Nuclear magnetic resonance detection automatic sampling device

Abstract

The utility model relates to a kind of nuclear magnetic detection automatic sampling device, including the carousel in the side of nuclear magnetic resonance spectrometer, and the drive mechanism of driving carousel rotation, the carousel is fixed with the side arm of several arrangements along circumference, telescopic mechanism is installed on the side arm along vertical telescopic, the protruding end of telescopic mechanism is installed with lifting plate, through hole placing cavity along vertical is opened on the lifting plate, annular airbag is fixed with the communicating gas charging and discharging device in the inner wall of placing cavity, the moving track of annular airbag passes through the sampling port of the nuclear magnetic resonance spectrometer directly above.The utility model utilizes the clamping and release of test tube by the inflation and deflation of annular airbag, both can firmly fixed test tube, prevent it from shaking or falling in moving process, can also release clamping when detecting, ensure that test tube is in stable state in detection process, guarantee the reliability of detection result.

Description

Technical Field

[0001] This utility model relates to the field of nuclear magnetic resonance (NMR) detection technology, and in particular to a sample introduction device used in NMR detection, specifically an automatic sample introduction device for NMR detection. Background Technology

[0002] In the field of nuclear magnetic resonance (NMR) testing, sample introduction is a crucial step affecting detection efficiency and result accuracy. Currently, traditional NMR sample introduction methods largely rely on manual operation. Operators must manually place the sample-filled test tube into the NMR spectrometer's inlet and manually remove it after the detection is complete. This method is not only labor-intensive, but the stability and accuracy of manual operation are also difficult to guarantee, easily leading to sample spillage and errors in detection results due to operational deviations. Furthermore, the manual, one-by-one operation is inefficient, especially when testing a large number of samples, severely hindering the overall detection progress. To address the drawbacks of manual operation, some automated sample feeding devices have emerged on the market. However, these devices still have many shortcomings in practical applications. Some devices have complex structural designs and inadequate clamping methods for test tubes. They typically use spring clamps to hold the test tubes, which in actual use either results in the test tubes shaking due to excessively loose clamping or damage to the test tubes or samples due to excessively tight clamping. Utility Model Content

[0003] This invention addresses the shortcomings of existing technologies by providing an automated sample introduction device for nuclear magnetic resonance (NMR) detection, which is not only simple in structure but also facilitates stable and reliable clamping of test tubes.

[0004] This utility model is achieved through the following technical solution: providing an automatic sample introduction device for nuclear magnetic resonance (NMR) detection, including a turntable located on one side of an NMR spectrometer and a drive mechanism for driving the turntable to rotate. Several side arms are fixedly arranged circumferentially on the turntable, and a telescopic mechanism that extends and retracts vertically is installed on the side arms. A lifting plate is installed at the extended end of the telescopic mechanism, and a vertically penetrating placement cavity is opened on the lifting plate. An annular gasbag connected to a gas filling and defilling device is fixedly installed on the inner wall of the placement cavity, and the movement trajectory of the annular gasbag passes directly above the sample inlet of the NMR spectrometer.

[0005] In use, the test tube containing the sample to be tested is inserted into the inner hole of the annular gasbag, and the gasbag is inflated to clamp the test tube. The drive mechanism rotates the turntable, moving the test tube clamped in the inner hole of the annular gasbag to directly above the sample inlet of the NMR spectrometer. Then, the telescopic mechanism moves the lifting plate down, allowing the test tube to enter the sample inlet of the NMR spectrometer. The gas in the annular gasbag is then released, and the annular gasbag loses its clamping grip on the test tube. The telescopic mechanism moves the lifting plate up. After the test is completed, the telescopic mechanism moves the lifting plate down, and the annular gasbag is placed back on the test tube. The annular gasbag is then inflated to clamp the test tube, and the telescopic mechanism moves the lifting plate up to remove the test tube.

[0006] As an optimization, the lifting plate extends below the side arm, and a guide post is fixed on the lifting plate, extending upward through the side arm. A guide hole adapted to the guide post is provided on the side arm. This optimized solution, by setting the guide post, uses the guide hole to guide the guide post when the lifting plate moves up and down, thereby preventing the lifting plate from tilting and ensuring that the test tube is aligned with the sample inlet of the nuclear magnetic resonance spectrometer.

[0007] As an optimization, the telescopic mechanism includes a vertically arranged hydraulic cylinder. The cylinder body is vertically fixed to the top of the side arm, and the piston rod of the hydraulic cylinder passes downward through the side arm and is fixedly connected to the lifting plate. This optimized telescopic mechanism uses a hydraulic cylinder, which is simple in structure and easy to use.

