A sample injection mechanism of a gas chromatograph-mass spectrometer

Abstract

The utility model discloses a gas chromatography-mass spectrometer's sample introduction mechanism, including gas chromatography-mass spectrometer body, the upper end of gas chromatography-mass spectrometer body is provided with the sample inlet, the left side fixed connection of gas chromatography-mass spectrometer body has the sample holder, the inner top of sample holder penetrates rotationally connected with first transmission shaft, first transmission shaft is connected through first meshing gear and first rotating shaft, first rotating shaft is connected with the output shaft of first motor, first motor sets up in the sample holder inside, first transmission shaft upper end fixed connection has the sample disc, and the sample of drawing is injected to the gas chromatography-mass spectrometer body through the sample inlet, and the automatic sample introduction is finished after, and the sample needle is adjusted frame rotation, makes the sample needle body be located solvent tank body top, and the cleaning solvent in the cleaning cavity is extracted through the sample needle body, and the inside cleaning of sample needle body is through the first electric telescopic link to the support frame push adjustment, thereby to the sample needle body position adjustment, and the cleaning solvent is discharged into the collection cavity.

Description

Technical Field

[0001] This utility model relates to the field of gas chromatography-mass spectrometry (GC-MS) sample introduction technology, specifically to a sample introduction mechanism for a GC-MS. Background Technology

[0002] A gas chromatography-mass spectrometry (GC-MS) instrument combines the functions of a gas chromatograph and a mass spectrometer. It is widely used for the separation and identification of complex components, combining the high resolution of GC with the high sensitivity of mass spectrometry. It is an effective tool for the qualitative and quantitative analysis of drugs and metabolites in biological samples. However, current GC-MS systems still require manual sampling by operators using the injection needle, which is labor-intensive, inefficient, and has limited applicability. To reduce manual operation, some sampling mechanisms now automate the process, where the injection needle draws the sample from the sample tube and injects it into the GC-MS instrument. In actual testing, to ensure accurate results, multiple parallel samples are usually prepared for testing the same sample. When samples are drawn using the injection needle, cross-contamination between samples is easily possible. Utility Model Content

[0003] The purpose of this section is to outline some aspects of the embodiments of this utility model and to briefly introduce some preferred embodiments. Simplifications or omissions may be made in this section, as well as in the abstract and title of this application, to avoid obscuring the purpose of these documents; however, such simplifications or omissions should not be used to limit the scope of this utility model.

[0004] In view of the problems existing in the sample introduction mechanism of the above and / or existing gas chromatography-mass spectrometry instruments, this utility model is proposed.

[0005] Therefore, the purpose of this utility model is to provide a sample introduction mechanism for a gas chromatography-mass spectrometry (GC-MS) instrument. Under the action of a third motor and a lead screw, the moving frame moves and adjusts to an appropriate position on the lead screw. The fixed frame is pushed by a third electric telescopic rod, which in turn drives the injection needle push rod to move upward through the limiting frame. The sample is extracted through the injection needle body. After the sample is automatically extracted, the injection needle adjustment frame is rotated and adjusted by a second motor, a second rotating shaft, a second meshing gear set, and a second transmission shaft. The extracted sample is injected into the main body of the GC-MS instrument through the injection port. After the sample is injected, the injection needle adjustment frame is rotated so that the injection needle body is above the solvent tank. The cleaning solvent in the cleaning chamber is extracted through the injection needle body to clean the inside of the injection needle body, and the cleaning solvent is discharged into the collection chamber.

[0006] To solve the above-mentioned technical problems, according to one aspect of the present invention, the present invention provides the following technical solution: A sample introduction mechanism for a gas chromatography-mass spectrometry (GC-MS) instrument includes a main body of the GC-MS instrument, an inlet at the upper end of the main body, a sample holder fixedly connected to the left side of the main body, a first drive shaft rotatably connected through the inner top of the sample holder, the first drive shaft being connected to a first rotating shaft via a first meshing gear, the first rotating shaft being connected to the output shaft of a first motor, the first motor being disposed inside the sample holder, a sample tray fixedly connected to the upper end of the first drive shaft, and a solvent container disposed near the rear of the upper end of the sample holder.

[0007] As a preferred embodiment of the sample introduction mechanism of the gas chromatography-mass spectrometry (GC-MS) instrument described in this utility model, the sample disk includes sample slots, and the upper end of the sample disk has sample slots arranged in a ring array, with sample tubes placed in the sample slots.

[0008] As a preferred embodiment of the sample introduction mechanism of the gas chromatography-mass spectrometry (GC-MS) instrument described in this utility model, the solvent tank includes a cleaning chamber, and the solvent tank has a cleaning chamber and a collection chamber inside, with the collection chamber located behind the cleaning chamber.

