Animal experiment equipment for low intensity transcranial photobiomodulation research

Abstract

This utility model relates to the field of animal experimental equipment for laser therapy technology research, specifically to an animal experimental device for low-intensity transcranial photobiological modulation research. It includes a base plate, an anesthesia machine mounted on one side of the base plate, a breathing mask fixedly connected to the output end of the anesthesia machine, an arc-shaped plate slidably mounted on the base plate, an arc-shaped block slidably mounted inside the arc-shaped plate, the arc-shaped block being connected to a drive unit, the drive unit driving the arc-shaped block to move inside the arc-shaped plate, a universal ball rotating at the lower end of the arc-shaped block, a pressure sleeve fitted on the outside of the universal ball, the pressure sleeve being threadedly connected to the arc-shaped block, the lower end of the universal ball passing through the pressure sleeve, a light source collimating lens fixed at the lower end of the universal ball, a support plate fixed on one side of the base plate, a laser emitter fixed on the support plate, and the laser emitter being connected to the light source collimating lens via an optical fiber. The light source collimating lens facilitates positioning, ensuring rapid and accurate irradiation of the target affected area of ​​the experimental animal by the laser.

Description

Technical Field

[0001] This utility model relates to the field of animal experimental equipment for laser therapy technology research, specifically to an animal experimental equipment for low-intensity transcranial photobiological modulation research. Background Technology

[0002] Photobiomodulation (PBM), formerly known as low-intensity laser therapy, is a non-invasive neuromodulation method widely used in neuroscience. Its characteristics include non-invasiveness, simplicity of operation, and high safety, thus playing an important role in the treatment of neurological diseases. Using red or near-infrared light, PBM can effectively treat a variety of neurological and psychological disorders, such as stroke, traumatic brain injury, Parkinson's disease, Alzheimer's disease, and major depressive disorder. PBM interacts with intracellular light-sensitive molecules by penetrating tissue, regulating cellular metabolism, enhancing mitochondrial function, promoting ATP production, improving meningeal lymphatic drainage, reducing neuroinflammation, and stimulating neuronal and synaptic growth. These effects make PBM a promising non-invasive treatment method applicable to the treatment of multiple central nervous system diseases, including ischemic stroke, neurodegenerative diseases, and epilepsy.

[0003] In theory, low-intensity transcranial photobiological modulation therapy platforms can be used to treat central nervous system diseases including Alzheimer's disease, Parkinson's disease, autism, anxiety disorders, and depression. However, a complete treatment system for human use has not yet been successfully developed and is currently in the animal testing phase. Animal experimental equipment for low-intensity transcranial photobiological modulation research on experimental animals (mainly mice) can serve as a reference for developing a complete system for human treatment. However, during the development of this animal experimental equipment, it was discovered that due to individual differences among experimental animals and the precision requirements of laser irradiation, accurately positioning and irradiating the affected area of ​​the experimental animal's brain via a collimating lens is a key problem that needs to be solved.

[0004] Existing technologies do not offer corresponding technical guidance. For example, patent document CN211301804U discloses a laser therapy device for irradiating the ear canal and pharynx, including a main unit, a fixing ring, and a fixing cylinder. The surface of the main unit is fixedly connected to the left end of the fixing cylinder via a wire. The fixing ring is fixedly connected to the surface of the wire. A shunt connector is fixedly connected to the inner cavity of the fixing cylinder. The left end of the shunt connector is electrically connected to the right end of the wire. A movable cylinder is movably connected to the right end of the fixing cylinder, and a first inner liner sleeve is fixedly connected to the inner cavity of the movable cylinder. A magnetic fixing frame is fixedly connected to the inner cavity of the first inner liner sleeve. A shunt line is electrically connected to the right end of the shunt connector, and a laser emitter is electrically connected to the right end of the shunt line. An elastic plug is fixedly connected to the surface of the laser emitter, and a magnetic ring is threaded onto the surface of the laser emitter. A first protective glass is fixedly connected to the surface of the movable cylinder. When using this laser therapy device, the main unit cannot be effectively positioned, making it inconvenient to use.

