Cooling device for use in cryopreservation of stem cells

Abstract

The utility model discloses a cooling device used in stem cell cryopreservation process, specifically relates to medical instrument technical field, including the cooling box, the lower end middle part of cooling box is fixedly connected with first motor, and the output of first motor is fixedly connected with heat exchange device, and the upper end of heat exchange device is fixedly connected with slide rod, and the outer wall sliding connection of slide rod has spring, and the upper end fixed connection of spring has the placement board, and the upper end swing joint of placement board has the test tube, and the upper end fixed connection of placement board has the buckle device, and the lower end fixed connection of cooling box has the support leg, the utility model discloses a cooling device used in stem cell cryopreservation process, and spring buckle is fixed test tube through the spring clamping force, can ensure that test tube is steady and does not displace even when device moves, rotates or is subjected to the external force vibration, and the spring buckle's elasticity design can be compatible with test tube of different diameters or lengths, need not to replace fixed component, improves the versatility and flexibility of device.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, specifically to a cooling device used in the process of stem cell cryopreservation. Background Technology

[0002] Existing stem cell cryopreservation cooling devices have shortcomings. On the one hand, the test tube fixation structure is poorly designed, lacking effective restraint and stable support, which easily leads to test tube shaking, displacement, or even tipping, affecting cell state. On the other hand, the cooling efficiency is insufficient, with uneven and slow temperature transfer, making it difficult to accurately meet the requirements of stem cell freezing curves, easily causing cell damage and death, and failing to guarantee high-activity preservation. Optimization and improvement are urgently needed to enhance equipment reliability and cryopreservation effectiveness.

[0003] Chinese patent document CN212378309U discloses a cooling device used in stem cell cryopreservation. It includes a cooling cylinder with symmetrical support legs fixedly connected to its bottom surface. A rotary motor is fixedly connected to the bottom surface of the cooling cylinder, and the output end of the rotary motor is fixedly connected to a rotating shaft via a reducer. A sealed bearing is fixedly embedded in the bottom surface of the cooling cylinder, and the top end of the rotating shaft passes through the sealed bearing and extends into the interior of the cooling cylinder. A turntable is fixedly connected to the top end of the rotating shaft, and symmetrical sliding rods are fixedly connected to the upper surface of the turntable. In this cooling device used for stem cell cryopreservation, the rotary motor is activated via a control panel, causing the rotary motor to drive the rotating shaft to rotate. The rotation of the shaft causes the turntable to drive the fixed plate on the sliding rod to rotate, thereby ensuring thorough mixing of the stem cells and cryopreservation solution in the test tube. Simultaneously, the rotation of the fixed plate allows the test tube to move continuously within the cooling cylinder, ensuring uniform cooling of the test tube.

[0004] Although the equipment described in the aforementioned literature can cryopreserve cells, its structure is relatively simple, it is not stable enough for placing test tubes, and its cooling efficiency is still insufficient, which reduces the practical value of the equipment. Utility Model Content

[0005] The main purpose of this invention is to provide a cooling device for use in the cryopreservation of stem cells, which can effectively solve the above-mentioned problems.

[0006] To achieve the above objectives, the technical solution adopted by this utility model is as follows: A cooling device used in stem cell cryopreservation includes a cooling chamber. A first motor is fixedly connected to the lower middle part of the cooling chamber. A heat exchange device is fixedly connected to the output end of the first motor. A sliding rod is fixedly connected to the upper end of the heat exchange device. A spring is slidably connected to the outer wall of the sliding rod. A placement plate is fixedly connected to the upper end of the spring. A test tube is movably connected to the upper end of the placement plate. A buckle device is fixedly connected to the upper end of the placement plate. A support leg is fixedly connected to the lower end of the cooling chamber. The heat exchange device includes a heat exchange box, the lower end of which is fixedly connected to the output end of the first motor; The buckling device includes a fixing base, the lower end of which is fixedly connected to the upper end of the mounting plate.

[0007] Preferably, cooling plates are fixedly connected to both sides of the cooling box, a radiator is fixedly connected to one side of the cooling plates, a controller is fixedly connected to the front end of the cooling box, and a sealing cover is fixedly connected to the top of the cooling box.

