A titrator for drug detection

Abstract

This utility model relates to the technical field of titration equipment, and in particular to a titrator for pharmaceutical testing; it improves the uniformity of contact between the reagent and the titrant during titration, thereby further improving the titration detection accuracy; it includes a main control unit and a dispensing mechanism, the dispensing mechanism including a peristaltic pump, a pump tube and a nozzle connected to one end of the pump tube, the peristaltic pump being electrically connected to the main control unit; it also includes a frame, a conical flask, a measuring cup and a clamping shaker, the other end of the pump tube extending into the measuring cup, the clamping shaker including a mounting bracket fixedly installed at the bottom of the frame, a mounting base installed on the mounting bracket, a hollow shaft rotatably installed on the mounting base, multiple jaws hinged to the top of the hollow shaft, multiple connecting rods, a drive rod slidably installed up and down inside the hollow shaft, a drive disk rotatably installed on the top of the drive rod, a first lifting drive that provides power for the up and down sliding of the drive rod and a rotary drive that provides power for the rotation of the hollow shaft, and a placement platform installed at the center of the top of the hollow shaft.

Description

Technical Field

[0001] This utility model relates to the technical field of titration equipment, and in particular to a titrator for pharmaceutical testing. Background Technology

[0002] Titration analysis is a method that involves adding a standard solution (titrant) of known and accurate concentration to a solution of the drug to be tested until the chemical reaction is complete, and then calculating the content of the drug component by measuring the volume and concentration of the standard solution consumed.

[0003] For example, utility model patent application CN203720158U discloses a titrator, including a main controller, a support, and a dripping mechanism. The dripping mechanism includes a peristaltic pump, a pump tube, and a nozzle connected to one end of the pump tube. The peristaltic pump is electrically connected to the main controller. The peristaltic pump mainly consists of a pump base, a rotor located inside the pump base and driven by a motor, two rollers connected to the rotor via roller shafts, and a pump tube fixing component formed along the outer circumference of the rollers. It is easy to store. Reinforcing fasteners are provided at the connection between the pump tubes to prevent air leakage and pump tube disconnection.

[0004] However, the above-mentioned device still has the following defects: during the titration operation, the container holding the reagent is in a static state, the titrant is dripped into the upper layer of the reagent and reacts, while the reagent at the bottom of the container does not react completely with the titrant, making it difficult to objectively reflect the amount of titrant required for the reagent reaction, thus affecting the detection accuracy of the reagent. Utility Model Content

[0005] To address the shortcomings of existing technologies, this invention provides a titrator for pharmaceutical testing that improves the uniformity of contact between the reagent and the titrant during titration, thereby further enhancing the accuracy of titration detection.

[0006] To achieve the above objectives, this utility model provides the following technical solution: a titrator for pharmaceutical testing, comprising a main control unit and a dispensing mechanism, the dispensing mechanism comprising a peristaltic pump, a pump tube, and a nozzle connected to one end of the pump tube, the peristaltic pump being electrically connected to the main control unit; characterized in that it further comprises a frame, a conical flask, a measuring cup, and a clamping shaker, the other end of the pump tube extending into the measuring cup, the clamping shaker comprising a mounting bracket fixedly mounted on the bottom of the frame, a mounting base mounted on the mounting bracket, a hollow shaft rotatably mounted on the mounting base, and multiple... The device comprises a gripper hinged to the top of a hollow shaft, multiple connecting rods, a drive rod slidably mounted inside the hollow shaft, a drive disk rotatably mounted on the top of the drive rod, a first lifting drive that provides power for the up-and-down sliding of the drive rod, and a rotary drive that provides power for the rotation of the hollow shaft. A placement platform is mounted at the center of the top of the hollow shaft, and the conical bottle is placed on the placement platform. One end of the gripper is used to clamp the placement platform, and the other end of the gripper is hinged to one end of the corresponding connecting rod. The other end of the connecting rod is hinged to the edge of the drive disk. Furthermore, the measuring cup is used to hold the titrant, and the conical flask is used to hold the reagent to be titrated; both the main control unit and the measuring cup are placed on the frame; multiple grippers are evenly distributed around the hollow shaft; the first lifting drive is preferably an electric telescopic cylinder, but other equivalent driving components that drive the drive rod to move up and down are also used; the rotary drive is preferably an electric motor and a transmission component, the output end of the electric motor is connected to the hollow shaft through the transmission component, the transmission component is preferably a gear set, but chains or belts can also be used; the frame is provided with a through-hole that allows the grippers to pass through and open and close; the hollow shaft is provided with a hollow cavity in the middle that allows the drive rod to pass through.

