A high pressure sample valve set for a formulation fplc analyzer

Abstract

The utility model discloses a kind of formula FPLC analyser high-pressure sampling valve group, it is related to sampling valve group technical field, including equipment shell, interface cover is fixedly installed in equipment shell top surface, control module is equipped in interface cover inside, driving assembly is equipped in equipment shell inside, detection module is equipped in the front end surface of driving assembly, transmission module is equipped in the front end surface of detection module, flow channel module is equipped in the outside of transmission module, heating module is equipped in the inside of flow channel module;The utility model is through the cooperation of control module, driving module, detection module, transmission module and flow channel module, accurately switches flow channel, improves practicality, realizes the ability of the sample in and out of multiple channels;Again by heating module, hot flow is passed into flow channel component inside, to control the temperature of material passed into flow channel inside, avoid mobile phase to stick together, improved practicality, realized the ability of improving device separation degree;Finally solve the problem of mobile phase sticking together when using existing equipment.

Description

Technical Field

[0001] This utility model relates to the field of injection valve assembly technology, and in particular to a high-pressure injection valve assembly for a formulation FPLC analyzer. Background Technology

[0002] FPLC is an abbreviation for Fast Protein Liquid Chromatography, a liquid chromatography technique specifically designed for the separation and purification of biomolecules (such as proteins, peptides, and nucleic acids) with high activity requirements. Liquid chromatography is a very important and widely used analytical and preparative technique, not limited to FPLC, but encompassing a large family of technologies. Existing liquid chromatography techniques mainly separate substances based on the difference in adhesion between the sample contents and the stationary phase. The injection valve assembly is crucial in equipment used for liquid chromatography; however, existing injection valve assemblies lack built-in temperature control mechanisms, generally requiring separate temperature control devices, which is not only energy-intensive but also inconvenient. Therefore, this invention addresses these problems by improving existing equipment. Utility Model Content

[0003] The purpose of this invention is to address the shortcomings of existing technologies by proposing a high-pressure injection valve assembly for a formulation FPLC analyzer.

[0004] To achieve the above objectives, the present invention adopts the following technical solution: a high-pressure injection valve assembly for a formulation FPLC analyzer, comprising a housing, an interface cover fixedly installed on the top surface of the housing, a control module inside the interface cover, a drive assembly inside the housing, a detection module on the front end of the drive assembly, a transmission module on the front end of the detection module, a flow channel module on the outside of the transmission module, and a heating module inside the flow channel module.

[0005] Preferably, the control module includes a circuit board, on which multiple interfaces and capacitor control elements are provided.

[0006] Preferably, the drive assembly includes a motor, which is fixedly installed inside the device housing and connected to a circuit board via wires and interfaces.

[0007] Preferably, the detection module includes a detection head, which is fixedly installed on the front right side of the equipment housing. A toothed plate is clamped at the detection port on the left end of the detection head, and the toothed plate is rotatably connected to the rotating end of the front end face of the motor.

[0008] Preferably, the transmission module includes a rotating shaft, the rear end of which is fixedly connected to a motor, the front end of the outer side of the rotating shaft is rotatably connected to a bearing, and a rotor is fixedly mounted on the front end of the rotating shaft.

[0009] Preferably, the flow channel module includes a valve body, which is screwed to the front end face of the stator around its back side. An inlet is provided in the middle of the front end face of the valve body. The inlet extends backward and connects to the flow channel groove, which is located inside the rotor. The other end of the flow channel groove extends forward. Side interfaces are provided around the inlet, and an oblique interface is provided on one side of the inlet.

[0010] Preferably, the heating module includes a valve body, with water inlets on both sides of the outer surface of the valve body. The water inlets are connected to a hot flow channel through a flow channel, which is located inside the valve body.

[0011] Compared with the prior art, the beneficial effects of this utility model are as follows: This utility model, through the cooperation of a control module, drive module, detection module, transmission module, and flow channel module, facilitates the detection of the flow channel status by the detection module and feedback to the control module. Then, the control module activates the drive module, which in turn drives the flow channel module to make precise adjustments, thereby accurately switching the flow channel and improving practicality, achieving the capability of multi-channel sample entry and exit. Furthermore, the heating module introduces heat into the flow channel assembly, thereby controlling the temperature of the material entering the flow channel, preventing mobile phase adhesion, improving practicality, and enhancing the separation capability of the device. Ultimately, it solves the problem of mobile phase adhesion during the use of existing equipment. Attached Figure Description

