Mouse oral experiment fixer

Abstract

The utility model discloses a mouse's oral cavity experiment fixer, and the purpose is to solve the problem that the opening degree of the cheek is difficult to adjust, relates to mouse experimental instrument technical field, including fixed plate, be equipped with four limbs limiting post on the fixed plate, be equipped with the adjustment mechanism that can be adjusted in front and back, left and right, up and down on the fixed plate, be equipped with two cheek expanding sheets on the adjustment mechanism, the adjustment mechanism includes two U type rods with cheek expanding sheet, two U type rods are connected through first two -way nut screw threads, the fixed plate is equipped with the sliding block of sliding, the sliding block with between first two -way nut is connected through height adjusting unit, the utility model discloses the position of two cheek expanding sheets is adjusted to the two kinds of continuous adjustment mode of screw thread connection and sliding block movement, realizes the fine adjustment of cheek expanding sheet in three directions, is suitable for different body type's mouse, not only can improve experimental efficiency, can also avoid the destruction of mouse's oral cavity.

Description

Technical Field

[0001] This utility model relates to the field of mouse experimental instruments technology, and in particular to a mouse oral cavity fixation device. Background Technology

[0002] Mouse oral cavity experiments are important tools for studying oral diseases, immune responses, and drug delivery. By establishing disease models, conducting experimental procedures, and analyzing samples, the mechanisms and treatments of oral-related diseases can be explored in depth. During experiments, a restraint device is required to immobilize the mouse. Common mouse restraint devices are flat and have four posts for securing the limbs and one post for securing the teeth. After the limbs or teeth are restrained with string, nuts are used to secure the string to the posts, thus immobilizing the mouse. However, this type of restraint often requires the use of other instruments to open the oral cavity. For the stability of these other instruments, the experimenter may need to hold the device, which is not conducive to the smooth conduct of the experiment.

[0003] To address the aforementioned issues, patent CN216365394U discloses a mouse oral surgery fixation device. This device consists of two second pillars with a cheek-expanding wire ring fitted onto each pillar. The cheek-expanding wire ring is clamped between the upper sleeve and the lower thin sleeve of the second pillar, and is secured by tightening screws.

[0004] However, the degree of opening of the mouse's cheeks in this patent is difficult to adjust: the patent adjusts the distance between the cheek-opening wire rings by pulling them to the appropriate position and then tightening them with screws, thereby opening the cheeks. However, because mice are small, the degree of opening of their cheeks needs to be fine-tuned. It is difficult to fine-tune the distance by tightening the screws, and improper adjustment of the distance can easily damage the mouse's oral cavity. Utility Model Content

[0005] This invention provides a mouse oral cavity fixation device to solve the problem of difficulty in adjusting the degree of cheek opening in existing mouse oral cavity fixation devices, thereby improving experimental efficiency and avoiding damage to the mouse's oral cavity.

[0006] To achieve the above objectives, the technical approach adopted by this utility model to solve its technical problem is as follows: A mouse oral cavity fixation device was designed. By setting an adjustment mechanism, the positions of two cheek expanders can be adjusted using two continuously adjustable methods: threaded connection and slider movement. This allows for fine adjustment of the cheek expanders along the front-back, left-right, and up-down directions of the fixation plate.

[0007] To achieve the above objectives, the technical solution adopted by this utility model to solve its technical problem is as follows: A mouse oral cavity restraint device includes a fixation plate with four limb limiting posts on the fixation plate; The fixed plate is equipped with an adjustment mechanism that can be adjusted forward and backward, left and right, and up and down; The adjustment mechanism is equipped with two cheek expanders.

[0008] Furthermore, the adjustment mechanism includes two U-shaped rods equipped with cheek expanders; The two U-shaped rods are connected by a first bidirectional nut thread; A slider is slidably mounted on the fixed plate, and the slider is connected to the first bidirectional nut via a height adjustment unit.

[0009] Furthermore, the height adjustment unit includes a connecting rod and a screw; The screw is connected to the slider, and a second nut is provided on the outer sleeve of the screw; The connecting rod is rotatably sleeved on the bottom of the second nut, and the connecting rod is rotatably connected to the first bidirectional nut.

[0010] Furthermore, a locking unit is provided between the slider and the fixed plate.

[0011] Furthermore, the locking unit includes two L-shaped locking blocks slidably connected to the slider; The two L-shaped blocks are connected by a spring; The fixing plate has a first groove that matches the slider.