[0008] Preferably, a cover plate is fixedly connected to the upper end of the heat exchange box, and heat dissipation holes are provided on the outer walls of both the heat exchange box and the cover plate, and a circulating cooling pipe is fixedly installed inside the cover plate.

[0009] Preferably, a temperature converter is fixedly connected to one end of the circulating cooling pipe, a temperature sensor is fixedly connected to one side of the temperature converter, and an air guide plate and a fixing plate are fixedly connected inside the heat exchange box.

[0010] Preferably, a second motor is fixedly connected to one side of the fixing plate, and a fan is fixedly connected to the output end of the second motor.

[0011] Preferably, a connecting seat is fixedly connected to one side of the fixed seat, a second buckle is movably connected to one end of the fixed seat, and a sliding groove cylinder is movably connected to one end of the connecting seat.

[0012] Preferably, a damping shaft is provided between the connecting seat and the sliding cylinder, and a spring is slidably connected inside the sliding cylinder, with one end of the spring fixedly connected to a telescopic rod.

[0013] Preferably, one end of the telescopic rod is fixedly connected to a retaining plate, and one side of the retaining plate is movably connected to a pull rod.

[0014] Compared with the prior art, the present invention has the following beneficial effects: This invention provides a cooling device for use during stem cell cryopreservation. The device is equipped with a heat exchange unit, and spring clips secure the test tubes with elastic clamping force, ensuring stability even when the device moves, rotates, or is subjected to external vibrations. The elastic design of the spring clips is compatible with test tubes of different diameters or lengths, eliminating the need to replace fixing components and improving the device's versatility and flexibility. A circulating cooling tube is wound around the test tubes to facilitate heat removal, and temperature changes are monitored in real time using a temperature converter and temperature sensor. Heat exchange chambers and the side walls of the cover are equipped with heat dissipation holes to facilitate heat exhaust. Combined with external cooling components, this effectively enhances the cooling effect. Furthermore, a second motor drives a fan, which, through a guide vane, promotes airflow and disperses the heat carried by the heat exchange tubes, further improving the device's cooling efficiency.

[0015] This invention provides a cooling device for use in stem cell cryopreservation. The device is equipped with a snap-fit ​​mechanism. The circulating cooling pipe continuously absorbs heat from the cooling cylinder through a heat-conducting medium, forming a highly efficient heat exchange channel. The introduction of a fan accelerates airflow on the surface of the cooling pipe, breaking the thermal boundary layer and maintaining a stable temperature difference between the cooling pipe and the surrounding environment, thereby significantly increasing the heat dissipation rate. The circulating cooling pipe can be designed in a spiral winding layout, covering the inner wall of the cooling cylinder or around the test tube. Combined with the airflow circulation of the fan, it ensures that the temperature in all areas of the cylinder is consistent, which avoids stem cell damage caused by local overheating or overcooling and improves the cryopreservation success rate. A damping shaft is provided so that the snap-fit ​​components can rotate, making it easy to fold the device when not in use. A spring is used to allow the telescopic rod to extend and retract within the sliding cylinder, facilitating the adjustment of different lengths and making the snap-fit ​​connection tighter with the help of the spring's retraction. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall structure of this utility model; Figure 2 This is a schematic diagram of the heat exchange device structure of this utility model; Figure 3 This is a side view of the heat exchange device of this utility model. Figure 4 This is a schematic diagram of the buckle device structure of this utility model; Figure 5 This is a side view of the structure of this utility model.

[0017] In the diagram: 1. Cooling box; 2. First motor; 3. Heat exchanger; 31. Heat exchange box; 32. Cover plate; 33. Circulating cooling pipe; 34. Temperature converter; 35. Air guide plate; 36. Fixing plate; 37. Second motor; 38. Fan; 4. Slide rod; 5. Spring; 6. Mounting plate; 7. Test tube; 8. Buckling device; 81. Fixing seat; 82. Connecting seat; 83. Damping shaft; 84. Slide groove cylinder; 85. Spring; 86. Telescopic rod; 87. Clamping plate; 88. Pull rod; 89. Second buckle; 9. Support leg. Detailed Implementation

[0018] To make the technical means, creative features, objectives and effects of this utility model easier to understand, the present utility model will be further described below in conjunction with specific embodiments.