[0012] The accompanying drawings, which are included to provide a further understanding of the present invention and form part of this application, illustrate exemplary embodiments of the present invention and, together with the description thereof, serve to explain the present invention and do not constitute an undue limitation thereof. In the drawings: Figure 1 This is a three-dimensional schematic diagram of the overall appearance of the device proposed in this utility model; Figure 2 This is a three-dimensional schematic diagram of the control module structure proposed in this utility model; Figure 3 This is a three-dimensional schematic diagram of the drive module structure proposed in this utility model; Figure 4 This is a three-dimensional schematic diagram of the detection module structure proposed in this utility model; Figure 5 This is a three-dimensional schematic diagram of the conductive module structure proposed in this utility model; Figure 6 This is a three-dimensional schematic diagram of the flow channel module structure proposed in this utility model; Figure 7 This is a three-dimensional schematic diagram of the heating module structure proposed in this utility model.

[0013] The numbers in the diagram are: 1. Equipment housing; 2. Interface cover; 3. Circuit board; 4. Motor; 5. Detection head; 6. Toothed plate; 7. Shaft; 8. Bearing; 9. Rotor; 10. Stator; 11. Valve body; 12. Sample inlet; 13. Flow channel; 14. Side interface; 15. Angled interface; 16. Water inlet; 17. Hot runner. Detailed Implementation

[0014] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0015] Example: See Figures 1 to 6 This utility model discloses a high-pressure injection valve assembly for a formulation FPLC analyzer, comprising a housing 1, an interface cover 2 fixedly mounted on the top surface of the housing 1, a control module inside the interface cover 2, a drive assembly inside the housing 1, a detection module at the front end of the drive assembly, a transmission module at the front end of the detection module, a flow channel module outside the transmission module, and a heating module inside the flow channel module. The control module includes a circuit board 3, which has multiple interfaces and a capacitor control element. The drive assembly includes a motor 4, which is fixedly mounted inside the housing 1 and connected to the circuit board 3 via wires and interfaces. The detection module includes a detection head 5. The detection head 5 is fixedly installed on the front right side of the equipment housing 1. The detection port on the left end of the detection head 5 is clamped with the outer periphery of the toothed plate 6. The toothed plate 6 is rotatably connected to the rotating end of the front end of the motor 4. The transmission module includes a rotating shaft 7. The rear end of the rotating shaft 7 is fixedly connected to the motor 4. The front end of the outer side of the rotating shaft 7 is rotatably connected to the bearing 8. The rotor 9 is fixedly installed on the front end of the rotating shaft 7. Through the cooperation of the control module, drive module, detection module, transmission module and flow channel module, it is convenient to detect the flow channel status through the detection module and feed it back to the control module. Then, the control module starts the drive module and drives the flow channel module to make precise adjustments through the transmission module, thereby accurately switching the flow channel and improving practicality.

[0016] In this utility model, to solve the problem of mobile phase adhesion during the use of existing equipment, the following technical solution is adopted: The flow channel module includes a valve body 11, which is screwed to the front end face of the stator 10 around its back side. An inlet 12 is provided in the middle of the front end face of the valve body 11. The inlet 12 extends backward and connects to the flow channel groove 13, which is located inside the rotor 9. The other end of the flow channel groove 13 extends forward. Side interfaces 14 are provided around the inlet 12, and a slanted interface 15 is provided on one side of the inlet 12. The heating module includes a valve body 11, with water inlets 16 on both sides of the outer side of the valve body 11. The water inlets 16 are connected to the hot flow channel 17 through the flow channel. The hot flow channel 17 is located inside the valve body 11. The heating module introduces heat into the flow channel assembly, thereby controlling the temperature of the material entering the flow channel, avoiding mobile phase adhesion, and improving practicality.