[0007] Preferably, the system further includes a three-dimensional mechanical slide, which comprises a transverse slide, a longitudinal slide, and a vertical slide. The peristaltic pump and the nozzle are both fixedly mounted on the vertical slide. Furthermore, the transverse slide, longitudinal slide, and vertical slide are arranged perpendicularly to each other in pairs. The pump tube is made of flexible, malleable tubing with sufficient redundancy to prevent the pump tube from detaching from the measuring cup or interfering with the movement of the peristaltic pump. The center line connecting the measuring cup, the nozzle, and the conical flask is parallel to the direction of travel of the transverse slide.

[0008] Preferably, a second lifting driver and a conductivity probe are mounted on the vertical slide. The conductivity probe is mounted on the vertical slide and slides up and down. The second lifting driver provides power for the lifting of the conductivity probe. The conductivity probe is electrically connected to the main control unit. Further, the second lifting driver is preferably an electric telescopic cylinder, but other equivalent driving components that drive the conductivity probe to lift are also acceptable. The distance between the conductivity probe and the dropper should be less than the size of the conical bottle mouth to ensure that the conductivity probe can be smoothly inserted into the conical bottle.

[0009] Preferably, it also includes an electronic balance, which is electrically connected to the main controller, and the measuring cup is placed on the electronic balance; furthermore, a pressure sensor is installed inside the electronic balance, which can convert the change in gravity into an electrical signal and transmit it to the main controller; it should be noted that the main controller, peristaltic pump, conductivity probe and electronic balance are all commercially available known products, and appropriate models of corresponding products can be selected according to requirements, without further limitation or elaboration here.

[0010] Preferably, the measuring end of the electronic balance is fixedly mounted with a placement rack, the placement rack is provided with an open placement groove that fits the outside of the measuring cup, the measuring cup is placed in the open placement groove, a fixing frame is mounted on the placement rack, and the pump tube is fixedly mounted on the fixing frame.

[0011] Preferably, a receiving hopper is fixedly installed on the fixing frame, and a flexible return pipe is provided at the outlet end of the receiving hopper, which extends into the measuring cup; furthermore, the pump pipe and the flexible return pipe are preferably flexible plastic pipes, so as to facilitate their removal from the measuring cup and avoid interference with the removal and placement of the measuring cup in the open placement slot.

[0012] Preferably, a position switch is installed on the transverse slide; further, the position switch is connected to the transverse slide via a main control unit signal, and there are two sets of position switches, which are respectively set to correspond to the positions of the receiving hopper and the conical bottle. When the dripper moves above the conical bottle or the receiving hopper, the transverse slide stops running to limit the position of the dripper.

[0013] Preferably, the mounting base is slidably mounted on a mounting frame, and a third lifting actuator is mounted on the mounting frame to provide power for the vertical sliding of the mounting base; furthermore, the third lifting actuator is preferably an electric telescopic cylinder, but other equivalent driving components that drive the mounting base to slide vertically can also be used.