[0005] Patent document CN20963044U discloses a multi-angle adjustable laser irradiation platform, including a base. Support legs are fixedly connected to the four corners of the lower surface of the base. The upper surface of the base is fixedly connected to the lower surface of a treatment device body. Fixed plates are fixedly connected to the front and back of the treatment device body. Opposite surfaces of the fixed plates are fixedly connected to one end of the front of a slide rod and one end of the back of the slide rod, respectively. A sliding sleeve is fitted onto the outer surface of the slide rod, and a first spring is fitted onto the outer surface of the slide rod. One end of the back of the first spring and one end of the front of the first spring are fixedly connected to the front of the sliding sleeve and the back of the inner wall of the fixed plate, respectively. A first slider is fixedly connected to the upper surface of the sliding sleeve, and a rope is fixedly connected to the back of the first slider. The first slider is slidably connected within a first groove, which is located on the upper surface of the inner wall of the medical device body. The rope is located within a through hole, which is located on the back of the rear fixed plate. The other end of the rope is fixedly connected to the outer surface of a driving device, and the front of the driving device is fixedly connected to the back of the fixed plate. The lower surface of the sliding sleeve is fixedly connected to the top end of the first electric push rod. A housing is provided on the outer surface of the laser emitter. Two second sliding grooves are opened on the upper surface of the base. A second slider is slidably connected in the second sliding groove. The upper surface of the second slider is fixedly connected to the lower surface of the support device. Two U-shaped plates are fixedly connected to the upper surface of the support device. Threaded caps are snapped onto the upper surface of the U-shaped plates. Threaded rods are threaded into the threaded caps. A rotating shaft is fixedly connected to the bottom end of the threaded rod. The rotating shaft is sleeved in a bearing. The bearing is snapped onto the upper surface of the pressure plate. The upper surface of the pressure plate is connected to the upper surface of the inner wall of the U-shaped plates through two telescopic rods. A tensioning strap is fixedly connected to the upper surface of the support device. The tensioning strap is inserted into a buckle. The lower surface of the buckle is fixedly connected to the upper surface of the support device. A mounting plate is fixedly connected to the bottom end of the first electric push rod. A third sliding groove is formed on the lower surface of the mounting plate, within which two third sliders are slidably connected. The opposing surfaces of the two third sliders are fixedly connected to the left and right ends of a second spring, respectively. A locking block is fixedly connected to the lower surface of the third slider, located within a slot on the upper surface of the laser emitter. An L-shaped handle is provided on the left side of the locking block. When this laser irradiation platform is working, the laser emitted by the laser emitter cannot be adjusted at multiple angles, limiting its applicable range. Utility Model Content

[0006] The main purpose of this invention is to provide an animal experimental device for low-intensity transcranial photobiological modulation research that emits laser light that can be adjusted at multiple angles and has a wide range of applications.

[0007] To achieve the above objectives, the technical solution provided by this utility model is as follows:

[0008] An animal experimental device for low-intensity transcranial photobiological modulation research includes a base plate, an anesthesia machine mounted on one side of the base plate, a breathing mask fixedly connected to the output end of the anesthesia machine, an arc-shaped plate slidably mounted on the base plate, an arc-shaped block slidably mounted on the inner side of the arc-shaped plate, the arc-shaped block being connected to a drive unit, the drive unit being able to drive the arc-shaped block to move within the arc-shaped plate, a universal ball rotatably mounted at the lower end of the arc-shaped block, a pressure sleeve sleeved on the outer side of the universal ball, the pressure sleeve being threadedly connected to the arc-shaped block, the lower end of the universal ball passing through the pressure sleeve, a light source collimating lens fixed at the lower end of the universal ball, a support plate fixed on one side of the base plate, a laser emitter fixed on the support plate, and the laser emitter being connected to the light source collimating lens via an optical fiber.

