A convenient and versatile integrated device for blood collection and serum microprocessing.

Abstract

This utility model relates to the field of medical device technology and discloses a convenient and versatile integrated blood collection and serum microprocessing device. It includes a housing, with a blood collection needle inlet installed at the front end of the housing. A blood collection needle is inserted into the inlet, and the end of the needle is connected to a capillary tube via a sealed tube. The end of the capillary tube is connected to a microfluidic system. A waste liquid outlet at the lower end of the microfluidic system is connected to a waste liquid chamber, and a drain port with a valve is located at the bottom of the waste liquid chamber. A waste liquid chamber replacement port is located at the lower end of the housing opposite to the waste liquid chamber. A storage tube is connected to the rear outlet of the microfluidic device, and a storage tube installation port is located at the tail end of the housing opposite to the storage tube. This device reduces manual intervention and errors; effectively improves blood collection efficiency; enables rapid and accurate blood sample collection, shortens blood collection time; and ensures serum quality.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, and particularly to the field of blood collection devices, specifically a convenient and versatile integrated device for blood collection and serum microprocessing. Background Technology

[0002] Traditional blood collection and serum processing equipment has many drawbacks. In the blood collection process, the connection between the lancet and the blood collection tube is relatively simple, lacking effective sealing and leak-proof measures, making blood leakage easy. Furthermore, the design of the blood collection tubes is not conducive to accurate collection and subsequent sample processing. In serum processing, centrifugation requires a separate centrifuge, which is bulky and complex to operate, not only time-consuming but also prone to sample loss due to improper handling. In addition, serum filtration is often ineffective, failing to remove impurities and microorganisms, thus affecting serum quality. Moreover, the entire blood collection and serum processing process requires the coordinated operation of multiple devices, with cumbersome connections and operating procedures, increasing the operational difficulty and workload for staff.

[0003] This is especially evident in the blood collection and serum processing stages: Traditional blood collection methods are mostly manual, resulting in inaccurate control of blood volume and long collection times. For example, in some primary healthcare units, a single blood collection takes an average of 3-5 minutes, affecting work efficiency.

[0004] The connection between the lancet and the blood collection tube is not secure, which can easily lead to blood leakage. Studies have shown that blood leakage occurs in about 10% of blood collection processes, which not only wastes blood samples but may also pollute the environment.

[0005] During blood collection, external factors such as temperature and humidity can easily cause blood samples to hemolyze or deteriorate, affecting the accuracy of test results.

[0006] In serum processing, centrifuges are typically large, require professional operation, and the centrifugation process takes a considerable amount of time. For example, a conventional centrifuge typically takes 10-15 minutes, making the entire serum processing inefficient.

[0007] Traditional filtration methods are ineffective at removing impurities and microorganisms from serum, resulting in poor serum quality. Statistics show that 20%-30% of impurities remain in serum even after conventional filtration.

[0008] The manual transfer of samples between equipment such as blood collection, centrifugation, and filtration can easily lead to sample contamination and loss. Summary of the Invention

[0009] This invention addresses several issues in current blood collection and serum processing, including inaccurate blood volume control leading to long collection times, unstable connection between blood collection needles and blood collection tubes causing blood leakage, external interference leading to hemolysis or deterioration of blood samples, large size of centrifuges requiring professional operation and long centrifugation times resulting in low serum processing efficiency, traditional filtration failing to effectively remove impurities and microorganisms leading to low serum quality, and manual sample transfer between devices causing sample contamination and loss. Therefore, this invention provides a convenient and versatile integrated device for blood collection and serum microprocessing.

[0010] This utility model is achieved using the following technical solution: A convenient and versatile integrated blood collection and serum microprocessing device includes a housing. A blood collection needle inlet is installed at the front end of the housing, and a blood collection needle is inserted into the inlet. The end of the blood collection needle is connected to a capillary tube via a sealed tube. The end of the capillary tube is connected to a microfluidic system. A waste liquid container is connected to the lower waste liquid outlet of the microfluidic system. A drain port with a valve is located at the bottom of the waste liquid container. A waste liquid container replacement port is located at the lower end of the housing opposite to the waste liquid container. A storage tube is connected to the rear outlet of the microfluidic device, and a storage tube installation port is located at the tail end of the housing opposite to the storage tube.

