A stem cell preparation packaging box

Abstract

The application relates to the field of cell storage and transportation boxes, and provides a stem cell preparation packaging box which comprises a box body and a cover body, a spacer is located in a containing cavity of the box body, a placing cavity is formed in the spacer, a main body of stem cell preparation is placed in the placing cavity, a fixing cavity is arranged on one side of the placing cavity, the fixing cavity is communicated with the placing cavity, a step is formed between the fixing cavity and the placing cavity, the fixing cavity is used for placing an outlet of the stem cell preparation, an upper surface of the spacer and an inner wall of the box body define a reserved area, the reserved area is used for containing the remaining part of the stem cell preparation, when the cover body is covered on the box body, the main body of the stem cell preparation is stably placed in the box body under the buckling action of the cover body, damage of a cell membrane and a cell structure of the stem cell caused by shearing force generated by shaking is avoided, and the survival rate of the stem cell in the transportation process is improved.

Description

Technical Field

[0001] This application relates to the field of cell storage and transport boxes, and more particularly to a packaging box for stem cell preparations. Background Technology

[0002] Stem cell preparations require specialized packaging to ensure cell viability and stability during storage and transportation. Existing packaging can cause stem cell preparations to collide with the sidewalls of the packaging during transport, generating fluid shear forces that increase the risk of stem cell membrane rupture and aggregation. Furthermore, stem cell preparations typically need to be stored at 2–8 degrees Celsius, which places higher demands on the thermal insulation performance of the packaging. Therefore, designing a novel packaging for stem cell preparations is of great significance. Utility Model Content

[0003] In view of the above, the purpose of this application is to provide a stem cell preparation packaging box, comprising: The box body and the cover provided on the box body; A spacer is located in the receiving cavity of the box body, dividing the receiving cavity of the box body into a first receiving cavity and a second receiving cavity, with the first receiving cavity located above the second receiving cavity; A placement cavity is provided on the spacer located in the first receiving cavity. The main body of the stem cell preparation is placed in the placement cavity. A fixing cavity is provided on one side of the placement cavity. The fixing cavity is connected to the placement cavity. A step is formed between the fixing cavity and the placement cavity. The fixing cavity is used to place the outlet of the stem cell preparation. The upper surface of the spacer and the inner wall of the box define a reserved area. The reserved area is used to accommodate the rest of the stem cell preparation.

[0004] In some embodiments, the spacer includes a first spacer and a second spacer, the first spacer being nested within the second spacer, the placement cavity being located on the first spacer, the fixing cavity being located on the second spacer, and the depth of the placement cavity being greater than the depth of the fixing cavity.

[0005] In some embodiments, the second spacer is provided with a clearance hole to prevent interference with the corner of the first spacer.

[0006] In some embodiments, the cover body has multiple storage areas.

[0007] In some embodiments, the sidewalls of the box and / or the cover are provided with anti-slip texture.

[0008] In some embodiments, the box body and the cover body are connected by a sealing strip.

[0009] In some embodiments, an ice pack is placed in the second receiving cavity.

[0010] In some embodiments, the bottom of the placement cavity is provided with a vent hole, which connects the first receiving cavity and the second receiving cavity.

[0011] In some embodiments, the bottom and inner wall of the box are bonded with thermal insulation material.

[0012] In some embodiments, the box body and the cover body are made of aluminum alloy.

[0013] The beneficial effects that this application can achieve are: The method provided in this application includes a placement cavity on a spacer in the first receiving cavity, in which the main body of the stem cell preparation is placed. A fixing cavity is provided on one side of the placement cavity, and the fixing cavity is connected to the placement cavity. A step is formed between the fixing cavity and the placement cavity. The fixing cavity is used to place the outlet of the stem cell preparation. The upper surface of the spacer and the inner wall of the box define a reserved area, which is used to accommodate the remaining part of the stem cell preparation. When the cover is placed on the box, the stem cell preparation can be stably positioned in the placement cavity under the pressing action of the cover, avoiding the influence of shear force caused by shaking during transportation on the activity of stem cells. Furthermore, the outlet of the stem cell preparation is stuck in the fixing cavity, which further improves the stability of the placement of the stem cell preparation.