[0012] Furthermore, two limiting components are provided between the U-shaped rod and the fixing plate, which are used to improve the stability of the corresponding U-shaped rod.

[0013] Furthermore, the limiting component includes a telescopic rod that is slidably connected to the fixed plate; The U-shaped rod is slidably sleeved on the end of the corresponding telescopic rod.

[0014] The beneficial effects of this utility model are as follows: Compared with the prior art, the improvement of this utility model lies in that... 1. This utility model connects the cheek expander to the adjustment mechanism and uses two continuously adjustable methods, namely threaded connection and slider movement, to adjust the position of the two cheek expanders, thereby achieving fine adjustment of the cheek expander along the length, width, and height of the fixed plate; 2. This utility model connects two U-shaped rods with a first bidirectional nut and connects the connecting rod and the screw with a second nut, thereby realizing the adjustment of the distance and height of the cheek expander. This not only achieves continuous fine adjustment, but also avoids damage to the mouse's oral cavity, making it suitable for mice of different sizes. 3. This utility model, by setting a slider, a first sliding groove and a locking unit, realizes the adjustment of the position of the cheek expander along the length direction of the fixed plate. The operation is simple and can be continuously fine-tuned. 4. This utility model improves the stability of the U-shaped rod and extends the service life of the fixture by setting a limiting component, which slides the telescopic rod on the side of the fixed plate and sets a limiting ring on the telescopic rod to limit the U-shaped rod. Attached Figure Description

[0015] To more clearly illustrate the technical solutions of the embodiments of this utility model, the accompanying drawings used in the embodiments will be briefly described below.

[0016] Figure 1 This is a top view of the overall structure of this utility model; Figure 2 This is a rear top view after the base has been removed; Figure 3 This is a front-view view after the base has been removed; Figure 4 This is a bottom view of the adjustment mechanism; Figure 5 yes Figure 2 A three-dimensional sectional view at point AA; Figure 6 yes Figure 5 A magnified view of a section at point B in the middle; In the picture: 1. Fixed plate; 11. First slide groove; 12. Second slide groove; 2. Neck expansion patch; 3. Limb restraint posts; 4. Limb restraint ropes; 5. Tooth positioning post; 51. Tooth positioning rope; 6. Adjustment mechanism; 61. U-shaped rod; 62. First double-acting nut; 63. Connecting ring; 64. Rotating ring; 65. Height adjustment unit; 651. Connecting rod; 652. Screw; 653. Second nut; 66. Slider; 67. Locking unit; 671. L-shaped locking block; 672. Spring; 673. Operating rod; 68. Limiting assembly; 681. Outer cylinder; 682. Inner rod; 683. Limiting ring; 684. Telescopic rod. Detailed Implementation

[0017] The technical solutions in the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments, not all embodiments.

[0018] Example 1 refer to Figure 1-6This utility model provides a mouse oral cavity testing restraint device, including a fixing plate 1; the fixing plate 1 is provided with tooth limiting posts 5 and four limb limiting posts 3, tooth limiting ropes 51 are sleeved on the tooth limiting posts 5, and limb limiting ropes 4 are connected to each limb limiting post 3; the fixing plate 1 is provided with an adjustment mechanism 6 that can be adjusted forward and backward, left and right, and up and down, and two cheek expanders 2 are connected to the adjustment mechanism 6. The cheek expanders 2 are used to assist in opening the mouse's oral cavity and expanding the cheeks to provide a good field of vision and operating space for further oral cavity experiments. The adjustment mechanism 6 is used to adjust the position of the cheek expanders 2 to suit mice of different sizes.

[0019] Furthermore, the adjustment mechanism 6 includes two U-shaped rods 61 and a first bidirectional nut 62; each of the two U-shaped rods 61 is connected to a gill expander 2; the first bidirectional nut 62 is connected to the two U-shaped rods 61 by forward and reverse threads and is located between the two U-shaped rods 61. Rotating the first bidirectional nut 62 can adjust the distance between the two U-shaped rods 61, thereby adjusting the distance between the two gill expanders 2; a slider 66 is slidably provided at the bottom of the fixing plate 1, and the slider 66 is connected to the first bidirectional nut 62 through a height adjustment unit 65, so that the positions of the two U-shaped rods 61 can be adjusted in the front-back, left-right, and up-down directions.

