A magnetic stirrer for biopharmaceuticals

Abstract

The utility model discloses a magnetic stirrer for biopharmacy belongs to biopharmacy technical field, including weighing mechanism, the top of weighing mechanism is provided with the placing table, the utility model sets up top seal subassembly, rotates the threaded rod, under the cooperation of threaded hole, the moving block moves along U -shaped support, and the moving block removes and drives top seal disc to remove and fit the top of pharmaceutical container, when top seal disc removes and fits the top of pharmaceutical container, hand holds the compression ring and drives its rotation, and the compression ring rotates and drives the threaded cylinder rotation, makes the threaded cylinder rotate and removes along the thread groove, and the threaded cylinder rotates and removes and drives the compression ring rotation and removes, when the compression ring removes and fits the lateral wall of threaded rod, stops rotating the compression ring, and the top seal disc can be used to the open end of pharmaceutical container and carries out the shielding seal operation, avoids the splashing of liquid medicine in the stirring process to the peripheral environment, causes the liquid medicine resource waste.

Description

Technical Field

[0001] This utility model belongs to the field of biopharmaceutical technology, specifically relating to a magnetic stirrer for biopharmaceutical applications. Background Technology

[0002] Biological drugs refer to a class of products used for prevention, treatment and diagnosis, which are manufactured by applying the research results of microbiology, biology, medicine, biochemistry and other sciences, from organisms, biological tissues, cells, organs and body fluids, and by comprehensively utilizing the principles and methods of microbiology, chemistry, biochemistry, biotechnology and pharmacy.

[0003] Chinese Patent Application No. 202121663687.9 discloses a magnetic stirrer for pharmaceutical use, including a base, a servo motor installed inside the base, an active magnetic block fixedly connected to the output end of the servo motor, a placement platform on the base, a pharmaceutical container placed on the placement platform, and a support mounted on the base. This invention can clamp and fix the pharmaceutical container, preventing it from tipping over due to vibration, effectively improving the stability of the stirrer during operation. It also prevents the magnetic stirring block from colliding with the inner wall of the pharmaceutical container during rotation, thus preventing damage. After stirring, it allows for easy removal of the magnetic stirring block from the pharmaceutical container, effectively improving the practicality of the stirrer.

[0004] In the aforementioned patent, when the liquid medicine is stirred inside the pharmaceutical container, the liquid medicine inside the pharmaceutical container is easily splashed into the surrounding environment due to the force, resulting in waste of liquid medicine resources; in addition, when an electronic balance is used to weigh the liquid medicine inside the pharmaceutical container, when there are foreign objects remaining on the electronic balance and the placement platform, it is easy to affect the accuracy of the weighing of the liquid medicine. Utility Model Content

[0005] To address the problems mentioned in the background section, this invention provides a magnetic stirrer for biopharmaceutical applications, featuring top sealing and adsorption / impurity removal capabilities.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a magnetic stirrer for biopharmaceutical use, comprising a weighing mechanism, a placement platform above the weighing mechanism, a support fixedly connected above the weighing mechanism and on one side of the placement platform, a pharmaceutical container above the placement platform, a magnetic stirring mechanism inside the support, an adsorption component on the side wall of the weighing mechanism, and a top sealing component on the side wall of the support.

[0007] Preferably, the top sealing assembly includes a U-shaped frame, a movable block, a top sealing plate, and a driving component. The U-shaped frame is fixedly connected to the side wall of the support, the movable block is slidably connected inside the U-shaped frame, the driving component is provided between the U-shaped frame and the movable block, and the top sealing plate is fixedly connected to one end of the movable block.

[0008] Preferably, the driving component includes a threaded hole, a threaded rod, a clamping ring, a threaded cylinder, and a threaded groove. The threaded rod is rotatably connected inside the U-shaped frame. A threaded hole is opened on the moving block at the position corresponding to the threaded rod. A threaded groove is opened on the top of the U-shaped frame. A threaded cylinder is threadedly connected inside the threaded groove. A clamping ring is fixedly connected to one end of the threaded cylinder.

[0009] Preferably, the top sealing assembly further includes a guide rod and a guide block. The guide block is fixedly connected to one end of the moving block near the U-shaped frame. A guide hole is provided on the guide block. A guide rod is fixedly connected inside the U-shaped frame and inside the guide hole.

[0010] Preferably, the adsorption assembly includes a mounting box, a vacuum cleaner, a vacuum hose, an elastic corrugated pipe, and a vacuum head. The mounting box is fixedly connected to the side wall of the weighing mechanism, the vacuum cleaner is fixedly connected to the side wall of the mounting box, a vacuum hose is fixedly connected to one end of the vacuum cleaner, an elastic corrugated pipe is fixedly connected to one end of the vacuum hose, and a vacuum head is fixedly connected to the end of the elastic corrugated pipe away from the vacuum hose.