[0017] Working principle: When using the high-pressure injection valve group of the FPLC analyzer of this utility model, firstly, power is supplied to all electrical equipment of the entire device, and then the flow channel module and heating module are assembled. After assembly, the injection port 12 opened in the middle of the front face of the valve body 11, the side interface 14 opened around the injection port 12, and the inclined interface 15 opened on one side of the injection port 12 are respectively connected to the quantitative loop, the first chromatographic column, the second chromatographic column and the detector to build a complete sample analysis flow path and prepare for subsequent sample colorimetric analysis. The testing phase is divided into two stages: the standard analysis stage and the backflushing stage. In the standard analysis stage, the sample enters through the injection port 12, flows through the internal channel of the valve body 11 into the flow channel 13 inside the rotor 9, and is then transferred by the flow channel 13 to the corresponding chromatographic column and other components to achieve the detection of the standard sample. In the backflushing stage, through the regulation of the circuit board 3 in the control module (which has multiple interfaces and capacitor control elements), combined with the driving action of the motor 4 in the drive assembly (the motor 4 is fixedly installed inside the equipment housing 1 and connected to the circuit board 3 through wires and interfaces), the motor 4 drives the rotating shaft 7 to rotate. The front end of the outer side of the rotating shaft 7 is rotatably connected to the bearing 8 fixedly installed inside the stator 10. When the rotating shaft 7 rotates, it synchronously drives the front rotor 9 to rotate. The rotation of the sub-9 changes the flow channel connectivity, causing the sample flow path to switch to backflush mode, thereby achieving rapid sample detection capability. During this process, the detection head 5 in the detection module (the detection head 5 is fixedly installed on the front right side of the device housing 1) will detect the flow channel status in real time. The toothed plate 6 is clamped around the detection port on the left end of the detection head 5, and the toothed plate 6 is rotatably connected to the rotating end of the front end of the motor 4. When the motor 4 rotates, it drives the toothed plate 6 to rotate synchronously. The detection head 5 obtains the flow channel status information by sensing the rotation of the toothed plate 6 and feeds the detected information back to the circuit board 3 of the control module. The circuit board 3 further precisely controls the operation of the motor 4 based on the feedback information, and drives the flow channel module to make corresponding adjustments through the transmission module to ensure the accuracy of the detection process. During the aforementioned testing process, the supply equipment introduces hot water into the hot flow channel 17 inside the valve body 11 through the water inlet 16. This allows for real-time temperature control of the sample flow during its flow. Increased temperature accelerates the diffusion rate of molecules in the mobile and stationary phases, enabling them to reach equilibrium more quickly. This reduces peak broadening, resulting in sharper, higher peaks, thereby improving column efficiency and resolution.

[0018] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A high-pressure injection valve assembly for a formulation FPLC analyzer, comprising a housing (1), characterized in that: An interface cover (2) is fixedly installed on the top surface of the device housing (1). A control module is provided inside the interface cover (2). A drive component is provided inside the device housing (1). A detection module is provided on the front end of the drive component. A transmission module is provided on the front end of the detection module. A flow channel module is provided on the outside of the transmission module. A heating module is provided inside the flow channel module.

2. The high-pressure injection valve assembly for a formulation FPLC analyzer according to claim 1, characterized in that: The control module includes a circuit board (3), which has multiple interfaces and capacitor control elements.

3. The high-pressure injection valve assembly for a formulation FPLC analyzer according to claim 1, characterized in that: The drive assembly includes a motor (4), which is fixedly installed inside the device housing (1) and connected to a circuit board (3) via wires and interfaces.

4. The high-pressure injection valve assembly for a formulation FPLC analyzer according to claim 1, characterized in that: The detection module includes a detection head (5), which is fixedly installed on the front right side of the equipment housing (1). A toothed plate (6) is clamped at the detection port on the left side of the detection head (5), and the toothed plate (6) is rotatably connected to the rotating end of the front end of the motor (4).

5. The high-pressure injection valve assembly for a formulation FPLC analyzer according to claim 1, characterized in that: The transmission module includes a rotating shaft (7), the rear end of which is fixedly connected to a motor (4), the front end of the outer side of the rotating shaft (7) is rotatably connected to a bearing (8), and a rotor (9) is fixedly installed on the front end of the rotating shaft (7).

6. The high-pressure injection valve assembly for a formulation FPLC analyzer according to claim 1, characterized in that: The flow channel module includes a valve body (11), which is screwed to the front end face of the stator (10) around the back side. A sample inlet (12) is provided in the middle of the front end face of the valve body (11). The sample inlet (12) extends backward and connects to the flow channel groove (13). The flow channel groove (13) is located inside the rotor (9). The other end of the flow channel groove (13) extends forward. Side interfaces (14) are provided around the sample inlet (12). An oblique interface (15) is provided on one side of the sample inlet (12).

7. The high-pressure injection valve assembly for a formulation FPLC analyzer according to claim 1, characterized in that: The heating module includes a valve body (11), and water inlets (16) are provided on both sides of the outer side of the valve body (11). The water inlets (16) are connected to the hot flow channel (17) through the flow channel. The hot flow channel (17) is located inside the valve body (11).

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