A multi-channel optical detection device

Abstract

The utility model discloses a kind of multi-channel optical detection devices, belong to optical detection technical field, including flow cell assembly, light source assembly and optical detection component, flow cell assembly includes multiple flow channels, the side of each flow channel is provided with first light inlet and second light inlet, the other side is provided with first light outlet and second light outlet, light inlet and light outlet are opposite, optical detection component is installed on light outlet;Light source assembly includes first light source and second light source, and first light source and second light source are respectively connected first light inlet and second light inlet by light guide component.The utility model is by being provided with multiple flow channels on flow cell assembly, can detect multiple solutions simultaneously, improve detection efficiency, and first light inlet and second light inlet are set on each flow channel, and two different wavelength light irradiation solution is realized, so that different compounds in solution can be detected in single flow channel, improve analysis efficiency.

Description

Technical Field

[0001] This utility model relates to the field of optical detection technology, and in particular to a multi-channel optical detection device. Background Technology

[0002] Many substances absorb ultraviolet or visible light due to their chemical composition. The absorption of light by a substance has been used for many years as the basis for detecting the presence of such substances and measuring their concentration. Most analytical instruments use mercury lamps, deuterium lamps, or xenon flash lamps as light sources to detect substances that absorb light in the ultraviolet (UV) region.

[0003] However, traditional optical detection devices typically pre-fill the sample liquid in the cuvette and keep it stationary after filling. They can only use a single wavelength of light to irradiate the substances in the liquid. However, when applied to sample liquids with a variety of compounds, different wavelengths of light are required for irradiation. This necessitates changing the wavelength of the light source output, making it impossible to quickly complete the optical analysis of multiple compounds and resulting in low operating efficiency. Utility Model Content

[0004] The purpose of this invention is to provide a multi-channel optical detection device to solve the problem of low efficiency in traditional liquid chromatography separation devices. It has the advantages of being able to simultaneously meet the optical analysis of sample liquids with different wavelengths of light, being convenient and efficient to operate, and having multiple channels to improve analysis efficiency.

[0005] To achieve the above objectives, the technical solution adopted by this utility model is as follows:

[0006] A multi-channel optical detection device includes a flow cell assembly, a light source assembly, and an optical detection assembly. The flow cell assembly includes multiple flow channels. Each flow channel has a first light inlet and a second light inlet on one side and a first light outlet and a second light outlet on the other side, with the light inlet and the light outlet facing each other.

[0007] The light source assembly includes a first light source and a second light source, both of which are connected to the first light inlet and the second light inlet respectively via a light guide assembly.

[0008] Preferably, the first light source emits light with a wavelength of nm, and the second light source emits light with a wavelength of nm.

[0009] Preferably, the light guide component is a beam splitter fiber, with a converging end and a branching end respectively provided at both ends of the beam splitter fiber. The converging end is connected to the light source, and the branching end is connected to the light inlet of the flow cell component.

[0010] Preferably, fiber optic adapters are installed on both the first and second optical inlets, and the branch ends are threadedly connected to the fiber optic adapters.

[0011] Preferably, both the first and second light sources include a light source housing, an LED light source, a light source cover plate, and a light interface, with the converging end threadedly connected to the light interface.

[0012] Preferably, the flow cell assembly further includes an inlet pipe and an outlet pipe, with the top end of the flow channel connected to the inlet pipe and the bottom end connected to the outlet pipe.

[0013] Preferably, the optical detection assembly includes a signal acquisition board, a plano-convex lens, and a light guide window. Light guide windows are provided at the ends of the light inlet and light outlet of the flow channel near the flow channel. The plano-convex lens is fixed inside the light outlet by a lens mounting base and a lens locking ring. The signal acquisition board is located outside the light outlet.