[0019] like Figure 1 and Figure 5As shown, the cooling device used in the stem cell cryopreservation process includes a cooling chamber 1. A first motor 2 is fixedly connected to the lower middle part of the cooling chamber 1. A heat exchange device 3 is fixedly connected to the output end of the first motor 2. A spring clip secures the test tubes with elastic clamping force, ensuring that the test tubes remain stable and do not shift even when the device moves, rotates, or is subjected to external vibration. The elastic design of the spring clip is compatible with test tubes of different diameters or lengths, eliminating the need to replace the fixing parts and improving the versatility and flexibility of the device. A slide rod 4 is fixedly connected to the upper end of the heat exchange device 3. A spring 5 is slidably connected to the outer wall of the slide rod 4. A mounting plate 6 is fixedly connected to the upper end of the spring 5. The test tube 7 is connected to the movable connection, and the upper end of the mounting plate 6 is fixedly connected to the buckle device 8. The circulating cooling tube continuously absorbs heat from the cooling cylinder through the heat transfer medium, forming an efficient heat exchange channel. The introduction of the fan can accelerate the air flow on the surface of the cooling tube, break the thermal boundary layer, and keep the temperature difference between the cooling tube and the surrounding environment stable, thereby greatly improving the heat dissipation rate. The circulating cooling tube can be designed in a spiral winding layout to cover the inner wall of the cooling cylinder or around the test tube. Combined with the airflow circulation of the fan, it ensures that the temperature of each area in the cylinder is consistent. This avoids stem cell damage caused by local overheating or overcooling and improves the cryopreservation success rate. The lower end of the cooling box 1 is fixedly connected to the support leg 9. The heat exchange device 3 includes a heat exchange box 31, the lower end of which is fixedly connected to the output end of the first motor 2; The latching device 8 includes a fixing seat 81, the lower end of which is fixedly connected to the upper end of the mounting plate 6; Cooling chamber 1 has cooling plates fixedly connected to both sides, a radiator fixedly connected to one side of the cooling plates, a controller fixedly connected to the front end of cooling chamber 1, and a sealing cover fixedly connected to the top of cooling chamber 1.

[0020] like Figure 2 and Figure 3 As shown, a cover plate 32 is fixedly connected to the upper end of the heat exchange box 31. Heat dissipation holes are provided on the outer walls of both the heat exchange box 31 and the cover plate 32. A circulating cooling pipe 33 is fixedly installed inside the cover plate 32. A temperature converter 34 is fixedly connected to one end of the circulating cooling pipe 33. A temperature sensor is fixedly connected to one side of the temperature converter 34. A guide plate 35 and a fixing plate 36 are fixedly connected inside the heat exchange box 31. A second motor 37 is fixedly connected to one side of the fixing plate 36. A fan 38 is fixedly connected to the output end of the second motor 37. The circulating cooling pipe 33 is wound around the test tube 7 to facilitate the removal of heat from the test tube 7. The temperature changes are monitored in real time with the help of the temperature converter 34 and the temperature sensor. Heat dissipation holes are provided on the side walls of both the heat exchange box 31 and the cover plate 32 to facilitate heat dissipation. Together with the external refrigeration components, the cooling effect of the equipment is effectively improved. In addition, the fan 38 driven by the second motor 37 rotates and promotes airflow through the guide plate 35 to blow away the heat carried out by the heat exchange tube, further improving the cooling efficiency of the equipment. like Figure 4 As shown, a connecting seat 82 is fixedly connected to one side of the fixed seat 81, a second buckle 89 is movably connected to one end of the fixed seat 81, a sliding cylinder 84 is movably connected to one end of the connecting seat 82, a damping shaft 83 is provided between the connecting seat 82 and the sliding cylinder 84, a spring 85 is slidably connected inside the sliding cylinder 84, a telescopic rod 86 is fixedly connected to one end of the spring 85, a locking plate 87 is fixedly connected to one end of the telescopic rod 86, and a pull rod 88 is movably connected to one side of the locking plate 87. The damping shaft 83 allows the buckle component to rotate, making it easy to fold the equipment when not in use. The spring 85 allows the telescopic rod 86 to extend and retract within the sliding cylinder 84, facilitating the adjustment of different lengths, and the retraction of the spring 85 makes the locking plate 87 more tightly connected.

