A quantitative dosing device for chemical synthesis

Abstract

The utility model discloses a kind of quantitative feeding device for chemical synthesis, it is related to quantitative feeding device technical field, the quantitative feeding device includes annular frame, the upper center position of annular frame is provided with inner disc seat, the upper end of inner disc seat is fixed with driving motor by screw, the output shaft of driving motor is welded with linkage shaft, the inside of linkage shaft is provided with sleeve cavity, the inside of sleeve cavity is provided with stirring shaft;It also includes: feeding tank, it is set on the outside position of the inner disc seat, feeding tank is provided with six, and six feeding tanks are equidistantly arranged, and the lower portion of feeding tank is provided with discharge conduit, it solves the quantitative dosing treatment of solution by the feeding bottle structure of the feeding device of existing adding, but in the process of adding, only through single feeding bottle is prone to interactive reaction, and feeding device cannot adapt to the installation and use of different size reaction tank, leading to the problem that there is limitation in the use of feeding device.

Description

Technical Field

[0001] This utility model relates to the technical field of quantitative feeding devices, specifically a quantitative feeding device for chemical synthesis. Background Technology

[0002] LYTACs are a technology that utilizes the lysosomal pathway to degrade extracellular and membrane proteins. LYTAC molecules can simultaneously bind to the extracellular domains of membrane proteins and lysosomal targeting receptors on the cell surface, forming a ternary complex that leads to protein internalization and degradation via the lysosomal pathway. During the chemical synthesis of LYTACs, various auxiliary reagents need to be added using a feeding device.

[0003] For example, the announcement number is CN212701938U (named "A Feeding Device for Pharmaceutical Chemical Synthesis"), which includes a reaction vessel, a reaction chamber inside the reaction vessel, a stirring and feeding shaft rotatably mounted on the reaction vessel, the upper end of the stirring and feeding shaft extending beyond the upper surface of the reaction vessel, a feeding port on the upper surface of the reaction vessel, a stirring blade integrally mounted on the lower end of the stirring and feeding shaft located inside the reaction vessel, a liquid chamber inside the stirring and feeding shaft, and several liquid outlet holes connected to the liquid chamber on the stirring and feeding shaft, with the diameter of the liquid outlet holes gradually decreasing from top to bottom; a feeding bottle is inserted into the stirring and feeding shaft, the feeding bottle is made of transparent material and the surface of the feeding bottle is marked with an identification layer indicating the volume of the feeding bottle. The feeding port is used to add the liquid to be reacted, while the stirring shaft liquid chamber is used to adjust the pH value or the concentration of a certain drug solution. The feeding bottle can be of different capacities such as 100ml, 200ml or 500ml. As long as the size of the bottle opening matches the size of the liquid chamber opening at the upper end of the stirring and feeding shaft, the feeding bottle can be inserted into the stirring and feeding shaft.

[0004] The above-mentioned feeding device quantitatively adds the solution through a feeding bottle structure. However, during the feeding process, cross-reactions can easily occur when using only a single feeding bottle. Furthermore, the feeding device cannot be adapted to the installation and use of reaction vessels of different sizes, resulting in limitations in its use. Therefore, we provide a quantitative feeding device for chemical synthesis. Utility Model Content

[0005] The purpose of this invention is to provide a quantitative feeding device for chemical synthesis, which solves the problems mentioned in the background art. Existing feeding devices use a feeding bottle structure to quantitatively add solutions, but during the feeding process, interactive reactions can easily occur when using only a single feeding bottle. Furthermore, the feeding device cannot be adapted to the installation and use of reaction vessels of different sizes, resulting in limitations in the use of the feeding device.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a quantitative feeding device for chemical synthesis, comprising an annular frame, an inner plate seat disposed at the upper center of the annular frame, a drive motor fixedly disposed at the upper end of the inner plate seat by screws, a linkage shaft welded to the output shaft of the drive motor, a sleeve cavity disposed inside the linkage shaft, and a stirring shaft disposed inside the sleeve cavity. Also includes: The feeding tank is located on the outer side of the inner plate seat. There are six feeding tanks, which are arranged at equal intervals. A discharge conduit is provided below the feeding tank, and a liquid level gauge is integrally formed on the inner wall of the feeding tank. The guide rails are located below the annular frame. There are three guide rails, which are arranged at equal intervals. A support rod is provided between the guide rails and the annular frame. The two ends of the support rod are welded to the guide rails and the annular frame, respectively. A threaded screw is disposed inside the guide rail, and a screw slider is slidably disposed on the threaded screw. A connecting bracket is welded to the lower end of the screw slider through a connecting rod. A clamping screw is rotatably disposed in the screw hole on the outer wall of the connecting bracket.