[0011] Preferably, a storage tube is fixedly connected to the side wall of the mounting box and to the periphery of the elastic corrugated tube. Positioning posts are fixedly connected to both sides of the end of the vacuum head near the storage tube. Positioning holes are opened inside the storage tube at the positions corresponding to the positioning posts.

[0012] Compared with the prior art, the beneficial effects of this utility model are: 1. This utility model is equipped with a top sealing assembly. By rotating the threaded rod, the moving block moves along the U-shaped frame with the cooperation of the threaded hole. The movement of the moving block drives the top sealing plate to move and fit against the top of the pharmaceutical container. After the top sealing plate moves and fits against the top of the pharmaceutical container, the clamping ring is squeezed and force is applied to drive it to rotate. The rotation of the clamping ring drives the threaded cylinder to rotate, so that the threaded cylinder rotates and moves downward along the threaded groove. The rotation and downward movement of the threaded cylinder drives the clamping ring to rotate and move downward. After the clamping ring moves and fits against the side wall of the threaded rod, the rotation of the clamping ring is stopped. The top sealing plate can be used to cover and seal the open end of the pharmaceutical container, so as to prevent the liquid medicine from splashing into the external environment during the stirring process and causing waste of liquid medicine resources.

[0013] 2. This utility model is equipped with an adsorption component. After the pharmaceutical container is placed on the placement platform, the vacuum cleaner is started and the vacuum head is moved to the periphery of the collection tube. The movement of the vacuum head causes the elastic corrugated tube to move and stretch. Then, the vacuum head is aligned with the placement platform and the weighing mechanism. Dust and other debris adhering to the placement platform and the weighing mechanism enter the interior of the elastic corrugated tube through the vacuum head, and then enter the dust bin of the vacuum cleaner through the vacuum pipe for collection. This facilitates the adsorption and cleaning of debris on the placement platform and the weighing mechanism, and avoids debris affecting the accuracy of weighing the liquid medicine inside the pharmaceutical container. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the structure of this utility model; Figure 2 This is a cross-sectional view of the movable block and the U-shaped frame of this utility model in connection. Figure 3 This utility model Figure 2 Enlarged view of point A in the middle; Figure 4 This is a cross-sectional view of the adsorption component of this utility model.

[0015] In the diagram: 1. Magnetic stirring mechanism; 2. Support frame; 3. Top sealing assembly; 31. U-shaped frame; 32. Moving block; 33. Top sealing plate; 34. Guide rod; 35. Drive component; 351. Threaded hole; 352. Threaded rod; 353. Pressure ring; 354. Threaded cylinder; 355. Threaded groove; 36. Guide block; 4. Weighing mechanism; 5. Adsorption assembly; 51. Mounting box; 52. Vacuum cleaner; 53. Vacuum hose; 54. Flexible corrugated pipe; 55. Vacuum head; 56. Storage cylinder; 6. Placement platform; 7. Pharmaceutical container. Detailed Implementation

[0016] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model. Example

[0017] Please see Figure 1-4 The present invention provides the following technical solution: a magnetic stirrer for biopharmaceutical use, including a weighing mechanism 4, a placement platform 6 above the weighing mechanism 4, a support 2 fixedly connected above the weighing mechanism 4 and on one side of the placement platform 6, a pharmaceutical container 7 above the placement platform 6, a magnetic stirring mechanism 1 inside the support 2, an adsorption component 5 on the side wall of the weighing mechanism 4, and a top sealing component 3 on the side wall of the support 2.

[0018] Specifically, the top sealing assembly 3 includes a U-shaped frame 31, a movable block 32, a top sealing plate 33, and a driving component 35. The U-shaped frame 31 is fixedly connected to the side wall of the support 2. The movable block 32 is slidably connected inside the U-shaped frame 31. The driving component 35 is disposed between the U-shaped frame 31 and the movable block 32. One end of the movable block 32 is fixedly connected to the top sealing plate 33. By adopting the above technical solution, the pharmaceutical container 7 is placed on the placement platform 6, and the components of the magnetic stirring mechanism 1 are inserted into the pharmaceutical container 7. The driving component 35 drives the moving block 32 to move down along the U-shaped frame 31. The moving block 32 moves down and drives the top sealing plate 33 to move down. When the top sealing plate 33 moves and fits against the top of the pharmaceutical container 7, the driving component 35 is stopped. During the subsequent stirring of the liquid medicine inside the pharmaceutical container 7 by the magnetic stirring mechanism 1, the top sealing plate 33 can be used to cover and seal the open end of the pharmaceutical container 7 to prevent the liquid medicine from splashing into the external environment during the stirring process and causing waste of liquid medicine resources.