[0020] Furthermore, the first bidirectional nut 62 is provided with a height adjustment unit 65; the height adjustment unit 65 includes a connecting rod 651 and a screw 652; the upper end of the screw 652 is connected to the slider 66, and the lower end is externally threaded to a second nut 653; the upper end of the connecting rod 651 is rotatably sleeved on the bottom of the second nut 653, and the lower end is rotatably connected to the first bidirectional nut 62. Rotating the second nut 653 can adjust the distance between the connecting rod 651 and the screw 652, thereby adjusting the height of the first bidirectional nut 62, and thus adjusting the height of the jaw expander 2.

[0021] Specifically, a rotating ring 64 is connected to the bottom of the connecting rod 651, and a connecting ring 63 is fixedly sleeved on the first bidirectional nut 62. The rotating ring 64 is rotatably sleeved on the connecting ring 63. When the first bidirectional nut 62 is rotated, since the rotating ring 64 is rotatably connected to the connecting ring 63, it will not affect the direction of the height adjustment unit 65. The height adjustment unit 65 is always vertically connected to the bottom of the fixed plate 1.

[0022] Furthermore, the bottom of the fixing plate 1 is provided with a first groove 11 that matches the slider 66, and the slider 66 is provided with a locking unit 67 for controlling the starting and locking of the slider 66.

[0023] Furthermore, the locking unit 67 includes two L-shaped locking blocks 671 and a spring 672 connecting the two L-shaped locking blocks 671. An operating rod 673 is connected to the L-shaped locking blocks 671. The slider 66 has a sliding channel for sliding the L-shaped locking blocks 671 and the operating rod 673. When the two operating rods 673 are pinched, the two L-shaped locking blocks compress the spring 672, so that the two L-shaped locking blocks 671 no longer press against the inner wall of the first sliding groove 11. Dragging the slider 66 can move the U-shaped rod 61 along the length direction of the fixed plate 1, thereby adjusting the position of the cheek expander 2.

[0024] In this embodiment, the principle of the adjustment mechanism 6 is as follows: rotating the first bidirectional nut 62 can adjust the distance between the two U-shaped rods 61, thereby adjusting the distance between the two gill expanders 2; rotating the second nut 653 can adjust the distance between the connecting rod 651 and the screw 652, thereby adjusting the height of the first bidirectional nut 62, thereby adjusting the height of the gill expander 2; since the rotating ring 64 is rotatably connected to the connecting ring 63, it will not affect the direction of the height adjustment unit 65, and the height adjustment unit 65 is always vertically connected to the bottom of the fixed plate 1; when the two operating rods 673 are released, under the elastic force of the spring 672, the two L-shaped blocks 671 abut against the inner wall of the first slide groove 11, so that the slider 66 is stably locked at the bottom of the fixed plate 1; when the two operating rods 673 are squeezed, the two L-shaped blocks squeeze the spring 672, so that the two L-shaped blocks 671 no longer abut against the inner wall of the first slide groove 11, and dragging the slider 66 can realize the movement of the U-shaped rod 61 along the length direction of the fixed plate 1, thereby adjusting the position of the gill expander 2.

[0025] Example 2 Based on Embodiment 1, in order to enable the U-shaped rod 61 to more stably adjust the position of the cheek expander 2 along the front-back, left-right, and up-down directions of the fixing plate 1 and extend the service life of the fixing device, Embodiment 2 has two limiting components 68 for limiting the U-shaped rod 61 slidably connected to the side of the fixing plate 1.

[0026] refer to Figure 6 The limiting component 68 includes a telescopic rod 684 and a limiting ring 683. Specifically, the telescopic rod 684 includes an outer cylinder 681 and an inner rod 682 movably sleeved inside the outer cylinder 681. The outer cylinder 681 is slidably connected to the side of the fixing plate 1, and the side of the fixing plate 1 is provided with two second sliding grooves 12 that match the outer cylinder 681. The inner rod 682 is connected to a limiting ring 683 that matches the U-shaped rod 61, and the U-shaped rod 61 is slidably sleeved inside the corresponding limiting ring 683.

[0027] In this embodiment, the principle of the limiting component 68 is as follows: During the process of adjusting the position of the cheek expander 2 by the adjusting mechanism 6, the U-shaped rod 61 moves along the length, width and height of the fixed plate 1. At this time, the outer cylinder 681 slides in the second slide groove 12, and the inner rod 682 slides in the outer cylinder 681. However, the limiting ring 683 is always at the same height as the second slide groove 12, which limits the U-shaped rod 61. The U-shaped rod 61 slides in the limiting ring 683. The limiting component 68 enhances the stability of the U-shaped rod 61.