[0011] During implementation, the outer shell serves to protect, support, and house the internal structure. The front end of the outer shell is equipped with a blood collection needle inlet, into which a blood collection needle is inserted. The end of the blood collection needle is connected to a capillary tube via a sealing tube. The inner diameter of the sealing tube is slightly smaller than the outer diameter of the capillary tube. An interference fit is used to achieve a seal and connection for further manipulation and processing of the blood. The end of the capillary tube is connected to a microfluidic system. The lower end of the microfluidic system has a waste liquid outlet connected to a waste liquid container. The waste liquid container adopts a detachable design for easy collection and disposal of waste liquid. The waste liquid tank has a smooth, corrosion-resistant interior, making it easy to clean and disinfect. Waste liquid generated during blood processing flows into the waste liquid tank for collection and storage due to gravity. A drain port with a valve is located at the bottom of the waste liquid tank, ensuring that waste liquid can only be discharged when needed. A waste liquid tank replacement port is located at the lower end of the outer shell, directly opposite the waste liquid tank. A storage tube is connected to the rear outlet of the microfluidic device. The storage tube is made of medical-grade polypropylene (PP) plastic, possessing excellent sealing and biocompatibility. The interior of the container is smooth and free of dead corners, making it easy to clean and disinfect. A storage tube installation port is located at the tail end of the outer shell, directly opposite the storage tube. A first spring is mounted between the front end face of the storage tube and the shell. A first inlet is located on the front end face of the storage tube, within the first spring. The device is centrally located and connected to a microfluidic system. A raised ring is located on the outer periphery of the front end of the storage tube. A fixed stop lever is fitted along the rear edge of the raised ring. The middle part of the fixed stop lever is mounted on the outer shell via a torsion spring. A slider switch is fixed at the top of the fixed stop lever, extending through the outer shell and engaging with an arc-shaped groove on the outer surface of the outer shell. A second spring is mounted between the top surface of the waste liquid tank and the outer shell. A second inlet is located in the center of the top surface of the waste liquid tank, situated in the center of the second spring, and is connected to the microfluidic system. A raised ring is located on the outer periphery of the top of the waste liquid tank. A fixed stop lever is fitted along the lower edge of the raised ring. The middle part of the fixed stop lever is mounted on the outer shell via a torsion spring. A slider switch is fixed at the bottom of the fixed stop lever, extending through the outer shell and engaging with an arc-shaped groove on the outer surface of the outer shell. The slider switches are distributed at the top and bottom of the device for easy operation of the corresponding functions and to prevent accidental operation.

[0012] Specifically, the microfluidic system includes a housing measuring 2.0 cm in length, 1.5 cm in width, and 1.5 cm in height. Inside the housing is a microchannel network. The inner surface of the microchannel network is treated with ammonia plasma to reduce blood sample adhesion. The microchannel network comprises connected straight and helical channels, constructed at the nanoscale for precise control of blood flow path and velocity. A passive microvalve is located at the front end of the straight channel. This passive microvalve operates without mechanical force or external power source, utilizing changes in fluid direction and pressure to switch on and off, allowing the fluid to automatically change direction or regulate flow under different conditions. It is used to open and close the fluid channel. The straight channel includes two U-shaped bends in opposite directions. At the rear end of the straight channel is a thin-film reciprocating structure... A pump provides the power for fluid flow. A spiral channel connects to the end of a straight channel, filled with nano-sized iron(III) oxide particles. These particles specifically bind to serum components in the blood, ensuring smooth flow and efficient separation within the microchannel. A magnetic field controller is located outside the spiral channel, adjusting its strength and direction to achieve rapid separation of serum components. The controller, arranged along the spiral channel, includes several miniature electromagnetic coils and a pressure sensor aligned axially along the spiral microchannel. The pressure sensor precisely controls the movement and separation of the iron(III) oxide particles. The spiral channel connects to a serum channel and a waste liquid channel. The serum channel connects to a rear outlet, and the waste liquid channel connects to a lower waste liquid outlet. Due to its miniaturization and integration, the microfluidic system can rapidly complete tasks within a very small volume. Controlling fluids at the micro- and nano-scale greatly simplifies experimental procedures and improves efficiency. Furthermore, it offers advantages such as low sample consumption, fast detection speed, ease of operation, multi-functional integration, small size, and portability.

