Multi-chamber microfluidic co-administration device

Abstract

The utility model relates to a related technical field of dosing equipment especially, and more particularly to a kind of multi-chamber microfluidic combined drug delivery device, including micro control chip, the upper surface of micro control chip is equipped with placing seat, the upper surface of placing seat is connected with medicine bottle, the inner side surface of second gear is connected with connecting rod, the outside of connecting rod is equipped with stirring blade.This multi-chamber microfluidic combined drug delivery device, after medicine injection pipe injection, micro controller linkage chip starts system, adjusts micro valve angle, and first micro pumping pump is sent to medicine pipe, controls dosage and speed, and micro drive motor is mixed with stirring blade through gear set, and multi-medicine is uniformly mixed, and medicine pipe is sent to connector, and process is connected efficiently and accurately, and second micro pumping pump is started, and water source is taken through water delivery pipe to flush residual in tank, and waste water is discharged from impurity discharge pipe, to prevent cross contamination, each stage component is simple to operate, reduce difficulty and maintenance cost, prolong service life.

Description

Technical Field

[0001] This utility model relates to the technical field of drug delivery devices, and in particular to a multi-chamber microfluidic combined drug delivery device. Background Technology

[0002] Microfluidic combined drug delivery devices combine microfluidic technology with the need for precise drug delivery. They integrate multi-chamber drug storage, driving, regulation, mixing, and delivery modules on a centimeter-scale chip, enabling the independent storage, precise timing, dosage, and ratio control and coordinated delivery of multiple drugs or different concentrations of the same drug. The core advantages are miniaturization, low drug consumption, and high precision. They are widely applicable to various drug delivery scenarios, including transdermal, vascular, and mucosal administration, increasing mixing efficiency from below 60% in traditional passive mixing to over 90%, achieving second-level uniform mixing. They can precisely maintain preset drug ratios, such as a 1:2 ratio of chemotherapy drugs to sensitizers, avoiding dosage errors caused by mixing deviations. For drug systems requiring in-situ reactions, such as drug-carrier material assembly, uniform perturbation can promote a full reaction, improving drug stability and activity. Therefore, a multi-chamber microfluidic combined drug delivery device is needed.

[0003] Existing multi-chamber microfluidic combined drug delivery devices, when used, are difficult to handle high-viscosity and easily agglomerated drugs due to simple passive diffusion. Uneven mixing leads to local concentration imbalance, affecting efficacy or increasing toxicity and side effects. Moreover, many of them are disposable and cannot be used for a long time.

[0004] To address the aforementioned issues, a search revealed a patent with publication number CN213285277U that discloses a wound micro-irrigation drug delivery device adapted to negative pressure wound therapy. The patent describes a device "comprising a silicone sheet and a micro-irrigation drug delivery tube; the silicone sheet has a wound surface on the front and a material surface on the back, the wound surface divided into several small pools with connecting gaps between adjacent pools, and several circular holes distributed on the material surface; the micro-irrigation drug delivery tube passes through the middle of the silicone sheet and exits from the side, with a drug delivery hole at each corresponding pool position. This device performs micro-irrigation drug delivery under the wound material, ensuring full contact between the active ingredient and the wound without affecting the function of the negative pressure material, achieving functions such as wound irrigation and bacteriological sampling under negative pressure wound therapy." While this device is easy to clean and can accommodate reusability to some extent, its insufficient stirring structure leads to uneven mixing of the drug within the microchannels, affecting the accuracy and efficacy of drug delivery.

[0005] In light of this, in-depth research into the aforementioned issues led to the creation of this case. Utility Model Content

[0006] The purpose of this invention is to provide a multi-chamber microfluidic combined drug delivery device to solve the problems mentioned in the background art. In use, the existing multi-chamber microfluidic combined drug delivery devices are difficult to handle with high viscosity and easily agglomerated drugs due to simple passive diffusion, uneven mixing leading to local concentration imbalance, affecting efficacy or increasing toxicity and side effects, and many are disposable and cannot be used for a long time.

[0007] To achieve the above objectives, this utility model provides the following technical solution: a multi-chamber microfluidic combined drug delivery device, comprising a microcontroller chip, a placement seat mounted on the upper surface of the microcontroller chip, a medicine bottle connected to the upper surface of the placement seat, a micro-infusion tube penetrating the lower surface of the medicine bottle, a micro-valve sleeved on the outer surface of the micro-infusion tube, a first micro-pump connected to one end surface of the micro-infusion tube, a micro-connecting tube connected to one end surface of the first micro-pump, a micro-controller mounted on the upper surface of the microcontroller chip, a micro-stirring vessel connected to the upper surface of the microcontroller chip, a micro-drive motor disposed on the upper surface of the micro-stirring vessel, a connecting shaft connected to the output end of the micro-drive motor, a first gear fixedly connected to one end surface of the connecting shaft, a second gear meshing with the outer surface of the first gear, a connecting rod connected to the inner surface of the second gear, a stirring blade sleeved on the outer side of the connecting rod, and a connector mounted on the upper surface of the microcontroller chip.

