Portable ice water bath biological sample sub-packaging box

Abstract

This utility model discloses a portable ice-water bath biological sample dispensing box, belonging to the field of biological sample technology. The dispensing box includes a box body, a support mechanism detachably placed on the top of the box body, and an ice-water mixing mechanism disposed inside the box body. The support mechanism includes a supporting shell, a turntable rotatably connected to the supporting shell, a test tube rack, and a cryopreservation box. Both the test tube rack and the cryopreservation box are provided with fixing frames, which are engaged with the turntable. The fixing frames are installed in the middle of the test tube rack. This utility model solves the problem of inconsistent cooling depth caused by different container sizes in the prior art by setting a preset height difference on the fixing frames, ensuring the uniformity of sample processing. At the same time, automatic temperature equalization is achieved by guiding density flow through a guide plate, and the support mechanism with handles and support height improves the convenience of operation and effectively prevents sample contamination.

Description

Technical Field

[0001] This utility model relates to the field of biological sample technology, and in particular to a portable ice-water bath biological sample dispensing box. Background Technology

[0002] In drug clinical trials, the collection, processing, and preservation of biological samples are crucial steps to ensure the accuracy of experimental data. Many samples need to be subjected to low-temperature treatment immediately after collection, such as being placed in an ice-water bath for aliquoting, in order to inhibit enzyme activity and ensure sample stability.

[0003] The current procedure involves placing test tubes or cryovials containing samples on a regular test tube rack and then immersing the entire rack in a portable ice box or ice-water bath. However, clinical trials often require the simultaneous processing of multiple types of samples, which are contained in containers of different sizes, such as taller test tubes and shorter cryovials.

[0004] When these containers of different heights are placed on a test tube rack on the same plane and immersed together in an ice-water bath, it is difficult for operators to accurately control the immersion depth of the samples in each container. This can lead to serious problems: the cooling height of the samples in different containers in contact with the ice water is inconsistent, with some being immersed too deeply and others too shallowly.

[0005] This non-standardized cooling process leads to differences in cooling rates and processing conditions between samples, affecting sample homogeneity and consequently impacting subsequent test results. For drug clinical trials that require a high degree of standardization, this operational inconsistency directly reduces the reliability and reproducibility of the test data.

[0006] Therefore, this invention proposes a portable ice-water bath biological sample dispensing box to address the shortcomings of existing technologies. Utility Model Content

[0007] In view of the problem that existing portable ice-water bath biological sample dispensing boxes make it difficult to ensure that test tubes and cryovials of different sizes are immersed in the ice-water bath at the same depth when cooling them at the same time, resulting in non-standardized cooling process, this utility model aims to provide a portable ice-water bath biological sample dispensing box with an improved structure that can effectively solve the above problems.

[0008] This utility model provides a portable ice-water bath biological sample dispensing box, including: a box body, a support mechanism, an ice-water mixing mechanism, a drain pipe, and a temperature display.

[0009] The support mechanism is detachably placed on the top of the box. The support mechanism includes a supporting shell, a turntable, a test tube rack, a cryopreservation box, and a fixing frame. A handle is fixedly connected to the top of the supporting shell. The turntable is rotatably connected to the supporting shell. The test tube rack and the cryopreservation box are both provided with the fixing frame, and the fixing frame is engaged with the turntable.

[0010] The ice-water mixing mechanism includes an ice cage, a top cover, a first guide plate, and a second guide plate. The ice cage is located inside the housing. The top cover is hinged to the top opening of the ice cage. The first guide plate and the second guide plate are both fixedly connected to the inner wall of the housing and are located on the adjacent side of the ice cage to guide the ice-water to form a density flow.

[0011] The drain pipe penetrates the outer wall of the enclosure; the temperature display is fixedly connected to the outer wall of the enclosure.

[0012] The mounting bracket is installed at the middle of the test tube rack, and the mounting bracket is installed at the top of the outer wall of the cryopreservation box.

[0013] Furthermore, the test tube rack and the cryopreservation box are engaged with the turntable via the fixing frame. The different installation positions of the fixing frame on different components create a preset height difference between the two, thereby solving the problem of inconsistent cooling depths for containers of different sizes.

[0014] Preferably, the preset height difference formed between the fixing frames ensures that when the test tubes in the test tube rack and the cryopreservation tubes in the cryopreservation box are immersed in the ice water in the box, the contact depth with the ice water is one-third of their height. This achieves precise and standardized cooling operation and ensures the uniformity of sample processing.