[0019] Specifically, the driving component 35 includes a threaded hole 351, a threaded rod 352, a clamping ring 353, a threaded cylinder 354, and a threaded groove 355. The threaded rod 352 is rotatably connected inside the U-shaped frame 31. A threaded hole 351 is provided on the moving block 32 at the position corresponding to the threaded rod 352. A threaded groove 355 is provided on the top of the U-shaped frame 31. The threaded cylinder 354 is threadedly connected inside the threaded groove 355. One end of the threaded cylinder 354 is fixedly connected to the clamping ring 353. By adopting the above technical solution, the clamping ring 353 is held and force is applied to drive it to rotate. The rotation of the clamping ring 353 drives the threaded cylinder 354 to rotate, so that the threaded cylinder 354 rotates and moves upward along the threaded groove 355. The rotation and upward movement of the threaded cylinder 354 drives the clamping ring 353 to rotate and move upward. When the clamping ring 353 moves away from the threaded rod 352, the threaded rod 352 is rotated again. With the cooperation of the threaded hole 351, the moving block 32 moves along the U-shaped frame 31. The movement of the moving block 32 can drive the top sealing plate 33 to move.

[0020] Specifically, the top sealing assembly 3 also includes a guide rod 34 and a guide block 36. The guide block 36 is fixedly connected to one end of the moving block 32 near the U-shaped frame 31. The guide block 36 has a guide hole. The guide rod 34 is fixedly connected inside the U-shaped frame 31 and inside the guide hole. By adopting the above technical solution, during the movement of the moving block 32, the guide block 36 moves along the guide rod 34 with the cooperation of the guide hole. With the cooperation of the guide block 36 and the guide rod 34, the movement of the moving block 32 can be guided, thereby improving the stability of the movement of the moving block 32.

[0021] In this embodiment, during the biopharmaceutical process, the pharmaceutical container 7 is placed on the placement platform 6, and the drug solution to be mixed is injected into the pharmaceutical container 7. During the injection process, the weighing mechanism 4 can be used to determine the amount of drug solution injected. Then, the component of the magnetic stirring mechanism 1 on the support 2 is moved and extended into the pharmaceutical container 7. Then, the threaded rod 352 is rotated, and with the cooperation of the threaded hole 351, the moving block 32 moves along the U-shaped frame 31. With the cooperation of the guide block 36 and the guide rod 34, the movement of the moving block 32 can be guided. The movement of the moving block 32 drives the top sealing plate 33 to move and fit against the top of the pharmaceutical container 7. When the top sealing plate... After the top of the pharmaceutical container 7 is moved to fit the top, the clamping ring 353 is held and force is applied to rotate it. The rotation of the clamping ring 353 causes the threaded cylinder 354 to rotate, so that the threaded cylinder 354 rotates and moves down along the threaded groove 355. The rotation and movement of the threaded cylinder 354 causes the clamping ring 353 to rotate and move down. When the clamping ring 353 moves to fit the side wall of the threaded rod 352, the rotation of the clamping ring 353 is stopped. The top sealing plate 33 can be used to cover and seal the open end of the pharmaceutical container 7 to prevent the liquid medicine from splashing into the external environment during the stirring process, thus avoiding waste of liquid medicine resources. Then, the magnetic stirring mechanism 1 is used to stir the liquid medicine inside the pharmaceutical container 7. Example

[0022] The difference between this embodiment and Embodiment 1 is that the adsorption assembly 5 includes a mounting box 51, a vacuum cleaner 52, a suction pipe 53, an elastic corrugated pipe 54, and a suction head 55. The mounting box 51 is fixedly connected to the side wall of the weighing mechanism 4, the vacuum cleaner 52 is fixedly connected to the side wall of the mounting box 51, one end of the vacuum cleaner 52 is fixedly connected to the suction pipe 53, one end of the suction pipe 53 is fixedly connected to the elastic corrugated pipe 54, and the end of the elastic corrugated pipe 54 away from the suction pipe 53 is fixedly connected to the suction head 55. Specifically, a storage tube 56 is fixedly connected to the side wall of the mounting box 51 and to the periphery of the elastic corrugated tube 54. Positioning posts are fixedly connected to both sides of the end of the vacuum head 55 near the storage tube 56. Positioning holes are opened inside the storage tube 56 at the positions corresponding to the positioning posts. By adopting the above technical solution, after the vacuum cleaner 52 is used, the flexible corrugated tube 54 is moved and stored inside the storage cylinder 56. The vacuum head 55 moves and approaches the storage cylinder 56. The movement of the vacuum head 55 causes the positioning post to move and engage with the positioning hole. With the cooperation of the positioning post and the positioning hole, the vacuum head 55 can be positioned and fixed, thereby limiting and fixing the flexible corrugated tube 54, ensuring the stability of the flexible corrugated tube 54 in storage.

