A three-dimensional microfluidic reaction device

Abstract

The utility model discloses a three -dimensional microfluidic reaction device, this three -dimensional microfluidic reaction device includes the upper plate, the middle plate and the lower plate, and the upper plate, the middle plate, the lower plate are overlapped together in proper order, the board surface on the side of upper plate to the middle plate is opened with the upper annular recess that head and tail are not communicated, the board surface on the side of lower plate to the middle plate is opened with the lower annular recess that head and tail are not communicated, is opened with the middle through -flow passage of the through -type in the middle plate, the upper annular recess is communicated with the lower annular recess through the middle through -flow passage, still is provided with the liquid inlet channel of communicating with the upper annular recess in the upper plate, still is provided with the liquid outlet channel of communicating with the lower annular recess in the lower plate. The three -dimensional microfluidic reaction device of the utility model has higher specific surface area and higher mass transfer heat transfer efficiency, and greatly improves the reaction channel length, and significantly improves the reaction quality and output.

Description

Technical Field

[0001] This utility model relates to microfluidic reaction equipment, specifically a three-dimensional microfluidic reaction device, and belongs to the technical field of microfluidic reaction equipment. Background Technology

[0002] In recent years, in the fields of fine chemicals, pharmaceutical synthesis, energy materials, and biotechnology, production has increasingly demanded precision, efficiency, and environmental friendliness. Traditional macroscopic reaction vessel equipment can no longer meet these process requirements.

[0003] Unlike traditional large reactors, microreactor technology applies chemical reaction processes within microstructures. Devices or apparatuses embodying this technology are called microreactors. When chemical reactions occur within a microscale space, mass and heat transfer efficiency can be significantly improved, as can selectivity and conversion rates, the safety and integration of the reaction process. By precisely controlling fluid flow, mass transfer, and heat transfer processes, the reaction can be made more efficient, continuous, and precise, thereby achieving production goals.

[0004] Microreactors contain numerous micro-reaction channels, which are the core structure of the device and provide a large specific surface area and high mass and heat transfer efficiency. However, most existing microreactors have planar reaction channels, which are insufficient to meet the demands of increasingly high-quality and high-efficiency production conditions. Utility Model Content

[0005] To address the shortcomings of existing planar channel-type microreactors, which suffer from relatively low reaction quality and efficiency and cannot meet the growing demands for high-quality and high-efficiency production, this invention provides a three-dimensional microfluidic reactor. By simultaneously constructing upper and lower plates with "snake"-shaped reaction grooves and a middle plate with a "satellite"-shaped through-flow reaction channel, a reaction channel with a unique three-dimensional structure is obtained through a staggered, overlapping, and interconnected approach. Furthermore, the reaction fluid undergoes at least one diversion and convergence within this unique three-dimensional reaction channel. Compared to existing planar reaction channels, this three-dimensional microfluidic reactor exhibits a higher specific surface area and higher mass and heat transfer efficiency, while significantly improving reaction quality and efficiency.

[0006] To achieve the above-mentioned technical objectives, the technical solution adopted by this utility model is as follows: A three-dimensional microfluidic reactor includes an upper plate, a middle plate, and a lower plate, which are stacked sequentially. An upper annular groove, not connected end-to-end, is formed on the surface of the upper plate facing the middle plate. A lower annular groove, also not connected end-to-end, is formed on the surface of the lower plate facing the middle plate. A through-flow channel is formed on the middle plate. The upper annular groove is connected to the lower annular groove via the through-flow channel. A liquid inlet channel, connected to the upper annular groove, is also formed through the upper plate. A liquid outlet channel, connected to the lower annular groove, is also formed through the lower plate.

[0007] Preferably, the upper annular groove includes an upper C-shaped end groove, an upper spiral groove, and an upper semi-circular end groove connected in sequence. The upper semi-circular end groove is located within the C-shaped notch formed by the upper C-shaped end groove. The liquid inlet channel is connected to the upper spiral groove.

[0008] Preferably, the upper annular groove is rectangular, circular, or elliptical on the surface of the upper plate. Preferably, the depth of the upper annular groove is 1 to 2 times the minimum width of the upper annular groove.

[0009] Preferably, the central flow channel includes a central flow channel and multiple outer flow channels. The multiple outer flow channels are distributed in a C-shape around the central flow channel, and each outer flow channel is connected to the central flow channel via an independent flow path. When the upper plate and the middle plate overlap, the central flow channel is connected to the upper semi-circular end slot, and the multiple outer flow channels are connected to the upper C-shaped end slot.

[0010] Preferably, the thickness of the middle plate is 1 to 3 times the minimum opening width of the central flow channel.

[0011] Preferably, the lower annular groove includes a lower C-shaped end groove, a lower loop-shaped groove, and a lower semi-circular end groove connected in sequence. The lower semi-circular end groove is located within the C-shaped notch formed by the lower C-shaped end groove. The liquid outlet channel is connected to the lower loop-shaped groove. When the lower plate and the middle plate overlap, the lower semi-circular end groove connects to the central flow channel, and the lower C-shaped end groove connects to multiple outer flow channels.

[0012] Preferably, the lower annular groove is rectangular, circular, or elliptical on the surface of the lower plate. Preferably, the depth of the lower annular groove is 1 to 2 times the minimum width of the lower annular groove.

[0013] Preferably, the upper plate has multiple non-interconnected upper annular grooves arranged in a row. The middle plate has multiple non-interconnected central flow channels arranged in a row. The lower plate has multiple non-interconnected lower annular grooves arranged in a row, with the liquid outlet channel independently located on the lower side of the row of lower annular grooves. When the upper, middle, and lower plates overlap, the liquid inlet channel is connected to the upper loop groove of the first upper annular groove, the C-shaped end groove of the first upper annular groove is connected to multiple outer flow channels of the first central flow channel, the upper semi-circular end groove of the first upper annular groove is connected to the lower loop groove of the first lower annular groove through the central flow channel of the first central flow channel, the lower C-shaped end groove of the first lower annular groove is connected to multiple outer flow channels of the second central flow channel, and the lower semi-circular end groove of the first lower annular groove is connected to the upper loop groove of the second upper annular groove through the central flow channel of the second central flow channel. The C-shaped end groove of the second upper annular groove is connected to multiple outer channels of the third central flow channel. The upper semi-circular end groove of the second upper annular groove is connected to the lower loop-shaped groove of the second lower annular groove through the central flow channel of the third central flow channel. Similarly, the upper loop-shaped groove of the last upper annular groove is connected to the lower semi-circular end groove of the last lower annular groove through the central flow channel of the penultimate central flow channel. The C-shaped end groove of the last upper annular groove is connected to multiple outer channels of the last central flow channel. The upper semi-circular end groove of the last upper annular groove is connected to the liquid outlet channel through the central flow channel of the last central flow channel. In other words, the multiple upper annular grooves, multiple central flow channels, and multiple lower annular grooves arranged in a row are interconnected to form a column-oriented combined reaction channel.