[0009] Specifically, a fixing plate is fixed to one side of the arc-shaped block, and a rotating wheel is rotatably connected to the fixing plate. The outer edge of the rotating wheel contacts the outer edge of the pressure sleeve. Rotating the rotating wheel can drive the pressure sleeve to rotate. The rotating wheel is made of iron, and a polygonal hole is concentrically opened at the lower end of the rotating wheel. The upper end of the polygonal rod is inserted into the polygonal hole, and a lower plate is rotatably connected to the lower end of the polygonal rod. An optical power meter is fixed at the upper end of the lower plate, and the optical power meter is electrically connected to the upper computer through a data cable.

[0010] Specifically, a magnet is fixed to the upper end of the polygonal rod, and the magnet magnetically attracts the rotating wheel.

[0011] Specifically, the arc-shaped block is slidably engaged in the arc-shaped groove on the inner side of the arc-shaped plate.

[0012] Specifically, the drive unit includes an ear plate fixed to one side of the arc-shaped block, a motor fixed on the ear plate, a gear concentrically fixed on the output shaft of the motor, an arc-shaped rack concentrically fixed on the arc-shaped plate on one side of the gear, the gear and the arc-shaped rack being connected, and the motor being electrically connected to the controller.

[0013] Specifically, both ends of the arc-shaped plate are fixed with sliders, and the base plate is provided with a groove corresponding to the slider. The slider slides and engages in the groove on one side. The length direction of the groove is parallel to the length direction of the base plate.

[0014] Specifically, a long groove is provided on one side of the base plate. The length direction of the long groove is parallel to the length direction of the slide groove. The long groove is connected to the slide groove on one side. The locking handle passes through the long groove and is threadedly connected to the slider on one side. A fixing sleeve is fixed on the locking handle and the fixing sleeve is tightly pressed against the base plate.

[0015] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0016] 1. The curved plate can drive the curved block and the light source collimator to move along the length of the base plate, which can easily make the light source collimator correspond to the affected area of ​​the experimental animal that needs to be irradiated.

[0017] 2. The arc-shaped block can move the collimating lens of the light source inside the arc-shaped plate, which makes it easier for the laser emitted by the collimating lens to be aimed at the affected area of ​​the experimental animal, and has a wide range of applications.

[0018] 3. The angle of the collimating lens of the light source can be adjusted after the pressure sleeve is loosened, which makes it convenient to adjust the laser emitted from the collimating lens of the light source at multiple angles. This makes it easier to aim the laser emitted from the collimating lens of the light source at the affected area of ​​the experimental animal, and it has a wide range of applications.

[0019] 4. The optical power meter allows for easy adjustment of the laser power, making it suitable for experimental animals of varying degrees of severity. The optical power meter is easy to install and remove without affecting the angle adjustment of the collimating lens.

[0020] 5. The collimating lens of the light source facilitates positioning and ensures that the laser can quickly and accurately irradiate the affected area of ​​the experimental animal.

[0021] 7. The multi-faceted rod allows the rotating wheel to rotate, which in turn causes the pressure sleeve to rotate. After the pressure sleeve rotates, it can press or release the universal ball, making it convenient to adjust the collimating lens of the light source.

[0022] 8. This animal experimental equipment is equipped with an anesthesia machine, which makes it convenient to anesthetize experimental animals before laser irradiation treatment, making laser treatment more convenient.

[0023] 9. By setting a locking handle and a fixing sleeve, the arc plate is easy to position, and the collimating lens of the light source has good stability during laser treatment.