[0023] In this embodiment, after placing the pharmaceutical container 7 on the placement platform 6, the vacuum cleaner 52 is started, and the vacuum head 55 is moved to the periphery of the storage cylinder 56. The movement of the vacuum head 55 causes the elastic corrugated tube 54 to move and stretch. The vacuum head 55 is then aligned with the placement platform 6 and the weighing mechanism 4. Dust and other debris adhering to the placement platform 6 and the weighing mechanism 4 enter the interior of the elastic corrugated tube 54 through the vacuum head 55, and then enter the dust bin in the vacuum cleaner 52 through the vacuum pipe 53 for collection. This facilitates the adsorption and cleaning of debris on the placement platform 6 and the weighing mechanism 4, and prevents debris from affecting the accuracy of weighing the liquid medicine inside the pharmaceutical container 7.

[0024] The vacuum cleaner 52 in this utility model is a previously disclosed technology, and the selected model is HA25.

[0025] The structure and principle of the magnetic stirring mechanism 1, which consists of a servo motor, an active magnetic block, a vertical rod, a stirring magnetic block, a limiting rod, a limiting block, and a spring, have been disclosed in a pharmaceutical magnetic stirrer disclosed in Chinese patent application number 202121663687.9. Its working principle is as follows: a servo motor is fixedly connected to the side wall of the weighing mechanism 4; an active magnetic block is fixedly connected to the output end of the servo motor; a limiting block is connected to the end of the support 2 away from the weighing mechanism 4 via a spring; and the vertical rod is slidably connected between the support 2 and the limiting block, and is located at the center of the pharmaceutical container 7. At this location, the stirring magnetic block is rotatably connected to the lower end of the vertical rod. The lower end of the vertical rod, near the stirring magnetic block, is symmetrically connected to a limit rod via a torsion spring. In use, the limit block is pulled outward to remove it from fixing the vertical rod. Then, the operator moves the vertical rod downward to move the stirring magnetic block into the lower part of the pharmaceutical container 7. The servo motor is then started, which drives the active magnetic block to rotate. Since like poles repel and unlike poles attract, the rotation of the active magnetic block can drive the stirring magnetic block to rotate, thereby stirring and mixing the liquid medicine in the pharmaceutical container 7.

[0026] The structure and principle of the weighing mechanism 4, which consists of a base and an electronic balance, in this utility model have been disclosed in a pharmaceutical magnetic stirrer disclosed in Chinese patent application number 202121663687.9. Its working principle is as follows: A base is fixedly connected to the bottom of the support 2, and an electronic balance is fixedly connected inside the base and below the placement platform 6. When in use, after the pharmaceutical container 7 is placed on the placement platform 6, the weight of the pharmaceutical container 7 and the placement platform 6 is weighed using the electronic balance. Then, the medicine is injected into the pharmaceutical container 7. At the same time, the weight of the pharmaceutical container 7, the medicine inside the pharmaceutical container 7, and the placement platform 6 are weighed using the electronic balance. Then, the difference between the two weights is calculated to know the weight of the medicine injected into the pharmaceutical container 7.