[0014] Preferably, the upper plate has multiple rows of upper annular grooves, with adjacent rows of upper annular grooves being horizontally symmetrical. The middle plate has multiple rows of staggered central flow channels. In addition to the first row of central flow channels, a single flow channel penetrating the middle plate is also provided at the staggered notch of each row of central flow channels. The lower plate has multiple rows of lower annular grooves, with a row of transverse connecting grooves provided on the upper and lower sides of the multiple rows of lower annular grooves respectively. The liquid outlet channel is independently provided on the lower side of the last row of lower annular grooves. When the upper plate, middle plate, and lower plate overlap, the multiple rows of upper annular grooves, multiple rows of central flow channels, and multiple rows of lower annular grooves respectively constitute multiple column-oriented combined reaction channels. The inlet channel is connected to the upper groove of the first annular groove in the first column of oriented combined reaction channels. The central flow channel of the last central flow channel in the first column of oriented combined reaction channels is connected to a single flow channel located below the second column of oriented combined reaction channels via the first transverse connecting groove in the lower row. This single flow channel is connected to the upper groove of the last annular groove in the second column of oriented combined reaction channels. The central flow channel of the first central flow channel in the second column of oriented combined reaction channels is connected to a single flow channel located above the third column of oriented combined reaction channels via the first transverse connecting groove in the upper row. This single flow channel is connected to the upper groove of the first annular groove in the third column of oriented combined reaction channels. Similarly, the upper groove of the first annular groove in the last column of oriented combined reaction channels is connected to the last transverse connecting groove in the upper row via a single flow channel located above that column of oriented combined reaction channels. The central flow channel of the last central flow channel in the last column of oriented combined reaction channels is connected to the outlet channel. That is, multiple column-oriented combined reaction channels are connected in series through multiple transverse connecting channels and multiple single-pass flow channels to form an S-shaped combined reaction channel.

[0015] Preferably, an upper connecting circular groove is also provided on the upper spiral groove. The upper spiral groove is connected to the liquid inlet channel, the central flow channel, or the transverse connecting groove through the upper connecting circular groove.

[0016] Preferably, a lower connecting circular groove is also provided on the lower spiral groove. The lower spiral groove is connected to the central flow channel through the lower connecting circular groove.

[0017] Preferably, the upper connecting groove is located on the upper loop groove opposite the upper semi-circular end groove. The lower connecting groove is located on the lower loop groove opposite the lower semi-circular end groove.

[0018] Preferably, the upper, middle, and lower plates are provided with corresponding through holes. Bolts are passed through these holes in sequence and tightened to achieve a stacked, combined fixing of the upper, middle, and lower plates.

[0019] In this invention, the proposed three-dimensional microfluidic reaction device comprises three plates: an upper plate, a middle plate, and a lower plate. An upper channel (i.e., an upper annular groove), a middle channel (i.e., a central flow channel), and a lower channel (i.e., a lower annular groove) are respectively formed on the upper, middle, and lower plates. After the upper, middle, and lower plates are stacked and fixed in sequence, the upper, middle, and lower channels are connected in a staggered manner to form a three-dimensional reaction channel. Simultaneously, a reaction liquid inlet channel and a reaction liquid outlet channel, connected to the three-dimensional reaction channel, are also formed on the upper and lower plates, respectively. The reaction liquid enters the three-dimensional reaction channel through the inlet channel, and is mixed and reacted sequentially as it flows through the upper channel (i.e., the upper annular groove), the middle channel (i.e., the central flow channel), and the lower channel (i.e., the lower annular groove), finally exiting through the outlet channel.

[0020] In this invention, the upper channel (i.e., the upper annular groove) on the upper plate has a "snake" structure, including an upper C-shaped end groove, an upper loop groove, and an upper semi-circular end groove connected in sequence. Each "snake" channel is a small reaction channel unit, which is arranged in a loop shape (e.g., rectangular, circular, elliptical, or other annular geometric shape) on the plane (i.e., the upper semi-circular end groove extends back to the C-shaped notch formed by the upper C-shaped end groove). On this "snake" channel, the liquid inlet is generally set on the upper loop groove (e.g., an upper connecting circular groove is set in the middle of the upper loop groove as a liquid inlet). The liquid inlet divides the upper loop groove into two flow channels (flow channel 1 and flow channel 2). The end of flow channel 1 is set as a disconnected upper C-shaped end groove, and the end of flow channel 2 is an upper semi-circular end groove. The center of the small semicircle of the upper semi-circular end groove coincides with the center of the upper C-shaped end groove, thus forming a "snake" structure that is not connected end to end. In other words, when the reaction liquid enters the small reaction channel unit through the inlet, it will first be split into two streams that enter channel 1 and channel 2 respectively, and finally flow into the upper C-shaped end groove and the upper semi-circular end groove respectively.

[0021] In this invention, the central channel (i.e., the central flow channel) in the middle plate has a "satellite" structure, including a central flow channel and multiple outer flow channels. The multiple outer flow channels are distributed in a C-shape (corresponding to and connected to the C-shaped end groove of the "snake" channel). The central flow channel (corresponding to and connected to the semi-circular end groove of the "snake" channel) is located at the center of the C-shape of the multiple outer flow channels, and each outer flow channel is connected to the central flow channel through an independent flow channel, thus forming a "satellite" through channel as a whole. That is to say, by setting a "satellite" through channel on the middle plate and correspondingly connecting the upper C-shaped end groove and the upper semi-circular end groove, the reaction liquid that is diverted in the "snake" channel of the upper plate is collected in the "satellite" through channel, which helps to improve the uniformity of the reaction liquid during the reaction process and effectively improves the reaction quality and reaction efficiency.

