Gene chip scanning apparatus

Abstract

The utility model relates to a kind of gene chip scanning equipment, including cabinet, automatic discharge mechanism and optical scanning mechanism are equipped in cabinet, optical scanning mechanism is set in the discharge side of automatic discharge mechanism;Automatic discharge mechanism includes stock bin mechanism and feeding mechanism;Optical scanning mechanism includes multiband fluorescence module, optical fiber light source, focusing scanning mechanism and scanning platform;Different wavelength fluorescence light source is provided by multiband fluorescence module to optical fiber light source;Scan module is set in the first light side of multiband fluorescence module in focusing scanning mechanism, focusing module is set in the second light side of multiband fluorescence module;Scanning platform is movably set in the second light side of multiband fluorescence module, for carrying tray and moving tray to scanning position.The utility model can realize the high-speed accurate scanning of gene chip, with higher processing precision and processing efficiency.

Description

Technical Field

[0001] This utility model relates to the field of gene chip scanning equipment, and in particular to a gene chip scanning device. Background Technology

[0002] Gene chips, also known as DNA microarrays, are an important high-throughput molecular biology technique. Their core characteristic lies in their ability to simultaneously, rapidly, and in parallel detect the expression levels or genotypes of thousands of genes. Scanning gene chips is a crucial step in the chip-based experimental process for acquiring raw data. Gene chip scanning requires scanners with high sensitivity, high resolution, high dynamic range, high signal-to-noise ratio, and multi-wavelength detection capabilities.

[0003] Gene chip scanning involves the detection light provided by a light source passing through an excitation filter and a beam splitter filter before reaching the glass slide sample via an objective lens. The light reflected from the slide sample then enters the objective lens and beam splitter filter before returning to the detector, which acquires the scanned image of the slide sample. Therefore, a gene chip scanner generally includes a light source, filters, and a scanning mechanism. Currently, common gene chip scanners use LED lights as the light source. However, this light source suffers from energy dispersion, poor image uniformity, and low scanning resolution. Furthermore, the loading and unloading mechanisms of these scanners are structurally complex and inefficient, severely impacting the scanning accuracy and processing efficiency of gene chip scanners. Utility Model Content

[0004] To address the technical problems existing in the prior art, the purpose of this utility model is to provide a gene chip scanning device to improve the scanning accuracy and processing efficiency of gene chip scanners.

[0005] To achieve the above-mentioned utility model objectives, this utility model provides a gene chip scanning device, including a housing, wherein an automatic feeding mechanism and an optical scanning mechanism are provided inside the housing, and the optical scanning mechanism is disposed on the feeding side of the automatic feeding mechanism;

[0006] The automatic discharging mechanism includes:

[0007] A hopper mechanism for storing trays on which glass slides are supported;

[0008] A loading and unloading mechanism is provided on the discharge side of the hopper mechanism for removing the material tray from the hopper mechanism and placing the material tray into the hopper mechanism;

[0009] The optical scanning mechanism includes:

[0010] Multi-band fluorescence module, used to provide different fluorescence light sources;

[0011] An optical fiber light source provides fluorescence light sources of different wavelengths through a multi-band fluorescence module, wherein the optical fiber light source is disposed on the light-incident side of the multi-band fluorescence module;

[0012] The focusing and scanning mechanism includes a scanning module and a focusing module. The scanning module is disposed on the first light-emitting side of the multi-band fluorescence module, and the focusing module is disposed on the second light-emitting side of the multi-band fluorescence module.

[0013] A scanning platform is movably positioned on the second light-emitting side of the multi-band fluorescence module to carry the material tray and move the material tray to the scanning position; the focusing module is positioned between the multi-band fluorescence module and the scanning platform.

[0014] According to one technical solution of this utility model, the multi-band fluorescence module further includes:

[0015] The optical fiber output port is connected to the optical fiber light source and is used to output light of different wavelengths;

[0016] The color filter switching module is equipped with multiple color filters, each of which is provided with an excitation filter and a beam-splitting filter.

[0017] A reflector and a focusing mirror are disposed between the optical fiber output port and the color filter switching module to allow the light output from the optical fiber output port to be incident on the excitation filter.

[0018] According to one technical solution of this utility model, the multi-band fluorescence module further includes:

[0019] An auxiliary light source is positioned between the scanning platform and the focusing module;

[0020] The multi-band fluorescence module bracket includes the fiber optic output port, the color filter switching module, the reflector, the light-collecting lens, and the auxiliary light source, all of which are mounted on the multi-band fluorescence module bracket.