[0021] The working principle of this utility model is as follows: A circulating cooling pipe 33 is wound around the test tube 7 through the heat exchange device 3 to facilitate the removal of heat from the test tube 7. The temperature change is monitored in real time by the temperature converter 34 and the temperature sensor. Heat dissipation holes are provided on the side walls of the heat exchange box 31 and the cover plate 32 to facilitate heat dissipation. Together with the external refrigeration components, the cooling effect of the equipment is effectively improved. In addition, the fan 38 is driven by the second motor 37 to rotate. The air guide plate 35 promotes circulation and blows away the heat carried out by the heat exchange tube, further improving the cooling efficiency of the equipment. The buckle device 8 is used, and the damping shaft 83 is set so that the buckle component can rotate, which makes it easy to fold the equipment when not in use. The spring 85 allows the telescopic rod 86 to extend and retract in the sliding cylinder 84, which facilitates the adjustment of different lengths. The retraction of the spring 85 makes the connection of the clamp plate 87 tighter.

[0022] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claims. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A cooling device used in stem cell cryopreservation, including a cooling box (1), characterized in that: The cooling box (1) is fixedly connected to the middle of the lower end of a first motor (2), and the output end of the first motor (2) is fixedly connected to a heat exchange device (3). The upper end of the heat exchange device (3) is fixedly connected to a slide rod (4), and the outer wall of the slide rod (4) is slidably connected to a spring (5). The upper end of the spring (5) is fixedly connected to a mounting plate (6), and the upper end of the mounting plate (6) is movably connected to a test tube (7). The upper end of the mounting plate (6) is fixedly connected to a buckle device (8), and the lower end of the cooling box (1) is fixedly connected to a support leg (9). The heat exchange device (3) includes a heat exchange box (31), the lower end of which is fixedly connected to the output end of the first motor (2); The buckle device (8) includes a fixing seat (81), the lower end of which is fixedly connected to the upper end of the mounting plate (6).

2. The cooling device used in stem cell cryopreservation according to claim 1, characterized in that: Cooling plates are fixedly connected to both sides of the cooling box (1), a radiator is fixedly connected to one side of the cooling plate, a controller is fixedly connected to the front end of the cooling box (1), and a sealing cover is fixedly connected to the top of the cooling box (1).

3. The cooling device used in stem cell cryopreservation according to claim 1, characterized in that: The upper end of the heat exchange box (31) is fixedly connected to a cover plate (32). The outer walls of the heat exchange box (31) and the cover plate (32) are provided with heat dissipation holes. A circulating cooling pipe (33) is fixedly installed inside the cover plate (32).

4. The cooling device used in stem cell cryopreservation according to claim 3, characterized in that: A temperature converter (34) is fixedly connected to one end of the circulating cooling pipe (33), and a temperature sensor is fixedly connected to one side of the temperature converter (34). An air guide plate (35) and a fixing plate (36) are fixedly connected inside the heat exchange box (31).

5. The cooling device used in stem cell cryopreservation according to claim 4, characterized in that: A second motor (37) is fixedly connected to one side of the fixed plate (36), and a fan (38) is fixedly connected to the output end of the second motor (37).

6. The cooling device used in stem cell cryopreservation according to claim 1, characterized in that: A connecting seat (82) is fixedly connected to one side of the fixed seat (81), a second buckle (89) is movably connected to one end of the fixed seat (81), and a sliding groove cylinder (84) is movably connected to one end of the connecting seat (82).

7. The cooling device used in stem cell cryopreservation according to claim 6, characterized in that: A damping shaft (83) is provided between the connecting seat (82) and the sliding cylinder (84). A spring (85) is slidably connected inside the sliding cylinder (84), and a telescopic rod (86) is fixedly connected to one end of the spring (85).

8. The cooling device used in stem cell cryopreservation according to claim 7, characterized in that: One end of the telescopic rod (86) is fixedly connected to a clamping plate (87), and a pull rod (88) is movably connected to one side of the clamping plate (87).

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