[0013] During use, blood enters the capillary tube through the lancet and then flows into the microfluidic system. Utilizing the power of the blood flow itself and gravity, it passes through a passive micro-valve and enters a micro-pump with a thin-film reciprocating structure. Powered by the micro-pump, it enters a spiral channel where serum is separated. Nano-iron oxide particles are evenly distributed under the influence of a magnetic field controller. These nano-iron oxide particles specifically bind with serum components in the blood to form complexes. The separated serum complexes are diverted into the serum channel and out of the microfluidic system under the traction of the magnetic field and the control of the passive micro-valve, entering the storage vessel. After the collected blood sample enters the storage vessel, the storage vessel provides a relatively stable environment for temporary storage of the blood sample or serum complexes. The remaining waste liquid is not controlled by the magnetic field and flows out along the waste liquid channel into the waste liquid chamber, where it accumulates. When waste liquid needs to be discharged, it is discharged through the drain port with a valve at the bottom of the waste liquid chamber. The removal of both the waste liquid tank and the reservoir tube is achieved through a sliding switch. Specifically, the sliding switch slides within an arc-shaped groove to avoid motion interference. The sliding switch drives the fixed stop lever to rotate, while the torsion spring rotates and applies pressure. The fixed stop lever moves away from the edge of the convex ring, releasing the waste liquid tank or reservoir tube. Under the action of the spring (first spring or second spring), the waste liquid tank or reservoir tube pops outward from the reservoir tube installation port or waste liquid tank replacement port. During replacement and installation, the waste liquid tank or reservoir tube is inserted through the reservoir tube installation port or waste liquid tank replacement port, and the spring is squeezed into place. The sliding switch resets under the action of the torsion spring.

[0014] When samples need to be transferred to subsequent testing or analysis stages, they are transferred out under the action of pressure difference. The overall structural design allows blood samples to be collected, processed, and stored in an orderly manner within the device. There are mechanical connections between each switch and the components they control. The slider switch and the storage tube are connected by a mechanical transmission structure. Pressing the slider switch triggers the storage tube to pop out. Similarly, the slider switch and the waste liquid tank work in the same way. Pressing the button opens the discharge channel of the waste liquid tank.

[0015] Compared with existing technologies, this utility model has the following advantages: The convenient and versatile integrated blood collection and serum microprocessing device provided by this utility model integrates the entire process of plasma separation, quantification, mixing, reaction, and detection into a microfluidic system, achieving fully automated operation, reducing manual intervention and errors; effectively improving blood collection efficiency, enabling rapid and accurate blood sample collection, and shortening collection time; ensuring serum quality by combining superparamagnetic iron oxide magnetic nanoparticles with a microfluidic chip integrated with a permeable membrane using microfluidic technology to achieve automatic plasma separation without complex operations such as centrifugation, and with fast separation speed and high efficiency; effectively simplifying the operation process: integrating blood collection and serum processing equipment reduces the connection and operation steps between devices, lowers operational difficulty, and improves equipment stability: ensuring no blood leakage during blood collection and serum processing, improving equipment stability and reliability. Attached Figure Description

[0016] Figure 1 This is a schematic diagram showing the overall structure of the present invention.

[0017] Figure 2 This is a schematic diagram showing the structure of the microfluidic system of this invention.

[0018] Figure 3 This diagram illustrates the installation of the storage tube of this utility model.

[0019] Figure 4 This diagram illustrates the installation of the waste liquid storage tank of this utility model.

[0020] In the diagram: 1-Outer shell, 2-Blood collection needle inlet, 3-Blood collection needle, 4-Capillary tube, 5-Microfluidic system, 501-Shell, 502-Straight channel, 503-Spiral channel, 504-Passive micro-valve, 505-Micro pump, 506-Nano iron oxide particles, 507-Magnetic field controller, 508-Serum channel, 509-Waste liquid channel, 6-Waste liquid tank, 7-Waste liquid tank replacement port, 8-Drain port, 9-Reservoir tube, 10-Reservoir tube installation port, 11-First spring, 12-Second spring, 13-First inlet, 14-Second inlet, 15-Protruding ring, 16-Fixed stop lever, 17-Torsion spring, 18-Sliding switch. Detailed Implementation

[0021] The specific embodiments of this utility model will now be described with reference to the accompanying drawings.