[0021] According to one technical solution of this utility model, the focusing module includes a focusing longitudinal moving device and an objective lens mounted on the focusing longitudinal moving device;

[0022] The scanning module includes a camera and an optical tube arranged from top to bottom.

[0023] According to one technical solution of this utility model, the optical tube is detachably connected to the acquisition camera.

[0024] According to one technical solution of this utility model, an aperture switching device is provided on the optical tube diameter.

[0025] According to one technical solution of this utility model, the housing includes:

[0026] Main body of the casing;

[0027] The first door panel is installed on the main body of the housing and is located on one side of the scanning module;

[0028] The second door panel is installed on the side of the main body of the casing and is located on the feeding side of the hopper mechanism.

[0029] According to one technical solution of this utility model, shock-absorbing pads are provided on the bottom surface of the main body of the casing.

[0030] According to one technical solution of this utility model, symmetrically arranged lifting handles are provided on both sides of the main body of the casing.

[0031] According to one technical solution of this utility model, the hopper mechanism includes:

[0032] The silo body has a discharge port and a discharge port on its two sides, which are arranged opposite to each other. The silo body has multiple material trays arranged longitudinally for material loading.

[0033] A hopper drive mechanism, the output end of which is connected to the hopper body, is used to drive the hopper body to move longitudinally;

[0034] The material tray positioning device includes a material tray sensor and a material tray positioning rack. The material tray positioning rack is disposed on the side of the hopper body and works in conjunction with the material tray sensor to position the material level on the material tray.

[0035] According to one technical solution of this utility model, the hopper mechanism further includes:

[0036] The material tray is designed to prevent leakage from the bottom plate and is positioned above the discharge port.

[0037] A material tray leakage prevention sensor is installed above the discharge port to detect whether the material tray is protruding from the discharge port.

[0038] According to one technical solution of this utility model, the loading and unloading mechanism is disposed on one side of the scanning platform, and the loading and unloading mechanism includes:

[0039] Hook support base;

[0040] A transverse module is disposed inside the housing, and the grab hook support is disposed on the transverse module. The transverse module is used to drive the grab hook support to move along the discharge direction of the hopper body.

[0041] The grab hook is mounted on the grab hook support base via a grab hook longitudinal motion module, which drives the grab hook to move longitudinally along the grab hook support base.

[0042] According to one technical solution of this utility model, the longitudinal motion module of the gripper hook includes a drive motor, a gear and a rack. The gripper hook is fixedly connected to the rack, and the rack is arranged longitudinally on the gripper hook support. The gear is arranged on the output shaft of the drive motor, and the rack meshes with the gear.

[0043] According to one technical solution of this utility model, the material tray is provided with a plurality of glass slide mounting slots, and a glass slide positioning structure is provided on one side of the glass slide mounting slot; a hook embedding slot is provided on one side of the material tray, and an opening is provided on one side of the hook embedding slot, and a hook engaging part is provided in the opening.

[0044] According to one technical solution of this utility model, the material tray is provided with a handle on the side opposite to the hook embedding groove.

[0045] According to one technical solution of this utility model, the hopper mechanism further includes:

[0046] Two material tray organizing blocks are disposed on one side of the discharge port, and the two material tray organizing blocks are disposed opposite to each other. A handle groove is formed between the two material tray organizing blocks. The handle groove is disposed along the length direction of the discharge port and is used to accommodate the handle.

[0047] According to one technical solution of this utility model, a positioning device is provided on the side of the material tray, which is used to cooperate with the positioning structure in the material position of the silo to position the material tray in the material position of the silo.

[0048] Compared with the prior art, this utility model has the following advantages:

[0049] This invention proposes a gene chip scanning device that uses an optical fiber light source to provide light of different wavelengths to a multi-band fluorescence module, thereby increasing the intensity of the scanning light source and improving the exposure efficiency of fluorescence scanning. This enables high-speed fluorescence scanning and effectively improves the scanning efficiency and imaging resolution of the optical scanning mechanism. Multiple trays are stored through a hopper mechanism, and the trays are automatically retrieved and placed in the hopper mechanism via a loading and unloading mechanism, achieving automatic loading and unloading of trays during the scanning process. This allows for efficient automatic scanning of multiple trays, significantly improving the efficiency of gene chip scanning. Compared to existing scanning devices, the gene chip scanning device provided by this invention can complete scanning of 5 times the number of slides in the same scanning time, exhibiting higher work efficiency. Furthermore, the gene chip scanning device provided by this invention is not only capable of gene chip scanning but is also compatible with bright-field pathological scanning, demonstrating broad applicability. Attached Figure Description

[0050] To more clearly illustrate the embodiments of this utility model or the technical solutions in the prior art, the drawings used in the embodiments will be briefly described below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without any creative effort.