[0024] 10. This animal experimental equipment, due to its high-precision control capabilities, safety, ease of operation, and wide applicability, can become an important tool for neuroscience animal experimental research. It can not only precisely adjust light intensity and irradiation area to meet the individualized needs of researching and treating different diseases, but also demonstrates good safety. Although this animal experimental equipment was developed for laboratory animals (mainly mice), it has technical reference and inspirational value for the development of low-intensity transcranial photobiological modulation therapy equipment for humans. Attached Figure Description

[0025] Figure 1 This is a front view of the present invention.

[0026] Figure 2 This is a schematic diagram showing the fit between the base plate and the curved plate.

[0027] Figure 3 This is a top view showing the fit between the base plate and the curved plate.

[0028] Figure 4 for Figure 3 Sectional view along direction AA.

[0029] Figure 5 for Figure 4 A magnified view of region C in the middle.

[0030] Figure 6for Figure 3 Sectional view along the BB direction.

[0031] Figure 7 for Figure 6 A magnified view of region D in the middle.

[0032] The components in the attached diagram are named as follows: 1. Base plate, 2. Support plate, 3. Laser emitter, 4. Slide groove, 5. Slider, 6. Long groove, 7. Locking handle, 8. Fixing sleeve, 9. Arc plate, 10. Arc rack, 11. Light source collimating lens, 12. Arc block, 13. Ear plate, 14. Motor, 15. Gear, 16. Universal ball, 17. Pressure sleeve, 18. Fixing plate, 19. Rotary wheel, 20. Multi-faceted rod, 21. Lower plate, 22. Optical power meter, 23. Anesthesia machine, 24. Breathing mask. Detailed Implementation

[0033] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0034] Example 1: Refer to Figures 1-7 As shown, an animal experimental device for low-intensity transcranial photobiological modulation research includes a base plate 1, an anesthesia machine 23 is provided on one side of the base plate 1, and a breathing mask 24 is fixedly connected to the output end of the anesthesia machine 23.

[0035] The experimental animal is placed on the base plate 1, and after wearing a breathing mask 24, the anesthesia machine 23 is activated to anesthetize the animal. This treatment platform is equipped with an anesthesia machine 23, which facilitates the anesthesia of the experimental animal before laser treatment, making the laser treatment more convenient.

[0036] An arc-shaped plate 9 is slidably mounted on the base plate 1, and an arc-shaped block 12 is slidably mounted on the inner side of the arc-shaped plate 9. Specifically, the arc-shaped block 12 is slidably engaged in an arc-shaped groove on the inner side of the arc-shaped plate 9. The arc-shaped block 12 is connected to a drive unit, which can drive the arc-shaped block 12 to move inside the arc-shaped plate 9.

[0037] Both ends of the arc plate 9 are fixed with sliders 5. The base plate 1 has a groove 4 corresponding to the slider 5. The slider 5 is slidably engaged in the groove 4 on one side. The length direction of the groove 4 is parallel to the length direction of the base plate 1.

[0038] A long groove 6 is provided on one side of the base plate 1. The length direction of the long groove 6 is parallel to the length direction of the slide groove 4. The long groove 6 is connected to the slide groove 4 on one side. The locking handle 7 passes through the long groove 6 and is threadedly connected to the slider 5 on one side. A fixing sleeve 8 is fixed on the locking handle 7 and the fixing sleeve 8 is tightly pressed against the base plate 1.

[0039] The drive unit includes an ear plate 13 fixed on one side of the arc-shaped block 12, a motor 14 fixed on the ear plate 13, a gear 15 concentrically fixed on the output shaft of the motor 14, an arc-shaped rack 10 concentrically fixed on the arc-shaped plate 9 on one side of the gear 15, the gear 15 and the arc-shaped rack 10 are connected, and the motor 14 is electrically connected to the controller.

[0040] A universal ball 16 is rotatably mounted on the lower end of the arc-shaped block 12. A pressure sleeve 17 is fitted on the outside of the universal ball 16. The pressure sleeve 17 is threadedly connected to the arc-shaped block 12. The lower end of the universal ball 16 passes through the pressure sleeve 17. A light source collimating lens 11 is fixed to the lower end of the universal ball 16. A support plate 2 is fixed on one side of the base plate 1. A laser emitter 3 is fixed on the support plate 2. The laser emitter 3 is connected to the light source collimating lens 11 through an optical fiber.