[0022] A convenient and versatile integrated device for blood collection and serum microprocessing, such as Figures 1-4As shown: A blood collection needle inlet 2 is installed at the front end of the outer shell 1, and a blood collection needle 3 is inserted inside the blood collection needle inlet 2. The end of the blood collection needle 3 is connected to a capillary tube 4 through a sealing tube. In this embodiment, the inner diameter of the capillary tube is 0.8 mm and the length is 0.8 cm to ensure smooth flow of blood samples while avoiding air bubbles and wall adhesion. The inner diameter of the sealing tube is slightly smaller than the outer diameter of the capillary tube, and the sealing and connection are achieved through an interference fit for further manipulation and processing of the blood. The end of the capillary tube 4 is connected to a microfluidic system 5, and the lower end of the microfluidic system 5 is connected to a waste liquid tank 6. The waste liquid tank 6 adopts a detachable design for easy collection and disposal of waste liquid. The interior of the waste liquid tank 6 is smooth, corrosion-resistant, and easy to clean and disinfect. Waste liquid generated during blood processing flows into the waste liquid tank 6 for collection and storage due to gravity. Figure 1 The shape of the waste liquid tank and the storage tube is only shown in the diagram. In this embodiment, the waste liquid tank 6 has a capacity of 30 microliters to ensure that it can hold the waste liquid generated during the separation process. At the same time, it has good sealing performance to prevent waste liquid leakage and pollution. The bottom of the waste liquid tank 6 is provided with a drain port 8 with a valve to ensure that the waste liquid can be discharged when needed. The outer shell 1 has a waste liquid tank replacement port 7 at the lower end of the waste liquid tank 6. The rear outlet of the microfluidic device is connected to the storage tube 9. The storage tube 9 is made of medical-grade plastic polypropylene PP, which has good sealing performance and biocompatibility. The inside of the container is smooth and without dead corners, making it easy to clean and disinfect. In this embodiment, the storage tube has a capacity of 40 microliters to ensure that it can hold the separated serum sample. The outside of the container has clear markings and scales to facilitate the identification and recording of the serum sample volume. The outer shell 1 has a storage tube installation port 10 at the tail end of the storage tube 9. A first spring 11 is installed between the front end face of the storage tube 9 and the shell 501. The end face has a first inlet 13, which is located in the center of the first spring 11 and is connected to the microfluidic system 5; the front end of the storage tube 9 has a convex ring 15, and a fixed stop bar 16 is clamped on the rear edge of the convex ring 15. The middle part of the fixed stop bar 16 is mounted on the outer shell 1 through a torsion spring 17. A sliding switch 18 is fixed at the top of the fixed stop bar 16. The sliding switch 18 passes through the outer shell 1 and cooperates with the arc-shaped sliding groove on the outer surface of the outer shell 1; the top surface of the waste liquid tank 6 is between the outer shell 501 and the outer shell 501. A second spring 12 is mounted on the top. A second inlet 14 is located in the center of the top surface of the waste liquid tank 6, and is connected to the microfluidic system 5. A protruding ring 15 is provided on the outer periphery of the top of the waste liquid tank 6. A fixed stop bar 16 is clamped on the lower edge of the protruding ring 15. The middle part of the fixed stop bar 16 is mounted on the outer shell 1 via a torsion spring 17. A slider switch 18 is fixed at the bottom of the fixed stop bar 16. The slider switch 18 extends out of the outer shell 1 and engages with the arc-shaped groove on the outer surface of the outer shell 1. The slider switches 18 are distributed at the top and bottom of the device for convenient operation of the corresponding functions and to avoid accidental operation. Specifically, the microfluidic system 5 includes a housing 501. In this embodiment, the housing 501 has dimensions of 2.0 cm in length, 1.5 cm in width, and 1.5 cm in height. A microchannel network is installed inside the housing 501. The inner surface of the microchannel network is treated with ammonia plasma to reduce blood sample adhesion. The microchannel network includes a connected straight channel 502 and a spiral channel 503, constructed at the nanoscale for precise control of blood flow path and velocity. A passive microvalve 504 is located at the front end of the straight channel 502. The passive microvalve 504 does not rely on mechanical force for opening and closing and requires no external power source. It utilizes the direction and pressure changes of the fluid itself to achieve switching, allowing the fluid to automatically change its flow direction or achieve flow regulation under different conditions. It is used to open and close the fluid channel. The straight channel includes two U-shaped bends in opposite directions. A thin-film reciprocating micropump 505 is located at the rear end of the straight channel 502 for... Providing the power for fluid flow, a spiral channel 503 is connected to the end of a straight channel 502. The spiral channel 503 is filled with nano-ferric oxide particles 506, which specifically bind to serum components in the blood to ensure smooth flow and efficient separation within the microchannel. A magnetic field controller 507 is located outside the spiral channel 503. The magnetic field controller can adjust the magnetic field strength and direction as needed to achieve rapid separation of serum components. The magnetic field controller 507 is arranged along the spiral channel 503 and includes several miniature electromagnetic coils and a pressure sensor arranged axially along the spiral microchannel. The pressure sensor is used to precisely control the movement and separation process of the nano-ferric oxide particles. A serum channel 508 and a waste liquid channel 509 are connected to the end of the spiral channel 503. The serum channel 508 is connected to the rear outlet, and the waste liquid channel 509 is connected to the lower waste liquid outlet. Due to its miniaturization and integration features, the microfluidic system 5 can quickly complete its tasks within a very small volume. Controlling fluids in micro- and nano-scale spaces greatly simplifies experimental procedures and improves efficiency. Furthermore, it offers numerous advantages such as low sample consumption, fast detection speed, ease of operation, multi-functional integration, small size, and portability.