[0051] Figure 1 A schematic view of a gene chip scanning device according to an embodiment of the present invention;

[0052] Figure 2 This is a schematic diagram illustrating the internal structure of a gene chip scanning device according to an embodiment of the present invention.

[0053] Figure 3 This is a schematic diagram illustrating the internal structure of a gene chip scanning device according to an embodiment of the present invention.

[0054] Figure 4 This is a schematic diagram illustrating the structure of the automatic discharging mechanism according to an embodiment of the present invention.

[0055] Figure 5 This schematic diagram illustrates the structure of the hopper mechanism according to an embodiment of the present invention.

[0056] Figure 6 This is a schematic diagram illustrating the structure of the loading and unloading mechanism according to an embodiment of the present utility model.

[0057] Figure 7 This schematic diagram illustrates the structure of the loading and unloading mechanism from another angle according to an embodiment of the present invention.

[0058] Figure 8 This is a schematic diagram illustrating the structure of the longitudinal motion module of the gripper hook according to an embodiment of the present invention.

[0059] Figure 9 This is a schematic diagram illustrating the structure of the tray according to an embodiment of the present invention;

[0060] Figure 10 This schematic diagram illustrates the structure of the optical scanning mechanism according to an embodiment of the present invention.

[0061] Figure 11 The schematic diagram illustrates the structure of the scanning module and the focusing module according to an embodiment of the present utility model.

[0062] Figure 12 The schematic diagram illustrates the structure of the multi-band fluorescence module according to an embodiment of the present invention.

[0063] The correspondence between component names and reference numerals in the accompanying drawings is as follows:

[0064] 1. Housing; 2. Material hopper mechanism; 3. Loading and unloading mechanism; 4. Multi-band fluorescence module; 5. Fiber optic light source; 6. Scanning platform; 7. Scanning module; 8. Focusing module; 9. Material tray;

[0065] 11. Main body of the casing; 12. First door panel; 13. Second door panel; 14. Shock-absorbing feet; 15. Lifting handle;

[0066] 21. Hopper body; 22. Hopper drive mechanism; 23. Tray sensor; 24. Tray positioning rack; 25. Tray anti-rear leakage base plate; 26. Tray anti-front leakage sensor; 27. Tray sorting block;

[0067] 31. Lateral movement module; 32. Grappling hook support; 33. Grappling hook longitudinal movement module;

[0068] Linear guide rail 311; slider 312;

[0069] Drive motor 341; Gear 342; Rack 343;

[0070] Fiber optic output port 41; color filter switching module 42; reflector 43; light collector 44; auxiliary light source 45; multi-band fluorescence module bracket 46;

[0071] Color filter block 421; turntable 422; color filter block rotation motor 423;

[0072] Camera 71; Optical tube diameter 72;

[0073] Focusing longitudinal movement device 81; objective lens 82;

[0074] Slide mounting groove 91; slide positioning structure 92; hook embedding groove 93; handle 94; positioning device 95. Detailed Implementation

[0075] The description of the embodiments in this specification should be taken in conjunction with the accompanying drawings, which should form part of the complete specification. In the drawings, the shape or thickness of the embodiments may be exaggerated and may be indicated in a simplified or convenient manner. Furthermore, parts of the various structures in the drawings will be described separately; it is worth noting that elements not shown in the figures or not described in words are in a form known to those skilled in the art.

[0076] The description of the embodiments herein, including any references to direction and orientation, is for ease of description only and should not be construed as limiting the scope of protection of this utility model. The following description of preferred embodiments involves combinations of features, which may exist independently or in combination; this utility model is not particularly limited to the preferred embodiments. The scope of this utility model is defined by the claims.