[0022] In this utility model, the lower channel (i.e., the lower annular groove) opened on the lower plate is also a "snake" structure, including a lower C-shaped end groove (which corresponds to and is connected to multiple outer flow channels of the "satellite" through channel), a lower loop groove, and a lower semi-circular end groove (which corresponds to and is connected to the central flow channel of the "satellite" through channel). Unlike the "snake" channel in the upper plate, the flow direction of the reaction liquid in the lower plate's "snake" channel is exactly the opposite. The reaction liquid enters from the lower C-shaped end groove and the lower semi-circular end groove, and then exits through flow channels 1 and 2 respectively from the lower connecting circular groove on the lower loop-shaped groove (for example, a lower connecting circular groove is provided in the middle of the lower loop-shaped groove as an outlet). In other words, the reaction liquid, after being collected in the "satellite" through-channel of the middle plate, will be diverted again after entering the lower plate's "snake" channel, and finally collected and discharged in the lower connecting circular groove of the lower loop-shaped groove. That is, vertically, an upper plate's "snake" channel is connected in series with a lower plate's "snake" channel through a middle plate's "satellite" through-channel, forming a special three-dimensional reaction channel. The reaction liquid flows and reacts simultaneously in this special three-dimensional reaction channel, undergoing at least one diversion and re-collection process, thus greatly improving the reaction efficiency and quality.

[0023] In this invention, to further improve the reaction efficiency and quality of the reaction solution, multiple "snake-like" structured upper channels (it should be noted that when multiple rows of upper channels are provided on the upper plate, the upper annular grooves of adjacent rows are horizontally symmetrical, that is, the upper C-shaped end groove and upper semi-circular end groove of one row of upper annular grooves are located on the upper side, while the upper C-shaped end groove and upper semi-circular end groove of the other row of upper annular grooves are located on the lower side), multiple "satellite-like" structured middle channels, and multiple "snake-like" structured lower channels are provided in rows or columns. Then, the liquid inlet channel-upper channel-middle channel are arranged in sequence. The reaction channel is formed by connecting the lower channel, middle channel, upper channel, middle channel, and so on (i.e., the number of upper channels is one more than the number of lower channels, and the number of middle channels is the sum of the number of upper and lower channels) in series to form a three-dimensional reaction channel with a column-oriented (i.e., longitudinal) or row-oriented (i.e., transverse) structure (preferably, when the reactor is placed vertically, the three-dimensional reaction channel has a longitudinally extending structure). This allows the reaction liquid to undergo multiple diversion and re-convergence processes in the reaction channel, and further extends the flow path of the reaction liquid in the reaction channel, thereby significantly improving the reaction efficiency and reaction quality.

[0024] Furthermore, to further improve the reaction efficiency and quality of the reaction liquid in the reaction channel, multiple "snake"-shaped upper channels, multiple "satellite"-shaped middle channels, and multiple "snake"-shaped lower channels can be opened on the upper plate, middle plate, and lower plate in a matrix distribution (i.e., multi-column and multi-row distribution). Any two adjacent columns (or rows, which can be converted by rotating the entire reaction device 90°) of the longitudinal three-dimensional reaction channels are connected by a single-pass flow channel on the middle plate and a transverse connecting groove on the lower plate, ultimately forming an S-shaped combined three-dimensional reaction channel structure. (Taking a 3-column longitudinal three-dimensional reaction channel as an example: First, the upper connecting groove of the "snake" channel on the upper plate of the first column of reaction channels is connected to the liquid inlet channel; the central flow channel of the "satellite" through channel at the bottom of the first column of reaction channels is connected to the front end of the transverse connecting groove located below the first and second columns of reaction channels; the rear end of this transverse connecting groove is connected to the single-pass flow channel below the central flow channel of the "satellite" through channel at the bottom of the second column of reaction channels.) One end is connected to the other end of the single-pass flow channel, which is connected to the upper connecting groove of the "snake" channel at the bottom of the second row of reaction channels; then: the central flow channel of the "satellite" through channel at the top of the second row of reaction channels is connected to the front end of the transverse connecting groove located above the second and third rows of reaction channels, and the rear end of the transverse connecting groove is connected to one end of the single-pass flow channel above the central flow channel of the "satellite" through channel at the top of the third row of reaction channels, and the other end of the single-pass flow channel is connected to the upper connecting groove of the "snake" channel at the top of the third row of reaction channels; finally: the central flow channel of the "satellite" through channel at the bottom of the third row of reaction channels is connected to the liquid outlet channel independently opened at the bottom of the "snake" channel on the top plate of the third row of reaction channels.

[0025] In this utility model, it should be noted that the terms "first," "last," "front," and "rear" are distinguishing descriptive terms used for the convenience of describing the technical solution of this utility model. Unless otherwise specified, when multiple upper channels, middle channels, lower channels, single-pass flow channels, or transverse connecting grooves are arranged in a vertical column, the top end of the column is "front," the bottom end is "rear," the topmost channel, fluid, or connecting groove of the column is "first," and the bottommost channel, flow channel, or connecting groove of the column is "last." Similarly, when multiple upper channels, middle channels, lower channels, single-pass flow channels, or transverse connecting grooves are arranged in a horizontal row, the leftmost end of the row is "front," the rightmost end is "rear," the leftmost channel, fluid, or connecting groove of the row is "first," and the rightmost channel, flow channel, or connecting groove of the row is "last."

[0026] In this invention, the thickness of the upper plate is 1-500 mm, preferably 3-100 mm, and more preferably 5-50 mm. The thickness of the middle plate is 1-200 mm, preferably 3-80 mm, and more preferably 5-40 mm. The thickness of the lower plate is 1-500 mm, preferably 3-100 mm, and more preferably 5-50 mm. Both the inlet and outlet channels are circular through holes, and their diameters are independently 0.1-50 mm, preferably 0.3-20 mm, and more preferably 0.5-10 mm.

[0027] Compared with the prior art, the beneficial technical effects of this utility model are as follows: 1: The three-dimensional microfluidic reaction device of this invention is designed with an upper annular groove with a flow-diverting structure, a satellite-type central channel with a flow-collecting structure, and an upper annular groove with a flow-diverting structure. By stacking and connecting the three in space, a three-dimensional reaction channel with flow-diverting and secondary flow-collecting functions is obtained. Compared with the existing planar reaction channel, it significantly improves the mass and heat transfer efficiency of the reaction liquid, greatly increases the length of the reaction channel, and significantly improves the reaction quality and yield.

