A medicine dissolution tester

Abstract

The utility model provides a kind of medicine dissolution tester, belong to tablet dissolution test field, including dissolution tester ontology, the inside fixed connection of dissolution tester ontology has dissolution cup, the top fixed connection of dissolution tester ontology has rear frame, the top fixed connection of rear frame has upper motor, the output shaft of upper motor is fixedly connected with rotating screw column by coupling, the outer wall of rotating screw column is movably connected with movable long plate.The utility model can realize the effect of automatic dosing in laboratory by setting dissolution tester ontology, dissolution cup, rear frame, upper motor, rotating screw column, movable long plate, limiting long column, stirring motor, stirring paddle, cover plate, limiting frame, electric push rod, push plate, lower frame and heating pipe column.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical testing equipment technology, and more specifically, to a pharmaceutical dissolution apparatus. Background Technology

[0002] Drug dissolution testing is a key test item for evaluating the rate and extent of drug dissolution from the formulation under specified conditions in oral solid dosage forms (such as tablets and capsules). The main significance of drug dissolution testing is that (1) oral solid dosage forms need to be dissolved in the body before they can be absorbed and exert their effects. Dissolution directly reflects whether the drug can be effectively dissolved, thus simulating and evaluating its clinical efficacy. (2) For different batches of the same drug from different manufacturers, dissolution testing can verify the stability of their production processes, avoid quality fluctuations caused by process differences, and ensure batch-to-batch consistency of drugs. (3) Guiding formulation development: In the new drug development stage, dissolution testing can be used to screen formulations (such as excipient types) and optimize processes, helping to develop formulations with better dissolution performance and higher bioavailability.

[0003] A drug dissolution apparatus is a tool for determining the dissolution rate of drugs.

[0004] In the prior art, Chinese patent publication number CN219084900U discloses "a dissolution tester," which includes a double-layer frame, a water bath installed between the two sides of the inner wall of the double-layer frame, and a dissolution cup. A through-channel communicating with the water bath is opened on the outer side of the double-layer frame. The dissolution cup is placed within the through-channel and flush with the surface of the double-layer frame. A sliding rail is provided on the outer side of the double-layer frame, and an insert plate covering the through-channel is installed on the inner side of the sliding rail. A U-shaped groove is provided on the outer side of the insert plate, and a fitting component is provided on the inner side of the U-shaped groove. This utility model, through a partition, a sliding groove, and a limiting post, combined with an insert plate, a slider, a movable groove, a movable block, a spring sheet, and a protective layer, changes the original snap-on cup lid to a sliding type. The movable block can pass through... The expansion and contraction displacement within the moving tank controls the opening and closing of the U-shaped groove. When the stirring rod enters the U-shaped groove, the protective layer can cooperate with the U-shaped groove to form a through hole, wrapping around the stirring rod for fixation. However, the following defects still exist: The dissolution determination method is usually operated as follows: Take a specified volume (generally 900 ml unless otherwise specified) of dissolution medium and place it in each dissolution cup. Heat it until the temperature of the dissolution medium is constant at 37.0℃ ± 0.5℃. Take the test sample and put it into the dissolution cup. Start timing from the moment the test sample contacts the dissolution medium until the specified sampling time. Take an appropriate amount of solution at the specified sampling point and immediately filter it through a suitable microporous membrane (the filtration of each container should be completed within 30 seconds from sampling). Take the clear filtrate and determine the dissolution amount per tablet (capsule, bag) according to the method specified under the variety item. The lack of automatic drug addition after heating means that during dissolution testing, operators typically need to remain at the dissolution apparatus, quickly adding the sample after heating to begin the dissolution process. This affects the overall accuracy and hinders the efficient use of the instrument. Furthermore, manual drug addition can lead to variations in the way the sample is added to the dissolution vessel (e.g., whether it's added slowly along the vessel wall or whether it sticks to the wall), affecting the accuracy of the test results. This is especially problematic during process optimization, where even minor experimental differences can significantly impact the final accuracy. The aforementioned device also lacks height adjustment functionality. Theoretically, the solution should be drawn from the designated sampling point at the specified sampling time. However, in practice, operators of different heights often have slightly different sampling heights, causing deviations in the dissolution test results. Therefore, a new drug dissolution apparatus is proposed. Summary of the Invention

[0005] The technical problem to be solved by this utility model is to overcome the shortcomings of the prior art and provide a drug dissolution apparatus that can overcome or at least partially solve the above problems.