[0077] like Figures 1 to 12 As shown, the gene chip scanning device provided by this utility model includes a housing 1, within which an automatic feeding mechanism and an optical scanning mechanism are provided. The optical scanning mechanism is located on the feeding side of the automatic feeding mechanism and is used to scan the material tray 9 output by the automatic feeding mechanism and the glass slide carried by the material tray. In this utility model, the feeding direction parallel to the automatic feeding mechanism is defined as the transverse direction, and the feeding direction perpendicular to the automatic feeding mechanism is defined as the longitudinal direction.

[0078] The automatic feeding mechanism includes a hopper mechanism 2 and a loading / unloading mechanism 3. The hopper mechanism 2 stores the tray 9 containing the glass slides. The loading / unloading mechanism 3 is located on the discharge side of the hopper mechanism 2 and is used to remove the tray 9 from the hopper mechanism 2 and place the tray 9 back into the hopper mechanism 2. Through the hopper mechanism 2 and the loading / unloading mechanism 3, automatic loading and unloading of the tray 9 during scanning can be achieved.

[0079] The optical scanning mechanism includes a multi-band fluorescence module 4, a fiber optic light source 5, a focusing and scanning mechanism, and a scanning platform 6. The fiber optic light source 5 is located on the light-incident side of the multi-band fluorescence module 4. The fiber optic light source 5 provides light of different wavelengths, and the multi-band fluorescence module 4 provides different fluorescence sources depending on the fiber optic light source 5. The focusing and scanning mechanism includes a scanning module 7 and a focusing module 8. The scanning module 7 is located on the first light-emitting side of the multi-band fluorescence module 4, and the focusing module 8 is located on the second light-emitting side of the multi-band fluorescence module 4. The scanning module 7 is used for digitally capturing images of the slide, and the focusing module 8 is used for focusing the slide. The scanning platform 6 is movable and located on the second light-emitting side of the multi-band fluorescence module 4, used to carry the material tray 9 and move the material tray 9 to the scanning position. The focusing module 8 is located between the multi-band fluorescence module 4 and the scanning platform 6. Figure 2 As shown, in this embodiment of the invention, the upper part of the multi-band fluorescence module 4 is the first light emission direction, and the lower part of the multi-band fluorescence module 4 is the second light emission direction. In this embodiment of the invention, the loading and unloading mechanism 3 is located behind the optical scanning mechanism. The loading and unloading mechanism 3 and the optical scanning mechanism are arranged in a front-to-back manner, which greatly reduces the width of the scanning device and improves the user experience.

[0080] In the embodiments of this utility model, preferably, such as Figure 10As shown, the multi-band fluorescence module 4 includes an optical fiber output port 41, a color filter switching module 42, a reflector 43, and a focusing mirror 44. The optical fiber output port 41 is connected to an optical fiber light source and is used to output light of different wavelengths. The color filter switching module 42 is provided with multiple color filters 421. Each color filter 421 has a blocking filter and a dichroic mirror. A first light outlet and a second light outlet are provided on the top and bottom surfaces of each color filter 421. A light inlet is provided on the side of the color filter 421. The light generated by the light source passes through the reflector 43 and the focusing mirror 44 and then enters the color filter 421 through the light inlet. After passing through the blocking filter and the dichroic mirror, it is output from the second light outlet to the slice. The light reflected from the slice passes through the second light outlet and the first light outlet in sequence and enters the scanning module 8. The color filter switching module 42 can be a combination of a turntable 422 and a color filter rotation motor 423. Color filters 421 are mounted on the turntable 422. The color filter rotation motor 423 rotates to switch the color filters 421 located on the optical path, achieving the output of different fluorescent light sources. A reflector 43 and a focusing mirror 44 are positioned between the fiber optic output port 41 and the color filter switching module 42, used to input the light output from the fiber optic output port 41 to the excitation filter on the color filter 421. By changing the path of the light emitted from the fiber optic output port 41 through the reflector 43, and by collecting and converging the energy of the light emitted from the reflector 43 through the focusing mirror 44 before incident on the color filter 421, the energy of the fluorescent light source provided by the color filter switching module 42 can be effectively increased, thereby improving the scanning resolution during the final imaging of the scanning mechanism. Preferably, the optical path bending angle generated by the reflector 43 is 90°, further reducing the size of the multi-band fluorescent module 4. The multi-band fluorescence module 4 is compatible with up to 10 fluorescence bands, meeting the scanning needs of most products.

