Mouse sleep deprivation device based on IVC cage

Abstract

The utility model relates to experimental device technical field, concretely is a mouse sleep deprivation device based on IVC cage, including IVC cage, its characterized in that: the IVC cage includes box and lid, be provided with controller on the lid, the lower bottom of lid installs adjustable angle's camera and light, the lower bottom of lid still be provided with stepper motor, the output of stepper motor is downward and installs the rotating rod, the lower end of rotating rod is provided with interference chain, the interference chain is articulated type multisection chain, and the articulation axle is connected between the chain link, and the torsional spring is covered on the articulation axle. The sleep deprivation device of the utility model can be embedded in the IVC mouse cage, need not to store separately, can carry out long -term mouse sleep deprivation experiment in situ, solves the problem that the traditional mouse sleep deprivation device experiment prepares long time and cannot carry out large -scale experiment simultaneously.

Description

Technical Field

[0001] This invention relates to the field of experimental device technology, specifically to a mouse sleep deprivation device based on an IVC cage. Background Technology

[0002] Sleep deprivation devices are the basic tools for creating animal models of sleep deprivation. Mouse sleep deprivation models are frequently used in basic research on sleep disorders and sleep disturbances. Traditional mouse sleep deprivation devices are all independent experimental devices. Before the experiment, mice need to be removed from their cages and placed in the sleep deprivation device, and given 3-5 days to adapt to the new environment. The preparation time before the experiment is long and can easily cause stress to the mice. At the same time, the number of sleep deprivation devices is limited, making it impossible to conduct large-scale experiments at the same time. Experiments conducted in batches are more prone to experimental errors. Utility Model Content

[0003] To address the problems of the prior art, this invention provides a mouse sleep deprivation device based on an IVC cage. The sleep deprivation device can be embedded in the IVC cage and does not require separate storage. It can be used for long-term mouse sleep deprivation experiments in situ, solving the problems of long preparation time and inability to conduct large-scale experiments simultaneously with traditional mouse sleep deprivation devices.

[0004] To achieve the above objectives, this utility model provides the following technical solution: a mouse sleep deprivation device based on an IVC cage, comprising an IVC cage, characterized in that: the IVC cage includes a box body and a box cover, a controller is provided on the box cover, an adjustable-angle camera and a light are installed on the bottom surface of the box cover, a stepper motor is also provided on the bottom surface of the box cover, the output end of the stepper motor faces downward and is equipped with a rotating rod, an interference chain is provided at the lower end of the rotating rod, the interference chain is a hinged multi-section chain, the links are connected by a hinge shaft, and a torsion spring is sleeved on the hinge shaft.

[0005] By adopting the above structural design, the sleep deprivation device is integrated into the box body, lid, and other structures of the IVC cage, allowing sleep deprivation experiments to be conducted in situ without transferring mice, thus reducing stress caused by environmental transfer. The adjustable-angle camera facilitates all-round monitoring of the mouse's status, and the lighting can simulate circadian rhythms or assist in waking the mouse. In the articulated interference chain with torsion springs, the torsion springs give the chain links elasticity and mobility, allowing them to better adapt to the internal space of the cage. When the stepper motor drives its rotation, it can effectively disturb the mouse to achieve sleep deprivation, improving the reliability of sleep deprivation and the adaptability of the device to the IVC cage.

[0006] Preferably, the lid of the box has a slot for placing a water bottle, and the box contains a drinking pipe that passes through the slot and is connected to the water bottle.

[0007] With the above structural design, the slot on the lid is used to place the water bottle. Together with the drinking tube inside the box, it allows mice to drink water conveniently during the sleep deprivation experiment without the need for a complex additional arrangement of the water supply structure. This not only ensures the basic physiological needs of the mice, but also, combined with the integrated design of the IVC cage, further improves the ease of use and practicality of the experimental device.

[0008] Preferably, the rotating rod is connected to the middle position of the interference chain, and both ends of the interference chain are rotatably connected to rollers, with the rollers closely attached to the inner wall of the housing.

[0009] With the above structural design, the rotating rod is connected to the middle of the interference chain, and rollers are set at both ends of the interference chain to fit tightly against the inner wall of the box. On the one hand, the rollers can reduce the friction between the interference chain and the inner wall of the box when rotating, thus extending the service life of the device; on the other hand, it makes the rotation of the interference chain more stable, and can form an interference area more evenly in the box, improving the uniformity and effect of sleep deprivation. In addition, the hinged chain links with torsion springs enhance the flexibility of the interference chain, which can better adapt to the activity of mice and the characteristics of the box space.

[0010] Preferably, a ventilation opening is provided on the side wall of the box lid, which allows the box to communicate with the outside.

[0011] The above structural design allows the ventilation openings on the side wall of the box to connect the box with the outside world, ensuring air circulation inside the box. This simulates the normal breeding environment for mice, reduces stress response caused by environmental confinement, and makes the experimental conditions closer to the natural state, thereby improving the accuracy and reliability of the sleep deprivation experiment results.

[0012] Preferably, the camera, the lighting lamp, and the stepper motor are all electrically connected to the controller.

[0013] With the above structural design, the camera, lighting, and stepper motor are all electrically connected to the controller, realizing automated centralized control of each component. This allows experimenters to accurately adjust the monitoring angle of the camera, the on / off state of the lighting, and the operating parameters of the stepper motor, simplifying the experimental operation process and improving the controllability and efficiency of the experiment.