[0009] As a preferred embodiment of the sample introduction mechanism of the gas chromatography-mass spectrometry instrument described in this utility model, the sample holder includes a second drive shaft, and the top end of the sample holder is rotatably connected to the second drive shaft. The second drive shaft is located to the right of the first drive shaft, and the upper end of the second drive shaft is fixedly connected to the injection needle adjustment bracket.

[0010] In a preferred embodiment of the sample introduction mechanism of the gas chromatography-mass spectrometry (GC-MS) instrument described in this utility model, the second transmission shaft is connected to the second rotating shaft via a second meshing gear set, the second rotating shaft is connected to the output shaft of the second motor, and the second motor is disposed inside the sample holder.

[0011] As a preferred embodiment of the sample introduction mechanism of the gas chromatography-mass spectrometry instrument described in this utility model, a lead screw is rotatably connected to the inner wall of the sample injection needle adjustment frame, the upper end of the lead screw passes through the sample injection needle adjustment frame and is connected to the output shaft of the third motor, a movable frame is provided through the lead screw, and a support guide rod is fixedly connected to the inner wall of the sample injection needle adjustment frame, the support guide rod passes through the movable frame.

[0012] In a preferred embodiment of the sample introduction mechanism of the gas chromatography-mass spectrometry (GC-MS) instrument described in this utility model, a first electric telescopic rod is fixedly installed on the left side of the movable frame, and a support frame is fixedly connected to the left end of the first electric telescopic rod.

[0013] In a preferred embodiment of the sample introduction mechanism of the gas chromatography-mass spectrometry (GC-MS) instrument described in this utility model, a second electric telescopic rod is fixedly and continuously installed on both the front and rear sides of the support frame. A clamp is fixedly connected to the inner end of the second electric telescopic rod, and a protective pad is fixedly connected to the inner side wall of the clamp.

[0014] As a preferred embodiment of the sample introduction mechanism of the gas chromatography-mass spectrometry instrument described in this utility model, the inner side of the protective pad is in contact with the sample injection needle body, a sample injection needle push rod is provided through the upper part of the sample injection needle body, and a limit frame is provided on the outer ring of the sample injection needle push rod near the top.

[0015] As a preferred embodiment of the sample introduction mechanism of the gas chromatography-mass spectrometry (GC-MS) instrument described in this utility model, a support plate frame is fixedly connected to the inner wall of the support frame, a third electric telescopic rod is fixedly installed at the upper end of the support plate frame, the third electric telescopic rod is located on the right side of the sample injection needle body, a fixing frame is fixedly connected to the upper end of the third electric telescopic rod, and the fixing frame and the limiting frame are fixedly connected.

[0016] Compared with the prior art, the beneficial effects of this utility model are as follows: Under the action of the third motor and the lead screw, the moving frame moves and adjusts to an appropriate position on the lead screw. The fixed frame is pushed by the third electric telescopic rod, thereby driving the injection needle push rod to move upward through the limit frame. The sample is extracted through the injection needle body. After the sample is automatically extracted, the injection needle adjustment frame is rotated and adjusted by the action of the second motor, the second rotating shaft, the second meshing gear group and the second transmission shaft. The extracted sample is injected into the main body of the gas chromatography-mass spectrometer through the injection port. After the sample is injected, the injection needle adjustment frame is rotated so that the injection needle body is above the solvent tank. The cleaning solvent in the cleaning chamber is extracted through the injection needle body to clean the inside of the injection needle body. The support frame is pushed and adjusted by the first electric telescopic rod, thereby adjusting the position of the injection needle body and draining the cleaning solvent into the collection chamber. Attached Figure Description

[0017] To more clearly illustrate the technical solutions of the embodiments of this utility model, the present utility model will be described in detail below with reference to the accompanying drawings and detailed embodiments. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. Among them: Figure 1 This is a schematic diagram of the overall structure of this utility model; Figure 2 This is a schematic diagram of the cross-sectional structure of the sample frame of this utility model; Figure 3 This is a schematic diagram of the cross-sectional structure of the support frame of this utility model; Figure 4This is a schematic diagram of the sample tray structure of this utility model; Figure 5 This is a schematic diagram of the solvent tank structure of this utility model.