[0081] In the embodiments of this utility model, preferably, such as Figure 10 As shown, the multi-band fluorescence module 4 includes an auxiliary light source 45, which is positioned between the scanning platform 6 and the focusing module 8 to provide supplementary lighting, thereby increasing the incident light intensity of the focusing module 8 and improving the scanning imaging effect. In a preferred embodiment of this invention, the fiber optic output port 41, the color filter switching module 42, the reflector 43, the light-collecting mirror 44, and the auxiliary light source 45 can all be mounted on the multi-band fluorescence module bracket 46 to reduce the size of the multi-band fluorescence module 4, which is beneficial for miniaturization and integration of the device.

[0082] In the embodiments of this utility model, preferably, such as Figure 9As shown, the scanning module 7 includes an acquisition camera 71 and an optical tube 72 arranged sequentially from top to bottom. The acquisition camera 71 is used to acquire the required image. The optical tube 72 is detachably connected to the acquisition camera 71, allowing for easy replacement of optical tubes 72 with different magnifications to meet the magnification requirements of different products. An aperture switching device is also provided at the lower end of the optical tube 72, which has apertures of different diameters. This device is used to adjust the aperture size at the light incident end of the optical tube 72, thereby adapting different apertures to image acquisition at different magnifications to achieve better imaging results.

[0083] The focusing mechanism 8 includes a focusing longitudinal movement device 81 and an objective lens 82. The objective lens 82 is mounted on the focusing longitudinal movement device 81. The focusing longitudinal movement device 81 drives the objective lens 82 to move longitudinally within the housing 1 to achieve precise focusing and reach the desired sharpest focal plane. The objective lens 82 mainly serves a magnifying function. The objective lens 82 is detachably connected to the focusing longitudinal movement device 81, allowing for the configuration of different magnification objectives according to different usage needs.

[0084] In the embodiments of this utility model, preferably, such as Figure 1 As shown, the housing 1 includes a housing body 11, a first door panel 12, and a second door panel 13. The first door panel 12 is installed on the housing body 1 and is located on one side of the focusing scanning mechanism for easy observation and maintenance of the scanning mechanism. The second door panel 13 is installed on the side of the housing body 11 and is located on the feeding side of the hopper mechanism 2 for easy placement of the material tray 9 on the hopper mechanism 2 for feeding the hopper mechanism 2.

[0085] In the embodiments of this utility model, preferably, such as Figure 1 As shown, shock-absorbing pads 14 are provided on the bottom surface of the main body 11 of the housing to isolate the influence of external vibrations as much as possible and avoid vertical movement during multi-band scanning, which could lead to poor stitching. Symmetrically arranged lifting handles 15 are provided on both sides of the main body 11 of the housing. The main function of the lifting handles 15 is to facilitate the handling of the equipment, otherwise, there may be uncertain impacts on the internal parts of the equipment.

[0086] In the embodiments of this utility model, preferably, such as Figure 3 and 4As shown, the hopper mechanism 2 includes a hopper body 21, a hopper drive mechanism 22, and a tray positioning device. A discharge port and a feed port are respectively provided on both sides of the hopper body 21, facing each other. Multiple trays with material positions are arranged longitudinally within the hopper body 21. The output end of the hopper drive mechanism 22 is connected to the hopper body 21 to drive the hopper body 21 to move longitudinally. Preferably, the hopper drive mechanism 22 can be a combination of a drive motor and a lead screw, with a hopper mounting plate on the lead screw, connected to the side of the hopper body 21. The tray positioning device includes a tray sensor 23 and a tray positioning rack 24. The tray positioning rack 24 is located on the side of the hopper body 21, and the positions of the teeth on the tray positioning rack 24 correspond one-to-one with the material positions on the tray. The teeth on the tray positioning rack 24 cooperate with the tray sensor 23 to perform longitudinal positioning of the material positions on the tray, sensing whether the movement of each tray layer is in place.

[0087] In the embodiments of this utility model, preferably, such as Figure 4 As shown, the hopper mechanism 2 also includes a rear leakage prevention base plate 25 and a front leakage prevention sensor 26. The rear leakage prevention base plate 25 is located above the discharge port of the hopper body 21 to prevent the hopper from moving towards the discharge side when discharging material. The front leakage prevention sensor 26 is located above the discharge port of the hopper body 21 to detect the protrusion of the hopper at the discharge port.