[0006] To achieve the above-mentioned objectives, this utility model provides the following technical solution: The present invention is as follows: a drug dissolution apparatus includes a dissolution apparatus body, a dissolution cup fixedly connected inside the dissolution apparatus body, a rear frame fixedly connected to the top of the dissolution apparatus body, an upper motor fixedly connected to the top of the rear frame, a rotating threaded column fixedly connected to the output shaft of the upper motor via a coupling, a movable long plate movably connected to the outer wall of the rotating threaded column, a limiting long column movably connected to the top of the movable long plate, and a stirring motor fixedly connected to the top of the movable long plate.

[0007] The output shaft of the stirring motor is fixedly connected to a stirring paddle via a coupling. A cover plate is fixedly connected to the outer wall of the stirring paddle. A limit frame is fixedly connected to the top of the dissolution apparatus body. An electric push rod is fixedly connected inside the limit frame. A push plate is fixedly connected to one end of the electric push rod. A lower frame is fixedly connected to the bottom of the dissolution apparatus body. A heating tube column is fixedly connected inside the lower frame.

[0008] As a preferred technical solution of this utility model, the bottom of the dissolution apparatus body is fixedly connected with an electric lifting column, and the number of electric lifting columns is four.

[0009] As a preferred technical solution of this utility model, the bottom end of the electric lifting column is fixedly connected to a base, and the bottom area of ​​the base is larger than the bottom area of ​​the electric lifting column.

[0010] As a preferred technical solution of this utility model, a side bolt is movably connected to one side of the dissolution apparatus body, and a side handle is movably connected to the outer wall of the side bolt.

[0011] As a preferred technical solution of this utility model, a liquid inlet threaded pipe is fixedly connected to one side of the dissolution apparatus body, and a threaded lock is movably connected to the outer wall of the liquid inlet threaded pipe.

[0012] As a preferred technical solution of this utility model, a liquid outlet threaded tube is fixedly connected to one side of the dissolution apparatus body, and a threaded lock is movably connected to the outer wall of the liquid outlet threaded tube.

[0013] As a preferred technical solution of this utility model, the top of the movable long plate is movably connected to the outer wall of the limiting long column, and the length of the limiting long column is equal to the length of the rotating threaded column.

[0014] As a preferred technical solution of this utility model, the inside of the cover plate is fixedly connected to the outer wall of the stirring paddle, and the top of the cover plate is provided with an opening.

[0015] Compared with the prior art, the beneficial effects of this utility model are as follows: 1. By configuring the dissolution apparatus body, dissolution cup, rear frame, upper motor, rotating threaded column, movable long plate, limiting long column, stirring motor, stirring paddle, cover plate, limiting frame, electric push rod, push plate, lower frame, and heating column, automatic dosing can be achieved in the laboratory. This reduces the time experimental operators spend waiting for water temperature, reduces their workload, lowers the overall complexity of the work, and improves the accuracy of the overall work, which is conducive to the efficient use of the testing instrument. At the same time, mechanical dosing provides better uniformity, which helps to improve the accuracy and uniformity of the test results.

[0016] 2. The electric lifting base column, base, side bolts and side handle make it easy to move the whole structure and make it easier for experimental operators of different heights to use the tester. This improves the tester's adaptability to the environment and is conducive to the use of the tester in multiple scenarios. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the structure of the drug dissolution apparatus provided by this utility model; Figure 2 A bottom view of the structure of the drug dissolution apparatus provided by this utility model; Figure 3 A top view of the structure of the drug dissolution apparatus provided by this utility model; Figure 4 A side sectional view of the drug dissolution apparatus provided by this utility model; Figure 5 A front cross-sectional view of the drug dissolution apparatus provided by this utility model.