[0007] Preferably, an outer ring disc is welded to the outer wall of the linkage shaft, and a through hole is provided inside the outer ring disc. A connecting rod carrier is welded to the outer wall of the stirring shaft, and an inner rotor is welded to the lower end of the stirring shaft.

[0008] Preferably, a reference rod is welded to the upper end of the connecting rod carrier, and an extension screw is welded to the upper end of the reference rod. The extension screw is connected to the through hole inside the outer ring disc, and a limit nut is installed on the outer wall of the extension screw. The size of the limit nut is larger than the diameter of the through hole.

[0009] Preferably, a discharge port is provided at the center of the bottom of the feeding tank, and a discharge valve is connected to the lower end of the discharge port. The discharge end of the discharge valve is connected to the starting end of the discharge conduit.

[0010] Preferably, the feeding conduit is provided with support rods on both sides, and the two ends of the two support rods are welded to the feeding tank and the annular frame, respectively.

[0011] Preferably, guide rods are provided on both sides of the threaded screw, and both guide rods are integral with the guide rail. The screw slider is guided and slidably connected to the guide rail through the two guide rods.

[0012] Preferably, one end of the guide rail is provided with a transmission throttle, which is connected to the threaded screw inside the guide rail via a coupling.

[0013] Preferably, a supporting connecting rod is provided between the inner plate seat and the annular frame. There are six supporting connecting rods, and the two ends of the six supporting connecting rods are welded to the inner plate seat and the annular frame, respectively.

[0014] Compared with the prior art, the beneficial effects of this utility model are: 1. This utility model uses a rotating transmission handle to drive a threaded screw to rotate, which in turn drives the screw slider to slide along a guide rail. This allows the connecting bracket to be adjusted to the connection position with the edge of the reaction tank. Then, the clamping screw is rotated to abut against the outer wall of the reaction tank edge for positioning, thereby achieving the purpose of adaptive installation of a quantitative feeding device. Through the insertion connection between the stirring shaft and the sleeve cavity, the height of the inner rotor can be adjusted to meet the stirring needs of reaction tanks of different depths. After the height adjustment is completed, an upper limit nut is installed on the extension screw for positioning. This allows it to be adapted to the installation and use of reaction tanks of different sizes, reducing limitations.

[0015] 2. Six feeding tanks are used to add different chemical synthesis reagents. The amount is measured by a liquid level gauge. After the amount is measured, the discharge valve is opened when it is necessary to add more material. The chemical synthesis reagent inside the feeding tank is discharged into the reaction vessel through the discharge pipe. This achieves the purpose of quantitative addition of chemical synthesis reagents and avoids the problem of cross-reaction that can easily occur when using only a single feeding bottle. Attached Figure Description

[0016] Figure 1 This is a front view of the quantitative feeding device for chemical synthesis according to this utility model. Figure 2 This is a top view of the quantitative feeding device for chemical synthesis according to this utility model; Figure 3 This is a bottom view of the structure of the quantitative feeding device for chemical synthesis according to this utility model; Figure 4 This is a cross-sectional view of the linkage shaft and stirring shaft structure of this utility model; Figure 5 This is an enlarged schematic diagram of part A of the present invention; In the diagram: 1. Annular frame; 2. Feeding tank; 3. Support rod; 4. Liquid level gauge; 5. Discharge guide pipe; 6. Inner disc seat; 7. Drive motor; 8. Supporting rod; 9. Linkage shaft; 10. Outer ring disc; 11. Stirring shaft; 12. Connecting rod carrier; 13. Inner rotor; 14. Support rod; 15. Guide rail; 16. Transmission handle; 17. Connecting bracket; 18. Clamping screw; 19. Discharge port; 20. Discharge valve; 21. Reference rod; 22. Extension screw; 23. Threaded screw; 24. Guide rod; 25. Screw slider; 26. Sleeve cavity; 27. Through hole; 28. Limit nut. Detailed Implementation