[0028] 2: The three-dimensional microfluidic reaction device of this utility model has a simple structure, is easy to operate, can meet the production conditions with higher standards, and has excellent socio-economic potential. Attached Figure Description

[0029] Figure 1 This is a three-dimensional structural diagram of the three-dimensional microfluidic reaction device of this utility model.

[0030] Figure 2 This is a side view of the three-dimensional microfluidic reaction device of this utility model.

[0031] Figure 3 This is a schematic diagram of the AA section structure.

[0032] Figure 4 This is a schematic diagram of the BB cross-section structure.

[0033] Figure 5 This is a schematic diagram of the CC section structure.

[0034] Figure 6 This is a schematic diagram showing the connection between the upper annular groove, the central flow channel, and the lower annular groove.

[0035] Figure 7 This is a schematic diagram showing the connection of multiple upper annular grooves, a central flow channel, and a lower annular groove.

[0036] Figure 8 This is a schematic diagram of the planar structure of an S-shaped combined reaction channel.

[0037] Figure 9 This is a schematic diagram of the three-dimensional structure of an S-shaped combined reaction channel.

[0038] Reference numerals: 1: Upper plate; 101: Upper annular groove; 1011: Upper C-shaped end groove; 1012: Upper spiral groove; 1013: Upper semi-circular end groove; 1014: Upper connecting circular groove; 102: Liquid inlet channel; 103: Upper fixing hole; 2: Middle plate; 201: Central flow channel; 2011: Central flow channel; 2012: Outer flow channel; 2013: Flow channel; 202: Single flow channel; 203: Central fixing hole; 3: Lower plate; 301: Lower annular groove; 3011: Lower C-shaped end groove; 3012: Lower spiral groove; 3013: Lower semi-circular end groove; 3014: Lower connecting circular groove; 302: Liquid outlet channel; 303: Lower fixing hole; 304: Transverse connecting groove. Detailed Implementation

[0039] The technical solution of this utility model is illustrated below. The scope of protection of this utility model includes, but is not limited to, the following embodiments.

[0040] A three-dimensional microfluidic reactor includes an upper plate 1, a middle plate 2, and a lower plate 3, which are stacked sequentially. An upper annular groove 101, not connected end-to-end, is formed on the surface of the upper plate 1 facing the middle plate 2. A lower annular groove 301, not connected end-to-end, is formed on the surface of the lower plate 3 facing the middle plate 2. A through-flow channel 201 is formed on the middle plate 2. The upper annular groove 101 is connected to the lower annular groove 301 through the through-flow channel 201. A liquid inlet channel 102, connected to the upper annular groove 101, is also provided through the upper plate 1. A liquid outlet channel 302, connected to the lower annular groove 301, is also provided through the lower plate 3.

[0041] Preferably, the upper annular groove 101 includes an upper C-shaped end groove 1011, an upper spiral groove 1012, and an upper semi-circular end groove 1013 connected in sequence. The upper semi-circular end groove 1013 is located in the C-shaped notch enclosed by the upper C-shaped end groove 1011. The liquid inlet channel 102 is connected to the upper spiral groove 1012.

[0042] Preferably, the upper annular groove 101 is rectangular, circular, or elliptical on the surface of the upper plate 1. Preferably, the depth of the upper annular groove 101 is 1 to 2 times the minimum width of the upper annular groove 101.

[0043] Preferably, the central flow channel 201 includes a central flow channel 2011 and multiple outer flow channels 2012. The multiple outer flow channels 2012 are distributed in a C-shape around the central flow channel 2011, and each outer flow channel 2012 is connected to the central flow channel 2011 via an independent flow channel 2013. When the upper plate 1 and the middle plate 2 coincide, the central flow channel 2011 is connected to the upper semi-circular end groove 1013, and the multiple outer flow channels 2012 are connected to the upper C-shaped end groove 1011.

[0044] Preferably, the thickness of the middle plate 2 is 1 to 3 times the minimum opening width of the central flow channel 201.

[0045] Preferably, the lower annular groove 301 includes a lower C-shaped end groove 3011, a lower loop groove 3012, and a lower semi-circular end groove 3013 connected in sequence. The lower semi-circular end groove 3013 is located in the C-shaped notch enclosed by the lower C-shaped end groove 3011. The liquid outlet channel 302 is connected to the lower loop groove 3012. When the lower plate 3 coincides with the middle plate 2, the lower semi-circular end groove 3013 is connected to the central flow channel 2011, and the lower C-shaped end groove 3011 is connected to multiple outer flow channels 2012.

[0046] Preferably, the lower annular groove 301 is rectangular, circular, or elliptical on the surface of the lower plate 3. Preferably, the depth of the lower annular groove 301 is 1 to 2 times the minimum width of the lower annular groove 301.

[0047] Preferably, the upper plate 1 has multiple upper annular grooves 101 arranged in a row and not interconnected. The middle plate 2 has multiple central flow channels 201 arranged in a row and not interconnected. The lower plate 3 has multiple lower annular grooves 301 arranged in a row and not interconnected, and the liquid outlet channel 302 is independently opened on the lower side of the row of lower annular grooves 301. When the upper plate 1, middle plate 2, and lower plate 3 overlap, the liquid inlet channel 102 is connected to the upper groove 1012 of the first upper annular groove 101, the C-shaped end groove 1011 of the first upper annular groove 101 is connected to the multiple outer channels 2012 of the first central flow channel 201, the upper semi-circular end groove 1013 of the first upper annular groove 101 is connected to the lower groove 3012 of the first lower annular groove 301 through the central channel 2011 of the first central flow channel 201, the lower C-shaped end groove 3011 of the first lower annular groove 301 is connected to the multiple outer channels 2012 of the second central flow channel 201, and the lower semi-circular end groove 3013 of the first lower annular groove 301 is connected to the upper groove 1012 of the second upper annular groove 101 through the central channel 2011 of the second central flow channel 201. The C-shaped end groove 1011 of the second upper annular groove 101 is connected to the multiple outer channels 2012 of the third central channel 201. The upper semi-circular end groove 1013 of the second upper annular groove 101 is connected to the lower circular groove 3012 of the second lower annular groove 301 through the central channel 2011 of the third central channel 201. And so on. The upper circular groove 1012 of the last upper annular groove 101 is connected to the lower semi-circular end groove 3013 of the last lower annular groove 301 through the central channel 2011 of the penultimate central channel 201. The C-shaped end groove 1011 of the last upper annular groove 101 is connected to the multiple outer channels 2012 of the last central channel 201. The upper semi-circular end groove 1013 of the last upper annular groove 101 is connected to the liquid outlet channel 302 through the central channel 2011 of the last central channel 201. Multiple upper annular grooves 101, multiple central flow channels 201, and multiple lower annular grooves 301 arranged in a row are interconnected to form a column-oriented combined reaction channel.

