the connector 330 form a spring structure to create an elastic part 332. When the two ends of the connector 330 are connected to the connecting post 320 and the receiving cylinder 310 respectively, the elastic part 332 is in a stretched state, forming a structure similar to a trampoline. Part of the force exerted by the mouse on the receiving cylinder 310 can be released through the elastic part 332 of the connector 330, thereby reducing the interference of force on imaging during its struggle and further reducing the possibility and degree of image jitter during imaging. In practical applications, in addition to the spring structure, the elastic part 332 can also be made of an elastic material or use other types of elastic structures, depending on the specific application requirements.

[0038] In some embodiments, the base plate 100 is provided with mounting holes 101, and the connecting post 320 can cooperate with the mounting holes 101. The mounting holes 101 are provided in a plurality of parallel arrays distributed on the base plate 100.

[0039] Understandably, such as Figure 1 , Figure 2 and Figure 3 As shown, multiple mounting holes 101 are arrayed and distributed on the base plate 100. When replacing the receiving cylinder 310 of different sizes, the position of the connecting post 320 may need to be adjusted accordingly. At this time, the connecting post 320 can be matched with different mounting holes 101 to adjust its position accordingly to meet the usage requirements. Furthermore, other components can be installed through the mounting holes 101 for expansion, increasing expandability and facilitating use. In practical applications, the specific number and distribution of mounting holes 101 can be set according to actual usage needs.

[0040] In some embodiments, the accommodating tube 310 is provided with a cut structure parallel to the axis of the accommodating tube 310 to form an observation window 302 that exposes the head and torso of the mouse in the cavity 301.

[0041] Understandably, younger mice, which may be in a physiological state where their eyes are not yet open, are unable to crawl to the front of the container 310 on their own. Figure 1 and Figure 2 As shown, by providing a cut structure parallel to the axis of the accommodating cylinder 310 on its upper side, an unobstructed observation window 302 is formed on its upper side. The observation window 302 exposes the head and torso of the mouse in the inner cavity 301, facilitating the experimenter's assistance in moving the mouse. The head fixing piece 210 is connected to the support assembly for easy use. In practical applications, the observation window 302 can also be modified according to actual usage needs.

[0042] In some embodiments, the accommodating tube 310 is provided with a cut structure inclined to the axis of the accommodating tube 310 to form an observation window 302 that exposes the head of the mouse in the cavity 301.

[0043] Understandably, such as Figure 3 As shown, Figure 3 The illustration shows another embodiment of the container 310. For older mice, which are already in an open-eyed physiological state and can crawl autonomously towards the front of the container 310, an oblique cut structure is provided on the upper front side of the container 310, forming an observation window 302 only on the upper front side of the container 310. This exposes only the mouse's head in the inner cavity 301, allowing the rear half of the container 310 to form a fully enclosed structure corresponding to the mouse's torso. This effectively restricts the movement of the mouse's torso and further reduces the interference of the mouse's hind limbs struggling on imaging. In practical applications, the size and shape of the observation window 302 can be set according to actual usage needs.

[0044] In some embodiments, the accommodating cylinder 310 is provided with a blocking part 312, which is located in front of the mouse's head in the inner cavity 301 and has an avoidance notch corresponding to the breathing position of the mouse's head.

[0045] Understandably, such as Figure 3 As shown, the front of the receiving tube 310 is provided with a blocking part 312. When the mouse is placed in the inner cavity 301, the blocking part 312 is located in front of the mouse's head, which helps to prevent the mouse's forelimbs from scratching its nose and face, or even the area where the head fixation piece 210 is located, thus reducing interference with imaging. The upper side of the blocking part 312 is provided with a downwardly recessed avoidance notch (not shown in the figure) to avoid obstructing the mouse's breathing position and prevent interference with the mouse's normal breathing, making it easy to use. In actual applications, the specific structure of the blocking part 312 can be set according to the actual needs of use.