[0008] As an optimization, the telescopic mechanism and guide rod on the same side arm are arranged radially along the turntable, with the telescopic mechanism located on the side of the guide rod furthest from the turntable. This optimized solution places the telescopic mechanism on the side of the guide rod furthest from the turntable, allowing it to be closer to the center of the lifting platform and better ensuring that the lifting platform is in a horizontal position.

[0009] As an optimization, the outer periphery of the turntable is provided with several vertical surfaces corresponding to each side arm, and each side arm is fixedly connected to each vertical surface. This optimization scheme facilitates the connection between the side arms and the turntable by setting vertical surfaces, reducing manufacturing difficulty.

[0010] As an optimization, a rubber protective layer is fixed to the edge of the turntable. This optimization effectively prevents the turntable from being damaged by collisions with other objects during rotation.

[0011] As an optimization, a base plate is also included. The drive mechanism and the nuclear magnetic resonance spectrometer are both mounted on the top surface of the base plate. The sample inlet axis of the nuclear magnetic resonance spectrometer and the rotation axis of the turntable both extend vertically. This optimized design, by setting up a base plate, integrates the drive mechanism and the nuclear magnetic resonance spectrometer into a single unit, improving the overall integrity of the device and facilitating its movement.

[0012] The beneficial effects of this utility model are as follows: the inflation and deflation of the annular airbag realizes the clamping and release of the test tube, which can not only firmly fix the test tube and prevent it from shaking or falling during movement, but also release the clamp during the test, ensuring that the test tube is in a stable state during the test and guaranteeing the reliability of the test results. Attached Figure Description

[0013] Figure 1 This is a schematic diagram of the overall three-dimensional structure of this utility model; Figure 2 This is a two-dimensional structural schematic diagram of the present invention from a second perspective; Figure 3 This is a three-dimensional structural diagram of the present invention from a third-person perspective; As shown in the figure: 1. Nuclear magnetic resonance spectrometer; 2. Turntable; 3. Side arm; 4. Hydraulic cylinder; 5. Lifting plate; 6. Placement cavity; 7. Annular airbag; 8. Guide column; 9. Guide hole. Detailed Implementation

[0014] To clearly illustrate the technical features of this solution, the following detailed implementation method will be used to describe the solution.

[0015] like Figure 1 The present invention discloses an automatic sample introduction device for nuclear magnetic resonance detection, including a turntable 2 located on one side of a nuclear magnetic resonance spectrometer 1, and a drive mechanism for driving the turntable 2 to rotate. The nuclear magnetic resonance spectrometer 1 is a prior art device used to perform nuclear magnetic resonance detection on samples placed in a test tube with an injection port. The top of the spectrometer 1 is provided with an injection port for placing the sample to be tested.

[0016] To improve the overall integrity of the device in this embodiment, this embodiment also includes a horizontally arranged base plate. The drive mechanism and the nuclear magnetic resonance spectrometer are both mounted on the top surface of the base plate. The sample inlet axis of the nuclear magnetic resonance spectrometer and the rotation axis of the turntable both extend in the vertical direction.

[0017] The driving mechanism in this embodiment uses a motor. The output shaft of the motor extends vertically upward, and the center of the turntable is fixed to the upper end of the motor output shaft. When the output shaft of the motor rotates according to the set requirements, it drives the turntable to rotate, thereby realizing the position change of the sample.

[0018] Several side arms 3 are fixedly mounted on the turntable 2, arranged circumferentially. Each side arm 3 has an LED status indicator on its top, which can display the sample detection status corresponding to that side arm, such as pending detection, in detection, or detected. The side arms are mainly used to mount components such as hydraulic cylinders and drive them to rotate together with the turntable.

[0019] A telescopic mechanism that extends vertically is installed on the side arm 3. A lifting plate 5 is installed at the extended end of the telescopic mechanism, and the lifting plate extends above the sample inlet of the nuclear magnetic resonance spectrometer 1. A vertically penetrating placement cavity 6 is opened on the lifting plate 5. The placement cavity 6 is circular, and an annular gasbag 7 connected to the gas filling and defilling device is fixed on the inner wall of the placement cavity 6. The movement trajectory of the annular gasbag 7 passes directly above the sample inlet of the nuclear magnetic resonance spectrometer 1.

[0020] The annular airbag is inflated and deflated using an inflation / deflation device. When the annular airbag is full of gas, the inner wall of the airbag clamps the test tube. After deflation, the inner diameter of the annular airbag is larger than the outer diameter of the test tube. In this embodiment, the inflation / deflation device uses an air pump to inflate and deflate the annular airbag, making it more convenient to use. During inflation, the annular airbag expands and clamps the test tube; during deflation, it releases the clamp, thus achieving both fixation and release of the test tube.

