Reaction vessel foamer

Abstract

The utility model discloses a kind of reaction kettle foaming devices, including filter core with micropore and the tubular body being communicated with filter core open end, the filter core is the prism structure of the cylindrical cavity inside being equipped with. The open end of the right side of the filter core is connected with the left end of the tubular body by connecting seat. The utility model passes through adopting prism filter core, actively constructs multiple preferential gas outlet points, accurately controls the gas outlet position, effectively solves the problem of uneven gas outlet caused by the uncontrollable of traditional cylindrical filter core gas outlet point position, ensures the uniformity of dissolved oxygen concentration in biological reaction kettle, improves the success rate of cell culture.

Description

Technical Field

[0001] This utility model relates to the field of bioreactor technology, specifically to a reactor foamer used in bioreactors to provide uniform aeration for cell culture medium. Background Technology

[0002] In fields such as cell culture in bioreactors, it is necessary to continuously and evenly introduce oxygen-rich microbubbles into the culture medium using an aeration device to ensure that cells have sufficient oxygen contact. Furthermore, cells are relatively fragile during cultivation, so the bubbles must be small and uniform. The size and uniformity of the aeration directly determine the success or failure of cell culture: excessively large bubbles can cause cell death, while uneven oxygen distribution can lead to some cells experiencing hypoxia, slow metabolism, or even death, while other areas may be damaged due to over-aeration.

[0003] Traditional aeration filter cartridges mostly adopt a cylindrical structure. Theoretically, a cylinder has circumferential symmetry and the wall thickness between the inner and outer walls is equal. However, it has inherent defects in the microscopic gas release mechanism: under low pressure and small gas volume conditions, gas will preferentially escape from the weakest point of the material with the least resistance. However, since the filter cartridge wall thickness is equal everywhere, the point where gas can be released is uncertain. This results in bubbles being generated only from certain unpredictable local areas, leading to uneven oxygen distribution in the reactor and failing to meet the stringent requirements for uniform aeration in high-quality cell culture. Utility Model Content

[0004] This invention proposes a reactor foamer, the purpose of which is to solve the problem of uneven gas output caused by the uncontrollable gas outlet point of traditional filter cartridges.

[0005] The technical solution of this utility model is as follows: A reactor foaming device includes a filter element with micropores and a tube connected to the open end of the filter element. The filter element is a prismatic structure with an internal cylindrical cavity.

[0006] As a further improvement of this utility model, the open end on the right side of the filter element is connected to the left end of the tube body via a connecting seat.

[0007] As a further improvement of this utility model, a through hole is provided in the center of the connecting seat, and the left end of the tube body is inserted into the through hole.

[0008] As a further improvement of this utility model, the left end face of the tube is located to the right of the left end face of the connecting seat, so that a welding bevel is formed between the left end face of the tube and the inner wall of the through hole of the connecting seat.

[0009] As a further improvement of this utility model, the left end of the connecting seat is provided with an annular boss for tight fitting with the inner wall of the cylindrical cavity.

[0010] As a further improvement of this utility model, the right end of the pipe body is provided with a reduced diameter interface for connecting with the gas transmission pipe, and the outer wall of the reduced diameter interface is provided with tapered reverse teeth.

[0011] As a further improvement of this utility model, the outer surface of the filter element is hexagonal prism-shaped.

[0012] Compared with the prior art, the present invention has the following advantages: (1) The filter element body of this device adopts a prismatic structure with an internal cylindrical cavity. The distance between the middle of each tangent plane on the outer surface of the prismatic structure and the inner wall of the cylindrical cavity is the smallest, and the wall thickness is the thinnest, resulting in the lowest resistance value for gas passage. This forms multiple optimal escape points evenly distributed around the circumference. Under small gas flow rates, the gas will preferentially escape from the above-mentioned evenly distributed points, thereby ensuring the uniformity of dissolved oxygen concentration in the reactor and improving the success rate of cell culture.

[0013] (2) The tube body and the connecting seat of this device are naturally formed by the staggered arrangement of the end faces, which makes it easy to weld from the left side. Not only is the connection firm and reliable, but the weld is not exposed after the filter element is installed, which is aesthetically pleasing.

[0014] (3) The tube body of this device can be quickly and securely connected to the gas pipeline through the reduced diameter interface with reverse teeth on the right side. Attached Figure Description

[0015] Figure 1 This is a three-dimensional structural schematic diagram of the foaming device in the reactor according to an embodiment of the present utility model (viewpoint 1). Figure 2 This is a three-dimensional structural diagram of the foaming device in the reactor according to an embodiment of the present utility model (viewpoint two). Figure 3 This is a cross-sectional structural diagram of the foaming device in the reactor according to an embodiment of the present invention; Figure 4 for Figure 3 Sectional view of AA.

[0016] The reference numerals in the figures include: 1. Filter element; 2. Connector; 3. Tube body; 4. Back teeth; 5. Welding bevel. Detailed Implementation

[0017] The technical solution of this utility model will now be described in detail with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments.