[0008] Preferably, the medicine bottles are arranged in four groups and symmetrically distributed, and a medicine inlet tube is fixedly connected to the upper surface of the medicine bottles.

[0009] Preferably, a miniature drug delivery tube is connected through the inner surface of the placement seat.

[0010] Preferably, a micro-stirring tank is connected through one end surface of the micro-connecting tube.

[0011] Preferably, a water tank is connected to the upper surface of the micro control chip, a micro water supply pipe is connected through the upper surface of the water tank, a second micro pump is connected to one end of the micro water supply pipe, a micro water delivery pipe is connected to the upper surface of the second micro pump, and a micro stirring tank is connected to one end of the micro water delivery pipe.

[0012] Preferably, a support frame is installed on the upper surface of the micro-stirring tank, a micro-drive motor is installed on the upper surface of the support frame, a sealing plate is fixedly connected to the inner surface of the micro-stirring tank, a connecting rod is connected through the inner surface of the sealing plate, and a waste discharge pipe is connected to the lower surface of the micro-stirring tank.

[0013] Preferably, a micro-drug delivery tube is connected to one end surface of the micro-stirring tank, a connector is connected to one end surface of the micro-drug delivery tube, and a connector head is connected through one side surface of the connector.

[0014] Compared with the prior art, the beneficial effects of this utility model are: the multi-chamber microfluidic combined drug delivery device; 1. During the drug injection stage, after the drug is injected into the vial through the inlet tube, the microcontroller, in conjunction with the microcontroller chip, starts the system. It can precisely adjust the opening and closing angle of the micro valve according to the drug administration requirements. Combined with the stable pumping action of the first micro pump, the drug in the inlet tube is accurately delivered to the micro delivery tube. This enables flexible control of the dosage and delivery speed from the source, avoiding dosage deviation. For multi-drug administration scenarios, the device's mixing and dispensing capabilities are particularly outstanding. After the micro drive motor is started, it drives the first gear to rotate through the connecting shaft, which in turn drives the second gear to rotate. The second gear then drives the stirring blade to rotate at high speed in the micro mixing tank through the connecting rod. This can uniformly stir and mix multiple drugs in the tank, ensuring that different drugs are fully integrated to exert synergistic effects. After stirring is completed, the micro delivery tube is opened to deliver the mixed drug to the connector. The drug is then quickly administered by inserting the tube through the connector. The entire process, from drug injection, control, stirring to delivery, is tightly connected and the components work smoothly, greatly improving the efficiency and accuracy of multi-drug administration.

[0015] 2. The user-friendly cleaning design significantly enhances maintenance convenience and practicality. After use, the miniature mixing tank requires no manual disassembly or cleaning. Simply activate the second miniature pump, which draws clean water from the tank via a miniature water delivery pipe and precisely delivers it to the miniature mixing tank through a miniature water supply pipe. The water flow helps to flush away residual drugs inside the tank, and the wastewater generated during cleaning can be quickly discharged through the drain pipe. The entire cleaning process is highly automated, efficient, labor-saving, and thorough, effectively preventing cross-contamination of residual drugs and ensuring the safety of subsequent drug administration. From the miniature controller and first miniature pump in the drug delivery stage, to the miniature drive motor in the mixing stage, and then to the second miniature pump and water delivery pipeline in the cleaning stage, all functions can be switched without complicated operations. This not only reduces the operational difficulty for medical staff but also reduces device maintenance costs and extends service life. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the overall appearance and structure of the present utility model; Figure 2 This is a schematic diagram of the connection structure between the medicine bottle and the miniature drug delivery tube of this utility model; Figure 3 This is a schematic diagram of the structure of the water tank connected to the miniature water supply pipe of this utility model; Figure 4 This is a schematic diagram of the internal structure of the miniature mixing tank of this utility model; Figure 5 This utility model Figure 4 Enlarged structural diagram at point A in the middle.