[0048] Preferably, multiple rows of upper annular grooves 101 are formed on the upper plate 1, with adjacent rows of upper annular grooves 101 being horizontally symmetrical. Multiple rows of staggered central flow channels 201 are formed on the middle plate 2. In addition to the first row of central flow channels 201, a single flow channel 202 penetrating the middle plate 2 is also provided at the staggered notch of each row of central flow channels 201. Multiple rows of lower annular grooves 301 are formed on the lower plate 3, with a row of transverse connecting grooves 304 provided on the upper and lower sides of the multiple rows of lower annular grooves 301 respectively. The liquid outlet channel 302 is independently formed on the lower side of the last row of lower annular grooves 301. When the upper plate 1, middle plate 2, and lower plate 3 overlap, the multiple rows of upper annular grooves 101, the multiple rows of central flow channels 201, and the multiple rows of lower annular grooves 301 respectively constitute multiple column-oriented combined reaction channels. The liquid inlet channel 102 is connected to the upper groove 1012 of the first upper annular groove 101 of the first column of oriented combined reaction channels. The center channel 2011 of the last central channel 201 of the first column of oriented combined reaction channels is connected to the single channel 202 located below the second column of oriented combined reaction channels via the first transverse connecting groove 304. The single channel 202 is connected to the upper groove 1012 of the last upper annular groove 101 of the second column of oriented combined reaction channels. The center channel 2011 of the first central channel 201 of the second column of oriented combined reaction channels is connected to the single channel 202 located above the third column of oriented combined reaction channels via the first transverse connecting groove 304. The single channel 202 is connected to the upper groove 1012 of the first upper annular groove 101 of the third column of oriented combined reaction channels. Similarly, the upper ring groove 1012 of the first upper annular groove 101 of the last column of oriented combined reaction channels is connected to the last transverse connecting groove 304 in the upper row through a single-pass flow channel 202 located on the upper side of the column of oriented combined reaction channels. The central flow channel 2011 of the last central flow channel 201 of the last column of oriented combined reaction channels is connected to the liquid outlet channel 302. That is, multiple oriented combined reaction channels are connected in series through multiple transverse connecting grooves 304 and multiple single-pass flow channels 202 to form an S-shaped combined reaction channel.

[0049] Preferably, an upper connecting circular groove 1014 is also provided on the upper spiral groove 1012. The upper spiral groove 1012 is connected to the liquid inlet channel 102, the central flow channel 201, or the transverse connecting groove 304 through the upper connecting circular groove 1014.

[0050] Preferably, a lower connecting circular groove 3014 is also provided on the lower spiral groove 3012. The lower spiral groove 3012 is connected to the central flow channel 201 through the lower connecting circular groove 3014.

[0051] Preferably, the upper connecting circular groove 1014 is disposed on the upper loop groove 1012 opposite to the upper semi-circular end groove 1013. The lower connecting circular groove 3014 is disposed on the lower loop groove 3012 opposite to the lower semi-circular end groove 3013.

[0052] Preferably, upper fixing holes 103, middle fixing holes 203, and lower fixing holes 303 are respectively provided on the upper plate 1, middle plate 2, and lower plate 3. Bolts are passed through the upper fixing holes 103, middle fixing holes 203, and lower fixing holes 303 in sequence and then tightened to achieve the stacked combination fixation of the upper plate 1, middle plate 2, and lower plate 3. Example 1

[0053] like Figure 1-9 As shown, a three-dimensional microfluidic reactor includes an upper plate 1, a middle plate 2, and a lower plate 3, which are stacked sequentially. An upper annular groove 101, not connected end-to-end, is formed on the surface of the upper plate 1 facing the middle plate 2. A lower annular groove 301, not connected end-to-end, is formed on the surface of the lower plate 3 facing the middle plate 2. A through-flow channel 201 is formed on the middle plate 2. The upper annular groove 101 is connected to the lower annular groove 301 through the through-flow channel 201. A liquid inlet channel 102, connected to the upper annular groove 101, is also provided through the upper plate 1. A liquid outlet channel 302, connected to the lower annular groove 301, is also provided through the lower plate 3. Example 2

[0054] The embodiment 1 is repeated, except that the upper annular groove 101 includes an upper C-shaped end groove 1011, an upper spiral groove 1012, and an upper semi-circular end groove 1013 connected in sequence. The upper semi-circular end groove 1013 is located in the C-shaped notch enclosed by the upper C-shaped end groove 1011. The liquid inlet channel 102 is connected to the upper spiral groove 1012. Example 3

[0055] Repeat Example 2, except that the upper annular groove 101 is circular on the surface of the upper plate 1. Example 4

[0056] Repeat Example 2, except that the upper annular groove 101 is rectangular on the surface of the upper plate 1. Example 5

[0057] Repeat Example 4, except that the opening depth of the upper annular groove 101 is 1.5 times the minimum opening width of the upper annular groove 101. Example 6

[0058] Repeat Example 4, except that the opening depth of the upper annular groove 101 is twice the minimum opening width of the upper annular groove 101. Example 7

[0059] The embodiment 6 is repeated, except that the central flow channel 201 includes a central flow channel 2011 and multiple outer flow channels 2012. The multiple outer flow channels 2012 are distributed in a C-shape around the central flow channel 2011, and each outer flow channel 2012 is connected to the central flow channel 2011 through an independent flow channel 2013. When the upper plate 1 and the middle plate 2 coincide, the central flow channel 2011 is connected to the upper semi-circular end groove 1013, and the multiple outer flow channels 2012 are connected to the upper C-shaped end groove 1011. Example 8

[0060] Repeat Example 7, except that the thickness of the middle plate 2 is 1.5 times the minimum opening width of the central flow channel 201. Example 9