[0014] Compared with the prior art, this utility model provides a titrator for pharmaceutical testing, which has the following beneficial effects: In this titrator, by placing a conical flask on the platform, the first lifting driver is activated and drives the driving rod downwards. The driving disc pulls the bottom of each gripper downwards, while the top of the gripper clamps the outer wall of the conical flask for clamping and limiting. The nozzle is moved above the conical flask. After the peristaltic pump is activated, the titrant in the measuring cup is dripped into the conical flask through the pump tube and the nozzle. At the same time, the rotary driver drives the hollow shaft to rotate, and the conical flask rotates synchronously with the hollow shaft. During the rotation, the pharmaceutical reagent and the titrant in the conical flask are fully contacted, improving the uniformity of contact between the pharmaceutical reagent and the titrant during titration, promoting complete titration, and further improving the titration detection accuracy. Attached Figure Description

[0015] Figure 1This is a three-dimensional structural schematic diagram of the present invention; Figure 2 This is a top view schematic diagram of the structure of this utility model; Figure 3 This is the utility model Figure 2 Schematic diagram of the cross-sectional structure at point AA; Figure 4 This is the utility model Figure 1 A magnified schematic diagram of the structure at point B in the middle; Figure 5 This is a three-dimensional structural diagram of the clamping and shaking device of this utility model. Figure 6 This is the utility model Figure 3 A magnified three-dimensional structural diagram of part C in the middle; The attached diagram is labeled as follows: 1. Main control unit; 2. Peristaltic pump; 3. Pump tube; 4. Dropper; 5. Stand; 6. Conical flask; 7. Measuring cup; 8. Mounting bracket; 9. Mounting base; 10. Hollow shaft; 11. Gripper; 12. Drive rod; 13. Drive disc; 14. First lifting actuator; 15. Rotary actuator; 16. Placement stage; 17. Horizontal slide; 18. Vertical slide; 19. Vertical slide; 20. Second lifting actuator; 21. Conductivity probe; 22. Electronic balance; 23. Placement rack; 24. Open placement slot; 25. Fixing frame; 26. Receiving hopper; 27. Flexible reflux tube; 28. Position switch; 29. ​​Third lifting actuator; 30. Connecting rod. Detailed Implementation To enable those skilled in the art to better understand the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings.

[0016] As described in the background art, in a titrator, during the titration process, the container holding the reagent is in a static state, the titrant is dripped onto the upper layer of the reagent and reacts, while the reagent at the bottom of the container does not react completely with the titrant, making it difficult to objectively reflect the amount of titrant required for the reagent reaction, thus affecting the detection accuracy of the reagent.

[0017] To solve this technical problem, this utility model provides a titrator for pharmaceutical testing, which is applied to the titration and testing of pharmaceuticals.

[0018] It should be noted that, unless otherwise specified, the embodiments and features and technical solutions in the present invention can be combined with each other.

[0019] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0020] Example 1 Please refer to Figures 1-6 A titrator for pharmaceutical testing includes: a main control unit 1 and a dispensing mechanism. The dispensing mechanism includes a peristaltic pump 2, a pump tube 3, and a nozzle 4 connected to one end of the pump tube 3. The peristaltic pump 2 is electrically connected to the main control unit 1. The device further includes a frame 5, a conical flask 6, a measuring cup 7, and a clamping shaker. The other end of the pump tube 3 extends into the measuring cup 7. The clamping shaker includes a mounting bracket 8 fixedly mounted on the bottom of the frame 5, a mounting base 9 mounted on the mounting bracket 8, a hollow shaft 10 rotatably mounted on the mounting base 9, and multiple grippers 11 hinged to the top of the hollow shaft 10. The system includes multiple connecting rods 30, a drive rod 12 that slides up and down inside the hollow shaft 10, a drive disk 13 that is rotatably mounted on the top of the drive rod 12, a first lifting drive 14 that provides power for the up and down sliding of the drive rod 12, and a rotary drive 15 that provides power for the rotation of the hollow shaft 10. A placement platform 16 is installed at the middle of the top of the hollow shaft 10. The conical bottle 6 is placed on the placement platform 16. One end of the gripper 11 is used to clamp the placement platform 16, and the other end of the gripper 11 is hinged to one end of the corresponding connecting rod 30. The other end of the connecting rod 30 is hinged to the edge of the drive disk 13. Furthermore, the measuring cup 7 is used to hold the titrant, and the conical flask 6 is used to hold the reagent to be titrated; both the main control unit 1 and the measuring cup 7 are placed on the frame 5; multiple grippers 11 are evenly distributed around the hollow shaft 10; the first lifting drive 14 is preferably an electric telescopic cylinder, but other equivalent driving components that drive the drive rod 12 to move up and down are also used; the rotary drive 15 is preferably an electric motor and a transmission component, the output end of the electric motor is connected to the hollow shaft 10 through the transmission component, the transmission component is preferably a gear set, but chains or belts can also be used; the frame 5 is provided with a through-hole that allows the grippers 11 to pass through and open and close; the hollow shaft 10 is provided with a hollow cavity in the middle that allows the drive rod 12 to pass through.