[0018] The diagram shows: 1. Dissolution apparatus body; 2. Dissolution cup; 3. Rear frame; 4. Upper motor; 5. Rotating threaded column; 6. Movable long plate; 7. Limiting long column; 8. Stirring motor; 9. Stirring paddle; 10. Cover plate; 11. Limiting frame; 12. Electric push rod; 13. Push plate; 14. Lower frame; 15. Heating column; 16. Electric lifting base column; 17. Base; 18. Side bolt; 19. Side handle; 20. Inlet threaded pipe; 21. Threaded lock one; 22. Outlet threaded pipe; 23. Threaded lock two. Detailed Implementation

[0019] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model.

[0020] Therefore, the following detailed description of the embodiments of this utility model is not intended to limit the scope of the claimed utility model, but merely to illustrate some embodiments of the utility model. All other embodiments obtained by those skilled in the art based on the embodiments of this utility model without inventive effort are within the scope of protection of this utility model.

[0021] It should be noted that, unless otherwise specified, the embodiments and features and technical solutions in the present invention can be combined with each other.

[0022] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0023] As shown in 1-5, this embodiment proposes a drug dissolution apparatus, including a dissolution apparatus body 1, a dissolution cup 2 fixedly connected inside the dissolution apparatus body 1, a rear frame 3 fixedly connected to the top of the dissolution apparatus body 1, an upper motor 4 fixedly connected to the top of the rear frame 3, a rotating threaded column 5 fixedly connected to the output shaft of the upper motor 4 via a coupling, a movable long plate 6 movably connected to the outer wall of the rotating threaded column 5, a limiting long column 7 movably connected to the top of the movable long plate 6, and a stirring motor 8 fixedly connected to the top of the movable long plate 6.

[0024] The output shaft of the stirring motor 8 is fixedly connected to the stirring paddle 9 via a coupling. The outer wall of the stirring paddle 9 is fixedly connected to the cover plate 10. The top of the dissolution apparatus body 1 is fixedly connected to the limiting frame 11. The inside of the limiting frame 11 is fixedly connected to the electric push rod 12. One end of the electric push rod 12 is fixedly connected to the push plate 13. The bottom of the dissolution apparatus body 1 is fixedly connected to the lower frame 14. The inside of the lower frame 14 is fixedly connected to the heating tube column 15.

[0025] As shown in 1-5, in a preferred embodiment, based on the above method, the bottom of the dissolution apparatus body 1 is fixedly connected with an electric lifting base column 16, and there are four electric lifting base columns 16, which can adjust the working height of the whole structure. The bottom end of the electric lifting base column 16 is fixedly connected with a base 17, and the bottom area of ​​the base 17 is larger than the bottom area of ​​the electric lifting base column 16, which improves the working stability of the whole structure. A side bolt 18 is movably connected to one side of the dissolution apparatus body 1, and a side handle 19 is movably connected to the outer wall of the side bolt 18, which facilitates the movement of the whole structure.

[0026] A liquid inlet threaded pipe 20 is fixedly connected to one side of the dissolution apparatus body 1. A threaded locking buckle 21 is movably connected to the outer wall of the liquid inlet threaded pipe 20 to facilitate the addition of water for heating to the dissolution apparatus body 1. A liquid outlet threaded pipe 22 is fixedly connected to one side of the dissolution apparatus body 1. A threaded locking buckle 23 is movably connected to the outer wall of the liquid outlet threaded pipe 22 to facilitate the discharge of water from the dissolution apparatus body 1.

[0027] The top of the movable long plate 6 is movably connected to the outer wall of the limiting long column 7, and the length of the limiting long column 7 is equal to the length of the rotating threaded column 5, which allows the movable long plate 6 to move in a stable straight line. The inside of the cover plate 10 is fixedly connected to the outer wall of the stirring paddle 9, and the top of the cover plate 10 is provided with an opening, which facilitates the entry of the medicine into the dissolution cup 2 from the top of the cover plate 10.