[0018] In the diagram: 1. Main body of the gas chromatography-mass spectrometry (GC-MS) instrument; 2. Sample inlet; 3. Sample holder; 301. Second drive shaft; 302. Second meshing gear set; 303. Second rotating shaft; 304. Second motor; 305. Injection needle adjustment bracket; 306. Lead screw; 307. Third motor; 308. Moving frame; 309. Support guide rod; 310. First electric telescopic rod; 311. Support frame; 312. Second electric telescopic rod; 313. Clamp; 314. Injection needle body; 315. Injection needle push rod; 316. Support plate frame; 317. Third electric telescopic rod; 318. Fixing frame; 319. Limiting frame; 4. First drive shaft; 5. First meshing gear set; 6. First rotating shaft; 7. First motor; 8. Sample tray; 801. Sample tank; 802. Sample tube; 9. Solvent tank; 901. Cleaning chamber; 902. Collection chamber. Detailed Implementation

[0019] To make the above-mentioned objectives, features and advantages of this utility model more apparent and understandable, the specific embodiments of this utility model will be described in detail below with reference to the accompanying drawings.

[0020] Secondly, this utility model is described in detail with reference to the schematic diagrams. When describing the embodiments of this utility model, for ease of explanation, the cross-sectional views showing the device structure may be partially enlarged, not according to the usual scale. Furthermore, the schematic diagrams are merely examples and should not limit the scope of protection of this utility model. In addition, in actual manufacturing, the three-dimensional spatial dimensions of length, width, and depth should be included.

[0021] To make the objectives, technical solutions, and advantages of this utility model clearer, the embodiments of this utility model will be described in further detail below with reference to the accompanying drawings.

[0022] This invention provides a sample introduction mechanism for a gas chromatography-mass spectrometry (GC-MS) instrument. Under the action of a third motor and a lead screw, the movable frame moves and adjusts to an appropriate position on the lead screw. The fixed frame is pushed by a third electric telescopic rod, which in turn drives the injection needle push rod to move upward through the limiting frame. The sample is extracted through the injection needle body. After automatic sample extraction, the injection needle adjustment frame is rotated and adjusted by a second motor, a second rotating shaft, a second meshing gear set, and a second transmission shaft. The extracted sample is injected into the main body of the GC-MS instrument through the injection port. After automatic sample injection, the injection needle adjustment frame is rotated so that the injection needle body is positioned above the solvent tank. The cleaning solvent in the cleaning chamber is extracted through the injection needle body to clean the inside of the injection needle body, and the cleaning solvent is discharged into the collection chamber.

[0023] Figures 1-5The diagram shown is an overall structural schematic of one embodiment of the sample introduction mechanism of a gas chromatography-mass spectrometry (GC-MS) instrument according to this invention. Please refer to [link / reference]. Figures 1-5 The sample introduction mechanism of a gas chromatography-mass spectrometry (GC-MS) instrument according to this embodiment includes a GC-MS main body 1, an inlet 2 at the upper end of the GC-MS main body 1, a sample holder 3 fixedly connected to the left side of the GC-MS main body 1, a first drive shaft 4 rotatably connected through the inner top end of the sample holder 3, the first drive shaft 4 being connected to a first rotating shaft 6 via a first meshing gear 5, the first rotating shaft 6 being connected to the output shaft of a first motor 7, the first motor 7 being disposed inside the sample holder 3, a sample tray 8 fixedly connected to the upper end of the first drive shaft 4, and a solvent tank 9 disposed near the rear side of the upper end of the sample holder 3.

[0024] The sample tray 8 includes a sample slot 801. The sample tray 8 has a sample slot 801 arranged in a ring array at its upper end. A sample tube 802 is placed in the sample slot 801. The solvent tank 9 includes a cleaning chamber 901. The solvent tank 9 has a cleaning chamber 901 and a collection chamber 902 inside. The collection chamber 902 is located behind the cleaning chamber 901.

[0025] The upper end of the sample holder 3 is opened into the receiving groove near the rear. The solvent tank 9 is placed in the receiving groove. The first motor 7 drives the first transmission shaft 4 to rotate through the first rotating shaft 6 and the first meshing gear 5, thereby driving the sample tray 8 to rotate. This is used to adjust the position of other sample tubes 802 placed on the sample tray 8 for sampling. The cleaning solvent in the cleaning chamber 901 is drawn out through the injection needle body 314 to clean the inside of the injection needle body 314. The support frame 311 is pushed and adjusted by the first electric telescopic rod 310, thereby adjusting the position of the injection needle body 314 and draining the cleaning solvent into the collection chamber 902. This process is repeated multiple times. A liquid level detection sensor is set on the injection needle body 314 near the needle tip to detect whether the needle tip is in contact with the liquid, preventing dry pumping and ensuring consistent insertion depth, thereby ensuring the reproducibility of sampling. A displacement sensor is set to detect and control the amount of sample drawn by the injection needle body 314.