[0046] In some embodiments, the support assembly includes a support column 220 and a connecting beam 230. The support column 220 is provided in two and is located on both sides of the receiving tube 310. The two ends of the connecting beam 230 are respectively connected to the two support columns 220. The head fixing member 210 is detachably connected to the middle of the connecting beam 230 and is located on the upper side of the observation window 302.

[0047] Understandably, such as Figure 1 , Figure 2 and Figure 3As shown, two support columns 220 are respectively located on the left and right sides of the receiving cylinder 310. The two ends of the connecting beam 230 are respectively connected to the upper parts of the two support columns 220. The head fixing member 210 is located in the middle of the connecting beam 230 and is detachably connected to the connecting beam 230 through a threaded part (not shown in the figure). The above structure is simple and reasonable, the connection is stable and reliable, and it is easy to use. In practical applications, the bracket assembly can also adopt a suspension structure, such as using a single support column 220 and a connecting beam 230. The head fixing member 210 and the connecting beam 230 can also be detachably connected by a snap-fit ​​method. The specific configuration can be changed according to the actual needs of use.

[0048] Furthermore, the two ends of the connecting beam 230 are respectively provided with through holes (not shown in the figure) and opening slots 201. The upper sides of the two supports 220 are threaded with locking screws 250. One of the two locking screws 250 passes through the through hole and through the end of the connecting beam 230, and the other passes through the opening slot 201 and through the end of the connecting beam 230. The connecting beam 230 can move horizontally relative to the support 220, so that the corresponding locking screw 250 enters or disengages from the opening slot 201.

[0049] Understandably, such as Figure 1 and Figure 2 As shown, locking screws 250 are threaded onto the upper sides of both left and right support pillars 220. The left end of the connecting beam 230 has an opening slot 201, and its right end has a through hole (not shown in the figure). The right-side locking screw 250 passes through the through hole to the right end of the connecting beam 230, allowing the right end of the connecting beam 230 to rotate relative to the support pillar 220 it is connected to. The left-side locking screw 250 passes through the opening slot 201 to the left end of the connecting beam 230. In use, the locking screws 250 on both sides can be tightened to press the left and right ends of the connecting beam 230 respectively, thus fixing the connecting beam 230 in place. (Refer to...) Figure 2 When it is necessary to move the head fixing component 210 or the connecting beam 230 away from the upper side of the observation window 302, the locking screws 250 on both sides can be loosened, and the connecting beam 230 can be rotated horizontally relative to the right-side support column 220. Utilizing the opening structure on one side of the slot 201, the locking screw 250 on the left side can be disengaged from or enter the slot 201 accordingly, enabling the connecting beam 230 to be quickly rotated open or closed, facilitating adaptation to different usage situations. In practical applications, the through hole can also be located at the left end of the connecting beam 230, with the slot 201 located at the right end of the connecting beam 230; the specific configuration can be determined according to actual usage requirements.

[0050] In some embodiments, the longitudinal position of the head fixing member 210 relative to the receiving cylinder 310 is adjustable. It is understood that mice of different ages will not only have certain differences in body size, but also in the height and position of their heads. By setting the longitudinal position of the head fixing member 210 relative to the receiving cylinder 310 to be adjustable, it is possible to better adapt to mice of different ages and improve adaptability.

[0051] Specifically, such as Figure 1 , Figure 2 and Figure 3 As shown, the support assembly also includes a mounting base 240. Two mounting bases 240 are provided and are located on both sides of the receiving cylinder 310. The support column 220 is connected to the base plate 100 through the mounting base 240. The support column 220 can be moved up and down relative to the mounting base 240 to adjust its position, thereby changing the height position of the connecting beam 230 and the longitudinal position of the head fixing member 210 relative to the receiving cylinder 310, so as to better adapt to mice of different ages and improve adaptability.