[0088] In the embodiments of this utility model, preferably, such as Figure 3 and 4 As shown, the loading / unloading mechanism 3 is located on one side of the scanning platform 6. The loading / unloading mechanism 3 includes a transverse module 31, a hook support base 32, and a hook 33. The transverse module 31 is located along the inner edge of the main body 11 of the housing, and the hook support base 32 is located on the top surface of the transverse module 31. The transverse module 31 is used to drive the hook support base 32 to move along the discharge direction of the hopper body 21. The hook 33 is mounted on the hook support base 32 via a hook longitudinal motion module 34, which is used to drive the hook 33 to move longitudinally along the hook support base 32. The transverse module 31 can be in the form of a linear guide rail and a slider. The transverse module 31 includes a linear guide rail 311 and a slider 312. The hook support base 32 is located on the side of the slider 312 and above the scanning platform 6. When the hook support base 32 moves along the linear guide rail 311, the tray 9 falls onto the scanning platform 6.

[0089] In the embodiments of this utility model, preferably, such as Figure 5As shown, the longitudinal motion module 34 of the gripper hook can adopt a gear and rack meshing method. The longitudinal motion module 34 of the gripper hook includes a drive motor 341, a gear 342 and a rack 343. The gripper hook 33 is fixedly connected to the rack 343. The rack 343 is arranged longitudinally on the gripper hook support 32. The gear 342 is arranged on the output shaft of the drive motor 341. The rack 343 meshes with the gear 342. The drive motor 341 drives the gear 342, and the gear 342 drives the rack 343 to move longitudinally, thereby realizing the longitudinal movement of the gripper hook 33.

[0090] In the embodiments of this utility model, preferably, such as Figure 7 As shown, the tray 9 is provided with multiple slide mounting slots 91. A slide positioning structure 92 is provided on one side of the slide mounting slot 91. The slide positioning structure 92 can be in the form of an elastic buckle. One end of the elastic buckle is fixedly connected to the slide mounting slot 9. When the elastic buckle is pushed upward to make it elastically deform, the slide can be placed into the slide mounting slot 9. Then, the elastic buckle is released to restore its original shape and engage with the slide, thus restricting the slide within the slide mounting slot 9 to improve the stability of the slide on the tray 9.

[0091] In a preferred embodiment of this utility model, the scanning platform 9 is a high-strength scanning platform with good stability, fast motion stabilization, and high overall motion efficiency; all scanning axes are equipped with closed-loop feedback, which can continuously query the accuracy of the position; the loading and unloading mechanism also adopts closed-loop feedback of magnetic grating, which can accurately determine the position status of the target.

[0092] The working process of this utility model is as follows:

[0093] A hook insertion groove 93 is provided on one side of the material tray 9. An opening is provided on one side of the hook insertion groove 93, and a hook engaging part is provided in the opening. Through the hook insertion groove 93 with an opening on one side, the hook 33 on the hook support 32 can move longitudinally into the hook insertion groove 93 during loading and unloading, and engage with the hook engaging part, thereby improving the efficiency of the loading and unloading mechanism 3 in acquiring the material tray 9, and thus improving the loading and unloading efficiency of the loading and unloading mechanism 3.

[0094] A handle 94 is provided on the side of the material tray 9 facing away from the hook insertion groove 93. The hopper mechanism 2 also includes two material tray organizing blocks 27, which are set on one side of the material discharge port of the hopper body 21. The two material tray organizing blocks 27 are arranged opposite each other and form a handle groove between the two material tray organizing blocks 27. The handle groove is set along the length direction of the material discharge port and is used to accommodate the handle 94. The lateral position of the material tray 9 in the material loading position of the hopper can be adjusted by the material tray organizing blocks 27. By adjusting so that the handles 94 are all set in the handle groove, it is ensured that the multiple material trays 9 in the hopper body 21 are evenly distributed, thereby improving the precise movement of the transverse moving module 31 in the loading and unloading mechanism 3 and the precise engagement of the hook 33 with the hook insertion groove 93 on the material tray 9.

[0095] A positioning device 95 is provided on the side of the material tray 9, which is used to cooperate with the positioning structure on the material level in the hopper body 21 to perform lateral positioning of the material tray 9 within the material level. The positioning device 95 can be a plunger set in a groove on the side of the material tray 9. The plunger is telescopically set on the side of the material tray 9. The positioning structure on the material level can be a positioning groove adapted to the plunger. When the plunger retracts into the groove as the material tray 9 moves within the material level, until the material tray 9 moves to the correct position, the plunger extends and engages with the positioning groove, thereby achieving lateral positioning of the material tray 9 within the material level.