[0061] Repeat Example 7, except that the thickness of the middle plate 2 is twice the minimum opening width of the central flow channel 201. Example 10

[0062] The embodiment 9 is repeated, except that the lower annular groove 301 includes a lower C-shaped end groove 3011, a lower loop groove 3012, and a lower semi-circular end groove 3013 connected in sequence. The lower semi-circular end groove 3013 is located in the C-shaped notch enclosed by the lower C-shaped end groove 3011. The liquid outlet channel 302 is connected to the lower loop groove 3012. When the lower plate 3 coincides with the middle plate 2, the lower semi-circular end groove 3013 is connected to the central flow channel 2011, and the lower C-shaped end groove 3011 is connected to multiple outer flow channels 2012. Example 11

[0063] The same embodiment 10 is repeated, except that the lower annular groove 301 is circular on the surface of the lower plate 3. Example 12

[0064] The same embodiment 10 is repeated, except that the lower annular groove 301 is rectangular on the surface of the lower plate 3. Example 13

[0065] Example 12 is repeated, except that the opening depth of the lower annular groove 301 is 1.5 times the minimum opening width of the lower annular groove 301. Example 14

[0066] The embodiment 12 is repeated, except that the opening depth of the lower annular groove 301 is twice the minimum opening width of the lower annular groove 301. Example 15

[0067] The embodiment 14 is repeated, except that multiple upper annular grooves 101 arranged in a row and not interconnected are formed on the upper plate 1. Multiple central flow channels 201 arranged in a row and not interconnected are formed on the middle plate 2. Multiple lower annular grooves 301 arranged in a row and not interconnected are formed on the lower plate 3, and the liquid outlet channel 302 is independently formed on the lower side of the row of lower annular grooves 301. When the upper plate 1, middle plate 2, and lower plate 3 overlap, the liquid inlet channel 102 is connected to the upper groove 1012 of the first upper annular groove 101, the C-shaped end groove 1011 of the first upper annular groove 101 is connected to the multiple outer channels 2012 of the first central flow channel 201, the upper semi-circular end groove 1013 of the first upper annular groove 101 is connected to the lower groove 3012 of the first lower annular groove 301 through the central channel 2011 of the first central flow channel 201, the lower C-shaped end groove 3011 of the first lower annular groove 301 is connected to the multiple outer channels 2012 of the second central flow channel 201, and the lower semi-circular end groove 3013 of the first lower annular groove 301 is connected to the upper groove 1012 of the second upper annular groove 101 through the central channel 2011 of the second central flow channel 201. The C-shaped end groove 1011 of the second upper annular groove 101 is connected to the multiple outer channels 2012 of the third central channel 201. The upper semi-circular end groove 1013 of the second upper annular groove 101 is connected to the lower circular groove 3012 of the second lower annular groove 301 through the central channel 2011 of the third central channel 201. And so on. The upper circular groove 1012 of the last upper annular groove 101 is connected to the lower semi-circular end groove 3013 of the last lower annular groove 301 through the central channel 2011 of the penultimate central channel 201. The C-shaped end groove 1011 of the last upper annular groove 101 is connected to the multiple outer channels 2012 of the last central channel 201. The upper semi-circular end groove 1013 of the last upper annular groove 101 is connected to the liquid outlet channel 302 through the central channel 2011 of the last central channel 201. Multiple upper annular grooves 101, multiple central flow channels 201, and multiple lower annular grooves 301 arranged in a row are interconnected to form a column-oriented combined reaction channel. Example 16

[0068] The embodiment 15 is repeated, except that multiple rows of upper annular grooves 101 are formed on the upper plate 1, with adjacent rows of upper annular grooves 101 being horizontally symmetrical. Multiple rows of staggered central flow channels 201 are formed on the middle plate 2. In addition to the first row of central flow channels 201, a single flow channel 202 penetrating the middle plate 2 is also provided at the staggered notch of each row of central flow channels 201. Multiple rows of lower annular grooves 301 are formed on the lower plate 3, and a row of transverse connecting grooves 304 is provided on the upper and lower sides of the multiple rows of lower annular grooves 301 respectively. The liquid outlet channel 302 is independently formed on the lower side of the last row of lower annular grooves 301. When the upper plate 1, middle plate 2, and lower plate 3 overlap, the multiple rows of upper annular grooves 101, the multiple rows of central flow channels 201, and the multiple rows of lower annular grooves 301 respectively constitute multiple column-oriented combined reaction channels. The liquid inlet channel 102 is connected to the upper groove 1012 of the first upper annular groove 101 of the first column of oriented combined reaction channels. The center channel 2011 of the last central channel 201 of the first column of oriented combined reaction channels is connected to the single channel 202 located below the second column of oriented combined reaction channels via the first transverse connecting groove 304. The single channel 202 is connected to the upper groove 1012 of the last upper annular groove 101 of the second column of oriented combined reaction channels. The center channel 2011 of the first central channel 201 of the second column of oriented combined reaction channels is connected to the single channel 202 located above the third column of oriented combined reaction channels via the first transverse connecting groove 304. The single channel 202 is connected to the upper groove 1012 of the first upper annular groove 101 of the third column of oriented combined reaction channels. Similarly, the upper ring groove 1012 of the first upper annular groove 101 of the last column of oriented combined reaction channels is connected to the last transverse connecting groove 304 in the upper row through a single-pass flow channel 202 located on the upper side of the column of oriented combined reaction channels. The central flow channel 2011 of the last central flow channel 201 of the last column of oriented combined reaction channels is connected to the liquid outlet channel 302. That is, multiple oriented combined reaction channels are connected in series through multiple transverse connecting grooves 304 and multiple single-pass flow channels 202 to form an S-shaped combined reaction channel. Example 17

[0069] The same embodiment 16 is repeated, except that an upper connecting circular groove 1014 is also provided on the upper spiral groove 1012. The upper spiral groove 1012 is connected to the liquid inlet channel 102, the central flow channel 201, or the transverse connecting groove 304 through the upper connecting circular groove 1014. Example 18

[0070] The same embodiment 17 is repeated, except that a lower connecting circular groove 3014 is also provided on the lower loop groove 3012. The lower loop groove 3012 is connected to the central flow channel 201 through the lower connecting circular groove 3014. Example 19

[0071] Example 18 is repeated, except that the upper connecting circular groove 1014 is disposed on the upper loop groove 1012 opposite to the upper semi-circular end groove 1013. The lower connecting circular groove 3014 is disposed on the lower loop groove 3012 opposite to the lower semi-circular end groove 3013. Example 20

[0072] The same method as embodiment 19 is used, except that upper fixing holes 103, middle fixing holes 203, and lower fixing holes 303 are respectively provided on the upper plate 1, middle plate 2, and lower plate 3. Bolts are passed through the upper fixing holes 103, middle fixing holes 203, and lower fixing holes 303 in sequence and then tightened to achieve the stacked combination fixation of the upper plate 1, middle plate 2, and lower plate 3.