[0017] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0018] Please see Figure 1-5 An embodiment of this utility model is provided: a quantitative feeding device for chemical synthesis, including an annular frame 1, an inner plate seat 6 is provided at the upper center of the annular frame 1, a drive motor 7 is fixedly provided at the upper end of the inner plate seat 6 by screws, a linkage shaft 9 is welded on the output shaft of the drive motor 7, a sleeve cavity 26 is provided inside the linkage shaft 9, and a stirring shaft 11 is provided inside the sleeve cavity 26. Also includes: The feeding tank 2 is located on the outer side of the inner plate seat 6. There are six feeding tanks 2, and the six feeding tanks 2 are arranged at equal intervals. The feeding pipe 5 is located below the feeding tank 2, and the liquid level gauge 4 is integrally formed on the inner wall of the feeding tank 2. The guide rail 15 is located below the annular frame 1. There are three guide rails 15, and the three guide rails 15 are arranged at equal intervals. A support rod 14 is provided between the guide rail 15 and the annular frame 1. The two ends of the support rod 14 are welded to the guide rail 15 and the annular frame 1 respectively. A threaded screw 23 is disposed inside the guide rail 15, and a screw slider 25 is slidably disposed on the threaded screw 23. A connecting bracket 17 is welded to the lower end of the screw slider 25 through a connecting rod. A clamping screw 18 is rotatably disposed in the screw hole on the outer wall of the connecting bracket 17.

[0019] In use, the annular frame 1 is installed on the upper part of the chemical synthesis reaction vessel according to the diameter of the vessel. Then, the transmission handle 16 is rotated to drive the threaded screw 23 to rotate, which in turn drives the screw slider 25 to slide along the guide rail 15. This allows the connecting bracket 17 to be adjusted to the connection position with the edge of the reaction vessel. Then, the clamping screw 18 is rotated to abut against the outer wall of the edge of the reaction vessel for positioning, thereby achieving the purpose of adaptive installation of the quantitative feeding device. The six feeding tanks 2 are used to add different chemical synthesis reagents. The liquid level gauge 4 is used for quantitative feeding. After quantitative feeding, when feeding is needed, the discharge valve 20 is opened, and the chemical synthesis reagents inside the feeding tank 2 are discharged into the interior of the reaction vessel through the discharge conduit 5, achieving the purpose of quantitative feeding of chemical synthesis reagents. The stirring shaft 11 is connected to the sleeve cavity 26 by insertion, so that the height of the inner rotating blade 13 can be adjusted to meet the stirring needs of reaction vessels of different depths. After the height adjustment is completed, the upper limit nut 28 is installed on the extension screw 22 for positioning.

[0020] Please see Figure 3 and Figure 5 An outer ring disc 10 is welded to the outer wall of the linkage shaft 9, and a through hole 27 is provided inside the outer ring disc 10. A connecting rod carrier 12 is welded to the outer wall of the stirring shaft 11, and an inner impeller 13 is welded to the lower end of the stirring shaft 11. The outer ring disc 10 welded to the outer wall of the linkage shaft 9 serves to facilitate the insertion and positioning of the extension screw 22. Please refer to [link / reference]. Figure 3 and Figure 5 A reference rod 21 is welded to the upper end of the connecting rod carrier 12. An extension screw 22 is welded to the upper end of the reference rod 21. The extension screw 22 is connected to the through hole 27 inside the outer ring disc 10. A limit nut 28 is installed on the outer wall of the extension screw 22. The size of the limit nut 28 is larger than the diameter of the through hole 27. The reference rod 21 welded to the upper end of the connecting rod carrier 12 serves to connect and support the extension screw 22. Please refer to [link / reference]. Figure 2 and Figure 3 A discharge port 19 is located at the center of the bottom of the feeding tank 2. A discharge valve 20 is connected to the lower end of the discharge port 19. The discharge end of the discharge valve 20 is connected to the starting end of the discharge conduit 5. The discharge port 19 at the center of the bottom of the feeding tank 2 assists in discharging material from the bottom of the feeding tank 2. Please refer to [link / reference]. Figure 1 The feeding conduit 5 has support rods 3 on both sides. The two ends of the support rods 3 are welded to the feeding tank 2 and the annular frame 1, respectively. The support rods 3 on both sides of the feeding conduit 5 serve to support and connect the feeding tank 2 and the annular frame 1. Please refer to [link / reference]. Figure 3 Guide rods 24 are provided on both sides of the threaded screw 23. Both guide rods 24 are integrally formed with the guide rail 15. The screw slider 25 is guided and slidably connected to the guide rail 15 through the two guide rods 24. The guide rods 24 on both sides of the threaded screw 23 assist in guiding the sliding of the screw slider 25. Please refer to [link / reference]. Figure 3 A transmission handle 16 is provided at one end of the guide rail 15. The transmission handle 16 is connected to the threaded screw 23 inside the guide rail 15 via a coupling. The transmission handle 16 at one end of the guide rail 15 drives the threaded screw 23 to rotate in both directions. Please refer to [link / reference]. Figure 2 A supporting rod 8 is provided between the inner plate seat 6 and the annular frame 1. There are six supporting rods 8. The two ends of the six supporting rods 8 are welded to the inner plate seat 6 and the annular frame 1 respectively. The supporting rod 8 provided between the inner plate seat 6 and the annular frame 1 serves to support and connect the inner plate seat 6.