[0096] The working process of this utility model is as follows:

[0097] Open the positioning device 95 of the slide mounting slot 91, put the slide into the material tray 9, and then hold the handle 94 to insert the material tray 9 into the material hopper 21 through the discharge port on the material hopper body 21, and push the material tray 9 until the plunger is embedded in the positioning slot and stops.

[0098] The hopper drive mechanism 22 drives the hopper body 21 to move longitudinally from top to bottom, one material position at a time. When the material tray 9 is placed into the hopper body 21, the material tray 9 is blocked by the material tray anti-leakage bottom plate 25 to prevent the material tray 9 from leaking out from the discharge side of the hopper body 21. The material tray anti-front leakage sensor 26 detects the position of the material tray 9 on the discharge side of the hopper body 21. If the material tray 9 is placed too far forward (i.e. protruding along the discharge side of the hopper body 21), a warning is issued. If the material tray 9 is placed well, the hopper drive mechanism 22 continues to drive the hopper body 21 to move downward. Finally, the material tray is sorted by the material tray sorting block 27 to make the distribution of the material tray 9 more uniform. After sorting, the hopper drive mechanism 22 moves the hopper body 21 to the material tray to be scanned, and the loading and unloading mechanism 3 picks it up.

[0099] After the material tray 9 is detected to have moved into position by the material tray sensor 23, a position signal is sent. The transverse module 31 drives the hook support 32 to move to the docking position. The drive motor 341 drives the gear 342 to rotate, causing the hook 33 to move down and embed into the hook embedding groove 93 of the material tray 9. The transverse module 31 moves in the opposite direction, thereby moving the material tray 9 to the scanning platform 6. After scanning is completed, the transverse module 31 moves towards the hopper body 21 until the material tray 9 is pushed into the hopper body 21.

[0100] The loading and unloading mechanism 3 transports the material tray 9 to the scanning platform 6. The scanning platform 6 moves to read the QR code and identify the scanning area. After the scanning area is determined, the focusing longitudinal moving device 81 moves the objective lens 82 to perform multi-point focusing and determine the focal plane height at each position. Then, the scanning platform 6 moves to the scanning start position and provides light of different wavelengths through the fiber optic light source 5. The color filter rotating motor 423 rotates the turntable 422 to switch different color filters 421 to provide different light sources and perform scanning in different bands. During scanning, the acquisition camera 71 acquires the required image. After one slide is scanned, the next slide is scanned. After multiple slides in each material tray 9 have been scanned, the material is discharged.

[0101] It should be noted that the above description represents a preferred embodiment of this utility model. While preferred embodiments have been described, those skilled in the art, upon understanding the basic inventive concept of this utility model, can make various improvements and modifications without departing from the principles described herein. These improvements and modifications should also be considered within the scope of protection of this utility model. Therefore, the appended claims are intended to be interpreted as including both the preferred embodiments and all changes and modifications falling within the scope of the embodiments of this utility model.

Claims

1. A gene chip scanning device, comprising a housing, characterized in that, The housing is equipped with an automatic discharging mechanism and an optical scanning mechanism, with the optical scanning mechanism located on the discharging side of the automatic discharging mechanism. The automatic discharging mechanism includes: A hopper mechanism for storing trays on which glass slides are supported; A loading and unloading mechanism is provided on the discharge side of the hopper mechanism for removing the material tray from the hopper mechanism and placing the material tray into the hopper mechanism; The optical scanning mechanism includes: An optical fiber light source provides fluorescence light sources of different wavelengths through a multi-band fluorescence module, wherein the optical fiber light source is disposed on the light-incident side of the multi-band fluorescence module; The focusing and scanning mechanism includes a scanning module and a focusing module. The scanning module is disposed on the first light-emitting side of the multi-band fluorescence module, and the focusing module is disposed on the second light-emitting side of the multi-band fluorescence module. A scanning platform is movably positioned on the second light-emitting side of the multi-band fluorescence module to carry the material tray and move the material tray to the scanning position; the focusing module is positioned between the multi-band fluorescence module and the scanning platform.