[0015] Preferably, the specific structure of the engaging connection between the fixing frame and the turntable is as follows: the fixing frame has slots on both sides, and the turntable is provided with engaging parts that cooperate with the slots of the fixing frame. A stable and detachable engaging connection is achieved through the cooperation between the engaging parts and the slots.

[0016] Preferably, the density flow guided by the first guide plate and the second guide plate can effectively drive the water in the tank to circulate automatically, and achieve automatic temperature equalization of the ice water bath in the tank without the need for additional power stirring, ensuring that the temperature is consistent throughout the tank.

[0017] Preferably, the bottom of the supporting shell has a support height, which ensures that when the supporting shell, together with the test tube rack and cryopreservation box, is moved out and placed on the work surface using the handle, the test tubes and cryopreservation tubes can be prevented from directly contacting the work surface, thus effectively preventing cross-contamination of the samples.

[0018] Preferably, the connection between the turntable and the supporting shell is a closed design. The closed design can effectively prevent water or condensate inside the box from overflowing onto the work surface through the connection gap, thus keeping the operating environment dry and clean.

[0019] Preferably, the temperature display is used to display the temperature of the ice water inside the chamber in real time, so that the operator can monitor whether the cooling conditions meet the test procedures. The drain pipe is used to conveniently drain the water inside the chamber when the temperature is insufficient or when the ice water needs to be replaced, simplifying maintenance operations.

[0020] Preferably, as a specific layout, the drain pipe is located at the bottom of the side wall of the tank, in a position that facilitates the complete emptying of the liquid inside the tank, and the temperature display is located at the top of the side wall of the tank, in a position that allows the operator to observe the reading at eye level while standing.

[0021] This utility model has the following beneficial effects: 1. This utility model solves the problem in the prior art that it is difficult to ensure that samples of different specifications are immersed in ice water at the same depth, which leads to non-standard cooling treatment. By setting a fixed frame with a preset height difference on the test tube rack and cryopreservation box, it enables test tubes and cryopreservation tubes to accurately contact one-third of the height of ice water, thus ensuring the standardization of cooling treatment.

[0022] 2. This utility model solves the problems of uneven temperature distribution and local overcooling or overheating in the ice-water bath in the prior art by setting an ice cage in the box and setting a first guide plate and a second guide plate on the adjacent side of the ice cage. It realizes the guidance of ice water to form a density flow and drive the water body to circulate automatically, thus realizing the automatic temperature uniformity of the ice-water bath.

[0023] 3. This utility model solves the problems of cumbersome operation when changing ice water and contamination caused by the sample rack contacting the work surface when removed, by setting a support shell with a handle and providing support height at the bottom of the support shell. It realizes that all samples can be removed at once by means of the handle, and the test tubes and cryopreservation tubes are prevented from contacting the work surface when placed. The operation is convenient and hygienic, and sample contamination is effectively prevented. Attached Figure Description

[0024] Figure 1 This is a front view of a portable ice-water bath biological sample dispensing box proposed in this utility model; Figure 2 A perspective view of a portable ice-water bath biological sample dispensing box proposed in this utility model; Figure 3 This is a split view of the support mechanism of a portable ice-water bath biological sample dispensing box proposed in this utility model; Figure 4 This is a split diagram of the ice-water mixing mechanism of a portable ice-water bath biological sample dispensing box proposed in this utility model.

[0025] Legend: 1. Box body; 2. Support mechanism; 201. Cryopreservation box; 202. Test tube rack; 203. Fixing rack; 204. Turntable; 205. Support shell; 206. Handle; 3. Ice-water mixing mechanism; 301. Top cover; 302. Flow guide plate one; 303. Flow guide plate two; 304. Drain pipe; 305. Temperature display; 306. Ice cage. Detailed Implementation

[0026] To make the objectives, technical solutions, and advantages of this utility model clearer, the technical solutions in the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this utility model, and not all of them. All other embodiments obtained by those skilled in the art based on the embodiments of this utility model without creative effort are within the scope of protection of this utility model.