[0052] In practical applications, there are several ways to adjust the position of the support column 220 relative to the mounting base 240 vertically. For example, the support column 220 and the mounting base 240 can be connected by a threaded connection. By rotating the support column 220, the position of the support column 220 relative to the mounting base 240 can be adjusted vertically by utilizing the threaded connection. Alternatively, the support column 220 can be inserted longitudinally into the mounting base 240 and can move vertically. The mounting base 240 is equipped with a locking threaded component. By tightening the threaded component, the threaded component presses against the wall of the support column 220 to achieve locking. Loosening the threaded component releases the locking of the support column 220, allowing the support column 220 to move vertically to adjust its position. The specific connection structure between the support column 220 and the mounting base 240 can be set according to actual usage requirements.

[0053] In addition, the support column 220 can be detachably connected to the mounting base 240 or the base plate 100. By disassembling and replacing the support column 220 with different height dimensions, the longitudinal position of the head fixing member 210 relative to the receiving cylinder 310 can be adjusted. Alternatively, the longitudinal position of the head fixing member 210 relative to the receiving cylinder 310 can be changed by changing the height position of the receiving cylinder 310. The specific setting can be made according to actual practical needs.

[0054] The embodiments of the present utility model have been described in detail above with reference to the accompanying drawings. However, the present utility model is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present utility model.

Claims

1. A fixation device for mouse research, characterized in that, include: Base plate; The first fixing mechanism includes a head fixing component and a support assembly disposed on the base plate. The head fixing component is detachably connected to the support assembly and is used to fix the head of the mouse. The second fixing mechanism is disposed on the base plate and includes a receiving cylinder having an inner cavity for containing a mouse. The wall of the inner cavity can restrict the movement of the mouse's trunk. The receiving cylinder is provided with an observation window communicating with the inner cavity. The observation window can expose at least the head of the mouse in the inner cavity for observation of the mouse.

2. The fixation device for mouse research according to claim 1, characterized in that, The second fixing mechanism further includes a connecting component, through which the receiving cylinder is connected to the base plate, and the receiving cylinder can be disassembled and replaced relative to the connecting component and / or the second fixing mechanism can be disassembled and replaced relative to the base plate.

3. The fixation device for mouse research according to claim 2, characterized in that, The connecting assembly includes connecting posts and connecting members. Multiple connecting posts are provided and spaced apart on the base plate. Multiple connecting members are provided corresponding to the connecting posts. One end of the connecting member is connected to the corresponding connecting post, and the other end of the connecting member is provided with a hook. The side of the receiving cylinder is provided with an ear plate, and the hook is detachably hooked onto the ear plate.

4. The fixation device for mouse research according to claim 3, characterized in that, An elastic portion is provided between the two ends of the connector. When the two ends of the connector are respectively connected to the connecting post and the receiving cylinder, the elastic portion is in a stretched state.

5. The fixation device for mouse research according to claim 4, characterized in that, The base plate is provided with mounting holes, and the connecting column can cooperate with the mounting holes. Multiple mounting holes are arranged in an array on the base plate.

6. The fixation device for mouse research according to claim 1, characterized in that, The accommodating tube has a cut structure parallel to the axis of the accommodating tube to form an observation window that exposes the head and torso of the mouse in the cavity.

7. The fixation device for mouse research according to claim 1, characterized in that, The accommodating tube has a cut structure inclined to the axis of the accommodating tube to form an observation window that exposes the head of the mouse in the cavity.

8. The fixation device for mouse research according to claim 1, characterized in that, The accommodating tube is provided with a blocking part, which is located in front of the mouse's head in the inner cavity and has an avoidance notch corresponding to the breathing position of the mouse's head.

9. The fixation device for mouse research according to claim 1, characterized in that, The support assembly includes two pillars and a connecting beam. Two pillars are provided and are located on both sides of the receiving tube. The two ends of the connecting beam are respectively connected to the two pillars. The head fixing member is detachably connected to the middle of the connecting beam and is located on the upper side of the observation window.

10. The fixation device for mouse research according to claim 9, characterized in that, The longitudinal position of the head fixing member relative to the receiving cylinder is adjustable.

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