[0014] Compared with the prior art, the beneficial effects of this utility model are: Integrating the sleep deprivation device into the structure of the IVC cage, such as the box and lid, allows for in-situ sleep deprivation experiments without transferring mice, reducing stress caused by environmental transfer. An adjustable-angle camera facilitates comprehensive monitoring of the mouse's condition, while the lighting can simulate circadian rhythms or assist in waking the mouse. In the articulated interference chain with torsion springs, the torsion springs provide elasticity and mobility to the chain links, allowing for better adaptation to the internal space of the cage. When the stepper motor drives its rotation, it effectively disturbs the mouse to achieve sleep deprivation, improving the reliability of sleep deprivation and the device's adaptability to IVC cages. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the structure of this utility model; Figure 2 This is a schematic diagram of the bottom structure of the box cover of this utility model; Figure 3 This is a side view of the internal structure of this utility model; Figure 4 This is a connection diagram of the controller of this utility model. Detailed Implementation

[0016] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0017] Please see Figure 1-4 This utility model provides a technical solution: a mouse sleep deprivation device based on an IVC cage, comprising an IVC cage, which includes a box body 1 and a box cover 2. The box cover 2 and the box body 1 are detachably connected by snaps or hinges, facilitating the insertion and removal of mice into or from the box body 1. A controller 3 is mounted on the upper surface of the box cover 2. The controller 3 can be a microcontroller or PLC with programming capabilities, used for centralized control of the operation of various components of the device. An adjustable-angle high-definition camera 5 and a lighting lamp 9 are mounted on the lower surface of the box cover 2.

[0018] A stepper motor 6 is also fixed on the bottom surface of the box cover 2. The output end of the stepper motor 6 faces downward, and a rotating rod 7 is connected to the output shaft. The lower end of the rotating rod 7 is connected to the middle position of the interference chain 8.

[0019] The interference chain 8 is a hinged multi-section chain, with adjacent links hinged together by a hinge shaft. A torsion spring is fitted on the hinge shaft, providing elastic restoring force to the links. This gives the links flexible rotation and a certain degree of cushioning, making them more adaptable to the interference needs of the internal space of the box 1 and the activities of mice. Both ends of the interference chain 8 are also rotatably connected to rollers 10 via bearings. When the device is working, the rollers 10 are in close contact with the inner wall of the box 1 to reduce friction between the interference chain 8 and the inner wall of the box during rotation, improving rotational smoothness and extending the device's lifespan.

[0020] The lid 2 has a slot 4 for placing experimental water bottles; the body 1 has a drinking tube 11, one end of which passes through the slot 4 and connects to the water bottle outlet, and the other end extends to a suitable height inside the body 1 for the mice to drink water, ensuring the mice's drinking needs during the experiment.

[0021] Ventilation openings 12 are provided on the side wall of the box cover 2. The ventilation openings 12 are covered with dustproof nets, which not only allow air circulation between the box 1 and the outside world and maintain the freshness of the air inside the box, but also prevent external dust from entering and polluting the experimental environment.

[0022] Working principle: When sleep deprivation is required in mice, the stepper motor 6 is activated via the controller 3. The output shaft of the stepper motor 6 drives the rotating rod 7 to rotate, which in turn drives the interference chain 8 to rotate around the axis of the rotating rod 7. Since the interference chain 8 is a hinged multi-link chain with torsion springs, and the rollers 10 at both ends are close to the inner wall of the box, the interference chain 8 can rotate smoothly and flexibly within the box 1, continuously interfering with the mouse's activity space and preventing the mouse from entering a stable sleep state, thereby achieving the purpose of sleep deprivation. At the same time, the adjustable-angle camera 5 facilitates all-round monitoring of the mouse's status, and the lighting 9 can simulate circadian rhythms or assist in waking the mouse.

[0023] Contents not described in detail in this specification are existing technologies known to those skilled in the art. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A mouse sleep deprivation device based on an IVC cage, comprising an IVC cage, characterized in that: The IVC cage includes a box body (1) and a box cover (2). A controller (3) is provided on the box cover (2). An adjustable-angle camera (5) and a lighting lamp (9) are installed on the bottom surface of the box cover (2). A stepper motor (6) is also provided on the bottom surface of the box cover (2). The output end of the stepper motor (6) faces downward and is equipped with a rotating rod (7). An interference chain (8) is provided at the lower end of the rotating rod (7). The interference chain (8) is a hinged multi-section chain. The links are connected by a hinge shaft, and a torsion spring is sleeved on the hinge shaft.

2. The mouse sleep deprivation device based on an IVC cage according to claim 1, characterized in that: The lid (2) has a slot (4) for placing water bottles. The body (1) has a drinking pipe (11) inside. The drinking pipe (11) passes through the slot (4) and is connected to the water bottle.

3. The mouse sleep deprivation device based on an IVC cage according to claim 1, characterized in that: The rotating rod (7) is connected to the middle position of the interference chain (8), and both ends of the interference chain (8) are rotatably connected to rollers (10), which are in close contact with the inner wall of the box (1).

4. A mouse sleep deprivation device based on an IVC cage according to claim 1, characterized in that: A ventilation opening (12) is also provided on the side wall of the box cover (2), which allows the box body (1) to communicate with the outside world.

5. A mouse sleep deprivation device based on an IVC cage according to claim 1, characterized in that: The camera (5), the lighting lamp (9) and the stepper motor (6) are all electrically connected to the controller (3).

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