A new device for magnetic separation

Abstract

The utility model discloses a novel device for magnetic separation applied to the field of magnetic separation device, through setting magnet on one movable clamping plate, realize the variability of magnet position, and magnet can be with the clamping plate automatic adhesion different size test tube surface to guarantee stable magnetic separation effect, through the cooperation and setting of protection compression ring, second reset spring and guide slide bar, when placing test tube, can use the hand that holds test tube to press down protection compression ring, until test tube is placed into completion, after this, protection compression ring is reset and moves up under the action of second reset spring, and protection compression ring cooperates with guide slide bar and can play the protection effect to the part of test tube that exceeds the upside of top plate, and it is not easy to receive the direct collision of outside, through setting the support structure as tubular body, the support structure of tubular body can stabilize the support of top plate, can also carry out the protection to clamping plate, avoids that clamping plate receives external collision.

Description

Technical Field

[0001] This utility model relates to the field of magnetic separation devices, and in particular to a novel device for magnetic separation. Background Technology

[0002] A magnetic separation rack is a tool commonly used in biological laboratories for the magnetic separation of cells, proteins, or nucleic acids. It typically consists of a magnetic base and a set of magnetic beads. In experiments, the magnetic beads are functionalized and specifically bind to the target molecule, which is then separated from the mixed solution by the magnetic adsorption of the magnetic separation rack.

[0003] A search revealed, for example, an improved porous magnetic separator disclosed in patent publication number CN222499089U, which includes a support base. A support plate is fixedly connected to the top of the support base, and a clamping plate is fitted onto the support plate. Multiple first slots are symmetrically chiseled at the top of the clamping plate, and multiple inner grooves are circumferentially chiseled at equal intervals on the inner wall of each first slot. A tension spring is fixedly connected to each inner groove. Using the above-mentioned adjustment structure, when using the magnetic separator, a reagent tube can be inserted into the first slot, and the clamping plate is opened by squeezing. At the same time, the clamping plate is adjusted by the extension and retraction of the tension spring to contact the outer wall of the reagent tube, thus clamping the reagent tube. After the reagent tube is fixed, the connecting plate is slidably adjusted in the groove according to the distance between the reagent tube and the support plate, so that the magnet contacts the reagent tube and enriches the magnetic material of the sample to be separated from the solution. This effectively achieves the effect of automatically adjusting the size of the first slot according to the size of different reagent tubes, thereby fixing and clamping them.

[0004] However, the position of the magnet in the aforementioned magnetic separator is fixed, which results in different distances between the magnet and test tubes of different diameters. For example, the magnetic beads inside the test tube with a smaller diameter are subjected to less magnetic force, and correspondingly, their separation effect is relatively poor. Utility Model Content

[0005] The core of this invention lies in solving the problem of fixing the position of the magnet in the prior art through the cooperation of the magnet and the clamping plate. At the same time, it can also provide good protection for the test tube.

[0006] To solve the above problems, the present invention adopts the following technical solution.

[0007] A novel device for magnetic separation includes a top plate and a support base arranged vertically, with a support structure connecting the support base and the top plate.

[0008] The top plate is arrayed with multiple tube-insertion through holes, and multiple clamping plates are arrayed in a ring on the inner side of the tube-insertion through holes;

[0009] A first return spring is horizontally connected between the clamping plate and the support structure, and a magnet is embedded in the inner surface of one of the clamping plates.

[0010] By placing the magnet on one of the movable clamping plates, the magnet can automatically conform to the surface of test tubes of different sizes as the clamping plate is attached, thereby ensuring a stable magnetic separation effect.

[0011] Furthermore, a guide plate is fixed to the upper end of the clamping plate. The guide plate is inclined and multiple guide plates form a flared, upward-facing trumpet shape.

[0012] Furthermore, a protective pressure ring is coaxially arranged on the upper side of the tube insertion hole, and a second reset spring is connected between the protective pressure ring and the top plate. The inner diameter of the protective pressure ring is larger than the diameter of the tube insertion hole.

[0013] Furthermore, a guide slide rod is vertically fixed to the lower end of the protective pressure ring. The guide slide rod slides vertically through the top plate, and the second reset spring is fixed between the guide slide rod and the bottom surface of the top plate.