[0021] For details, please refer to Figures 1-3 It also includes a three-dimensional mechanical slide, which comprises a transverse slide 17, a longitudinal slide 18, and a vertical slide 19. The peristaltic pump 2 and the nozzle 4 are both fixedly mounted on the vertical slide 19. Furthermore, the transverse slide 17, the longitudinal slide 18, and the vertical slide 19 are arranged perpendicularly to each other in pairs. The pump tube 3 is made of flexible plastic tube with sufficient redundancy to prevent the pump tube 3 from detaching from the measuring cup 7 or interfering with the movement of the peristaltic pump 2. The center line connecting the measuring cup 7, the nozzle 4, and the conical flask 6 is parallel to the travel direction of the transverse slide 17.

[0022] For details, please refer to Figure 3 and Figure 5The mounting base 9 is slidably mounted on the mounting frame 8, and the mounting frame 8 is equipped with a third lifting drive 29 that provides power for the vertical sliding of the mounting base 9; furthermore, the third lifting drive 29 is preferably an electric telescopic cylinder, but other equivalent driving components that drive the mounting base 9 to slide vertically can also be used.

[0023] The titrator for pharmaceutical testing provided in this embodiment uses a three-dimensional mechanical slide to move the nozzle 4 and peristaltic pump 2 in three-dimensional space. When disassembling or assembling the conical flask 6, the three-dimensional mechanical slide moves away from above the conical flask 6 to prevent interference with the loading and unloading of the conical flask 6. The third lifting drive 29 drives the mounting base 9 to move up and down to adaptively adjust the nozzle height of the conical flask 6 to meet the usage requirements of conical flasks 6 of various sizes.

[0024] Example 2 The titrator for reagent detection provided in Example 1 has been further optimized. For details, please refer to [link / reference needed]. Figure 1 and Figure 4 A second lifting driver 20 and a conductivity probe 21 are installed on the vertical slide 19. The conductivity probe 21 is slidably mounted on the vertical slide 19. The second lifting driver 20 provides power for the lifting of the conductivity probe 21. The conductivity probe 21 is electrically connected to the main control unit 1. Furthermore, the second lifting driver 20 is preferably an electric telescopic cylinder, but other equivalent driving components that drive the conductivity probe 21 to lift can also be used. The distance between the conductivity probe 21 and the dropper 4 should be less than the size of the mouth of the conical bottle 6 to ensure that the conductivity probe 21 can be smoothly inserted into the conical bottle 6.

[0025] For details, please refer to Figures 1-3 It also includes an electronic balance 22, which is electrically connected to the main control unit 1, and a measuring cup 7 is placed on the electronic balance 22. Furthermore, a pressure sensor is installed inside the electronic balance 22, which can convert the change in gravity into an electrical signal and transmit it to the main control unit 1. It should be noted that the main control unit 1, the peristaltic pump 2, the conductivity probe 21 and the electronic balance 22 are all commercially available products. Appropriate models of corresponding products can be selected according to the requirements. No further limitations or elaborations are made here.