[0073] When the reaction solution is reacted using the three-dimensional microfluidic reaction device of this invention, the upper plate 1, the middle plate 2, and the lower plate 3 are first stacked together in sequence to form a structure as shown in the figure. Figure 1 The combined structure shown. At this time, the upper annular groove 101 of the upper plate 1, the central flow channel 201 of the middle plate 2, and the lower annular groove 301 of the lower plate 3 are arranged sequentially... Figure 6 The method shown is to connect them in series sequentially to form a similar structure. Figure 7 The diagram shows multiple column-oriented reaction channels, and adjacent column-oriented reaction channels ultimately form lines such as 8 through the series connection of the single-pass flow channel 202 and the transverse connecting groove 304. Figure 9The S-shaped combined reaction channel shown has an inlet channel 102 connected to the upper ring groove 1012 of the upper annular groove 101 at the top of the first row of reaction channels (connection position is the upper connecting circular groove 1014); the outlet channel 302 is connected to the central flow channel 2011 of the central flow channel 201 at the bottom of the last row of reaction channels. The reaction liquid is input from the inlet channel 102, and is diverted at the upper connecting circular groove 1014 of the first upper annular groove 101, flowing through the flow channels on the left and right sides of the upper ring groove 1012 to the upper C-shaped end groove 1011 and the upper semi-circular end groove 1013 respectively. The reaction liquid in the upper C-shaped end groove 1011 flows into the multiple outer flow channels 2012 of the first central flow channel 201, and the reaction liquid in the upper semi-circular end groove 1013 flows into the first central flow channel 201. The central flow channel 2011 facilitates the first collection of the reaction liquid. The collected reaction liquid then enters the lower connecting circular groove 3014 of the first lower annular groove 301 and is diverted again. The reaction liquid here flows through the flow channels on the left and right sides of the lower U-shaped groove 3012 to the lower C-shaped end groove 3011 and the lower semi-circular end groove 3013, respectively. The reaction liquid in the lower C-shaped end groove 3011 flows into the multiple outer flow channels 2012 of the second central flow channel 201, and the reaction liquid in the lower semi-circular end groove 3013 flows into the central flow channel 2011 of the second central flow channel 201, thus facilitating the second collection of the reaction liquid. The reaction liquid after the second collection enters the upper connecting circular groove 1014 of the second upper annular groove 101 and continues to be diverted. This process continues until the reaction liquid flows through the entire three-dimensional reaction channel. It should be noted that when the reaction liquid flows to the lowest or highest end of each reaction channel, it is transferred to the next reaction channel via a transversely arranged transverse connecting groove 304, that is, the reaction liquid is transported to the reaction liquid inlet at the lowest or highest end of the next reaction channel (generally the upper connecting circular groove 1014 of the upper annular groove 101 at the lowest or highest end of that reaction channel). The above process is repeated until the reaction is completed.

Claims

1. A three-dimensional microfluidic reaction device, characterized in that: The three-dimensional microfluidic reaction device includes an upper plate (1), a middle plate (2), and a lower plate (3), which are stacked together in sequence. An upper annular groove (101) with no connection between the beginning and end is provided on the side of the upper plate (1) facing the middle plate (2). A lower annular groove (301) with no connection between the beginning and end is provided on the side of the lower plate (3) facing the middle plate (2). A through-type central flow channel (201) is provided on the middle plate (2). The upper annular groove (101) is connected to the lower annular groove (301) through the central flow channel (201). An inlet channel (102) connected to the upper annular groove (101) is also provided through the upper plate (1). An outlet channel (302) connected to the lower annular groove (301) is also provided through the lower plate (3).

2. The three-dimensional microfluidic reaction device according to claim 1, characterized in that: The upper annular groove (101) includes an upper C-shaped end groove (1011), an upper spiral groove (1012), and an upper semi-circular end groove (1013) connected in sequence; the upper semi-circular end groove (1013) is located in the C-shaped notch enclosed by the upper C-shaped end groove (1011); the liquid inlet channel (102) is connected to the upper spiral groove (1012).

3. The three-dimensional microfluidic reaction device according to claim 2, characterized in that: The upper annular groove (101) is rectangular, circular or elliptical on the surface of the upper plate (1).

4. The three-dimensional microfluidic reaction device according to claim 3, characterized in that: The opening depth of the upper annular groove (101) is 1 to 2 times the minimum opening width of the upper annular groove (101).

5. The three-dimensional microfluidic reaction device according to claim 2, characterized in that: The central flow channel (201) includes a central flow channel (2011) and multiple outer flow channels (2012); the multiple outer flow channels (2012) are distributed in a C-shape around the central flow channel (2011) in the circumferential direction, and each outer flow channel (2012) is connected to the central flow channel (2011) through an independent runoff channel (2013); when the upper plate (1) and the middle plate (2) coincide, the central flow channel (2011) is connected to the upper semi-circular end groove (1013), and the multiple outer flow channels (2012) are connected to the upper C-shaped end groove (1011).

6. The three-dimensional microfluidic reaction device according to claim 5, characterized in that: The thickness of the middle plate (2) is 1 to 3 times the minimum opening width of the central flow channel (201).

7. The three-dimensional microfluidic reaction device according to claim 5, characterized in that: The lower annular groove (301) includes a lower C-shaped end groove (3011), a lower circular groove (3012), and a lower semi-circular end groove (3013) connected in sequence; the lower semi-circular end groove (3013) is located in the C-shaped notch enclosed by the lower C-shaped end groove (3011); the liquid outlet channel (302) is connected to the lower circular groove (3012); when the lower plate (3) coincides with the middle plate (2), the lower semi-circular end groove (3013) is connected to the central flow channel (2011), and the lower C-shaped end groove (3011) is connected to multiple outer flow channels (2012).