[0021] The telescopic mechanism of this embodiment includes a hydraulic cylinder 4 arranged vertically. The cylinder body of the hydraulic cylinder 4 is vertically fixed to the top of the side arm 3. The piston rod of the hydraulic cylinder 4 passes downward through the side arm 3 and is fixedly connected to the lifting plate 5. By extending and retracting the piston rod of the hydraulic cylinder, the lifting plate is driven to perform lifting and lowering movements, thereby realizing the raising and lowering of the test tube.

[0022] The lifting plate 5 extends to the lower part of the side arm 3 at the end away from the placement cavity. A guide post 8 is fixed on the lifting plate 5 and passes through the side arm 3 upward. A guide hole 9 adapted to the guide post 8 is opened on the side arm 3. The guide post is slidably connected to the inner wall of the guide hole. The guide hole restricts the deflection of the guide post and guides the up and down movement of the lifting plate, ensuring the stability and accuracy of the lifting plate movement.

[0023] The telescopic mechanism and guide rod on the same side arm are arranged radially along the turntable, and the telescopic mechanism is located on the side of the guide rod away from the turntable. The guide column and hydraulic cylinder form a rotation limit for the lifting plate to prevent the lifting plate from rotating and ensure that the test tube is aligned with the injection port.

[0024] To facilitate the connection between the side arms and the turntable, the outer circumferential side of the turntable is provided with several vertical surfaces corresponding to each side arm. Each side arm is fixed to its respective vertical surface, and the number of side arms is 6 to 12. In this embodiment, there are 8 vertical surfaces, arranged sequentially along the circumference. One side arm is welded to each vertical surface, for a total of 8 side arms. This allows for the simultaneous delivery of 8 test tubes, ensuring continuous sample introduction and improving detection efficiency.

[0025] The turntable has a rubber protective layer around its edge to prevent damage from collisions with other objects during rotation. The turntable is made of transparent acrylic material for easy observation of its internal components.

[0026] To improve automation, this embodiment also includes a processor electrically connected to the motor, hydraulic cylinder, air pump, and nuclear magnetic resonance spectrometer 1. Following a preset program and logic, the processor controls the coordinated operation of each component to complete a series of operations, including automatic sample introduction and detection. The processor configuration can be set according to actual conditions; for ease of understanding, this embodiment provides one processor configuration: The motor drives the turntable to rotate, causing the placement cavity on the target lifting plate to rotate directly above the sample inlet; The hydraulic cylinder is controlled to drive the target lifting plate to descend, allowing the test tube in the placement chamber to enter the sample inlet; Control the air pump to deflate the annular airbag in the target placement cavity, thereby releasing the annular airbag from clamping the test tube; After the nuclear magnetic resonance spectrometer completes the detection of the test tube, the hydraulic cylinder is controlled to drive the target lifting plate to descend, so that the annular airbag is placed on the top of the test tube. The air pump is controlled to inflate the annular airbag in the target placement cavity, so that the annular airbag clamps the test tube. The hydraulic cylinder is controlled to drive the target lifting plate to rise and reset, and the test tube is taken out from the sample inlet.

[0027] The working principle of this embodiment is as follows: When using this utility model, firstly, the operator inserts the test tube containing the sample into the inner hole of the annular air bladder. The processor controls the air pump to inflate the annular air bladder 7, and uses the clamping force generated by the expansion of the air bladder to fix the test tube and prevent it from shaking or falling off during movement. Subsequently, the processor sends a command to the motor to drive the turntable 2 to rotate, so that the side arm 3 containing the target test tube and the lifting plate 5 move with the turntable 2. When the target test tube reaches directly above the sample inlet of the nuclear magnetic resonance spectrometer 1, the processor controls the motor to stop working, thus completing the precise delivery of the sample. During the sample introduction stage, the processor controls the hydraulic cylinder 4 on the corresponding side arm 3 to operate. The piston rod of the hydraulic cylinder 4 extends, driving the lifting plate 5 to descend. Under the action of the guide mechanism, namely the guide column 8 and the guide hole 9, the lifting plate 5 moves smoothly downward, allowing the test tube to accurately enter the sample inlet. Afterward, the processor controls the air pump to release the air from the annular airbag 7 in the placement cavity 6, releasing the clamp, and raises the lifting plate to detach the annular airbag from the test tube, ensuring that the test tube is in a stable state during the detection process, facilitating detection by the nuclear magnetic resonance spectrometer 1. After the test is completed, the processor controls the hydraulic cylinder 4 to drive the lifting plate 5 to descend, so that the placement chamber 6 fits over the top of the test tube. Then, it controls the air pump to inflate, allowing the annular airbag 7 to clamp the test tube again. Finally, the processor controls the piston rod of the hydraulic cylinder 4 to retract, driving the lifting plate 5 to rise and reset, removing the test tube from the sample inlet, completing one test cycle. Throughout the entire process, the actions of each component are precisely controlled by the processor according to a preset program, ensuring the automation, efficiency, and accuracy of the detection process.

