A constant temperature tank for liquid raw material

Abstract

The utility model relates to a technical field of chemical equipment, concretely relates to a constant temperature material tank of raw liquid medicine, the utility model provides a constant temperature material tank of raw liquid medicine, including jar body, the jacket that sets up in the jar body outside, with the temperature control system that jacket intercommunication and drive motor, drive motor's output shaft reaches into jar body inside and is connected with a root center stirring axle, at least a group frame type wall scraping stirrer is arranged on the center stirring axle, the jar body inside still perpendicularly arranged with the anti -shaking cylinder that is parallel with center stirring axle, the anti -shaking cylinder inside rotatory joint has a high -speed dispersion axle that is driven by independent motor, at least one dispersion disc is arranged to the lower extreme of high -speed dispersion axle, the bottom of jar body is set to the conical bottom that is convex to the center, is equipped with the discharge gate with valve in the lowest place of conical bottom, and is equipped with a plurality of shower nozzles in the top in jar body.

Description

Technical Field

[0001] This utility model relates to the field of chemical equipment technology, specifically to a constant temperature dispensing tank for raw material liquid. Background Technology

[0002] Active pharmaceutical ingredients (APIs) are the basic raw materials used in the pharmaceutical, bioengineering, or fine chemical industries to prepare final formulations (such as tablets, injections, and creams). They are typically liquid or semi-liquid systems containing active ingredients. The homogeneity of the API determines the consistency of the active ingredient content in the formulation, temperature stability affects the bioavailability of the active ingredient, and cleanliness relates to product safety. Therefore, APIs require integrated processing using specialized equipment to achieve "uniform mixing + precise temperature control + residue-free cleaning."

[0003] Existing constant-temperature mixing tanks for active pharmaceutical ingredients mostly adopt the traditional structure of "single stirring paddle + jacketed temperature control," which has the following prominent problems: First, the stirring range is limited, and high-viscosity materials are prone to forming "dead zones" on the tank wall, resulting in uneven mixing and material residue; Second, there is a lack of targeted dispersion function, and agglomerated particles (such as crystals and undissolved excipients) in the material cannot be effectively dispersed, affecting the quality of the mixing; Third, the tank is difficult to clean, and material residues adhering to the inner wall are prone to microbial growth or cross-contamination, making it difficult to meet the cleanliness requirements of the new version of GMP (Good Manufacturing Practice for Pharmaceuticals); Fourth, the temperature control response is lagging, and it cannot match the changes in the specific heat capacity of the material in real time, resulting in local overheating or insufficient cooling, which damages the stability of the active ingredients. Utility Model Content

[0004] The purpose of this invention is to provide a constant-temperature mixing tank for raw material liquids that provides uniform mixing, efficient dispersion, precise temperature control, and easy cleaning, thereby solving problems such as insufficient mixing, large temperature fluctuations, and cleaning residues in existing equipment.

[0005] The technical solution provided by this utility model is a constant temperature dispensing tank for raw material liquid, including a tank body, a jacket disposed outside the tank body, a temperature control system connected to the jacket, and a drive motor. The output shaft of the drive motor extends into the tank body and is connected to a central stirring shaft. At least one set of frame-type wall scraping agitators is disposed on the central stirring shaft.

[0006] Inside the tank, there is also a vertically installed anti-shaking cylinder parallel to the central stirring shaft. Inside the anti-shaking cylinder, there is a rotatably connected high-speed dispersing shaft driven by an independent motor. At least one dispersing disc is installed at the lower end of the high-speed dispersing shaft.

[0007] The bottom of the tank is a conical bottom that bulges towards the center. A discharge port with a valve is provided at the lowest point of the conical bottom, and multiple spray heads are provided at the top of the tank.

[0008] As a preferred technical solution of this utility model, the outline of the frame-type wall scraper is adapted to the shape of the inner wall of the tank, and there are two frame-type wall scrapers symmetrically arranged. The edges of the frame-type wall scraper are detachably provided with flexible scrapers that slide against the inner wall of the tank.

[0009] As a preferred technical solution of this utility model, the flexible scraper has a U-shaped structure, with both ends of the U-shaped structure fitting against the inner wall of the tank, and the middle part being fixedly connected to the frame-type scraper agitator by bolts.