[0027] Example: Please refer to Figures 1 to 4 This utility model provides a portable ice-water bath biological sample dispensing box, which aims to solve the problems in the prior art that make it difficult to ensure that test tubes and cryopreservation tubes of different specifications are immersed in ice water at the same depth, and that the ice water temperature distribution in the box 1 is uneven and the operation of changing ice water is cumbersome. like Figure 1 and Figure 2 As shown, the portable ice-water bath biological sample dispensing box includes a box 1, which serves as the carrier of the entire device and an environmental support mechanism 2 for accommodating the ice-water bath. The support mechanism 2 is detachably placed on the top of the box 1 and is used to accommodate and position the test tube rack 202 to be processed, the cryopreservation box 201, and the ice-water mixing mechanism 3. like Figure 3 As shown, the support mechanism 2 includes a support shell 205, a handle 206 and a turntable 204 are fixedly connected to the top of the support shell 205, and a test tube rack 202 and a cryopreservation box 201 are rotatably connected to the support shell 205. Both are provided with a fixing frame 203, and the fixing frame 203 is engaged with the turntable 204. like Figure 4As shown, the ice-water mixing mechanism 3 includes an ice cage 306, which is disposed inside the housing 1. The top opening of the ice cage 306 is hinged with a top cover 301, a first guide plate 302 and a second guide plate 303, both of which are fixedly connected to the inner wall of the housing 1 and disposed on the adjacent side of the ice cage 306 to guide the ice-water to form a density flow. The drain pipe 304 passes through the outer wall of the housing 1 and is fixedly connected to the outer wall of the housing 1. The mounting position of the fixing bracket 203 on the test tube rack 202 is the middle of the test tube rack 202, and the mounting position of the fixing bracket 203 on the cryopreservation box 201 is the top of the outer wall of the cryopreservation box 201, so that a preset height difference is formed between the fixing brackets 203 of the two. Please refer to Figure 3 The mounting position of the fixing bracket 203 on the test tube rack 202 is the middle of the test tube rack 202, and the mounting position of the fixing bracket 203 on the cryopreservation box 201 is the top of the outer wall of the cryopreservation box 201. This difference in the mounting positions of the middle and the top of the outer wall creates a preset height difference between the fixing brackets 203 of the two. Meanwhile, slots are provided on both sides of the fixing frame 203, and corresponding engaging parts are provided on the turntable 204 to engage with the slots of the fixing frame 203. In the assembled state, the fixing frame 203 is engaged with the engaging parts of the turntable 204 through the slots. This engaging structure of fixing frame 203 and turntable 204 ensures that the test tube rack 202 and cryopreservation box 201 can be stably fixed on the turntable 204, and the direction can be adjusted by rotating the turntable 204. Furthermore, when the support mechanism 2 is placed on the box 1, the preset height difference ensures that when the test tubes in the test tube rack 202 and the cryopreservation tubes in the cryopreservation box 201 are immersed in the ice water in the box 1, the contact depth with the ice water is one-third of the height, thus achieving standardized cooling treatment.

[0028] As a preferred embodiment, in order to achieve standardized cooling, the preset height difference ensures that when the test tubes in the test tube rack 202 and the cryopreservation tubes in the cryopreservation box 201 are immersed in the ice water in the box 1, the contact depth with the ice water is one-third of the height. As another preferred embodiment, in order to achieve a stable snap-fit ​​connection, slots are provided on both sides of the fixing frame 203, and the turntable 204 is provided with a snap-fit ​​part that matches the slots of the fixing frame 203 to achieve a snap-fit ​​connection. As another preferred embodiment, in order to achieve automatic temperature equalization, the density flow guided by the first guide plate 302 and the second guide plate 303 can drive the water in the tank 1 to circulate automatically and achieve automatic temperature equalization. As another preferred embodiment, in order to prevent sample contamination, the bottom of the support shell 205 has a support height so as to prevent the test tubes and cryovials from contacting the work surface when the support shell 205 together with the test tube rack 202 and the cryopreservation box 201 are moved out and placed by the handle 206. As another preferred embodiment, in order to prevent ice water from overflowing, the connection between the turntable 204 and the supporting shell 205 is a closed design to prevent water in the box 1 from overflowing onto the work surface. As another preferred embodiment, in order to facilitate monitoring and water replacement, the temperature display 305 is used to display the temperature inside the tank 1 in real time, and the drain pipe 304 is used to drain the water inside the tank 1 when the temperature is insufficient. As another preferred embodiment, in order to optimize the layout and function, the drain pipe 304 is disposed at the bottom of the side wall of the housing 1, and the temperature display 305 is disposed at the top of the side wall of the housing 1.