[0014] Furthermore, the support structure is a tubular body, and the support structure is sleeved on the outside of multiple clamping plates corresponding to a tube through hole. The support structure is vertically fixed between the support base and the top plate.

[0015] Furthermore, the circumferential side of the support structure is provided with multiple axial observation through holes at equal intervals, and the clamping plate and the observation through holes are distributed alternately.

[0016] Furthermore, a rubber pad is provided at the bottom of the support structure, and the rubber pad is fixed to the support base.

[0017] Compared with existing technologies, the advantages of this utility model are:

[0018] (1) This solution achieves the variability of the magnet position by setting the magnet on one of the movable clamping plates, and the magnet can automatically fit the surface of test tubes of different sizes with the clamping plate, thereby ensuring a stable magnetic separation effect.

[0019] (2) This scheme uses the combination of protective pressure ring, second reset spring and guide slide rod. When inserting the test tube, the hand holding the test tube can press down on the protective pressure ring until the test tube is inserted. After that, the protective pressure ring moves up and resets under the action of the second reset spring. The protective pressure ring and guide slide rod can protect the part of the test tube that exceeds the top plate and is not easily subjected to direct external impact (especially from lateral force).

[0020] (3) This solution sets the support structure as a tubular body, and the support structure is sleeved on the outside of multiple clamping plates corresponding to a tube through hole. The tubular support structure can provide stable support for the top plate and protect the clamping plates from external collisions. Attached Figure Description

[0021] Figure 1 This is a schematic diagram of the overall three-dimensional structure of this utility model;

[0022] Figure 2 This is a partial cross-sectional structural diagram of the present invention;

[0023] Figure 3 for Figure 2 A schematic diagram of the split structure;

[0024] Figure 4 This is a schematic diagram showing the disassembled structure of the support structure and clamping plate of this utility model.

[0025] Explanation of the labels in the diagram:

[0026] 1. Support base; 2. Top plate; 201. Tube insertion through hole; 3. Support structure; 301. Observation through hole; 4. Clamping plate; 5. Magnet; 6. First return spring; 7. Guide plate; 8. Protective pressure ring; 9. Second return spring; 10. Guide slide rod; 11. Rubber pad. Detailed Implementation

[0027] The technical solution will now be clearly and completely described with reference to the accompanying drawings in the embodiments of this utility model.

[0028] First implementation method:

[0029] Please see Figures 1-4 A novel device for magnetic separation includes a top plate 2 and a support base 1 arranged vertically. A support structure 3 connects the support base 1 and the top plate 2. The top plate 2 has an array of tube insertion holes 201. A plurality of clamping plates 4 are arranged in a ring array inside the tube insertion holes 201. A first return spring 6 is horizontally connected between the clamping plates 4 and the support structure 3. The clamping plates 4, in conjunction with the first return spring 6, can clamp test tubes of different diameters. A magnet 5 is embedded on the inner surface of one of the clamping plates 4. The magnet 5 is used to attract magnetic particles in the test tube to achieve magnetic separation.

[0030] This solution places the magnet 5 on one of the movable clamping plates 4, enabling the magnet 5 to be positioned variably. The magnet 5 can automatically conform to the surface of test tubes of different sizes as the clamping plate 4 is used, thereby ensuring a stable magnetic separation effect.

[0031] Among them, the upper end of the clamping plate 4 is fixed with a guide plate 7. The guide plate 7 is inclined and multiple guide plates 7 form a flared funnel shape with the opening facing upward. The flared funnel shape structure can increase the error rate during the test tube placement process, making it easier for the test tube to be aligned with the circular placement cavity formed by multiple clamping plates 4, thus making the test tube placement more convenient.

[0032] Among them, a rubber pad 11 is fixed on the upper surface of the support base 1. The soft rubber pad 11 can buffer and protect the inserted test tube, and prevent the test tube from directly hitting the support base 1 and causing the bottom of the test tube to break.

[0033] Second implementation method:

[0034] Based on the first embodiment, this embodiment provides a protective pressure ring 8 coaxially on the upper side of the tube insertion hole 201. A second return spring 9 is connected between the protective pressure ring 8 and the top plate 2. The inner diameter of the protective pressure ring 8 is larger than the diameter of the tube insertion hole 201. A guide slide rod 10 is vertically fixed at the lower end of the protective pressure ring 8. The guide slide rod 10 slides vertically through the top plate 2. The second return spring 9 is fixed between the guide slide rod 10 and the bottom surface of the top plate 2. The second return spring 9 is a tension spring.