2. The gene chip scanning device according to claim 1, characterized in that, The multi-band fluorescence module also includes: The optical fiber output port is connected to the optical fiber light source and is used to output light of different wavelengths; The color filter switching module is equipped with multiple color filters, each of which is provided with an excitation filter and a beam-splitting filter. A reflector and a focusing mirror are disposed between the optical fiber output port and the color filter switching module to allow the light output from the optical fiber output port to be incident on the excitation filter.

3. The gene chip scanning device according to claim 2, characterized in that, The multi-band fluorescence module also includes: An auxiliary light source is positioned between the scanning platform and the focusing module; The multi-band fluorescence module bracket includes the fiber optic output port, the color filter switching module, the reflector, the light-collecting lens, and the auxiliary light source, all of which are mounted on the multi-band fluorescence module bracket.

4. The gene chip scanning device according to claim 1, characterized in that, The focusing module includes a focusing longitudinal moving device and an objective lens mounted on the focusing longitudinal moving device; The scanning module includes a camera and an optical tube arranged from top to bottom.

5. The gene chip scanning device according to claim 4, characterized in that, The optical tube is detachably connected to the acquisition camera.

6. The gene chip scanning device according to claim 4, characterized in that, An aperture switching device is provided on the optical tube.

7. The gene chip scanning device according to claim 1, characterized in that, The housing includes: Main body of the casing; The first door panel is installed on the main body of the housing and is located on one side of the scanning module; The second door panel is installed on the side of the main body of the casing and is located on the feeding side of the hopper mechanism.

8. The gene chip scanning device according to claim 7, characterized in that, Shock-absorbing pads are provided on the bottom surface of the main body of the casing.

9. The gene chip scanning device according to claim 7, characterized in that, Symmetrically arranged lifting handles are provided on both sides of the main body of the casing.

10. The gene chip scanning device according to claim 1, characterized in that, The silo mechanism includes: The silo body has a discharge port and a discharge port on its two sides, which are arranged opposite to each other. The silo body has multiple material trays arranged longitudinally for material loading. A hopper drive mechanism, the output end of which is connected to the hopper body, is used to drive the hopper body to move longitudinally; The material tray positioning device includes a material tray sensor and a material tray positioning rack. The material tray positioning rack is disposed on the side of the hopper body and works in conjunction with the material tray sensor to position the material level on the material tray.

11. The gene chip scanning device according to claim 10, characterized in that, The silo mechanism also includes: The material tray is designed to prevent leakage from the bottom plate and is positioned above the discharge port. A material tray leakage prevention sensor is installed above the discharge port to detect whether the material tray is protruding from the discharge port.

12. The gene chip scanning device according to claim 10, characterized in that, The loading and unloading mechanism is disposed on one side of the scanning platform, and the loading and unloading mechanism includes: Hook support base; A transverse module is disposed inside the housing, and the grab hook support is disposed on the transverse module. The transverse module is used to drive the grab hook support to move along the discharge direction of the hopper body. The grab hook is mounted on the grab hook support base via a grab hook longitudinal motion module, which drives the grab hook to move longitudinally along the grab hook support base.

13. The gene chip scanning device according to claim 12, characterized in that, The longitudinal motion module of the gripper hook includes a drive motor, a gear, and a rack. The gripper hook is fixedly connected to the rack, and the rack is arranged longitudinally on the gripper hook support. The gear is arranged on the output shaft of the drive motor, and the rack meshes with the gear.

14. The gene chip scanning device according to claim 10, characterized in that, The tray is provided with multiple slide mounting slots, and a slide positioning structure is provided on one side of each slide mounting slot; a hook embedding slot is provided on one side of the tray, and an opening is provided on one side of the hook embedding slot, with a hook engaging part provided inside the opening.

15. The gene chip scanning device according to claim 14, characterized in that, The tray has a handle on the side opposite to the hook insertion groove.

16. The gene chip scanning device according to claim 15, characterized in that, The silo mechanism also includes: Two material tray organizing blocks are disposed on one side of the discharge port, and the two material tray organizing blocks are disposed opposite to each other. A handle groove is formed between the two material tray organizing blocks. The handle groove is disposed along the length direction of the discharge port and is used to accommodate the handle.

17. The gene chip scanning device according to claim 14, characterized in that, The side of the tray is provided with a positioning device, which is used to cooperate with the positioning structure in the material position of the silo to position the tray in the material position of the silo.

Images