[0014] Preferably, an outer shielding shell is installed on the outside of the flow cell assembly and the optical detection assembly.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] This utility model improves detection efficiency by setting multiple flow channels on the flow cell assembly, which allows for the simultaneous detection of different types of solutions. Furthermore, each flow channel is equipped with a first light inlet and a second light inlet, which can introduce two wavelengths of light to irradiate the solution. Based on the different absorption of different wavelengths of light by different compounds, a single flow channel can detect different compounds in the solution, thus satisfying the requirement of simultaneous detection of multiple solutions by multiple wavelengths of light. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the overall structure of the multi-channel optical detection device of this utility model.

[0018] Figure 2 This is a schematic diagram of the flow channel distribution structure of this utility model.

[0019] Figure 3 This is a schematic diagram of the assembly of the first and second light sources of this utility model.

[0020] Figure 4 This is a schematic diagram of the installation structure of the light guide component of this utility model.

[0021] Figure 5 This is a schematic diagram of the light source structure of this utility model.

[0022] Figure 6 This is a schematic diagram of the optical detection component of this utility model installed on the flow cell component.

[0023] Figure 7 This is an exploded structural diagram of the optical detection component of this utility model.

[0024] In the diagram: 1. Flow cell assembly; 11. Flow channel; 111. Liquid inlet fitting; 112. Liquid outlet fitting; 12. First light inlet; 13. Second light inlet; 14. First light outlet; 15. Second light outlet; 16. Fiber optic adapter; 2. Light source assembly; 21. First light source; 211. Light source housing; 212. LED light source; 213. Light source cover; 214. Optical interface; 22. Second light source; 23. Light guide assembly; 231. Converging end; 232. Splitting end; 3. Optical detection assembly; 31. Signal acquisition board; 32. Plano-convex lens; 321. Lens mounting base; 322. Lens locking ring; 33. Light guide window; 34. Sealing gasket; 4. Outer shielding shell. Detailed Implementation

[0025] To make the technical means, creative features, objectives and effects of this utility model easier to understand, the present utility model will be further described below in conjunction with specific embodiments.

[0026] like Figure 1 As shown, a multi-channel optical detection device is disclosed, including a flow cell assembly 1, a light source assembly 2, and an optical detection assembly 3. The light source assembly 2 is used to emit ultraviolet or visible light, the flow cell assembly 1 allows sample liquid to flow through, and the optical detection assembly 3 realizes the acquisition of optical signals. The operating principle of the entire device is as follows:

[0027] A sample solution containing multiple compounds enters the flow cell assembly 1. Light is then used to illuminate the solution passing through the flow cell assembly 1. The compounds in the solution absorb light of specific wavelengths, producing specific absorption peaks. The accompanying optical detection assembly 3 measures the absorbance of the sample at different wavelengths and sends the signals to a host computer, thereby analyzing the composition and concentration of the compounds. This describes the operating principle of a single liquid sample solution and a single wavelength of light. However, in practical applications, different compounds can absorb light of different wavelengths, and when there are many types of samples, they need to be analyzed separately. Therefore, the original device structure needs further optimization to allow for the simultaneous detection of multiple sample solutions using multiple wavelengths of light.

[0028] like Figure 1-3 As shown, the flow cell assembly 1 includes multiple flow channels 11. Each flow channel 11 has a first light inlet 12 and a second light inlet 13 on one side and a first light outlet 14 and a second light outlet 15 on the other side, with the light inlet and the light outlet facing each other. The light source assembly 2 includes a first light source 21 and a second light source 22. The first light source 21 and the second light source 22 are both connected to the first light inlet 12 and the second light inlet 13 respectively through a light guide assembly 23.