[0026] The sample holder 3 includes a second drive shaft 301. The second drive shaft 301 is rotatably connected through the top of the sample holder 3. The second drive shaft 301 is located on the right side of the first drive shaft 4. The upper end of the second drive shaft 301 is fixedly connected to the injection needle adjustment bracket 305. The second drive shaft 301 is connected to the second rotating shaft 303 through the second meshing gear set 302. The second rotating shaft 303 is connected to the output shaft of the second motor 304. The second motor 304 is located inside the sample holder 3.

[0027] Under the action of the second motor 304, the second rotating shaft 303, the second meshing gear set 302, and the second transmission shaft 301, the injection needle adjustment frame 305 is rotated and adjusted, and the extracted sample is injected into the main body 1 of the gas chromatography-mass spectrometry instrument through the injection port 2. The rotation angle is detected and controlled by setting an angle encoder.

[0028] A lead screw 306 is rotatably connected to the inner wall of the injection needle adjustment frame 305. The upper end of the lead screw 306 passes through the injection needle adjustment frame 305 and is connected to the output shaft of the third motor 307. A movable frame 308 is installed through the lead screw 306. A support guide rod 309 is fixedly connected to the inner wall of the injection needle adjustment frame 305. The support guide rod 309 passes through the movable frame 308. A support plate frame 316 is fixedly connected to the inner wall of the support frame 311. A third electric telescopic rod 317 is fixedly installed at the upper end of the support plate frame 316. The third electric telescopic rod 317 is located on the right side of the injection needle body 314. A fixed frame 318 is fixedly connected to the upper end of the third electric telescopic rod 317. The fixed frame 318 and the limiting frame 319 are fixedly connected.

[0029] Under the action of the third motor 307 and the lead screw 306, the moving frame 308 moves on the lead screw 306 to adjust to an appropriate position. The third electric telescopic rod 317 pushes the fixed frame 318, thereby causing the limiting frame 319 to drive the injection needle push rod 315 to move upward, and extract the sample through the injection needle body 314. Conversely, the sample is squeezed out from the injection needle body 314.

[0030] A first electric telescopic rod 310 is fixedly installed on the left side of the movable frame 308. A support frame 311 is fixedly connected to the left end of the first electric telescopic rod 310. A second electric telescopic rod 312 is fixedly installed through the front and rear sides of the support frame 311. A clamp 313 is fixedly connected to the inner end of the second electric telescopic rod 312. A protective soft pad is fixedly connected to the inner side wall of the clamp 313. The inner side of the protective soft pad is in contact with the injection needle body 314. An injection needle push rod 315 is installed through the upper part of the injection needle body 314. A limit frame 319 is provided near the top of the outer ring of the injection needle push rod 315.

[0031] The injection needle push rod 315 is moved between the limiting frame 319, and the second electric telescopic rod 312 pushes the clamp 313 to clamp and fix the injection needle body 314. Under the action of the protective soft pad, the clamping surface of the injection needle body 314 is prevented from being damaged, thus providing protection.

[0032] Combination Figures 1-5The sample introduction mechanism of a gas chromatography-mass spectrometry (GC-MS) instrument according to this embodiment is used as follows: The injection needle push rod 315 is moved between the limiting frames 319. The second electric telescopic rod 312 pushes the clamping frame 313 to clamp and fix the injection needle body 314. The protective pad prevents damage to the clamping surface of the injection needle body 314, thus providing protection. Under the action of the third motor 307 and the lead screw 306, the moving frame 308 moves on the lead screw 306 to adjust to an appropriate position. The third electric telescopic rod 317 pushes the fixing frame 318, thereby causing the limiting frame 319 to drive the injection needle push rod 315 to move upward, and the injection needle body 314 injects the sample. The sample is extracted, or conversely, squeezed out from the injection needle body 314. Under the action of the second motor 304, the second rotating shaft 303, the second meshing gear set 302, and the second transmission shaft 301, the injection needle adjustment frame 305 is rotated and adjusted. The extracted sample is injected into the main body 1 of the gas chromatography-mass spectrometry instrument through the injection port 2. The injection needle body 314 is rotated above the solvent tank 9. The cleaning solvent in the cleaning chamber 901 is extracted through the injection needle body 314 to clean the inside of the injection needle body 314. The support frame 311 is pushed and adjusted by the first electric telescopic rod 310, thereby adjusting the position of the injection needle body 314 and discharging the cleaning solvent into the collection chamber 902.

