A chromatographic column temperature control device

Abstract

The utility model relates to a kind of chromatographic column temperature control device.It solves the technical problems that the internal temperature uniformity of existing chromatographic column cannot be controlled etc..Including chromatographic column shell and the column tube being set in the inside center of chromatographic column shell, chromatographic column shell circumferential outside is equipped with heating assembly, several heat pipe fittings are arranged in the inside of chromatographic column shell and are located in the circumferential outside of column tube, the circumferential outside of heat pipe fitting has heat pipe fin, the opposite corresponding same end of heat pipe fitting is extended to the outside of the end of chromatographic column shell and forms condensing assembly, condensing assembly is abutted with heating assembly by heat conduction assembly.The advantage is that: using multiple heat pipe fittings to be hexagonally symmetrical distribution, completely eliminate the temperature gradient caused by traditional single side or asymmetric heating, ensure that chromatographic column shell inside is in highly consistent stable temperature in entire length and circumferential direction.

Description

Technical Field

[0001] This utility model belongs to the field of chromatography column technology, and specifically relates to a chromatography column temperature control device. Background Technology

[0002] Industrial-grade preparative chromatography columns are core equipment for achieving ton-scale product purification. As column diameter increases, temperature uniformity control becomes a critical bottleneck, with radial heat transfer efficiency decreasing sharply. Due to the extremely low thermal conductivity of chromatographic packing material, heat from traditional external column ovens struggles to penetrate to the column center. Existing conventional temperature control structures require either increasing the thickness of the heat-conducting structure (which occupies the flow channels and reduces column efficiency) or decreasing the size of the heat conductor (which results in insufficient heat flux and inadequate temperature control). Summary of the Invention

[0003] The purpose of this invention is to address the above-mentioned problems by providing a chromatographic column temperature control device.

[0004] To achieve the above objectives, the present invention adopts the following technical solution: a chromatographic column temperature control device, comprising a chromatographic column shell and a column tube disposed at the center of the inner side of the chromatographic column shell, wherein a heating component is provided on the outer circumferential side of the chromatographic column shell, and a plurality of heat pipe components are provided inside the chromatographic column shell and distributed on the outer circumferential side of the column tube, wherein the heat pipe components have heat pipe fins on the outer circumferential side, and the corresponding ends of the heat pipe components extend to the outer end of the chromatographic column shell to form a condensation component, and the condensation component abuts against the heating component through a heat-conducting component.

[0005] In the aforementioned chromatographic column temperature control device, the number of heat pipes is 6-36, and the heat pipes are arranged in a hexagonal symmetrical distribution centered on the axis of the column shell. This hexagonal symmetrical distribution creates a uniform and stable temperature field across the cross-section of the column shell, ensuring a consistent reaction environment throughout the column. This is crucial for the accuracy and reproducibility of chromatographic analysis. The simultaneous operation of multiple heat pipes significantly increases the heat transfer area and channels, enabling rapid response to temperature changes and rapid heating and cooling. Furthermore, the symmetrical distribution makes the heat input and output more balanced mechanically, reducing the risk of deformation or damage caused by uneven thermal stress.

[0006] In the aforementioned column temperature control device, the number of heat pipe fins is several, and all heat pipe fins extend axially along the heat pipe component. The heat pipe fins are evenly distributed circumferentially around the axis of the heat pipe component and extend outwards. The axial extension and circumferentially even distribution of the heat pipe fins significantly increase the contact area between the heat pipe component and the air or medium inside the column shell. This large surface area allows the heat pipe component to more effectively absorb or release heat, thereby rapidly transferring the heat from the heating element to the interior and ensuring high thermal conductivity of the entire system.

[0007] In the aforementioned column temperature control device, the condenser assembly has heat dissipation fins, and one end of the heat pipe extending to the outer side of the column shell is disposed inside the heat dissipation fins. The heat dissipation fins greatly increase the surface area of ​​the condenser end of the heat pipe, and through convection with the external environment, quickly dissipate the heat brought by the core of the heat pipe.

