An emulsifying homogenizing device for adjuvant in vaccine production

Abstract

This utility model relates to the field of adjuvant emulsification technology, specifically an adjuvant emulsification and homogenization device for vaccine production. It includes a base plate, a controller fixedly connected to the top of the base plate, a placement platform fixedly connected to the top of the base plate, and a storage box placed on the top of the placement platform. It also includes a primary processing unit disposed on the top of the base plate and a secondary refining unit disposed on the outer surface of the primary processing unit. When this utility model is in operation, the controller is turned on and the adjuvant is placed into the primary processing unit. The primary processing unit breaks down large agglomerates and reduces viscosity. The adjuvant then enters the secondary refining unit for further emulsification and homogenization. Finally, the emulsified adjuvant flows into the storage box.

Description

Technical Field

[0001] This utility model relates to the field of adjuvant emulsification technology, specifically to an adjuvant emulsification and homogenization device for vaccine production. Background Technology

[0002] In vaccine production, viscous adjuvants such as water-in-oil and polymer adjuvants (with viscosities often reaching 2000-5000 mPa·s) are used in over 60% of vaccines, including those for influenza, due to their ability to enhance immunogenicity. However, these viscous adjuvants have strong intermolecular forces and poor flowability. The single-stage shear structure of traditional homogenizing equipment is insufficient to create enough penetration to break up the internal agglomeration of the material, resulting in a droplet size deviation of up to ±2 μm after emulsification and the presence of localized uncemented lumps. More importantly, the new GMP regulations explicitly require that vaccine adjuvant emulsification uniformity reach over 98%. Traditional equipment, due to insufficient emulsification uniformity, can no longer meet this core standard when processing viscous adjuvants, becoming a key bottleneck restricting vaccine production quality. Utility Model Content

[0003] The purpose of this invention is to provide an adjuvant emulsification and homogenization device for vaccine production, so as to solve the problems mentioned in the background art.

[0004] To achieve the above objectives, this utility model provides the following technical solution: It includes a base plate, a controller fixedly connected to the top of the base plate, a placement platform fixedly connected to the top of the base plate, a storage box placed on the top of the placement platform, and further includes:

[0005] A primary processing unit is set on the top of the base plate, and a secondary fine unit is set on the outer surface of the primary processing unit;

[0006] The primary processing unit includes a transmission tube, with a support foot fixedly connected to the bottom of the transmission tube and a feed hopper fixedly connected to the top of the transmission tube. A servo motor is also fixedly connected to the outer surface of the transmission tube, and a discharge port is fixedly connected to the end of the transmission tube away from the servo motor. A rotating rod is fixedly connected to the output end of the servo motor, and a propeller is fixedly connected to the outer surface of the rotating rod. A cutting plate is fixedly connected to the end of the rotating rod away from the servo motor.

[0007] Preferably, the bottom of the support foot is fixedly connected to the top of the base plate, and the end of the discharge port away from the transmission pipe is connected to the secondary fine unit.

[0008] Preferably, the secondary precision unit includes a hydraulic press, the outer surface of which is fixedly connected to a telescopic rod, and the output end of the telescopic rod is fixedly connected to a push plate;

[0009] The secondary fine unit also includes a square plate, on the outer surface of which a high-pressure micro-jet mechanism is uniformly arranged.

[0010] Preferably, the bottom of the hydraulic press is fixedly connected to the top of the controller, and the outer surface of the square plate is fixedly connected to the end of the discharge port away from the transmission pipe.

[0011] Preferably, the pusher plate is located inside the square plate, and the end of the high-pressure microjet mechanism away from the square plate is fixedly connected to the outer surface of the storage box.

[0012] Preferably, the high-pressure microjet mechanism includes a microfluidic channel, with an insertion notch at one end of the microfluidic channel near the square plate. Slides are fixedly connected to both sides of the microfluidic channel, and a movable baffle is slidably connected to the outer surface of the slide. An extrusion magnet is placed on the top of the movable baffle, and a support column is fixedly connected to the bottom of the movable baffle. An electromagnetic plate is fixedly connected to one end of the support column.

[0013] Preferably, one end of the microfluidic channel is fixedly connected to the outer surface of the square plate, and the other end of the microfluidic channel is fixedly connected to the outer surface of the storage box.