[0028] The automated nuclear magnetic resonance (NMR) sampling device of this embodiment has the following advantages: 1. It achieves automated operation. The entire testing process, from fixing the test tube, conveying, injecting, testing, and taking it out, is completed by the processor controlling each component to work together according to the preset program, reducing manual intervention and lowering the cost and labor intensity of manual operation. 2. Improved detection efficiency: The turntable drives multiple side arms 3 and related components to operate, enabling continuous detection of multiple samples, avoiding the tedious manual operation of each sample, and greatly improving the overall detection efficiency. 3. Ensures operational accuracy. During sample transport, the motor-driven turntable 2 rotates to accurately deliver the test tube directly above the injection port. During injection and retrieval, the guiding mechanism (guide column 8 and guide hole 9 cooperate) ensures that the lifting plate 5 moves smoothly, allowing the test tube to accurately enter or be removed from the injection port, reducing detection errors caused by operational deviations. 4. Enhanced test tube stability: The inflation and deflation of the ring-shaped airbag 7 enables the clamping and release of the test tube, which not only firmly fixes the test tube to prevent it from shaking or falling during movement, but also releases the clamp during testing, ensuring that the test tube remains stable during the testing process and guaranteeing the reliability of the test results. 5. Improved operational safety: Automated operation reduces contact between personnel and moving parts of the equipment, lowering the risk of safety accidents caused by touching rotating turntables and other components.

[0029] Of course, the above description is not limited to the examples above. Technical features of this utility model not described can be implemented by or using existing technology, and will not be repeated here. The above embodiments and drawings are only used to illustrate the technical solution of this utility model and are not intended to limit this utility model. This utility model has been described in detail with reference to preferred embodiments. Those skilled in the art should understand that any changes, modifications, additions or substitutions made by those skilled in the art within the scope of this utility model do not depart from the spirit of this utility model and should also fall within the protection scope of the claims of this utility model.

Claims

1. A nuclear magnetic detection auto-sampler characterized by: The instrument includes a turntable (2) located on one side of the nuclear magnetic resonance spectrometer (1) and a drive mechanism for driving the turntable (2) to rotate. Several side arms (3) arranged in the circumferential direction are fixed on the turntable (2). A telescopic mechanism that extends and retracts in the vertical direction is installed on the side arms (3). A lifting plate (5) is installed at the extended end of the telescopic mechanism. A vertically penetrating placement cavity (6) is opened on the lifting plate (5). An annular airbag (7) connected to the gas filling and defilling device is fixed on the inner wall of the placement cavity (6). The movement trajectory of the annular airbag (7) passes directly above the sample inlet of the nuclear magnetic resonance spectrometer (1).

2. The automated sample introduction device for nuclear magnetic resonance detection according to claim 1, characterized in that: The lifting plate (5) extends to the bottom of the side arm (3), and a guide post (8) is fixed on the lifting plate (5) and passes through the side arm (3) upward. A guide hole (9) adapted to the guide post (8) is opened on the side arm (3).

3. A nuclear magnetic detection automatic sampling device according to claim 2, characterized in that: The telescopic mechanism includes a hydraulic cylinder (4) arranged vertically. The cylinder body of the hydraulic cylinder (4) is vertically fixed to the top of the side arm (3). The piston rod of the hydraulic cylinder (4) passes downward through the side arm (3) and is fixedly connected to the lifting plate (5).

4. The NMR automatic sampling device according to claim 2, characterized in that: The telescopic mechanism and guide rod on the same side arm are arranged radially along the turntable, and the telescopic mechanism is located on the side of the guide rod away from the turntable.

5. The NMR automatic sampling device according to claim 1, characterized in that: The outer circumferential side of the turntable is provided with several vertical surfaces corresponding to each side arm, and each side arm is fixed to each vertical surface.

6. The NMR detection automatic sampling device according to claim 1, characterized in that: The edge of the turntable is fixed with a rubber protective layer.

7. The NMR automatic sampling device according to claim 1, characterized in that: It also includes a base plate, and the drive mechanism and the nuclear magnetic resonance spectrometer are both mounted on the top surface of the base plate. The sample inlet axis of the nuclear magnetic resonance spectrometer and the rotation axis of the turntable both extend in the vertical direction.

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