[0023] In use, blood enters the capillary tube 4 through the blood collection needle 3 and then enters the microfluidic system. Utilizing the power of the blood flow itself and gravity, it passes through the passive micro-valve 504 and enters the micro-pump 505, which has a thin-film reciprocating structure. Under the power provided by the micro-pump 505, it enters the spiral channel 503, where serum is separated. Nano-iron oxide particles 506 are evenly distributed under the influence of the magnetic field controller 507. The nano-iron oxide particles 506 specifically bind with the serum components in the blood to form complexes. The separated serum complexes are diverted to the serum channel 508 and flow out of the microfluidic system under the traction of the magnetic field and the control of the passive micro-valve 504, entering the storage tube 9. After the collected blood sample enters the storage tube 9, the storage tube 9 provides a relatively stable environment for temporary storage of blood samples or serum complexes. The remaining waste liquid is not controlled by the magnetic field and flows out through the waste liquid channel 509 into the waste liquid chamber 6, where it accumulates. When it is necessary to remove the waste liquid, it is discharged through the drain port 8 with a valve at the bottom of the waste liquid chamber 6. The removal of the waste liquid tank 6 and the reservoir tube 9 is achieved through the sliding switch 18. Specifically, the sliding switch 18 slides in the arc-shaped groove to avoid motion interference. The sliding switch 18 drives the fixed stop 16 to rotate, and at the same time, the torsion spring 17 rotates and applies pressure. The fixed stop 16 moves away from the edge of the convex ring 15, releasing the waste liquid tank 6 or the reservoir tube 9. The waste liquid tank 6 or the reservoir tube 9 pops outward under the action of the first spring or the second spring, popping out from the reservoir tube installation port 10 or the waste liquid tank replacement port 7. When replacing or installing, the waste liquid tank 6 or the reservoir tube 9 is inserted into the reservoir tube installation port 10 or the waste liquid tank replacement port 7, and the spring is squeezed into place. The sliding switch 18 is reset under the action of the torsion spring.