[0008] In the aforementioned column temperature control device, the heat-conducting component includes a thermally conductive silicone grease layer disposed between the heat dissipation fins and the column shell, with the heat pipe axially penetrating the thermally conductive silicone grease layer at the end near the heat dissipation fins. The thermally conductive silicone grease layer fills the microscopic gaps between the heat dissipation fins and the column shell, forming a highly efficient heat path. This allows the heat from the heating component to be transferred to the condenser end of the heat pipe with almost no loss, achieving tight coupling between the heating and cooling systems and improving overall energy efficiency.

[0009] In the aforementioned column temperature control device, the distance between the heat pipe component and the column tube gradually increases from one end near the heat dissipation fins to the other end. This significantly enhances the circulation dynamics and heat transfer efficiency of the working fluid inside the heat pipe, which is especially crucial for medium and large-sized chromatographic columns.

[0010] In the aforementioned chromatographic column temperature control device, the tilt angle between the heat pipe and the column tube is 5°-10°, and the diameter of the heat pipe accounts for 0.5%-2% of the diameter of the chromatographic column shell. The tilted design helps to arrange more or longer heat pipes in a limited space, ensuring that the heat pipes have sufficient heat transfer capacity without being too crowded and affecting the internal airflow or structural strength.

[0011] In the above-mentioned chromatographic column temperature control device, the chromatographic column shell is made of metal material, the diameter of the chromatographic column shell is 1.0m, and the height of the chromatographic column shell is 2.0m.

[0012] In the above-mentioned column temperature control device, the diameter of the heat pipe is 1.0 cm and the length of the heat pipe is 2.1 m.

[0013] In the above-mentioned column temperature control device, the height of the heat dissipation fins is 15mm and the thickness of the heat dissipation fins is 0.2mm.

[0014] Compared with existing technologies, the advantages of this utility model are: 1. This device utilizes multiple heat pipes arranged in a hexagonal symmetrical pattern, completely eliminating the temperature gradient caused by traditional unilateral or asymmetrical heating, and ensuring that the interior of the chromatographic column shell is at a highly consistent and stable temperature throughout its length and circumference.

[0015] 2. The design of the thermally conductive silicone grease layer and the heat pipe components in close contact allows the heat from the heating components to be transferred to the heat pipe components with almost no loss. At the same time, in conjunction with the heat pipe fins, the heat is concentrated and used efficiently in the target area, reducing energy waste and achieving energy-saving operation.

[0016] 3. The heat pipe condenser end of the device extends to the outside of the shell and integrates heat dissipation fins, forming a huge effective heat dissipation area. There is no need for a complex external forced cooling system. Passive heat dissipation alone can meet the cooling needs under most operating conditions. The system structure is simplified, the cost is reduced, and the reliability is improved. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the structure of this utility model.

[0018] Figure 2 This is a structural cross-sectional view of the present invention.

[0019] Figure 3 This is a structural cross-sectional view of the present invention from another perspective.

[0020] In the figure: 1. Column shell, 11. Heat pipe fitting, 2. Heat pipe fins, 21. Condensation assembly, 3. Heat dissipation fins, 31. Thermal conductive assembly, 4. Thermal conductive silicone grease layer, 41. Detailed Implementation

[0021] The present invention will now be described in further detail with reference to the accompanying drawings and specific embodiments.

[0022] like Figure 1-3 As shown, a chromatographic column temperature control device includes a chromatographic column housing 1 and a column tube 11 disposed at the center of the inner side of the chromatographic column housing 1. A heating assembly is provided around the outer periphery of the chromatographic column housing 1. Several heat pipe components 2 are distributed around the outer periphery of the column tube 11 within the chromatographic column housing 1. Each heat pipe component 2 has heat pipe fins 21 around its outer periphery. Corresponding ends of the heat pipe components 2 extend to the outer end of the chromatographic column housing 1 to form a condensation assembly 3. The condensation assembly 3 abuts against the heating assembly via a heat-conducting assembly 4. The heating assembly is a temperature control jacket with a spiral flow channel or a column oven, or other external heating device.