[0041] In this embodiment, moving the arc-shaped plate 9 allows the position of the collimating lens 11 of the light source to change along the length of the base plate 1. After the position of the arc-shaped plate 9 is adjusted, rotating the locking handle 7 allows the fixing sleeve 8 to press tightly against the base plate 1, thus positioning the arc-shaped plate 9.

[0042] When the motor 14 is started, the motor 14 drives the gear 15 to rotate. Under the meshing action of the gear 15 and the arc rack 10, the arc block 12 and the light source collimating lens 11 can rotate inside the arc plate 9, which can make the position of the light source collimating lens 11 change in the circumferential direction of the arc plate 9.

[0043] Rotating the wheel 19 causes the pressure sleeve 17 to rotate. After the pressure sleeve 17 releases the universal ball 16, the collimating lens 11 of the light source can swing around the center of the universal ball 16, which can change the angle of the collimating lens 11 of the light source and thus adjust the irradiation angle of the laser. This makes it convenient to accurately irradiate the affected area of ​​the experimental animal with the laser, and therefore has a wide range of applications.

[0044] The collimating lens 11 facilitates positioning and ensures rapid and accurate laser irradiation of the affected area on the experimental animal. The locking handle 7, fixing sleeve 8, and curved plate 9 facilitate positioning, and the collimating lens 11 exhibits good stability during laser treatment.

[0045] The laser emitter 3 can generate laser light with a specific wavelength of 670nm-1270nm. When irradiating the affected area of ​​the experimental animal with laser, the size of the laser spot and the irradiation area can be effectively adjusted by the collimating lens 11.

[0046] Example 2: Based on Example 1, referring to... Figures 1-7As shown, a fixing plate 18 is fixed to one side of the arc-shaped block 12. A rotating wheel 19 is rotatably connected to the fixing plate 18. The outer edge of the rotating wheel 19 contacts the outer edge of the pressure sleeve 17. Rotating the rotating wheel 19 can drive the pressure sleeve 17 to rotate. The rotating wheel 19 is made of iron, and a polygonal hole is concentrically formed at the lower end of the rotating wheel 19. The upper end of the polygonal rod 20 is inserted into the polygonal hole. A magnet is fixed to the upper end of the polygonal rod 20, and the magnet magnetically attracts the rotating wheel 19. A lower plate 21 is rotatably connected to the lower end of the polygonal rod 20. An optical power meter 22 is fixed to the upper end of the lower plate 21. The optical power meter 22 is electrically connected to the host computer via a data cable. The optical power meter 22 is made of photosensitive material and can detect the laser output power.

[0047] The upper end of the polygonal rod 20 is inserted into the polygonal hole, allowing the rotating wheel 19 to be rotated easily. When the rotating wheel 19 rotates, the pressure sleeve 17 can also rotate, facilitating the clamping and releasing of the universal ball 16. After the pressure sleeve 17 releases the universal ball 16, it is convenient to adjust the angle of the light source collimating lens 11. After the pressure sleeve 17 clamps the universal ball 16, it can position the light source collimating lens 11.

[0048] After the upper end of the polygonal rod 20 is inserted into the polygonal hole, the magnet magnetically attracts the rotating wheel 19, which can prevent the polygonal rod 20 from coming out of the polygonal hole. Then, the lower plate 21 is rotated so that the laser emitted from the collimating lens 11 of the light source shines on the absorption target of the optical power meter 22, and the power value of the laser is displayed on the host computer.