[0010] As a preferred technical solution of this utility model, the anti-vibration cylinder is located between the frame-type scraper agitator and the central stirring shaft, and the dispersion plate connected to the bottom of the anti-vibration cylinder is located in the gap above the frame-type scraper agitator. The top of the anti-vibration cylinder is connected to the top of the tank by reinforcing ribs to enhance its firmness, and the interior of the anti-vibration cylinder is rotatably connected to the high-speed dispersion shaft by bearings.

[0011] As a preferred embodiment of this utility model, the temperature control system includes a spiral heat-conducting pipe disposed inside the jacket and multiple temperature sensors disposed at different heights inside the tank, wherein the temperature sensors are embedded in the side wall of the tank.

[0012] As a preferred technical solution of this utility model, the spray head is arranged circumferentially around the central stirring shaft, and the spray head is arranged in two staggered layers, wherein the inner layer of the spray head faces the middle of the conical bottom of the tank, and the outer layer of the spray head faces the inner wall of the tank. The spray head is connected to a high-pressure cleaning pump located outside the tank through a branch pipe, and a control valve is provided on the branch pipe.

[0013] As a preferred technical solution of this utility model, the top of the tank is provided with a feeding port and a cleaning port. The feeding port is located on one side of the anti-shaking cylinder and is located inside the tank facing the dispersing disc at the bottom of the anti-shaking cylinder.

[0014] The advantages of this utility model compared with the prior art are as follows:

[0015] 1. Residue-proof stirring design: The flexible scraper of the frame-type wall-scraping agitator can simultaneously scrape off the material on the tank wall, avoiding residue in the "dead zone"; the combination of U-shaped structure and bolt fixing ensures the scraping effect without damaging the inner wall, and the scraper can be quickly replaced to adapt to materials of different viscosities.

[0016] 2. Grading and Dispersion Mechanism: The central mixer, combined with the frame-type scraper mixer, achieves macroscopic mixing, while the high-speed dispersion disc inside the anti-vibration cylinder microscopically breaks up agglomerated particles, solving the problem of "not mixing finely" in traditional equipment.

[0017] 3. Precise temperature control system: The jacketed spiral heat pipe increases the heat exchange area, and the multi-position temperature sensor provides real-time feedback on the material temperature, which is linked to adjust the flow rate of the heat transfer medium to achieve a temperature accuracy within ±1℃, ensuring the stability of the active ingredients.

[0018] 4. Rapid and thorough cleaning: Double-layered staggered spray heads cover the tank walls, bottom, and agitator components, and high-pressure water flow can wash corners that are difficult to reach with traditional equipment; wastewater is discharged from the conical bottom outlet, resulting in high cleaning efficiency and no residue.

[0019] 5. Convenient discharge structure: The conical bottom design concentrates the material at the discharge port, and with the sanitary valve, it avoids "bridging" or residue, meeting the discharge requirements of continuous production. Attached Figure Description

[0020] Figure 1 This is a structural diagram of a constant-temperature dispensing tank for a raw material liquid according to the present invention.

[0021] Figure 2 This utility model discloses a three-dimensional cross-sectional structure of a constant-temperature dispensing tank for a raw material liquid. Figure 1 .

[0022] Figure 3 This utility model discloses a three-dimensional cross-sectional structure of a constant-temperature dispensing tank for a raw material liquid. Figure 2 .

[0023] Figure 4 This is a structural diagram of the central stirring shaft and frame-type scraper agitator of a constant-temperature dissolving tank for raw pharmaceutical liquid according to this utility model.