[0028] Application Examples In oral medicine research, mice are frequently used for oral experiments in fields such as oral diseases, immune responses, and drug testing. Periodontitis, a common and prevalent inflammatory and destructive disease of the periodontal tissues, is one of the leading causes of tooth loss in adults. Establishing a stable and reliable experimental animal model of periodontitis can provide a basis for exploring the etiology, clinical diagnosis, and treatment of periodontitis. After anesthetizing mice via intraperitoneal injection, the interdental space between the first and second molars is separated using a dental probe. Orthodontic stainless steel wire is used to ligate the cervical region of both maxillary first molars. The ligation wire is held by a needle holder and inserted from the distal palatal side of both maxillary first molars, encircling the first molars once, and then ligated and fixed at a location slightly mesial on the palatal side. Postoperatively, mice are fed a high-sugar diet, and the periodontal ligation is checked weekly, along with the condition of the periodontal tissues. The following describes the method of using a mouse oral experimental fixator based on this invention, using the establishment of a periodontitis animal model as an example.

[0029] Step 1: Place the anesthetized mouse on the fixation plate 1 and put the limb restraint ropes 4 on its limbs to fix the mouse stably on the fixation plate 1.

[0030] Step 2: Pinch the two operating levers 673 so that the two L-shaped blocks 671 are no longer pressed against the inner wall of the first slide groove 11. Drag the slider 66 to move the cheek expander 2 above the mouse's head. Then release the operating levers 673 and insert the slider 66 into the first slide groove 11.

[0031] Step 3: Rotate the first bidirectional nut 62 to bring the two U-shaped rods 61 closer together and adjust the two cheek expanders 2 to a suitable distance; rotate the second nut 653 to bring the two connecting rods 651 and the screw 652 closer together and adjust the height of the U-shaped rods 61 to adjust the cheek expanders 2 to a suitable height; rotate the first bidirectional nut 62 again to move the two U-shaped rods 61 further apart, and the cheek expanders 2 will open the mouse's mouth, providing sufficient operating space and surgical field of vision.

[0032] Step 4: Conduct oral examination.

[0033] It should be understood that the above detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

Claims

1. A mouse oral cavity restraint device, comprising a restraint plate (1) having four limb restraint posts (3) on the restraint plate (1); Its features are: The fixed plate (1) is provided with an adjustment mechanism (6) that can be adjusted in front and back, left and right, and up and down. The adjustment mechanism (6) is provided with two cheek expanders (2); The adjustment mechanism (6) includes two U-shaped rods (61) with cheek expanders (2); The two U-shaped rods (61) are threaded together by a first double-ended nut (62); A slider (66) is slidably provided on the fixed plate (1), and the slider (66) is connected to the first bidirectional nut (62) through a height adjustment unit (65).

2. The oral cavity fixation device for mice according to claim 1, characterized in that: The height adjustment unit (65) includes a connecting rod (651) and a screw (652); The screw (652) is connected to the slider (66), and the screw (652) is fitted with a second nut (653). The connecting rod (651) is rotatably sleeved on the bottom of the second nut (653), and the connecting rod (651) is rotatably connected to the first bidirectional nut (62).

3. The oral cavity fixation device for mice according to claim 2, characterized in that: A locking unit (67) is provided between the slider (66) and the fixing plate (1).

4. The oral cavity fixation device for mice according to claim 3, characterized in that: The locking unit (67) includes two L-shaped blocks (671) that are slidably connected to the slider (66); The two L-shaped blocks (671) are connected by a spring (672); The fixing plate (1) is provided with a first groove (11) that matches the slider (66).

5. The oral cavity fixation device for mice according to claim 1, characterized in that: Two limiting components (68) are also provided between the U-shaped rod (61) and the fixing plate (1), and the limiting components (68) are used to improve the stability of the corresponding U-shaped rod (61).

6. The oral cavity fixation device for mice according to claim 5, characterized in that: The limiting component (68) includes a telescopic rod (684) that is slidably connected to the fixed plate (1). The U-shaped rod (61) is slidably sleeved on the end of the corresponding telescopic rod (684).

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