[0023] like Figure 3 As shown, the number of heat pipes 2 is 6-36, and the heat pipes 2 are arranged in a hexagonal symmetrical distribution centered on the axis of the column shell 1. The hexagonal symmetrical distribution can form a uniform and stable temperature field on the cross-section of the column shell 1, ensuring that the reaction environment is consistent throughout the column shell 1. This is crucial for the accuracy and reproducibility of chromatographic analysis. The simultaneous operation of multiple heat pipes 2 greatly increases the heat transfer area and heat transfer channels, enabling rapid response to temperature changes and achieving rapid heating and cooling. Furthermore, the symmetrical distribution makes the heat input and output more balanced in the mechanical structure, reducing the risk of deformation or damage caused by uneven thermal stress.

[0024] The heat pipe fins 21 are numerous and extend axially along the heat pipe component 2. The heat pipe fins 21 are evenly distributed circumferentially around the axis of the heat pipe component 2 and extend outwards. The axial extension and circumferentially even distribution of the heat pipe fins 21 significantly increase the contact area between the heat pipe component 2 and the air or medium inside the chromatographic column shell 1. This large surface area allows the heat pipe component 2 to more effectively absorb or release heat, thereby rapidly transferring the heat from the heating element to the interior and ensuring high thermal conductivity of the entire system.

[0025] Combination Figure 1 and Figure 2 As shown, the condenser assembly 3 has heat dissipation fins 31, and one end of the heat pipe 2 extending to the outer side of the column housing 1 is disposed inside the heat dissipation fins 31. The heat dissipation fins 31 greatly increase the surface area of ​​the condenser end of the heat pipe 2, and the heat brought by the core of the heat pipe 2 is quickly dissipated through convection with the external environment.

[0026] The heat-conducting component 4 includes a thermally conductive silicone grease layer 41 disposed between the heat dissipation fins 31 and the column housing 1, with the heat pipe 2 axially penetrating the thermally conductive silicone grease layer 41 at the end near the heat dissipation fins 31. The thermally conductive silicone grease layer 41 fills the microscopic gaps between the heat dissipation fins 31 and the column housing 1, forming an efficient heat path. This allows the heat from the heating component to be transferred to the condenser end of the heat pipe 2 with almost no loss, achieving tight coupling between the heating system and the heat dissipation system and improving overall energy efficiency.

[0027] Specifically, the distance between the heat pipe 2 and the column tube 11 at one end near the heat dissipation fin 31 gradually increases from the distance at the other end to the distance at the other end near the column tube 11. This greatly enhances the circulation dynamics and heat transfer efficiency of the working fluid inside the heat pipe, which is especially crucial for medium and large chromatographic columns.

[0028] Furthermore, the tilt angle between the heat pipe 2 and the column tube 11 is 5°-10°, and the diameter of the heat pipe 2 accounts for 0.5%-2% of the diameter of the chromatographic column shell 1. The tilted design helps to arrange more or longer heat pipes 2 in a limited space, ensuring that the heat pipe 2 has sufficient heat transfer capacity, while not being too crowded to affect the internal airflow or structural strength.

[0029] Furthermore, the column housing 1 is made of metal, with a diameter of 1.0m and a height of 2.0m.

[0030] Meanwhile, the diameter of heat pipe 2 is 1.0 cm and the length of heat pipe 2 is 2.1 m.

[0031] Clearly, the height of the heat dissipation fin 31 is 15mm, and the thickness of the heat dissipation fin 31 is 0.2mm.

[0032] The principle of this embodiment is as follows: When it is necessary to raise the temperature from a low temperature to a high temperature and maintain a constant temperature, the heating component starts to work, heating the metal column shell 1. The heat is conducted through the highly thermally conductive column shell 1 to the thermally conductive silicone grease layer 41. At the same time, the thermally conductive silicone grease layer 41 transfers the heat to the heat pipe 2 in close contact with it with almost no loss. The heat pipe 2 efficiently dissipates the heat into the interior of the column shell 1 through the heat pipe fins 21. Meanwhile, multiple heat pipes 2 are symmetrically distributed in a hexagonal shape, forming a uniform and stable thermal field, heating evenly from all sides. When cooling is required or excess heat is generated during operation, the heat pipe 2 can release excess heat through the heat dissipation fins 31 to prevent the temperature from getting too high. The heat dissipation fins 31 have a huge surface area and efficiently dissipate heat to the surrounding environment through natural convection with the outside air or forced air cooling.