[0018] like Figures 1 to 2 As shown, this utility model provides a reactor foamer, including a filter element 1. (As indicated...) Figure 3 and Figure 4The filter element 1 is a prismatic structure with an internal cylindrical cavity. In this embodiment, the filter element 1 is hexagonal prism in shape. The filter element 1 is made of extremely fine stainless steel metal powder through high-temperature sintering, and has a large number of interconnected and uniformly distributed micropores inside.

[0019] Combination Figure 3 As shown, the filter element 1 is closed on the left side, and the open end on the right side is connected to a tube 3 for connection with the gas supply pipe via a stainless steel connector 2. Alternatively, the filter element 1 can be directly connected to the stainless steel tube 3 by welding or integral sintering.

[0020] Specifically, the connecting seat 2 is a multi-faceted frustum structure with a larger left end and a smaller right end. The shape of its larger end matches the shape of the opening end of the filter element 1, and a circular boss is provided in the middle of the left end. This circular boss is tightly fitted to the right end of the cylindrical cavity of the filter element 1. A through hole is provided in the center of the connecting seat 2 for the tube 3 to pass through. The left end face of the tube 3 is located to the right of the left end face of the connecting seat 2, so that a welding bevel 5 is formed between the left end face of the tube 3 and the inner wall of the through hole of the connecting seat 2.

[0021] The right end of the tube body 3 is provided with a reduced-diameter interface for connecting to the gas transmission pipe. Tapered teeth 4 are provided on the outer wall of this reduced-diameter interface to prevent the gas transmission pipe from falling off. After the reduced-diameter interface is inserted into the gas transmission pipe, it engages with the inner wall of the gas transmission pipe, achieving a quick and stable connection.

[0022] As an optional embodiment of this utility model, a check valve can be added to the gas supply pipe connected inside or outside the right end interface of the tube body 3 to prevent backflow of the culture medium. The check valve, also known as a one-way valve, is a common accessory in this field. For example, in a check hydrogen dissolving rod disclosed in Chinese utility model patent CN217756994U, a spring-loaded check valve is provided at the threaded connection between the connecting part and the mounting part. When liquid enters the check valve, the spring is compressed due to pressure, allowing flow. When the liquid stops flowing, the pressure decreases, the spring returns to its original position, and the check valve closes.

[0023] During assembly, first insert the tube body 3 into the through hole of the connecting seat 2, so that the left end face of the tube body 3 is located to the right of the left end face of the connecting seat 2. Then, weld the formed welding bevel 5 to fix the tube body 3 and the connecting seat 2. Next, press the boss on the left side of the connecting seat 2 into the cavity of the filter element 1 to make the two fit tightly. Then, sinter the two together. During the sintering process, micropores are formed on each side plane of the filter element 1, and the filter element 1 and the connecting seat 2 are firmly connected by the sintering bonding force.

[0024] Working principle: Oxygen enters through the gas supply pipe and is delivered to the cavity inside the filter element 1 via the pipe body 3. The gas pressure is initially equalized within the cavity, and driven by the pressure, it enters the liquid inside the reactor through the microporous channels on the side wall of the filter element 1. During this process, because the distance between the center of each tangential surface of the prism structure and the inner wall of the cylindrical cavity is minimal, and the wall thickness is thinnest, the resistance to gas passage is lowest. Therefore, the gas preferentially escapes from these evenly distributed weak points, thus forming small, uniform bubbles in the liquid, providing a uniform dissolved oxygen environment for cell culture.

[0025] It should be noted that, as will be apparent to those skilled in the art, this utility model is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of this utility model. The scope of this utility model is defined by the claims rather than the foregoing description.

Claims

1. A reactor foaming device, comprising a filter element (1) with micropores and a tube (3) connected to the open end of the filter element (1), characterized in that: The filter element (1) is a prismatic structure with an internal cylindrical cavity.

2. The reactor foaming device as described in claim 1, characterized in that: The open end on the right side of the filter element (1) is connected to the left end of the tube body (3) via a connecting seat (2).

3. The reactor foaming device as described in claim 2, characterized in that: The connecting seat (2) has a through hole in the center, and the left end of the tube body (3) is inserted into the through hole.

4. The reactor foaming device as described in claim 3, characterized in that: The left end face of the tube (3) is located to the right of the left end face of the connector (2), so that a welding bevel (5) is formed between the left end face of the tube (3) and the inner wall of the through hole of the connector (2).

5. The reactor foamer as described in claim 2, characterized in that: The left end of the connecting seat (2) is provided with an annular boss for tight fitting with the inner wall of the cylindrical cavity.

6. The reactor foaming device according to any one of claims 1 to 5, characterized in that: The right end of the pipe body (3) is provided with a reduced diameter interface for connecting with the gas transmission pipe, and the outer wall of the reduced diameter interface is provided with tapered inverted teeth (4).

7. The reactor foaming device according to any one of claims 1 to 5, characterized in that: The outer surface of the filter element (1) is hexagonal prism.

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