[0026] For details, please refer to Figures 1-3 A position switch 28 is installed on the transverse slide 17. Furthermore, the position switch 28 is connected to the transverse slide 17 via a signal from the main controller 1. There are two sets of position switches 28, which are respectively set to correspond to the positions of the receiving hopper 26 and the conical bottle 6. When the dripper 4 moves above the conical bottle 6 or the receiving hopper 26, the transverse slide 17 stops running to limit the position of the dripper 4. The position switch 28 adopts a conventional infrared switch or mechanical switch. The position switch 28 can ensure that the dripper 4 stops smoothly above the conical bottle 6 or the receiving hopper 26.

[0027] For details, please refer to Figure 1 The measuring end of the electronic balance 22 is fixedly equipped with a placement rack 23. The placement rack 23 is provided with an open placement groove 24 that fits the outside of the measuring cup 7. The measuring cup 7 is placed in the open placement groove 24. A fixing frame 25 is installed on the placement rack 23, and the pump tube 3 is fixedly installed on the fixing frame 25. The open placement groove 24 can limit the position of the measuring cup 7 to prevent the measuring cup 7 from shifting. The fixing frame 25 can limit the pump tube 3 to prevent the pump tube 3 from moving out of the measuring cup 7 on its own.

[0028] For details, please refer to Figures 3-4 A receiving hopper 26 is fixedly installed on the fixed frame 25. The outlet end of the receiving hopper 26 is provided with a flexible return pipe 27, which extends into the measuring cup 7. Furthermore, the pump pipe 3 and the flexible return pipe 27 are preferably flexible plastic pipes so as to facilitate their removal from the measuring cup 7 and avoid interference with the removal and placement of the measuring cup 7 in the open placement slot 24.

[0029] The titrator for drug detection provided in this embodiment, during drug titration, the second lifting drive 20 moves the conductivity probe 21 downward until it extends into the drug to be titrated in the conical flask 6. The conductivity probe 21 is used to measure the conductivity of the solution. The titrant is gradually added through the dropper 4 until the conductivity of the solution in the conical flask 6 changes significantly, thereby determining the concentration of the drug in the test solution. The electronic balance 22 can measure the amount of titrant used. Before titration, the dropper 4 is positioned above the receiving hopper 26. The peristaltic pump 2 is started, and the titrant enters the dropper 4 through the pump tube 3. The titrant dripping from the dropper 4 flows back into the measuring cup 7, indicating that the pump tube 3 and the dropper 4 are full of titrant. The reading M1 of the electronic balance 22 is recorded. Then, the dropper 4 moves above the conical flask 6 to titrate the drug in the conical flask 6. When the drug in the conical flask 6 drips... After the titration is completed, when a significant change in conductivity is detected in the conical flask 6 by the conductivity probe 21, the reading M2 of the electronic balance 22 is recorded. The amount of titrant used is M = M1 - M2 to obtain the amount of titrant used. This eliminates the influence of residual titrant in the pump tube 3 and the nozzle 4 on the amount of titrant used, so as to ensure the accuracy of the titrant measurement. At the same time, the titrant dripping into the receiving hopper 26 can be returned to the beaker to reduce the waste of titrant.

[0030] The titrator for reagent testing provided by this utility model is used as follows: A conical flask 6 containing the reagent is placed on the placement platform 16, and a measuring cup 7 containing the titrant is placed in the open placement slot 24. The first lifting drive 14 is activated, driving the drive rod 12 downwards. The drive disk 13 pulls the bottom of each gripper 11 downwards, while the top of the gripper 11 clamps the outer wall of the conical flask 6 to clamp and limit its position. Initially, the nozzle 4 is positioned above the receiving hopper 26. The peristaltic pump 2 is activated until the titrant dripping from the nozzle 4 falls into the receiving hopper 26 and flows into the measuring cup 7 through the flexible return tube 27. The initial reading of the electronic balance 22 is recorded by the main control unit 1. The three-dimensional mechanical slide moves the nozzle 4 to the conical flask 6. Above, the conductivity probe 21 is inserted into the solution inside the conical flask 6. After the peristaltic pump 2 is started, the titrant in the measuring cup 7 is dripped into the conical flask 6 through the pump tube 3 and the dropper 4. At the same time, the rotary driver 15 drives the hollow shaft 10 to rotate, and the conical flask 6 rotates synchronously with the hollow shaft 10. During the rotation, the reagent and the titrant in the conical flask 6 are fully contacted. When the conductivity probe 21 detects a significant change in conductivity, it transmits an electrical signal to the main control unit 1. The main control unit 1 records the reading of the electronic balance 22. The difference between the initial reading and the second reading is the amount of titrant used. The operator can perform subsequent data processing based on the reaction relationship between the titrant and the reagent, and finally obtain the content value of the reagent in the solution of the conical flask 6. In this utility model, unless otherwise explicitly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection, an electrical connection, or a connection that allows communication between them; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise explicitly limited. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