[0033] The specific embodiments described herein are merely illustrative examples illustrating the spirit of this utility model. Those skilled in the art to which this utility model pertains may make various modifications or additions to the described specific embodiments or use similar methods to substitute them, without departing from the spirit of this utility model or exceeding the scope defined by the appended claims.

[0034] Although this document frequently uses terms such as column shell 1, column tube 11, heat pipe component 2, heat pipe fin 21, condenser assembly 3, heat dissipation fin 31, thermally conductive assembly 4, and thermally conductive silicone grease layer 41, the possibility of using other terms is not excluded. These terms are used merely for the convenience of describing and explaining the essence of this invention; interpreting them as any additional limitation would contradict the spirit of this invention.

Claims

1. A chromatographic column temperature control device, comprising a chromatographic column housing (1) and a column tube (11) disposed at the center of the inner side of the chromatographic column housing (1), wherein a heating assembly is provided on the outer periphery of the chromatographic column housing (1), characterized in that, The chromatographic column housing (1) is provided with a number of heat pipe components (2) distributed around the column tube (11). The heat pipe components (2) have heat pipe fins (21) around their outer sides. The corresponding ends of the heat pipe components (2) extend to the outer side of the end of the chromatographic column housing (1) to form a condensation assembly (3). The condensation assembly (3) is in contact with the heating assembly through a heat conduction assembly (4).

2. The chromatographic column temperature control device according to claim 1, characterized in that, The number of heat pipes (2) is 6-36, and the heat pipes (2) are arranged in a hexagonal symmetrical distribution with the axis of the chromatographic column shell (1) as the center.

3. The chromatographic column temperature control device according to claim 1, characterized in that, The number of heat pipe fins (21) is several and all heat pipe fins (21) are extended along the axial direction of the heat pipe component (2). The heat pipe fins (21) are evenly distributed around the axis of the heat pipe component (2) and extend outward.

4. A chromatographic column temperature control device according to claim 1, 2, or 3, characterized in that, The condensation assembly (3) has heat dissipation fins (31), and the heat pipe (2) extends to the outer end of the end of the chromatographic column housing (1) and is disposed inside the heat dissipation fins (31).

5. The chromatographic column temperature control device according to claim 4, characterized in that, The heat-conducting component (4) includes a thermally conductive silicone grease layer (41) disposed between the heat dissipation fins (31) and the chromatographic column housing (1), and the heat pipe (2) axially penetrates the thermally conductive silicone grease layer (41) at one end near the heat dissipation fins (31).

6. The chromatographic column temperature control device according to claim 4, characterized in that, The distance between the heat pipe component (2) near the heat dissipation fins (31) and the column tube (11) gradually increases from the distance between the other end of the heat pipe component (2) and the column tube (11).

7. The chromatographic column temperature control device according to claim 1, characterized in that, The inclination angle between the heat pipe (2) and the column tube (11) is 5°-10°, and the diameter of the heat pipe (2) is 0.5%-2% of the diameter of the chromatographic column shell (1).

8. The chromatographic column temperature control device according to claim 1, characterized in that, The chromatographic column shell (1) is made of metal material, the diameter of the chromatographic column shell (1) is 1.0m, and the height of the chromatographic column shell (1) is 2.0m.

9. A chromatographic column temperature control device according to claim 1, characterized in that, The heat pipe (2) has a diameter of 1.0 cm and a length of 2.1 m.

10. A chromatographic column temperature control device according to claim 4, characterized in that, The height of the heat dissipation fins (31) is 15mm, and the thickness of the heat dissipation fins (31) is 0.2mm.

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