[0024] As shown in the figure:

[0025] 1. Tank body; 2. Jacket; 3. Drive motor; 4. Central stirring shaft; 5. Frame-type scraper agitator; 6. Anti-vibration cylinder; 7. Independent motor; 8. High-speed dispersion shaft; 9. Dispersion disc; 10. Conical bottom; 11. Discharge port; 12. Spray head; 13. Flexible scraper; 14. Spiral heat conduction pipe; 15. Temperature sensor; 16. Feed port; 17. Cleaning port. Detailed Implementation

[0026] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0027] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installed," "equipped with," and "connected," etc., should be interpreted broadly. For example, "connected" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be a connection within two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0028] Example 1:

[0029] As per the instruction manual Figure 1-4 As shown, this utility model provides a constant-temperature mixing tank for raw pharmaceutical materials, comprising a tank body 1, a jacket 2 disposed outside the tank body 1, a temperature control system connected to the jacket 2, and a drive motor 3; wherein the tank body 1 is made of 316L stainless steel (corrosion resistant, meeting GMP requirements), and is a vertical cylindrical container with a height-to-diameter ratio of approximately 2:1. The top has two openings: a feeding port 16 located on one side of the anti-vibration cylinder 6, facing the downward-facing dispersion disc 9, facilitating direct material falling into the mixing core area; and a cleaning port 17 for equipment maintenance or manual cleaning. The bottom is a conical bottom 10 with a 75° cone angle, at which a DN50 sanitary ball valve is installed as the discharge port 11. The valve is welded and sealed to the tank body 1 to prevent leakage.

[0030] This embodiment features a central stirring unit: the drive motor 3 is a variable frequency motor (7.5kW power, 50-200rpm speed), and its output shaft is connected to the central stirring shaft 4 (material 316L) via a coupling. A set of symmetrical frame-type wall-scraping agitators 5 are mounted on the shaft. The frame-type wall-scraping agitators 5 have stainless steel frames and are fixedly connected to the central stirring shaft 4 via multiple connecting plates, enabling stirring while driving the wall. Flexible scrapers 13 (5mm thick, food-grade silicone) are fixed to the edges. The flexible scrapers 13 have a U-shaped structure and are fixed to the frame-type wall-scraping agitators 5 in the middle with bolts, allowing them to slide along the tank wall to stir and scrape away residue.

[0031] This embodiment features a dispersion unit: a DN200 stainless steel cylinder 6, fixed to one side of the top of the tank 1, with the top connected to the tank top by four ∠50×5 angle steel reinforcing ribs. Inside the cylinder, a high-speed dispersion shaft 8 (material 316L) is installed via a deep groove ball bearing. The shaft is driven by an independent motor 7 (power 2.2kW, speed 1500rpm) connected by a coupling. A serrated dispersion disc 9 (diameter 150mm, polytetrafluoroethylene material) is installed at the lower end, positioned 100mm above the frame agitator, achieving a graded treatment of "mixing first and then dispersing".

[0032] In this embodiment, the jacket 2 is wrapped around the outside of the tank body 1 (100mm thick), and a spiral heat-conducting pipe 14 (φ25mm, copper-nickel alloy material) is coiled inside. The inlet of the heat-conducting pipe is connected to a steam / hot water source, and the outlet is connected to a steam trap / chiller. Three PT100 thermal resistors (accuracy ±0.1℃) are evenly embedded along the axial direction on the side wall of the tank body 1, located at 1 / 6, 1 / 2, and 5 / 6 of the liquid level, respectively. The signals are transmitted to an external PLC controller, which adjusts the steam / cold water flow of the heat-conducting pipe to maintain the material temperature within the set value ±1℃.

[0033] In this embodiment, 12 spray heads 12 (DN15, fan-shaped nozzles, 120° coverage angle) are installed on the top of the tank 1: 4 inner spray heads 12 face the center of the conical bottom 10, and 8 outer spray heads 12 face the tank wall. The spray heads 12 are connected to an external high-pressure cleaning pump (pressure 0.4MPa, flow rate 1m³ / h) via DN25 branch pipes. 3 / h), the branch pipe is equipped with an electromagnetic control valve, which can independently adjust the flow rate of each spray head 12. During cleaning, the high-pressure water jet impacts the tank wall, agitator and bottom residue, and the wastewater is discharged from the discharge port 11.

[0034] Working principle

[0035] 1. Feeding: The raw material liquid is injected into the tank 1 through the top feeding port 16 and falls above the high-speed dispersion plate 9.

[0036] 2. Mixing: Drive motor 3 starts, and central stirring shaft 4 drives frame-type scraper agitator 5 to rotate, realizing macroscopic mixing of materials; at the same time, independent motor 7 starts, and high-speed dispersing disk 9 breaks up agglomerated particles, completing microscopic dispersion.