[0024] When samples need to be transferred to subsequent testing or analysis stages, they are transferred out under the action of pressure difference. The overall structural design allows blood samples to be collected, processed, and stored in an orderly manner within the device. There is a mechanical connection between each switch and the component it controls. The slider switch 18 and the storage tube 9 are connected by a mechanical transmission structure. Pressing the slider switch 18 triggers the storage tube 9 to pop out. Similarly, the slider switch 18 and the waste liquid tank 6 work together. Pressing the button opens the discharge channel of the waste liquid tank 6.

[0025] In a trial of 100 patients, the pain score of patients using this lancet decreased by an average of 30%, and the blood collection success rate reached 99%. Compared with traditional blood collection methods, it reduces patient pain and discomfort and improves blood collection efficiency.

[0026] The collected blood samples were precisely and non-destructively transferred to the microfluidic region. In 50 transfer tests, the capillary transfer efficiency reached 100% without any loss or contamination of blood samples. This avoids contamination and loss of blood samples during transfer and improves the accuracy of serum separation.

[0027] This invention utilizes microfluidic technology combined with the rapid separation properties of nano-ferric oxide particles to achieve automated separation of serum and waste liquid. Compared with traditional serum separation methods, this technology increases the separation speed by 50% and achieves a serum purity of over 98%. It significantly improves the speed and efficiency of serum separation while reducing operational complexity and cost. The separated serum is automatically collected into a designated container for subsequent analysis or storage.

[0028] In 100 collection tests, the device achieved 100% serum collection efficiency without any serum contamination or loss. It simplifies the serum collection process and reduces the tediousness and errors associated with manual operation.

[0029] The separated waste liquid is automatically collected and stored in a designated location for subsequent treatment. In 50 waste liquid treatment tests, the device achieved 100% efficiency in waste liquid collection and treatment, with no leaks or environmental pollution occurring. This avoids indiscriminate discharge of waste liquid and environmental pollution, improving the device's environmental performance.

[0030] Example 1: Laboratory Blood Testing The effectiveness of improvements to various equipment and technologies in the laboratory blood testing process was evaluated, including lancet design, capillary material, microfluidic chip functionality, serum collection and waste disposal methods, in order to improve blood collection and serum separation efficiency, reduce operational difficulty, and enhance the reliability of test results.

[0031] Experimental Results and Application Effects 1. Improved efficiency: Significantly improved efficiency in blood collection and serum separation, with testing time significantly shortened compared to conventional methods.

[0032] 2. Simplified operation: Reduced operation difficulty, effectively reduced human error, and improved stability of the testing process.

[0033] 3. Result optimization: Ensure the purity and accuracy of blood samples, significantly improve the reliability of test results, and provide stronger support for clinical diagnosis.

[0034] Example 2: Home self-monitoring of biochemical indicators such as blood glucose and blood lipids This study aims to verify the effectiveness of a device design for home self-monitoring of biochemical indicators such as blood glucose and blood lipids in terms of convenience, accuracy, user health management awareness, and medical costs. It also aims to transmit and analyze data between a microfluidic chip and a smartphone app, allowing users to access their health data at any time.

[0035] Experimental Results and Application Effects 1. Convenient and accurate: Successfully achieves convenience and accuracy for home self-monitoring, allowing users to easily complete the test at home.

[0036] 2. Increased health awareness: Users' awareness and participation in health management have been enhanced, and users are paying more attention to their own health status.

[0037] 3. Cost reduction: It reduces medical costs, alleviates the burden on medical institutions, and eases the problem of strained medical resources.

[0038] Example 3: Application in mobile medical examination vehicle project to provide medical examination services to residents in remote areas The applicability of various blood testing equipment designs in the mobile medical examination vehicle project was tested, including optimized design of blood collection needles and capillaries, portability of microfluidic systems, serum collection containers and waste liquid treatment devices, to provide high-quality medical examination services for residents in remote areas, improve the efficiency of the medical examination vehicle and ensure the safe disposal of waste liquid.

[0039] Experimental Results and Application Effects 1. Service quality assurance: Successfully provide high-quality physical examination services to residents in remote areas, meeting their health needs.

[0040] 2. Improved efficiency: The mobile medical examination vehicle has improved its overall work efficiency, shortened residents' waiting time, and enabled more residents to receive medical examination services.

[0041] 3. Environmental protection and safety: Ensures the safe treatment of waste liquid, effectively avoids environmental pollution, and maintains the safety of the medical examination vehicle and its surrounding environment.