Claims

1. A titrator for pharmaceutical testing, comprising a main control unit (1) and a dispensing mechanism, the dispensing mechanism comprising a peristaltic pump (2), a pump tube (3), and a nozzle (4) connected to one end of the pump tube (3), the peristaltic pump (2) being electrically connected to the main control unit (1); characterized in that, It also includes a stand (5), a conical flask (6), a measuring cup (7), and a clamping shaker. The other end of the pump tube (3) extends into the measuring cup (7). The clamping shaker includes a mounting bracket (8) fixedly installed at the bottom of the stand (5), a mounting seat (9) installed on the mounting bracket (8), a hollow shaft (10) rotatably installed on the mounting seat (9), multiple jaws (11) hinged to the top of the hollow shaft (10), multiple connecting rods (30), a drive rod (12) slidably installed in the hollow shaft (10), and a rotatably installed on the drive rod (12). The top drive disk (13), the first lifting drive (14) that provides power for the up and down sliding of the drive rod (12), and the rotary drive (15) that provides power for the rotation of the hollow shaft (10) are provided. A placement platform (16) is installed at the middle of the top of the hollow shaft (10). The conical bottle (6) is placed on the placement platform (16). One end of the gripper (11) is used to clamp the placement platform (16). The other end of the gripper (11) is hinged to one end of the corresponding connecting rod (30). The other end of the connecting rod (30) is hinged to the edge of the drive disk (13).

2. The titrator for medicament detection according to claim 1, characterized in that, It also includes a three-dimensional mechanical slide, which includes a transverse slide (17), a longitudinal slide (18) and a vertical slide (19), and the peristaltic pump (2) and the nozzle (4) are both fixedly installed on the vertical slide (19).

3. The titrator for medicament detection according to claim 2, characterized in that, The vertical slide (19) is equipped with a second lifting driver (20) and a conductivity probe (21). The conductivity probe (21) is mounted on the vertical slide (19) and slides up and down. The second lifting driver (20) provides power for the lifting of the conductivity probe (21). The conductivity probe (21) is electrically connected to the main controller (1).

4. The titrator for drug detection according to claim 1 or 3, characterized by, It also includes an electronic balance (22), which is electrically connected to the main controller (1), and the measuring cup (7) is placed on the electronic balance (22).

5. The titrator for medicament detection according to claim 4, characterized in that, The measuring end of the electronic balance (22) is fixedly installed with a placement rack (23). The placement rack (23) is provided with an open placement slot (24) that fits the outside of the measuring cup (7). The measuring cup (7) is placed in the open placement slot (24). A fixing frame (25) is installed on the placement rack (23). The pump pipe (3) is fixedly installed on the fixing frame (25).

6. The titrator for medicament detection according to claim 5, wherein A receiving bucket (26) is fixedly installed on the fixed frame (25). The outlet end of the receiving bucket (26) is provided with a flexible return pipe (27), which extends into the measuring cup (7).

7. The titrator for agent detection according to claim 2, wherein A position switch (28) is installed on the transverse slide (17).

8. The titrator for agent detection according to claim 1, wherein The mounting base (9) is mounted on the mounting frame (8) in a sliding manner, and the mounting frame (8) is equipped with a third lifting drive (29) that provides power for the sliding of the mounting base (9) in a sliding manner.

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