[0037] 3. Temperature control: Temperature sensor 15 monitors the material temperature in real time. If the temperature deviates from the set value, the PLC controller adjusts the steam / cold water flow of the heat pipe - steam is introduced when heating and cold water is introduced when cooling to ensure temperature stability.

[0038] 4. Discharge: After mixing is completed, open the valve of the discharge port 11 of the conical bottom 10. The material flows into the discharge port 11 under the action of gravity and is completely discharged from the tank 1.

[0039] 5. Cleaning: Close all valves, inject clean water through cleaning port 17, start the high-pressure cleaning pump, spray high-pressure water from spray head 12 to rinse the residue in the tank, and discharge the wastewater from discharge port 11 to complete the equipment cleaning.

[0040] The present invention and its embodiments have been described above. This description is not restrictive, and the specific embodiments shown are only one of the embodiments of the present invention. The actual structure is not limited to this. In short, if a person skilled in the art is inspired by this description and designs a similar structure and embodiment without departing from the inventive spirit of the present invention, such design should fall within the protection scope of the present invention.

Claims

1. A constant-temperature dispensing tank for a raw material liquid, comprising a tank body (1), a jacket (2) disposed outside the tank body (1), a temperature control system communicating with the jacket (2), and a drive motor (3), characterized in that: The output shaft of the drive motor (3) extends into the tank (1) and is connected to a central stirring shaft (4). At least one set of frame-type wall scraping agitators (5) are provided on the central stirring shaft (4). Inside the tank (1), there is also a vertically arranged anti-shaking cylinder (6) parallel to the central stirring shaft (4). Inside the anti-shaking cylinder (6), there is a rotatably connected high-speed dispersing shaft (8) driven by an independent motor (7). At least one dispersing disc (9) is provided at the lower end of the high-speed dispersing shaft (8). The bottom of the tank (1) is configured as a conical bottom (10) protruding towards the center, and a discharge port (11) with a valve is provided at the lowest point of the conical bottom (10), and multiple spray heads (12) are provided at the top inside the tank (1).

2. The constant-temperature dispensing tank for the active ingredient liquid according to claim 1, characterized in that: The outline of the frame-type wall scraper (5) is adapted to the shape of the inner wall of the tank (1), and there are two frame-type wall scrapers (5) arranged symmetrically. The edge of the frame-type wall scraper (5) is detachably provided with a flexible scraper (13) that slides against the inner wall of the tank (1).

3. The constant-temperature dispensing tank for the active ingredient liquid according to claim 2, characterized in that: The flexible scraper (13) has a U-shaped structure. The two ends of the U-shaped structure are attached to the inner wall of the tank (1), and the middle part is fixedly connected to the frame-type scraper agitator (5) by bolts.

4. The constant-temperature dispensing tank for the active ingredient liquid according to claim 1, characterized in that: The anti-vibration cylinder (6) is located between the frame-type scraper mixer (5) and the central stirring shaft (4), and the dispersion plate (9) connected to the bottom of the anti-vibration cylinder (6) is located in the gap above the frame-type scraper mixer (5).

5. The constant-temperature dispensing tank for the active ingredient liquid according to claim 1, characterized in that: The temperature control system includes a spiral heat-conducting pipe (14) disposed inside the jacket (2) and multiple temperature sensors (15) disposed at different heights inside the tank (1), wherein the temperature sensors (15) are embedded in the side wall of the tank (1).

6. The constant-temperature dispensing tank for the active ingredient liquid according to claim 1, characterized in that: The spray head (12) is arranged circumferentially around the central stirring shaft (4), and the spray head (12) is arranged in two staggered layers, wherein the inner layer of the spray head (12) faces the middle of the conical bottom (10) of the tank (1), and the outer layer of the spray head (12) faces the inner wall of the tank (1).

7. The constant-temperature dispensing tank for the active ingredient liquid according to claim 1, characterized in that: The top of the tank (1) is provided with a feeding port (16) and a cleaning port (17). The feeding port (16) is located on one side of the anti-shaking cylinder (6) and is located inside the tank (1) facing the bottom of the anti-shaking cylinder (6) on the dispersion plate (9).

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