[0021] It will be apparent to those skilled in the art that this invention is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of this invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of this invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

Claims

1. A quantitative feeding device for chemical synthesis, comprising an annular frame (1), an inner plate seat (6) is provided at the upper center of the annular frame (1), a drive motor (7) is fixedly provided at the upper end of the inner plate seat (6) by screws, a linkage shaft (9) is welded on the output shaft of the drive motor (7), a sleeve cavity (26) is provided inside the linkage shaft (9), and a stirring shaft (11) is provided inside the sleeve cavity (26). Its features are: Also includes: The feeding tank (2) is located on the outer side of the inner plate seat (6). There are six feeding tanks (2), and the six feeding tanks (2) are arranged at equal intervals. A discharge pipe (5) is provided below the feeding tank (2). A liquid level gauge (4) is integrally formed on the inner wall of the feeding tank (2). The guide rail (15) is located below the ring frame (1). There are three guide rails (15) arranged at equal intervals. A support rod (14) is provided between the guide rail (15) and the ring frame (1). The two ends of the support rod (14) are welded to the guide rail (15) and the ring frame (1) respectively. A threaded screw (23) is disposed inside the guide rail (15), and a screw slider (25) is slidably disposed on the threaded screw (23). A connecting seat (17) is welded to the lower end of the screw slider (25) through a connecting rod. A clamping screw (18) is rotatably disposed in the screw hole on the outer wall of the connecting seat (17).

2. The quantitative feeding device for chemical synthesis according to claim 1, characterized in that: An outer ring disc (10) is welded to the outer wall of the linkage shaft (9), and a through hole (27) is provided inside the outer ring disc (10). A connecting rod carrier (12) is welded to the outer wall of the stirring shaft (11), and an inner rotor (13) is welded to the lower end of the stirring shaft (11).

3. The quantitative feeding device for chemical synthesis according to claim 2, characterized in that: A reference rod (21) is welded to the upper end of the connecting rod carrier (12), and an extension screw (22) is welded to the upper end of the reference rod (21). The extension screw (22) is connected to the through hole (27) inside the outer ring plate (10). A limit nut (28) is installed on the outer wall of the extension screw (22). The size of the limit nut (28) is larger than the diameter of the through hole (27).

4. The quantitative feeding device for chemical synthesis according to claim 1, characterized in that: The bottom center of the feeding tank (2) is provided with a discharge port (19), and the lower end of the discharge port (19) is connected to a discharge valve (20). The discharge end of the discharge valve (20) is connected to the starting end of the discharge conduit (5).

5. A quantitative feeding device for chemical synthesis according to claim 1, characterized in that: Both sides of the feeding conduit (5) are provided with support rods (3), and the two ends of the two support rods (3) are welded to the feeding tank (2) and the annular frame (1) respectively.

6. A quantitative feeding device for chemical synthesis according to claim 1, characterized in that: Guide rods (24) are provided on both sides of the threaded screw (23). Both guide rods (24) are integrated with the guide rail (15). The screw slider (25) is guided and slidably connected to the guide rail (15) through the two guide rods (24).

7. A quantitative feeding device for chemical synthesis according to claim 1, characterized in that: One end of the guide rail (15) is provided with a transmission handle (16), which is connected to the threaded screw (23) inside the guide rail (15) via a coupling.

8. A quantitative feeding device for chemical synthesis according to claim 1, characterized in that: A mounting link (8) is provided between the inner plate seat (6) and the annular frame (1). There are six mounting links (8), and the two ends of the six mounting links (8) are welded to the inner plate seat (6) and the annular frame (1) respectively.

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