[0029] The flow cell assembly 1 has multiple flow channels 11 arranged in parallel to accommodate the detection of various sample solutions, such as... Figure 2 As shown, there are nine flow channels 11, i.e., nine detection channels. One of the flow channels 11 can be used as a reference channel without liquid flow. The measurement value of the reference channel can be used for signal calibration. In order to enable the simultaneous detection of the composition and concentration of multiple compounds in a sample liquid within a flow channel 11, the first light inlet 12 and the second light inlet 13 on the flow cell assembly 1 are grouped together, allowing two types of light to be introduced into a single flow channel 11. By irradiating the sample liquid in the flow channel 11 with two different wavelengths of light, the absorption signals of different wavelengths of light are collected, facilitating subsequent analysis by the host computer. This multi-channel dual-wavelength light design greatly improves the detection efficiency. The first light inlet 12 and the second light inlet 13 are only used as light input ports. Different wavelengths of light are generated by the first light source 21 and the second light source 22 of the light source assembly 2. In order to achieve light transmission, a light guide assembly 23 is used to guide the light generated by the first light source 21 and the second light source 22 into each light inlet. Taking the application of 260nm and 280nm wavelength light as an example, the first light source 21 emits light with a wavelength of 260nm, and the second light source 22 emits light with a wavelength of 280nm. The 260nm wavelength light is used to detect DNA, and the 280nm wavelength light is used to detect protein. When the two wavelengths of light simultaneously irradiate the sample liquid in the flow channel 11, the composition and concentration of DNA and protein in the sample liquid can be analyzed simultaneously. If it is a traditional optical detection device, it can only switch light sources and perform optical detection operations multiple times, which is cumbersome and inefficient. Using the scheme of this application, the detection can be performed simultaneously, which greatly improves the detection efficiency.

[0030] The flow cell assembly 1 also includes an inlet pipe 111 and an outlet pipe 112. The top end of the flow channel 11 is connected to the inlet pipe 111 and the bottom end is connected to the outlet pipe 112. The inlet pipe 111 and the outlet pipe 112 are designed to facilitate connection to the sample liquid feeding device and the unloading device, thereby improving the ease of operation.

[0031] As described above, the flow cell assembly 1 has multiple flow channels 11 for simultaneous detection of multiple sample liquids. To ensure that different wavelengths of light can be input into each flow channel 11, a light guide assembly 23 is used to guide the light emitted by the first light source 21 and the second light source 22 into the flow channel 11. The light guide assembly 23 is a beam-splitting fiber, with a converging end 231 and a branching end 232 at each end. The converging end 231 is connected to the light source, and the branching end 232 is connected to the light inlet of the flow cell assembly 1. Figure 4As shown, a single optical fiber has a converging end 231 and multiple branching ends 232. Each branching end 232 is connected to an input port, and the converging end 231 is then connected to a light source. This allows the light emitted from one light source to be split into multiple input ports, reducing the number of light sources required. To facilitate the connection of the branching ends 232, fiber optic adapters 16 are installed on both the first input port 12 and the second input port 13. The branching ends 232 are threadedly connected to the fiber optic adapters 16, a threaded connection that facilitates assembly and disassembly.

[0032] The function of light source component 2 is to emit light, such as Figure 5 As shown, both the first light source 21 and the second light source 22 include a light source housing 211, an LED light source 212, a light source cover plate 213, and a light interface 214. The converging end 231 is threadedly connected to the light interface 214. The LED light source 212 generates light, which is emitted to the outside of the light source housing 211 via the light interface 214. The converging end 231 of the light guide component 23 is connected to the light interface 214 to conduct the light out. The converging end 231 is also threadedly connected for easy disassembly and assembly. The LED light source 212 is a light-emitting diode. In addition to LEDs, deuterium lamps or xenon lamps can also be used as light sources. The optical detection component 3 mentioned above is generally used in conjunction with the light source. For example, ultraviolet light can be collected using a fluorescence signal detection device. The signal acquisition of the absorbance of the compound by the optical detection component 3 is an existing technology, so the principle will not be elaborated further. The optical detection component 3, as a lower-level machine, transmits the signal to the upper-level machine to generate analysis results. This process is widely used in the field of optical detection and is not the subject of this application, so it will not be elaborated further.