[0014] Compared with the prior art, the beneficial effects of this utility model are: This utility model adopts a "spiral propulsion + toothed disc shearing" structure to form the first shearing force, which initially breaks up large agglomerated particles and reduces viscosity. By utilizing the triple action of "shearing + impact + cavitation effect", the particles are refined to 1-3μm and the emulsification uniformity is improved to more than 98%. Attached Figure Description

[0015] Figure 1 This is the front view of the present utility model;

[0016] Figure 2 This is a schematic diagram of the primary processing unit structure of this utility model;

[0017] Figure 3 This is a cross-sectional view of the primary processing unit structure of this utility model;

[0018] Figure 4 This is a schematic diagram of the secondary fine unit structure of this utility model;

[0019] Figure 5 This is a cross-sectional view of the secondary fine unit structure of this utility model;

[0020] Figure 6 This is a schematic diagram of the high-pressure microjet mechanism of this utility model;

[0021] In the diagram: 1. Base plate; 2. Primary processing unit; 3. Controller; 4. Secondary fine processing unit; 5. Placement platform; 6. Storage box; 21. Transfer pipe; 22. Support leg; 23. Discharge port; 24. Feed hopper; 25. Servo motor; 26. Rotating rod; 27. Propeller; 28. Cutting plate; 41. Hydraulic press; 42. Telescopic rod; 43. Push plate; 44. Square plate; 45. High-pressure micro-jet mechanism; 451. Microfluidic channel; 452. Inlet notch; 453. Slide rail; 454. Moving baffle; 455. Extrusion magnet; 456. Support column; 457. Electromagnetic plate. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0023] Please see Figures 1 to 6 This utility model provides a technical solution:

[0024] The system includes a base plate 1, a controller 3 fixedly connected to the top of the base plate 1, a placement platform 5 fixedly connected to the top of the base plate 1, a storage box 6 placed on the top of the placement platform 5, and also includes:

[0025] The primary processing unit 2 is set on the top of the base plate 1 and the secondary fine unit 4 is set on the outer surface of the primary processing unit 2;

[0026] When this utility model is in operation, the controller 3 is turned on and the adjuvant is put into the primary processing unit 2. The primary processing unit 2 will break up large agglomerated particles and reduce viscosity. Then the adjuvant will enter the secondary fine unit 4 to further emulsify the adjuvant evenly. Finally, the emulsified adjuvant flows into the storage box 6.

[0027] The primary processing unit 2 includes a transmission pipe 21. A support foot 22 is fixedly connected to the bottom of the transmission pipe 21, and a feed hopper 24 is fixedly connected to the top of the transmission pipe 21. A servo motor 25 is also fixedly connected to the outer surface of the transmission pipe 21. A discharge port 23 is fixedly connected to the end of the transmission pipe 21 away from the servo motor 25. A rotating rod 26 is fixedly connected to the output end of the servo motor 25. A propeller 27 is fixedly connected to the outer surface of the rotating rod 26. A cutting plate 28 is fixedly connected to the end of the rotating rod 26 away from the servo motor 25.

[0028] After the adjuvant enters the transfer pipe 21 through the feed hopper 24, the servo motor 25 drives the rotating rod 26 to rotate, thereby causing the propeller 27 and the cutting plate 28 to rotate. The propeller 27 pushes the high-viscosity adjuvant to the area of ​​the cutting plate 28, and the cutting plate 28 forms the first shearing force to initially break up large agglomerates and reduce viscosity.

[0029] The bottom of the support foot 22 is fixedly connected to the top of the base plate 1, and the end of the discharge port 23 away from the transmission pipe 21 is connected to the secondary fine unit 4.

[0030] The secondary fine unit 4 includes a hydraulic press 41, with a telescopic rod 42 fixedly connected to the outer surface of the hydraulic press 41, and a push plate 43 fixedly connected to the output end of the telescopic rod 42.

[0031] The secondary fine unit 4 also includes a square plate 44, on the outer surface of which a high-pressure micro-jet mechanism 45 is uniformly arranged.

[0032] The bottom of the hydraulic press 41 is fixedly connected to the top of the controller 3, and the outer surface of the square plate 44 is fixedly connected to the end of the discharge port 23 away from the transmission pipe 21.

[0033] The push plate 43 is located inside the square plate 44, and the end of the high-pressure micro-jet mechanism 45 away from the square plate 44 is fixedly connected to the outer surface of the storage box 6.

[0034] After passing through the primary processing unit 2, the adjuvant enters the square plate 44. The hydraulic press 41 drives the telescopic rod 42 to work and causes the push plate 43 to squeeze the adjuvant. The instantaneous pressure causes the adjuvant to enter the high-pressure micro-jet mechanism 45.