[0042] The scope of protection claimed by this utility model is not limited to the specific embodiments described above. Moreover, for those skilled in the art, this utility model can have various modifications and alterations. Any modifications, improvements, and equivalent substitutions made within the concept and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A convenient and versatile integrated device for blood collection and serum microprocessing, characterized in that: The device includes an outer shell (1), a blood collection needle inlet (2) installed at the front end of the outer shell (1), a blood collection needle (3) inserted inside the blood collection needle inlet (2), a capillary tube (4) connected to the end of the blood collection needle (3) through a sealing tube, a microfluidic system (5) connected to the end of the capillary tube (4), a waste liquid tank (6) connected to the lower waste liquid outlet of the microfluidic system (5), a drain port (8) with a valve at the bottom of the waste liquid tank (6), a waste liquid tank replacement port (7) opened at the lower end of the outer shell (1) facing the waste liquid tank (6); a storage tube (9) connected to the rear outlet of the microfluidic system (5), and a storage tube installation port (10) opened at the tail end of the storage tube (9) facing the outer shell (1).

2. The convenient and versatile integrated blood collection and serum microprocessing device according to claim 1, characterized in that: The microfluidic system (5) includes a housing (501), in which a microchannel network is installed. The microchannel network includes a straight channel (502) and a spiral channel (503) connected together. A passive microvalve (504) is provided at the front end of the straight channel (502), and a micropump (505) with a thin film reciprocating structure is provided at the rear end of the straight channel (502). A spiral channel (503) is connected to the end of the straight channel (502). The spiral channel (503) is filled with nano-iron oxide particles (506). A magnetic field controller (507) is provided outside the spiral channel (503). The magnetic field controller (507) is arranged along the spiral channel (503). A serum channel (508) and a waste liquid channel (509) are connected to the end of the spiral channel (503). The serum channel (508) is connected to the rear outlet, and the waste liquid channel (509) is connected to the lower waste liquid port.

3. The convenient and versatile integrated blood collection and serum microprocessing device according to claim 2, characterized in that: The shell (501) has the following dimensions: length 2.0 cm, width 1.5 cm, and height 1.5 cm.

4. The convenient and versatile integrated blood collection and serum microprocessing device according to claim 2, characterized in that: The magnetic field controller (507) includes several miniature electromagnetic coils and pressure sensors arranged along the axial direction of the spiral microchannel.

5. The convenient and versatile integrated blood collection and serum microprocessing device according to claim 1, characterized in that: A first spring (11) is mounted on the front end face of the storage tube (9) and the housing (501). A first inlet (13) is opened on the front end face of the storage tube (9). The first inlet (13) is located in the center of the first spring (11) and is connected to the microfluidic system (5). A convex ring (15) is provided on the outer periphery of the front end of the storage tube (9). A fixed stop bar (16) is clamped on the rear edge of the convex ring (15). The middle part of the fixed stop bar (16) is mounted on the housing (1) through a torsion spring (17). A slider switch (18) is fixed at the top of the fixed stop bar (16). The slider switch (18) passes through the housing (1) and cooperates with the arc-shaped sliding groove on the outer surface of the housing (1).

6. The convenient and versatile integrated blood collection and serum microprocessing device according to claim 1, characterized in that: A second spring (12) is mounted between the top surface of the waste liquid tank (6) and the shell (501). A second inlet (14) is opened in the center of the top surface of the waste liquid tank (6). The second inlet (14) is located in the center of the second spring (12) and is connected to the microfluidic system (5). A convex ring (15) is provided on the outer periphery of the top of the waste liquid tank (6). A fixed stop bar (16) is clamped on the lower edge of the convex ring (15). The middle part of the fixed stop bar (16) is mounted on the shell (1) through a torsion spring (17). A slider switch (18) is fixed at the bottom of the fixed stop bar (16). The slider switch (18) passes through the shell (1) and cooperates with the arc-shaped sliding groove on the outer surface of the shell (1).

7. The convenient and versatile integrated blood collection and serum microprocessing device according to claim 2, characterized in that: The straight channel includes two U-shaped bends in opposite directions.

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