[0029] Working principle: When dispensing samples, the test tube rack 202 and cryopreservation box 201, which are equipped with a fixing frame 203, are connected to the locking part of the turntable 204 through the slots on both sides of the fixing frame 203. Then, the entire support mechanism 2 is placed on the top of the box 1. Since the fixing frame 203 is installed in the middle of the test tube rack 202 and at the top of the outer wall of the cryopreservation box 201, the preset height difference between the two ensures that when the sample is immersed in the ice water in the box 1, the test tube and the cryopreservation tube are in contact with the ice water to a depth of one-third of the height, thus achieving standardized cooling. Rotating the turntable 204 can drive the test tube rack 202 and the cryopreservation box 201 to rotate synchronously, making it convenient for operators to store and retrieve samples. When the ice-water mixing mechanism 3 is working, the top cover 301 of the ice cage 306 is opened to add ice blocks into the ice cage 306. The low-temperature water produced by the melting ice blocks has the highest density. The guide plate 1 302 and guide plate 2 303, which are fixedly connected to the inner wall of the box 1, are located on the adjacent side of the ice cage 306, and will guide these low-temperature waters to form a specific density flow. The density flow can drive the water in the box 1 to circulate automatically, thereby achieving automatic temperature equalization. The temperature display 305, which is fixedly connected to the outer wall of the box 1, is used to display the temperature inside the box 1 in real time. When the temperature display 305 indicates that the temperature is insufficient and the water needs to be changed, the operator lifts the handle 206 fixedly connected to the top of the support shell 205. The handle 206 will move the support shell 205, along with the turntable 204, test tube rack 202 and cryopreservation box 201, out of the box 1. Because the support shell 205 has a support height at the bottom, when placed on the workbench, it avoids the test tubes and cryopreservation tubes from contacting the workbench, thus preventing contamination. At this time, the drain pipe 304 that runs through the outer wall of the box 1 can be opened to drain the old water in the box 1, completing the water change operation.

Claims

1. A portable ice-water bath biological sample dispensing kit, comprising: Box body (1), support mechanism (2) and ice-water mixing mechanism (3); The feature is that the support mechanism (2) is detachably placed on the top of the box (1). The support mechanism (2) includes: a supporting shell (205), a turntable (204), a test tube rack (202), and a cryopreservation box (201). A handle (206) is fixedly connected to the top of the supporting shell (205). The turntable (204) is rotatably connected to the supporting shell (205). Both the test tube rack (202) and the cryopreservation box (201) are provided with a fixing frame (203). The fixing frame (203) is engaged with the turntable (204). The fixing frame (203) is installed at the middle of the test tube rack (202) on the test tube rack (202). The fixing frame (203) is installed at the top of the outer wall of the cryopreservation box (201) on the cryopreservation box (201), so that a preset height difference is formed between the fixing frames (203) of the two.

2. The portable ice-water bath biological sample dispensing box according to claim 1, characterized in that, The ice-water mixing mechanism (3) includes: an ice cage (306), a first guide plate (302) and a second guide plate (303), a drain pipe (304), and a temperature display (305). The ice cage (306) is located inside the box (1). A top cover (301) is hinged to the top opening of the ice cage (306). The first guide plate (302) and the second guide plate (303) are both fixedly connected to the inner wall of the box (1) and are located on the adjacent side of the ice cage (306) to guide the ice water to form a density flow. The drain pipe (304) penetrates the outer wall of the box (1). The temperature display (305) is fixedly connected to the outer wall of the box (1).

3. The portable ice-water bath biological sample dispensing box according to claim 1, characterized in that, The preset height difference ensures that when the test tubes in the test tube rack (202) and the cryopreservation tubes in the cryopreservation box (201) are immersed in the ice water in the box body (1), the contact depth with the ice water is one-third of the height. The fixing frame (203) has slots on both sides, and the turntable (204) is provided with a locking part that matches the slots of the fixing frame (203) to achieve the locking connection.

4. A portable ice-water bath biological sample dispensing box according to claim 2, characterized in that, The density flow guided by the first guide plate (302) and the second guide plate (303) can drive the water in the tank (1) to circulate automatically and achieve automatic temperature equalization.

5. A portable ice-water bath biological sample dispensing box according to claim 1, characterized in that, The bottom of the support shell (205) has a support height to prevent the test tubes and cryopreservation tubes from contacting the work surface when the support shell (205) together with the test tube rack (202) and cryopreservation box (201) are moved out and placed by means of the handle (206).

6. A portable ice-water bath biological sample dispensing box according to claim 1, characterized in that, The connection between the turntable (204) and the supporting shell (205) is a closed design to prevent water in the box (1) from overflowing onto the work surface.

7. A portable ice-water bath biological sample dispensing box according to claim 2, characterized in that, The temperature display (305) is used to display the temperature inside the box (1) in real time, and the drain pipe (304) is used to drain the water inside the box (1) when the temperature is insufficient.

8. A portable ice-water bath biological sample dispensing box according to claim 2, characterized in that, The drain pipe (304) is located at the bottom of the side wall of the box (1), and the temperature display (305) is located at the top of the side wall of the box (1).

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