[0028] Specifically, when using this drug dissolution apparatus: The entire structure is moved to the working position using the side handle 19, causing the electric lifting column 16 to extend, allowing the dissolution apparatus body 1 to reach the appropriate working height. Rotation of the first threaded lock 21 locks the inlet threaded pipe 20 with the external water supply pipe. Rotation of the second threaded lock 23 locks the outlet threaded pipe 22. Water is added to the dissolution cup 2. The tablets to be tested are placed in the limiting frame 11. The upper motor 4 starts working, and the output shaft of the upper motor 4 rotates... The rotating threaded column 5 rotates, causing the movable long plate 6 to descend, thus placing the cover plate 10 over the inside of the dissolution cup 2. Water is added through the inlet threaded pipe 20, and the heating column 15 operates, causing the water temperature inside the dissolution apparatus 1 to rise, thereby heating the dissolution cup 2 to an appropriate temperature. At that time, the electric push rod 12 operates, and the extension of the electric push rod 12 causes the push plate 13 to push the medicine into the dissolution apparatus 1. The operation of the stirring motor 8 causes the stirring paddle 9 to stir, thereby dissolving the medicine.

[0029] All technical features in this embodiment can be freely combined according to actual needs.

[0030] The above embodiments are preferred implementations of this utility model. In addition, this utility model can also be implemented in other ways. Any obvious substitutions without departing from the concept of this technical solution are within the protection scope of this utility model.

Claims

1. A drug dissolution apparatus, comprising an apparatus body (1), characterized in that, The dissolution apparatus body (1) is fixedly connected to a dissolution cup (2), the top of the dissolution apparatus body (1) is fixedly connected to a rear frame (3), the top of the rear frame (3) is fixedly connected to an upper motor (4), the output shaft of the upper motor (4) is fixedly connected to a rotating threaded column (5) via a coupling, the outer wall of the rotating threaded column (5) is movably connected to a movable long plate (6), the top of the movable long plate (6) is movably connected to a limiting long column (7), and the top of the movable long plate (6) is fixedly connected to a stirring motor (8). The output shaft of the stirring motor (8) is fixedly connected to the stirring paddle (9) via a coupling. The outer wall of the stirring paddle (9) is fixedly connected to the cover plate (10). The top of the dissolution apparatus body (1) is fixedly connected to the limiting frame (11). The inside of the limiting frame (11) is fixedly connected to the electric push rod (12). One end of the electric push rod (12) is fixedly connected to the push plate (13). The bottom of the dissolution apparatus body (1) is fixedly connected to the lower frame (14). The inside of the lower frame (14) is fixedly connected to the heating tube column (15).

2. The drug dissolution apparatus according to claim 1, characterized in that, The bottom of the dissolution apparatus body (1) is fixedly connected to an electric lifting base column (16), and the number of electric lifting base columns (16) is four.

3. A drug dissolution apparatus according to claim 2, characterized in that, The bottom end of the electric lifting column (16) is fixedly connected to a base (17), and the bottom area of ​​the base (17) is larger than the bottom area of ​​the electric lifting column (16).

4. A drug dissolution apparatus according to claim 1, characterized in that, A side bolt (18) is movably connected to one side of the dissolution apparatus body (1), and a side handle (19) is movably connected to the outer wall of the side bolt (18).

5. A drug dissolution apparatus according to claim 1, characterized in that, The dissolution apparatus body (1) is fixedly connected to one side of a liquid inlet threaded pipe (20), and the outer wall of the liquid inlet threaded pipe (20) is movably connected to a threaded lock (21).

6. A drug dissolution apparatus according to claim 1, characterized in that, The dissolution apparatus body (1) is fixedly connected to one side of a liquid outlet threaded tube (22), and the outer wall of the liquid outlet threaded tube (22) is movably connected to a threaded lock two (23).

7. A drug dissolution apparatus according to claim 1, characterized in that, The top of the movable long plate (6) is movably connected to the outer wall of the limiting long column (7), and the length of the limiting long column (7) is equal to the length of the rotating threaded column (5).

8. A drug dissolution apparatus according to claim 1, characterized in that, The inside of the cover plate (10) is fixedly connected to the outer wall of the stirring paddle (9), and the top of the cover plate (10) is provided with an opening.

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