[0014] To make the above-mentioned objectives, features and advantages of this application more apparent and understandable, preferred embodiments are described below in detail with reference to the accompanying drawings. Attached Figure Description

[0015] To more clearly illustrate the technical solutions of the embodiments of this application, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this application and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0016] Figure 1 A schematic diagram of a stem cell preparation packaging box according to this application is shown; Figure 2 A schematic diagram of part A of this application is shown.

[0017] 1. Box body; 2. Cover body; 11. First receiving cavity; 12. Second receiving cavity; 13. Spacer; 131. Placement cavity; 132. Fixing cavity; 133. Reserved area; 14. First spacer; 15. Second spacer; 151. Clearance hole; 16. Vent hole. Detailed Implementation

[0018] The term "comprising" in the specification, claims, and accompanying drawings of this application is synonymous with "including," "containing," or "characterized in," and is inclusive of endpoints or open-ended, and does not exclude additional unstated elements or method steps. "Comprising" is a technical term used in the language of the claims, meaning that the stated element is present, but other elements may be added and still form a construction or method within the scope of the claims.

[0019] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures. In addition, the terms "first", "second", "third", etc. are used only to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0020] The storage and transportation of stem cell preparations place extremely high demands on the performance of packaging boxes. Existing technologies, during transportation, can easily lead to shear forces generated by the collision of cell fluids, damaging cell membranes. Furthermore, stem cell preparations typically require storage at 2–8 degrees Celsius, which places even higher demands on the thermal insulation performance of the packaging boxes. Therefore, designing a novel packaging box for stem cell preparations is of great significance.

[0021] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0022] In this document, the term "embodiment" means that a particular feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of this application. The appearance of this phrase in various places throughout the specification does not necessarily refer to the same embodiment, nor is it a separate or alternative embodiment mutually exclusive with other embodiments. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0023] See Figure 1This embodiment of a stem cell preparation packaging box includes: a box body 1 and a cover 2 disposed on the box body 1; a spacer 13, the spacer 13 being located in the receiving cavity of the box body 1, dividing the receiving cavity of the box body 1 into a first receiving cavity 11 and a second receiving cavity 12, the first receiving cavity 11 being located above the second receiving cavity 12; a placement cavity 131 is provided on the spacer 13 located in the first receiving cavity 11, the main body of the stem cell preparation is placed in the placement cavity 131, a fixing cavity 132 is provided on one side of the placement cavity 131, the fixing cavity 132 is connected to the placement cavity 131, a step is formed between the fixing cavity 132 and the placement cavity 131, the fixing cavity 132 is used for placing the outlet of the stem cell preparation, the upper surface of the spacer 13 and the inner wall of the box body 1 define a reserved area 133, the reserved area 133 is used to accommodate the remaining part of the stem cell preparation.

[0024] Specifically, during the transportation of stem cell preparations, they typically need to be refrigerated at 2–8°C with minimal shaking to ensure the activity of the stem cells. The spacer 13 within the box 1 separates the ice pack from the stem cell preparation, preventing damage to the cell membrane and internal cell structure due to localized overcooling. To reduce shear forces generated by shaking and maintain the integrity of the cell membrane and internal cell structure, a placement cavity 131 is provided in the spacer 13. The size of the placement cavity 131 is just large enough to embed the main body of the stem cell preparation, limiting its lateral movement. To further increase the stability of the stem cell preparation placement, a fixing cavity 132 is provided on one side of the placement cavity 131, and the fixing cavity 132 is connected to the placement cavity 131. The outlet for placing stem cell preparations is provided. The side wall of the fixed cavity 132 is fitted with the outer wall of the outlet of the stem cell preparation, and the fixed cavity 132 and the placement cavity 131 form a step to ensure that the main body of the stem cell preparation and the outlet can fit with the bottom of the placement cavity 131 and the fixed cavity 132, so that the liquid in the stem cell preparation is more evenly distributed in the placement cavity 131 and avoids local temperature differences. The isolation component is also provided with a reserved area 133 for placing the remaining part of the stem cell preparation. When the cover 2 is placed on the box 1, the bottom of the cover 2 is pressed on the stem cell preparation. There is a very small tolerance between the side of the cover 2 and the side of the box 1, which can ensure that the inner wall of the side of the cover 2 fits with the outer wall of the side of the box 1, so that the cover 2 is not easy to fall off.