[0049] The laser power can be adjusted via the laser emitter 3 as needed. When the laser power value displayed on the host computer is equal to the required laser power value, the adjustment of the laser emitter 3 is stopped. Then, after removing the polygonal rod 20, the lower plate 21, and the optical power meter 22, the laser emitted from the collimating lens 11 can be used to irradiate the affected area of ​​the experimental animal.

[0050] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. An animal experimental device for low-intensity transcranial photobiological modulation research, comprising a base plate (1), an anesthesia machine (23) disposed on one side of the base plate (1), and a breathing mask (24) fixedly connected to the output end of the anesthesia machine (23), characterized in that, An arc plate (9) is slidably arranged on the base plate (1). An arc block (12) is slidably arranged on the inner side of the arc plate (9). The arc block (12) is connected to the drive unit. The drive unit can drive the arc block (12) to move inside the arc plate (9). A universal ball (16) is rotatably arranged at the lower end of the arc block (12). A pressure sleeve (17) is sleeved on the outer side of the universal ball (16). The pressure sleeve (17) is threadedly connected to the arc block (12). The lower end of the universal ball (16) passes through the pressure sleeve (17). A light source collimating lens (11) is fixed at the lower end of the universal ball (16). A support plate (2) is fixed on one side of the base plate (1). A laser emitter (3) is fixed on the support plate (2). The laser emitter (3) is connected to the light source collimating lens (11) through an optical fiber.

2. The animal experimental apparatus for low intensity transcranial photobiomodulation research according to claim 1, wherein, A fixing plate (18) is fixed on one side of the arc-shaped block (12). A rotating wheel (19) is rotatably connected to the fixing plate (18). The outer edge of the rotating wheel (19) contacts the outer edge of the pressure sleeve (17). Rotating the rotating wheel (19) can drive the pressure sleeve (17) to rotate. A multi-faceted hole is concentrically opened at the lower end of the rotating wheel (19). The upper end of the multi-faceted rod (20) is inserted into the multi-faceted hole. The lower end of the multi-faceted rod (20) is rotatably connected to a lower plate (21). An optical power meter (22) is fixed at the upper end of the lower plate (21). The optical power meter (22) is electrically connected to the host computer through a data cable.

3. The animal experimental apparatus for low intensity transcranial photobiomodulation research according to claim 2, wherein, The wheel (19) is made of iron, and a magnet is fixed to the upper end of the multi-faceted rod (20). The magnet magnetically attracts the wheel (19).

4. The animal experimental apparatus for low intensity transcranial photobiomodulation research according to claim 1, wherein, The arc-shaped block (12) is slidably engaged in the arc-shaped groove on the inner side of the arc-shaped plate (9).

5. The animal experimental apparatus for low intensity transcranial photobiomodulation research according to claim 1, wherein, The drive unit includes an ear plate (13) fixed on one side of the arc-shaped block (12), a motor (14) fixed on the ear plate (13), a gear (15) concentrically fixed on the output shaft of the motor (14), an arc-shaped rack (10) concentrically fixed on the arc-shaped plate (9) on one side of the gear (15), the gear (15) is connected to the arc-shaped rack (10), and the motor (14) is electrically connected to the controller.

6. The animal experimental apparatus for low intensity transcranial photobiomodulation research according to claim 1, wherein, Both ends of the arc plate (9) are fixed with sliders (5), and the base plate (1) is provided with a groove (4) corresponding to the slider (5). The slider (5) is slidably engaged in the groove (4) on one side. The length direction of the groove (4) is parallel to the length direction of the base plate (1).

7. The animal experimental apparatus for low intensity transcranial photobiomodulation research according to claim 6, wherein, The base plate (1) has a long groove (6) on one side. The length direction of the long groove (6) is parallel to the length direction of the slide groove (4). The long groove (6) is connected to the slide groove (4) on one side. The locking handle (7) passes through the long groove (6) and is threadedly connected to the slider (5) on one side. A fixing sleeve (8) is fixed on the locking handle (7). The fixing sleeve (8) is tightly against the base plate (1).

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