[0033] like Figure 6 and Figure 7 As shown, the optical detection assembly 3 includes a signal acquisition board 31, a plano-convex lens 32, and a light guide window 33. Light guide windows 33 are provided at the ends of the light inlet and outlet of the flow channel 21 near the flow channel 11. The plano-convex lens 32 is fixed inside the outlet by a lens mounting base 321 and a lens locking ring 322. The signal acquisition board 31 is located outside the outlet. The plano-convex lens 32 and the light guide window 33 can convert the light introduced at the inlet into collimated light, thereby reducing the spot diameter and enhancing detection accuracy. The signal acquisition board 31 serves as an optical signal acquisition device and uploads the acquired signal to the host computer. As mentioned above, this is existing technology, and its principle will not be elaborated further here. Sealing gaskets 34 need to be installed at both the light inlet and outlet to prevent sample liquid leakage and damage to the acquisition board. The overall assembly principle of the light source assembly 3 is as follows:

[0034] First, install the light guide window 33 on the light outlet on one side of the flow cell assembly 1;

[0035] Next, fix the lens holder 321 on the light outlet, install the plano-convex lens 11 on the lens holder 321, and press it with the lens locking ring 322 to ensure no shaking;

[0036] After installing the sealing gasket 34 into the opening of the light outlet, install the signal acquisition board 31 onto one side of the flow cell assembly 1 and fix it with screws.

[0037] On the other side of the flow cell assembly 1, a light guide window 33 is also installed at the light inlet, which is used in conjunction with the sealing gasket 34. Then, the fiber optic adapter 16 is used to lock it in sequence to ensure a seal.

[0038] like Figure 1-4 As shown, an outer shielding shell 4 is installed on the outside of the flow cell assembly 1 and the optical detection assembly 3. Both the flow cell assembly 1 and the light source assembly 3 are installed inside the outer shielding shell 4. The outer shielding shell 4 can achieve electromagnetic shielding and reduce detection errors.

[0039] It will be apparent to those skilled in the art that this invention is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of this invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of this invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0040] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A multi-channel optical detection device, comprising a flow cell assembly (1), a light source assembly (2), and an optical detection assembly (3), characterized in that, The flow cell assembly (1) includes multiple flow channels (11). Each flow channel (11) has a first light inlet (12) and a second light inlet (13) on one side and a first light outlet (14) and a second light outlet (15) on the other side, with the light inlet and the light outlet facing each other. The light source assembly (2) includes a first light source (21) and a second light source (22), and the first light source (21) and the second light source (22) are respectively connected to the first light inlet (12) and the second light inlet (13) through a light guide assembly (23).

2. A multi-channel optical detection device according to claim 1, wherein, The first light source (21) emits light with a wavelength of 260nm, and the second light source (22) emits light with a wavelength of 280nm.

3. A multi-channel optical detection device according to claim 1, wherein, The light guide component (23) is a splitting fiber, with a convergence end (231) and a branch end (232) respectively provided at both ends of the splitting fiber. The convergence end (231) is connected to the light source, and the branch end (232) is connected to the light inlet of the flow cell component (1).

4. A multi-channel optical detection device according to claim 3, wherein, Fiber optic adapters (16) are installed on both the first optical inlet (12) and the second optical inlet (13), and the forked end (232) is threadedly connected to the fiber optic adapter (16).

5. A multi-channel optical detection device according to claim 3, wherein, The first light source (21) and the second light source (22) both include a light source housing (211), an LED light source (212), a light source cover plate (213) and an optical interface (214), and the converging end (231) is threadedly connected to the optical interface (214).

6. The multi-channel optical detection device of claim 1, wherein, The flow cell assembly (1) further includes an inlet pipe (111) and an outlet pipe (112). The top end of the flow channel (11) is connected to the inlet pipe (111), and the bottom end of the flow channel (11) is connected to the outlet pipe (112).

7. The multi-channel optical detection device of claim 1, wherein, The optical detection assembly (3) includes a signal acquisition board (31), a plano-convex lens (32), and a light guide window (33). The light guide window (33) is provided at the ends of the light inlet and light outlet of the flow channel (11) near the flow channel (11). The plano-convex lens (32) is fixed inside the light outlet by a lens mounting base (321) and a lens locking ring (322). The signal acquisition board (31) is located outside the light outlet.

8. A multi-channel optical detection device according to claim 1, characterized in that, An outer shielding shell (4) is installed on the outside of the flow cell assembly (1) and the optical detection assembly (3).

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