[0025] Furthermore, the spacer 13 includes a first spacer 14 and a second spacer 15, the first spacer 14 is nested inside the second spacer 15, the placement cavity 131 is located on the first spacer 14, the fixing cavity 132 is located on the second spacer 15, and the depth of the placement cavity 131 is greater than the depth of the fixing cavity 132.

[0026] Specifically, the first spacer 14 and the second spacer 15 are separable. The connection between the placement cavity 131 and the fixing cavity 132 is a continuous design. The depth of the placement cavity 131 is greater than the depth of the fixing cavity 132, so the connection is stepped. The height of the step is the height difference between the main body of the stem cell preparation and the outlet. Different specifications of stem cell preparations can be accommodated by changing the depth of the placement cavity 131 and / or the fixing cavity 132.

[0027] Furthermore, the second spacer 15 is provided with a clearance hole 151 to prevent interference with the corner of the first spacer 14.

[0028] See Figure 2 The placement cavity 131 of the first spacer 14 has a corner, and the second spacer 15 also has a corner to match the shape of the first spacer 14. When the first spacer 14 and the second spacer 15 are nested together, the corners of the first spacer 14 and the second spacer 15 are prone to interference, making it inconvenient for their installation and separation. Therefore, an avoidance hole 151 is provided at the corner of the second spacer to increase the reusability of the stem cell preparation packaging box.

[0029] In some embodiments, the cover 2 has multiple storage areas.

[0030] Specifically, the interior of the cover 2 has multiple dedicated storage areas for items such as infusion sets, temperature recorders, and certificates. These multiple storage areas allow for the separate storage of these items and ensure their fixed position. Alternatively, the cover 2 may have only one storage area, where the item is placed on top of the stem cell preparation, and the cover 2 is closed to complete the storage. Additionally, the items are covered with a waterproof bag to prevent damage from condensation caused by ice packs, which could hinder users from accessing information about the stem cell preparation.

[0031] Furthermore, in order to protect the stem cell preparation from light, a light-proof bag is placed between the stem cell preparation and the item inside the box 1, so that the stem cell preparation can be covered with a light-proof bag during infusion, or a light-proof bag can be directly placed over the stem cell preparation and then placed on the spacer 13, so that no additional light-proof bag is needed during stem cell preparation infusion.

[0032] In some embodiments, the sidewalls of the box body 1 and / or the cover body 2 are provided with anti-slip texture.

[0033] Since the surface of the packaging box is smooth, it is not convenient to open the packaging box. Anti-slip texture is set on the side wall of the box body 1 and / or the lid body 2 to increase friction and increase the convenience of operation.

[0034] In some embodiments, the box body 1 and the cover body 2 are connected by a sealing strip.

[0035] The box body 1 and the lid body 2 are sealed with a sealing strip to ensure the stability of the internal environment of the packaging box and to guarantee the activity of stem cells.

[0036] In some embodiments, an ice pack is placed in the second receiving cavity 12.

[0037] The second receiving cavity 12 is located below the first receiving cavity 11. An ice pack is placed in the second receiving cavity 12, which can maintain the low temperature requirement of the first receiving cavity 11 while preventing the ice pack from directly contacting the stem cell preparation, thus avoiding the problem of localized cooling. In addition, the cold storage capacity of the ice pack can ensure that the temperature of the stem cell preparation is maintained at 2-8 degrees Celsius within 24 hours, thus ensuring cell viability.