[0027] The working principle and usage process of this utility model are as follows: In the biopharmaceutical process of this utility model, the pharmaceutical container 7 is placed on the placement platform 6, the vacuum cleaner 52 is started, and the vacuum head 55 is moved to the periphery of the collection cylinder 56. The movement of the vacuum head 55 causes the elastic corrugated tube 54 to move and stretch. Then, the vacuum head 55 is aligned with the placement platform 6 and the weighing mechanism 4. Dust and other debris adhering to the placement platform 6 and the weighing mechanism 4 enter the interior of the elastic corrugated tube 54 through the vacuum head 55, and then enter the dust bin of the vacuum cleaner 52 through the vacuum pipe 53 for collection. This facilitates the adsorption and cleaning of debris on the placement platform 6 and the weighing mechanism 4, preventing debris from affecting the accuracy of weighing the liquid medicine inside the pharmaceutical container 7. Then, the liquid medicine to be stirred and mixed is injected into the pharmaceutical container 7. During the injection process, the weighing mechanism 4 can be used to determine the amount of liquid medicine injected. Then, the component of the magnetic stirring mechanism 1 on the bracket 2 is moved and extended into the pharmaceutical container 7, and then the threaded rod 3 is rotated. 52. With the cooperation of the threaded hole 351, the moving block 32 moves along the U-shaped frame 31. With the cooperation of the guide block 36 and the guide rod 34, the movement of the moving block 32 can be guided. The movement of the moving block 32 drives the top sealing plate 33 to move and fit against the top of the pharmaceutical container 7. After the top sealing plate 33 moves and fits against the top of the pharmaceutical container 7, the clamping ring 353 is squeezed and force is applied to drive it to rotate. The rotation of the clamping ring 353 drives the threaded cylinder 354 to rotate, so that the threaded cylinder 354 rotates and moves down along the threaded groove 355. The rotation and movement of the threaded cylinder 354 drives the clamping ring 353 to rotate and move down. After the clamping ring 353 moves and fits against the side wall of the threaded rod 352, the rotation of the clamping ring 353 stops. The top sealing plate 33 can be used to cover and seal the open end of the pharmaceutical container 7 to prevent the liquid medicine from splashing into the external environment during the stirring process, which would cause waste of liquid medicine resources. Then, the magnetic stirring mechanism 1 is used to stir the liquid medicine inside the pharmaceutical container 7.

[0028] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A magnetic stirrer for biopharmaceutical applications, comprising a weighing mechanism (4), a placement platform (6) above the weighing mechanism (4), a support (2) fixedly connected above the weighing mechanism (4) and to one side of the placement platform (6), a pharmaceutical container (7) above the placement platform (6), and a magnetic stirring mechanism (1) inside the support (2), characterized in that: An adsorption assembly (5) is provided on the side wall of the weighing mechanism (4), and a top sealing assembly (3) is provided on the side wall of the support (2).

2. The magnetic stirrer for biopharmaceutical use according to claim 1, characterized in that: The top sealing assembly (3) includes a U-shaped frame (31), a movable block (32), a top sealing plate (33), and a driving component (35). The U-shaped frame (31) is fixedly connected to the side wall of the support (2). The movable block (32) is slidably connected inside the U-shaped frame (31). The driving component (35) is provided between the U-shaped frame (31) and the movable block (32). The top sealing plate (33) is fixedly connected to one end of the movable block (32).

3. The magnetic stirrer for biopharmaceutical use according to claim 2, characterized in that: The driving component (35) includes a threaded hole (351), a threaded rod (352), a clamping ring (353), a threaded cylinder (354), and a threaded groove (355). The threaded rod (352) is rotatably connected inside the U-shaped frame (31). A threaded hole (351) is provided on the moving block (32) at the position corresponding to the threaded rod (352). A threaded groove (355) is provided on the top of the U-shaped frame (31). A threaded cylinder (354) is threadedly connected inside the threaded groove (355). A clamping ring (353) is fixedly connected to one end of the threaded cylinder (354).

4. A magnetic stirrer for biopharmaceutical use according to claim 2, characterized in that: The top sealing assembly (3) also includes a guide rod (34) and a guide block (36). The guide block (36) is fixedly connected to one end of the moving block (32) near the U-shaped frame (31). A guide hole is provided on the guide block (36). The guide rod (34) is fixedly connected inside the U-shaped frame (31) and inside the guide hole.

5. A magnetic stirrer for biopharmaceutical use according to claim 1, characterized in that: The adsorption assembly (5) includes a mounting box (51), a vacuum cleaner (52), a vacuum hose (53), an elastic corrugated pipe (54), and a vacuum head (55). The mounting box (51) is fixedly connected to the side wall of the weighing mechanism (4). The vacuum cleaner (52) is fixedly connected to the side wall of the mounting box (51). The vacuum hose (53) is fixedly connected to one end of the vacuum cleaner (52). The elastic corrugated pipe (54) is fixedly connected to one end of the vacuum hose (53). The vacuum head (55) is fixedly connected to the end of the elastic corrugated pipe (54) away from the vacuum hose (53).

6. A magnetic stirrer for biopharmaceutical use according to claim 5, characterized in that: A storage tube (56) is fixedly connected to the side wall of the mounting box (51) and to the periphery of the elastic corrugated tube (54). Positioning posts are fixedly connected to both sides of the end of the vacuum head (55) near the storage tube (56). Positioning holes are opened inside the storage tube (56) at the positions corresponding to the positioning posts.

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