[0035] The high-pressure microjet mechanism 45 includes a microfluidic channel 451. A notch 452 is provided at one end of the microfluidic channel 451 near the square plate 44. Slides 453 are fixedly connected to both sides of the microfluidic channel 451. A movable baffle 454 is slidably connected to the outer surface of the slides 453. An extrusion magnet 455 is placed on the top of the movable baffle 454. A support column 456 is fixedly connected to the bottom of the movable baffle 454. An electromagnetic plate 457 is fixedly connected to one end of the support column 456.

[0036] As the adjuvant enters the microfluidic channel 451, which has a pore size of 50 μm, the adjuvant, propelled by high pressure, enters the microfluidic channel 451 and generates shear force, further emulsifying the adjuvant evenly.

[0037] If the adjuvant residue in the microfluidic channel 451 is not removed, the adjuvant will clog the microfluidic channel 451 and affect the subsequent shearing effect. Therefore, when a microfluidic channel 451 becomes clogged, first remove the storage box 6, pull open the movable baffle 454 and put the extrusion magnet 455 into the microfluidic channel 451 through the insertion notch 452. Then continue to pass through the movable baffle 454. The electromagnetic plate at the bottom will attract the movable baffle 454 and squeeze out the adjuvant that has condensed and blocked the microfluidic channel 451.

[0038] One end of the microfluidic channel 451 is fixedly connected to the outer surface of the square plate 44, and the other end of the microfluidic channel 451 is fixedly connected to the outer surface of the storage box 6.

[0039] In the description of this disclosure, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to fixed connections, detachable connections, or integral connections; they can refer to mechanical connections or electrical connections; they can refer to direct connections or indirect connections through an intermediate medium; and they can refer to the internal communication between two components. Those skilled in the art can understand these terms according to the specific circumstances. The specific meanings of the above terms in this disclosure are as follows.

[0040] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. An adjuvant emulsification and homogenization device for vaccine production, comprising a base plate, a controller fixedly connected to the top of the base plate, a placement platform fixedly connected to the top of the base plate, and a storage box placed on the top of the placement platform, characterized in that, Also includes: A primary processing unit is set on the top of the base plate, and a secondary fine unit is set on the outer surface of the primary processing unit; The primary processing unit includes a transmission tube, with a support foot fixedly connected to the bottom of the transmission tube and a feed hopper fixedly connected to the top of the transmission tube. A servo motor is also fixedly connected to the outer surface of the transmission tube, and a discharge port is fixedly connected to the end of the transmission tube away from the servo motor. A rotating rod is fixedly connected to the output end of the servo motor, and a propeller is fixedly connected to the outer surface of the rotating rod. A cutting plate is fixedly connected to the end of the rotating rod away from the servo motor.

2. The adjuvant emulsification and homogenization device for vaccine production according to claim 1, characterized in that: The bottom of the support foot is fixedly connected to the top of the base plate, and the end of the discharge port away from the transmission pipe is connected to the secondary fine unit.

3. The adjuvant emulsification and homogenization apparatus for vaccine production according to claim 1, characterized in that: The secondary precision unit includes a hydraulic press, with a telescopic rod fixedly connected to the outer surface of the hydraulic press, and a push plate fixedly connected to the output end of the telescopic rod; The secondary fine unit also includes a square plate, on the outer surface of which a high-pressure micro-jet mechanism is uniformly arranged.

4. The adjuvant emulsification and homogenization apparatus for vaccine production according to claim 3, characterized in that: The bottom of the hydraulic press is fixedly connected to the top of the controller, and the outer surface of the square plate is fixedly connected to the end of the discharge port away from the transmission pipe.

5. The adjuvant emulsification and homogenization apparatus for vaccine production according to claim 4, characterized in that: The pusher plate is located inside the square plate, and the end of the high-pressure micro-jet mechanism away from the square plate is fixedly connected to the outer surface of the storage box.

6. The adjuvant emulsification and homogenization apparatus for vaccine production according to claim 5, characterized in that: The high-pressure microjet mechanism includes a microfluidic channel with an insertion notch at one end near the square plate. Slides are fixedly connected to both sides of the microfluidic channel, and a movable baffle is slidably connected to the outer surface of the slide. An extrusion magnet is placed on the top of the movable baffle, and a support column is fixedly connected to the bottom of the movable baffle. An electromagnetic plate is fixedly connected to one end of the support column.

7. The adjuvant emulsification and homogenization apparatus for vaccine production according to claim 6, characterized in that: One end of the microfluidic channel is fixedly connected to the outer surface of the square plate, and the other end of the microfluidic channel is fixedly connected to the outer surface of the storage box.

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