8. The three-dimensional microfluidic reaction device according to claim 7, characterized in that: The lower annular groove (301) is rectangular, circular or elliptical on the surface of the lower plate (3).

9. The three-dimensional microfluidic reaction device according to claim 8, characterized in that: The depth of the lower annular groove (301) is 1 to 2 times the minimum opening width of the lower annular groove (301).

10. The three-dimensional microfluidic reaction device according to claim 7, characterized in that: Multiple upper annular grooves (101) are arranged in a row and are not interconnected on the upper plate (1); multiple central flow channels (201) are arranged in a row and are not interconnected on the middle plate (2); multiple lower annular grooves (301) are arranged in a row and are not interconnected on the lower plate (3), and the liquid outlet channel (302) is independently opened on the lower side of the row of lower annular grooves (301); when the upper plate (1), the middle plate (2) and the lower plate (3) overlap, the liquid inlet channel (102) is connected to the upper groove (1012) of the first upper annular groove (101), and the C-shaped end groove (1011) of the first upper annular groove (101) is connected to the first The multiple outer channels (2012) of the central flow channel (201) are connected. The upper semi-circular end groove (1013) of the first upper annular groove (101) is connected to the lower circular groove (3012) of the first lower annular groove (301) through the central flow channel (2011) of the first central flow channel (201). The lower C-shaped end groove (3011) of the first lower annular groove (301) is connected to the multiple outer channels (2012) of the second central flow channel (201). The lower semi-circular end groove (3013) of the first lower annular groove (301) is connected to the second central flow channel (201) through the central flow channel (2011) of the second central flow channel (201). The upper annular groove (1011) is connected to the upper circular groove (1012); the C-shaped end groove (1011) of the second upper annular groove (101) is connected to the multiple outer channels (2012) of the third central channel (201); the upper semi-circular end groove (1013) of the second upper annular groove (101) is connected to the lower circular groove (3012) of the second lower annular groove (301) through the central channel (2011) of the third central channel (201), and so on. The upper circular groove (1012) of the last upper annular groove (101) is connected to the central channel (2011) of the second-to-last central channel (201) through the central channel (2011) of the second-to-last central channel (201). The lower semi-circular end groove (3013) of the last lower annular groove (301) is connected, the C-shaped end groove (1011) of the last upper annular groove (101) is connected to the multiple outer channels (2012) of the last central channel (201), and the upper semi-circular end groove (1013) of the last upper annular groove (101) is connected to the liquid outlet channel (302) through the central channel (2011) of the last central channel (201); that is, the multiple upper annular grooves (101), multiple central channels (201), and multiple lower annular grooves (301) arranged in a row are interconnected to form a column-oriented combined reaction channel.

11. The three-dimensional microfluidic reaction device according to claim 10, characterized in that: Multiple rows of upper annular grooves (101) are formed on the upper plate (1), with adjacent rows of upper annular grooves (101) being horizontally symmetrical; multiple rows of staggered central flow channels (201) are formed on the middle plate (2); in addition to the first row of central flow channels (201), a single flow channel (202) penetrating the middle plate (2) is also provided at the staggered notch of each row of central flow channels (201); multiple rows of lower annular grooves (301) are formed on the lower plate (3), and a row of transverse connecting grooves (304) is provided on the upper and lower sides of the multiple rows of lower annular grooves (301), and the liquid outlet channel (302) is independently formed on the last row. The lower side of the annular groove (301); when the upper plate (1), middle plate (2) and lower plate (3) overlap, the multiple rows of upper annular grooves (101), multiple rows of central flow channels (201) and multiple rows of lower annular grooves (301) respectively constitute multiple column-oriented combined reaction channels; wherein, the liquid inlet channel (102) is connected to the upper groove (1012) of the first upper annular groove (101) of the first column-oriented combined reaction channel, and the central flow channel (2011) of the last central flow channel (201) of the first column-oriented combined reaction channel is connected to the second column through the first transverse connecting groove (304). The single-pass flow channel (202) on the lower side of the column-oriented combined reaction channel is connected to the upper groove (1012) of the last upper annular groove (101) of the second column-oriented combined reaction channel; the central flow channel (2011) of the first central flow channel (201) of the second column-oriented combined reaction channel is connected to the single-pass flow channel (202) located on the upper side of the third column-oriented combined reaction channel through the first transverse connecting groove (304) in the upper row, and the single-pass flow channel (202) is connected to the upper groove (1012) of the first upper annular groove (101) of the third column-oriented combined reaction channel. 012) are connected; and so on, the upper groove (1012) of the first upper annular groove (101) of the last column of column-oriented combined reaction channels is connected to the last transverse connecting groove (304) of the upper row through the single-pass flow channel (202) located on the upper side of the column of column-oriented combined reaction channels; the center flow channel (2011) of the last central flow channel (201) of the last column of column-oriented combined reaction channels is connected to the liquid outlet channel (302); that is, multiple column-oriented combined reaction channels are connected in series through multiple transverse connecting grooves (304) and multiple single-pass flow channels (202) to form an S-shaped combined reaction channel.

12. The three-dimensional microfluidic reaction device according to claim 11, characterized in that: An upper connecting circular groove (1014) is also provided on the upper circular groove (1012); the upper circular groove (1012) is connected to the liquid inlet channel (102) or the central flow channel (201) or the transverse connecting groove (304) through the upper connecting circular groove (1014); and / or A lower connecting circular groove (3014) is also provided on the lower circular groove (3012); the lower circular groove (3012) is connected to the central flow channel (201) through the lower connecting circular groove (3014).

13. The three-dimensional microfluidic reaction device according to claim 12, characterized in that: The upper connecting circular groove (1014) is set on the upper spiral groove (1012) opposite to the upper semi-circular end groove (1013); the lower connecting circular groove (3014) is set on the lower spiral groove (3012) opposite to the lower semi-circular end groove (3013).

14. The three-dimensional microfluidic reaction device according to any one of claims 1-13, characterized in that: Upper fixing hole (103), middle fixing hole (203) and lower fixing hole (303) are respectively provided on the upper plate (1), middle plate (2) and lower plate (3); after passing the bolt through the upper fixing hole (103), middle fixing hole (203) and lower fixing hole (303) in sequence, tighten it to achieve the stacked combination fixation of the upper plate (1), middle plate (2) and lower plate (3).

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