[0017] In the diagram: 1. Microcontroller chip; 2. Placement base; 3. Medicine bottle; 4. Inlet tube; 5. Micro delivery tube; 6. Micro valve; 7. First micro pump; 701. Micro connecting tube; 8. Water tank; 9. Micro water delivery tube; 10. Second micro pump; 11. Micro water delivery tube; 12. Micro controller; 13. Micro mixing tank; 14. Support frame; 15. Micro drive motor; 16. Connecting shaft; 17. First gear; 18. Second gear; 19. Sealing plate; 20. Connecting rod; 21. Stirring blade; 22. Discharge tube; 23. Micro delivery tube; 24. Connector; 25. Connector head. Detailed Implementation

[0018] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0019] Please see Figure 1-5 This utility model provides a technical solution: a multi-chamber microfluidic combined drug delivery device, including a microcontroller chip 1, a placement seat 2 mounted on the upper surface of the microcontroller chip 1, a medicine bottle 3 connected to the upper surface of the placement seat 2, a micro-infusion tube 5 penetratingly connected to the lower surface of the medicine bottle 3, a micro-valve 6 sleeved on the outer surface of the micro-infusion tube 5, a first micro-pump 7 connected to one end surface of the micro-infusion tube 5, a micro-connecting tube 701 connected to one end surface of the first micro-pump 7, a micro-controller 12 mounted on the upper surface of the microcontroller chip 1, a micro-stirring tank 13 connected to the upper surface of the micro-stirring tank 13, a micro-drive motor 15 disposed on the upper surface of the micro-drive motor 15, a connecting shaft 16 connected to the output end of the micro-drive motor 15, a first gear 17 fixedly connected to one end surface of the connecting shaft 16, a second gear 18 meshing with the outer surface of the first gear 17, a connecting rod 20 connected to the inner surface of the second gear 18, a stirring blade 21 sleeved on the outer side of the connecting rod 20, and a connector 24 mounted on the upper surface of the microcontroller chip 1.

[0020] Furthermore, the medicine bottle 3 is provided in four sets and symmetrically distributed. The medicine inlet tube 4 is fixedly connected to the upper surface of the medicine bottle 3. The medicine bottle 3 is designed to store medicine and the medicine is injected into the medicine bottle 3 through the medicine inlet tube 4.

[0021] Furthermore, a micro-infusion tube 5 is connected through the inner surface of the placement seat 2. The micro-infusion tube 5 improves the effect of use. Then, the micro valve 6 is opened at the required angle, and the medicine in the inlet tube 4 is pumped into the micro-infusion tube 5 by the first micro pump 7.

[0022] Furthermore, a micro-stirring tank 13 is connected to one end of the micro-connecting tube 701. The micro-stirring tank 13 allows the drug to be stirred. The drug in the drug inlet tube 4 is then pumped into the micro-delivery tube 5 by the first micro-pump 7. The drug then enters the micro-valve 6 and is then transported to the micro-stirring tank 13 through the micro-connecting tube 701.

[0023] Furthermore, a water tank 8 is connected to the upper surface of the micro control chip 1, and a micro water supply pipe 9 is connected through the upper surface of the water tank 8. A second micro pump 10 is connected to one end of the micro water supply pipe 9, and a micro water delivery pipe 11 is connected to the upper surface of the second micro pump 10. A micro mixing tank 13 is connected to one end of the micro water delivery pipe 11. The micro water delivery pipe 11 enables water to be delivered, and then the second micro pump 10 can be started. The second micro pump 10 then outputs water from the water tank 8 through the micro water supply pipe 9, and then delivers it to the micro mixing tank 13 through the micro water delivery pipe 11 for cleaning. After cleaning is completed, the wastewater is discharged by opening the drain pipe 22.

[0024] Furthermore, a support frame 14 is installed on the upper surface of the micro-stirring tank 13, and a micro-drive motor 15 is installed on the upper surface of the support frame 14. A sealing plate 19 is fixedly connected to the inner surface of the micro-stirring tank 13, and a connecting rod 20 is connected through the inner surface of the sealing plate 19. A waste discharge pipe 22 is connected to the lower surface of the micro-stirring tank 13. The connecting rod 20 enables the stirring blade 21 to rotate. Then, the micro-drive motor 15 is started, and the micro-drive motor 15 drives the first gear 17 to rotate through the connecting shaft 16. Then, the first gear 17 drives the second gear 18 to rotate. When the second gear 18 rotates, the connecting rod 20 can drive the stirring blade 21 to stir the various drugs in the micro-stirring tank 13.