[0038] In some embodiments, the bottom of the placement cavity 131 is provided with a vent hole, which connects the first receiving cavity 11 and the second receiving cavity 12.

[0039] The vent allows the cold air from the ice pack in the second cavity 12 to slowly permeate into the first cavity 11, preventing the first cavity 11 from forming a "hot zone" due to sealing, and keeping the temperature of the first cavity 11 within a stable range of 2~8℃±1℃.

[0040] In some embodiments, the bottom and inner wall of the box body 1 are bonded with thermal insulation material.

[0041] It should be noted that the insulation material can be any combination of one or more of the following: nano-insulation materials, aerogel, and polyurethane, with a thickness of 0.1–50 mm. The insulation material can significantly reduce the influence of the external ambient temperature on the internal temperature of the box and prolong the time for the internal temperature to stabilize.

[0042] In some embodiments, the box body 1 and the cover body 2 are made of aluminum alloy.

[0043] It should be noted that the box body 1 and the lid 2 of the packaging box are made of high-strength aluminum alloy. Combined with the design of the bottom and inner wall of the box body 1 being bonded with heat-insulating material, the protective, durable and temperature control capabilities of the packaging box can be significantly improved.

[0044] The embodiments of this application have been described in detail above. Specific examples have been used to illustrate the principles and implementation methods of this application. The description of the above embodiments is only for the purpose of helping to understand the method and core ideas of this application. At the same time, for those skilled in the art, there will be changes in the specific implementation methods and application scope based on the ideas of this application. Therefore, the content of this specification should not be construed as a limitation of this application.

Claims

1. A packaging box for a stem cell preparation, characterized in that, include: Box body (1) and cover (2) provided on the box body (1); Spacer (13), the spacer (13) is located in the receiving cavity of the box body (1), dividing the receiving cavity of the box body (1) into a first receiving cavity (11) and a second receiving cavity (12), the first receiving cavity (11) being located above the second receiving cavity (12); A placement cavity (131) is provided on the spacer (13) located in the first receiving cavity (11). The main body of the stem cell preparation is placed in the placement cavity (131). A fixing cavity (132) is provided on one side of the placement cavity (131). The fixing cavity (132) communicates with the placement cavity (131). A step is formed between the fixing cavity (132) and the placement cavity (131). The fixing cavity (132) is used to place the outlet of the stem cell preparation. The upper surface of the spacer (13) and the inner wall of the box body (1) define a reserved area (133). The reserved area (133) is used to accommodate the rest of the stem cell preparation.

2. The stem cell preparation packaging box according to claim 1, characterized in that, The spacer (13) includes a first spacer (14) and a second spacer (15), the first spacer (14) is nested inside the second spacer (15), the placement cavity (131) is located on the first spacer (14), the fixing cavity (132) is located on the second spacer (15), and the depth of the placement cavity (131) is greater than the depth of the fixing cavity (132).

3. A stem cell preparation packaging box according to claim 2, characterized in that, The second spacer (15) is provided with a clearance hole (151) to prevent interference with the corner of the first spacer (14).

4. A stem cell preparation packaging box according to claim 1, characterized in that, The cover (2) has multiple storage areas.

5. A stem cell preparation packaging box according to claim 1, characterized in that, The side walls of the box body (1) and / or the cover body (2) are provided with anti-slip texture.

6. A stem cell preparation packaging box according to claim 1, characterized in that, The box body (1) and the cover body (2) are connected by a sealing strip.

7. A stem cell preparation packaging box according to claim 1, characterized in that, An ice pack is placed in the second receiving cavity (12).

8. A stem cell preparation packaging box according to claim 7, characterized in that, The bottom of the placement cavity (131) is provided with a vent hole (16), which connects the first receiving cavity (11) and the second receiving cavity (12).

9. A stem cell preparation packaging box according to claim 1, characterized in that, The bottom and inner wall of the box (1) are bonded with thermal insulation material.

10. A stem cell preparation packaging box according to claim 1, characterized in that, The box body (1) and the cover body (2) are made of aluminum alloy.

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