[0033] Although the present invention has been described above with reference to embodiments, various modifications can be made and components can be replaced with equivalents without departing from the scope of the present invention. In particular, as long as there is no structural conflict, the features in the embodiments disclosed in this invention can be combined with each other in any way. The lack of an exhaustive description of these combinations in this specification is merely for the sake of brevity and resource conservation. Therefore, the present invention is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims

1. A sample introduction mechanism for a gas chromatography-mass spectrometry (GC-MS) instrument, comprising the GC-MS instrument body (1), characterized in that: A sample inlet (2) is provided at the upper end of the main body (1) of the gas chromatography-mass spectrometry instrument. A sample rack (3) is fixedly connected to the left side of the main body (1). A first drive shaft (4) is rotatably connected through the inner top of the sample rack (3). The first drive shaft (4) is connected to a first rotating shaft (6) through a first meshing gear (5). The first rotating shaft (6) is connected to the output shaft of a first motor (7). The first motor (7) is located inside the sample rack (3). A sample tray (8) is fixedly connected to the upper end of the first drive shaft (4). A solvent tank (9) is provided near the rear side of the upper end of the sample rack (3).

2. The sample introduction mechanism of a gas chromatography-mass spectrometry (GC-MS) instrument according to claim 1, characterized in that: The sample tray (8) includes a sample groove (801). The sample tray (8) has a sample groove (801) arranged in a ring array at its upper end. A sample tube (802) is placed in the sample groove (801).

3. The sample introduction mechanism of a gas chromatography-mass spectrometry (GC-MS) instrument according to claim 1, characterized in that: The solvent tank (9) includes a cleaning chamber (901), and the solvent tank (9) has a cleaning chamber (901) and a collection chamber (902) inside. The collection chamber (902) is located behind the cleaning chamber (901).

4. The sample introduction mechanism of a gas chromatography-mass spectrometry (GC-MS) instrument according to claim 1, characterized in that: The sample holder (3) includes a second drive shaft (301). The top end of the sample holder (3) is rotatably connected to the second drive shaft (301). The second drive shaft (301) is located on the right side of the first drive shaft (4). The upper end of the second drive shaft (301) is fixedly connected to the injection needle adjustment bracket (305).

5. The sample introduction mechanism of a gas chromatography-mass spectrometry (GC-MS) instrument according to claim 4, characterized in that: The second drive shaft (301) is connected to the second meshing gear set (302) and the second rotating shaft (303). The second rotating shaft (303) is connected to the output shaft of the second motor (304). The second motor (304) is located inside the sample holder (3).

6. The sample introduction mechanism of a gas chromatography-mass spectrometry (GC-MS) instrument according to claim 4, characterized in that: The inner wall of the injection needle adjustment frame (305) is rotatably connected to a lead screw (306). The upper end of the lead screw (306) passes through the injection needle adjustment frame (305) and is connected to the output shaft of the third motor (307). A movable frame (308) is installed through the lead screw (306). A support guide rod (309) is fixedly connected to the inner wall of the injection needle adjustment frame (305). The support guide rod (309) passes through the movable frame (308).

7. The sample introduction mechanism of a gas chromatography-mass spectrometry (GC-MS) instrument according to claim 6, characterized in that: A first electric telescopic rod (310) is fixedly installed on the left side of the mobile frame (308), and a support frame (311) is fixedly connected to the left end of the first electric telescopic rod (310).

8. The sample introduction mechanism of a gas chromatography-mass spectrometry (GC-MS) instrument according to claim 7, characterized in that: The support frame (311) is fixedly provided with a second electric telescopic rod (312) on both the front and rear sides. The inner end of the second electric telescopic rod (312) is fixedly connected to a clamp (313), and the inner side wall of the clamp (313) is fixedly connected to a protective pad.

9. The sample introduction mechanism of a gas chromatography-mass spectrometry (GC-MS) instrument according to claim 8, characterized in that: The inner side of the protective pad is pressed against the injection needle body (314), and an injection needle push rod (315) is provided through the upper part of the injection needle body (314). A limit frame (319) is provided on the outer ring of the injection needle push rod (315) near the upper part.

10. The sample introduction mechanism of a gas chromatography-mass spectrometry (GC-MS) instrument according to claim 7, characterized in that: The inner wall of the support frame (311) is fixedly connected to the support plate frame (316), and the upper end of the support plate frame (316) is fixedly provided with a third electric telescopic rod (317). The third electric telescopic rod (317) is located on the right side of the injection needle body (314), and the upper end of the third electric telescopic rod (317) is fixedly connected to a fixing frame (318). The fixing frame (318) and the limiting frame (319) are fixedly connected.

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