[0025] Furthermore, a micro drug delivery tube 23 is connected to one end of the surface of the micro mixing tank 13, and a connector 24 is connected to one end of the surface of the micro drug delivery tube 23. A connector head 25 is connected through one side of the connector 24. The drug delivery tube can be connected through the connector head 25. After the mixing is completed, the micro drug delivery tube 23 is opened to deliver the drug into the connector 24. Then, the drug can be delivered by inserting the tube through the connector head 25.

[0026] Working principle: First, the medicine is injected into the medicine bottle 3 through the medicine inlet tube 4. Then, the microcontroller 12 activates the microcontroller chip 1, which then opens the micro valve 6 as needed. The medicine in the medicine inlet tube 4 is then pumped into the micro delivery tube 5 by the first micro pump 7, and then enters the micro valve 6. Finally, it is transported to the micro mixing tank 13 through the micro connecting tube 701. Next, the micro drive motor 15 is activated, and then the micro drive motor 15 drives the first gear 17 to rotate through the connecting shaft 16. The first gear 17 then drives the second gear 18 to rotate. When the time is right, the connecting rod 20 can drive the stirring blade 21 to stir the various drugs in the micro stirring tank 13. After the stirring is completed, the micro drug delivery tube 23 is opened to deliver the drug to the connector 24. Then, the drug can be delivered by inserting the tube through the connector 25. After the micro stirring tank 13 is used up, the second micro pump 10 can be started. Then, the second micro pump 10 outputs the water source in the water tank 8 through the micro water delivery tube 9. Then, the water can be delivered to the micro stirring tank 13 through the micro water delivery tube 11 for cleaning. After the cleaning is completed, the wastewater is discharged by opening the waste pipe 22.

[0027] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A multi-chamber microfluidic combined drug delivery device, comprising a microcontroller chip (1), characterized in that: A placement base (2) is mounted on the upper surface of the microcontrol chip (1). A medicine bottle (3) is connected to the upper surface of the placement base (2). A micro-infusion tube (5) is connected through the lower surface of the medicine bottle (3). A micro-valve (6) is sleeved on the outer surface of the micro-infusion tube (5). A first micro-pump (7) is connected to one end of the micro-infusion tube (5). A micro-connecting tube (701) is connected to one end of the first micro-pump (7). A micro controller (12) is mounted on the upper surface of the microcontrol chip (1). A micro stirring tank (13) is connected to the surface of the micro stirring tank (13). A micro drive motor (15) is provided on the upper surface of the micro driving motor (15). A connecting shaft (16) is connected to the output end of the micro drive motor (15). A first gear (17) is fixedly connected to one end surface of the connecting shaft (16). A second gear (18) is meshed with the outer surface of the first gear (17). A connecting rod (20) is connected to the inner surface of the second gear (18). A stirring blade (21) is sleeved on the outer side of the connecting rod (20). A connector (24) is installed on the upper surface of the micro control chip (1).

2. The multi-chamber microfluidic combined drug delivery device according to claim 1, characterized in that: The medicine bottle (3) is provided in four sets and symmetrically distributed, and the medicine inlet tube (4) is fixedly connected to the upper surface of the medicine bottle (3).

3. The multi-chamber microfluidic combined drug delivery device according to claim 1, characterized in that: The inner surface of the placement seat (2) is connected to a micro-infusion tube (5).

4. The multi-chamber microfluidic combined drug delivery device according to claim 1, characterized in that: A micro-stirring tank (13) is connected through one end of the surface of the micro-connecting tube (701).

5. The multi-chamber microfluidic combined drug delivery device according to claim 1, characterized in that: The upper surface of the micro control chip (1) is connected to a water tank (8), and the upper surface of the water tank (8) is connected to a micro water supply pipe (9). One end of the micro water supply pipe (9) is connected to a second micro pump (10), the upper surface of the second micro pump (10) is connected to a micro water delivery pipe (11), and one end of the micro water delivery pipe (11) is connected to a micro stirring tank (13).

6. The multi-chamber microfluidic combined drug delivery device according to claim 1, characterized in that: A support frame (14) is installed on the upper surface of the micro-stirring tank (13), a micro-drive motor (15) is installed on the upper surface of the support frame (14), a sealing plate (19) is fixedly connected to the inner surface of the micro-stirring tank (13), a connecting rod (20) is connected through the inner surface of the sealing plate (19), and a waste discharge pipe (22) is connected to the lower surface of the micro-stirring tank (13).

7. The multi-chamber microfluidic combined drug delivery device according to claim 1, characterized in that: The micro-stirring tank (13) is connected to a micro-drug delivery tube (23) at one end, and a connector (24) is connected to a one end of the micro-drug delivery tube (23). A connector head (25) is connected through one side of the connector (24).

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