[0035] Based on the above structural arrangement, when inserting the test tube, the protective ring 8 can be pressed down by the hand holding the test tube, and the second return spring 9 will be stretched until the test tube is inserted. After that, the protective ring 8 moves up and resets under the action of the second return spring 9. The protective ring 8, together with the guide slide rod 10, can protect the part of the test tube that extends beyond the top plate 2, making it less susceptible to direct external impact (especially from lateral forces).

[0036] The third implementation method:

[0037] Based on the first and second embodiments, the support structure 3 in this embodiment is a tubular body, and the support structure 3 is sleeved on the outside of the multiple clamping plates 4 corresponding to a tube through hole 201. The support structure 3 is vertically fixed between the support base 1 and the top plate 2. The tubular support structure 3 can not only provide stable support for the top plate 2, but also protect the clamping plates 4 to prevent the clamping plates 4 from being hit by external collisions (i.e., it plays a protective role for the test tube part located between the support base 1 and the top plate 2). In order to save the inner space of the support structure 3, the first return spring 6 is a tension spring. The outer surface of the clamping plate 4 is also fixed with a guide rod that penetrates the support structure 3. The first return spring 6 is fixed between the guide rod and the outer wall of the support structure 3.

[0038] Among them, the circumferential side end of the support structure 3 is provided with multiple axial observation holes 301 at equal intervals, and the clamping plate 4 is staggered with the observation holes 301 to facilitate the operator to observe the changes in the solution inside the test tube from the outside; of course, the tubular support structure 3 can also be made of transparent material, such as transparent acrylic material.

[0039] It should be further noted that, in order to ensure the stability of magnetic separation, the support base 1 of the device can be detachably fixed to the workbench using a conventional fixing structure (not shown in the figure), such as bolt fixing, to facilitate disassembly and assembly.

[0040] The above description is merely a preferred embodiment of this utility model; it encompasses all the protection scope of this utility model. Any equivalent substitutions or modifications made by those skilled in the art within the technical scope disclosed in this utility model, based on the technical solution and its improved concept, should be covered within the protection scope of this utility model.

Claims

1. A novel device for magnetic separation, comprising a top plate (2) and a support base (1) arranged vertically, wherein a support structure (3) connects the support base (1) and the top plate (2), characterized in that: The top plate (2) is provided with a plurality of tube-inserting through holes (201) arranged in an array, and a plurality of clamping plates (4) are arranged in an annular array on the inner side of the tube-inserting through holes (201); A first reset spring (6) is horizontally connected between the clamping plate (4) and the support structure (3), and a magnet (5) is embedded on the inner surface of one of the clamping plates (4).

2. The novel device for magnetic separation according to claim 1, characterized in that: The upper end of the clamping plate (4) is fixed with a guide plate (7), the guide plate (7) is inclined, and multiple guide plates (7) form a flared and upward-facing trumpet shape.

3. The novel device for magnetic separation according to claim 1, characterized in that: A protective pressure ring (8) is coaxially arranged on the upper side of the tube insertion through hole (201). A second reset spring (9) is connected between the protective pressure ring (8) and the top plate (2). The inner diameter of the protective pressure ring (8) is larger than the diameter of the tube insertion through hole (201).

4. A novel device for magnetic separation according to claim 3, characterized in that: The lower end of the protective pressure ring (8) is vertically fixed with a guide slide rod (10), which slides vertically through the top plate (2). The second reset spring (9) is fixed between the guide slide rod (10) and the bottom surface of the top plate (2).

5. A novel device for magnetic separation according to claim 1, characterized in that: The support structure (3) is a tubular body, and the support structure (3) is sleeved on the outside of multiple clamping plates (4) corresponding to a tube through hole (201). The support structure (3) is vertically fixed between the support base (1) and the top plate (2).

6. A novel device for magnetic separation according to claim 5, characterized in that: The support structure (3) has multiple axial observation through holes (301) equidistantly arranged on its circumferential side end, and the clamping plate (4) is staggered with the observation through holes (301).

7. A novel device for magnetic separation according to claim 5, characterized in that: The bottom of the support structure (3) is provided with a rubber pad (11), which is fixed to the support base (1).

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