A multifunctional mouse sleep deprivation experimental device

Abstract

The utility model discloses a multifunctional mouse sleep deprivation experiment device, including cold storage box, the cold storage box be provided with the door, the vent, be provided with interference lamp, interference stick mechanism and reciprocating cycle mechanism in the cold storage box, interference stick mechanism include horizontal sweep pole and vertical pole, vertical pole's one end is connected horizontal sweep pole, reciprocating cycle mechanism include fixed beam, driving wheel, from driving wheel, transmission chain, fixed beam is provided with slide rail, the fixed beam below slide rail is provided with the through slot, the slide rail is provided with the sliding block, vertical pole's other end pipe through groove and the bottom of sliding block are connected, sliding block side is provided with the connecting rod, the connecting rod is provided with the connecting piece, the connecting piece with transmission chain on a section of outer link plate fixed connection. The utility model discloses adopt reciprocating cycle formula interference stick method to the sleep interference of experimental mouse, integrated long time light irradiation and low temperature refrigeration interference function, the sleep interference situation of experimental mouse under long time light irradiation and low temperature is convenient to study, and the structure is ingenious, and the installation is convenient.

Description

Technical Field

[0001] This invention belongs to the technical field of mouse experimental equipment, and in particular relates to a multifunctional mouse sleep deprivation experimental device. Background Technology

[0002] Sleep deprivation research plays a vital role in neuroscience, psychology, and behavioral science, significantly advancing our understanding of sleep physiology, sleep disorder mechanisms, and their relationships with other physiological and psychological processes. Existing research largely focuses on single factors of sleep deprivation, lacking in-depth exploration of sleep deprivation exceeding 20 hours under prolonged light and cold conditions. Therefore, a novel experimental device is urgently needed to study sleep disturbances in mice under cold and bright light conditions.

[0003] Currently, commonly used sleep disruption methods mainly include reciprocating cyclic interference rods and rotating interference rods. Although reciprocating cyclic interference rods are widely used in experiments, their structure is relatively complex, maintenance is difficult, and their interference method is singular, failing to meet the need for flexible responses to different experimental conditions. Therefore, designing a reciprocating cyclic interference rod that combines long-term light exposure and low-temperature cooling is particularly important. This device can not only conveniently and effectively disrupt the sleep of experimental mice, but also achieve ease of installation and operation through its ingenious structural design, thus advancing research progress on the effects of low-temperature environments and long-term light exposure on mouse sleep.

[0004] This invention proposes a device that combines a reciprocating cyclic interference rod, a novel light source, and a cooling system, aiming to provide diverse sleep disturbance methods for experiments, improve the operability and reliability of experiments, and promote in-depth research in related fields. Utility Model Content

[0005] To address the aforementioned problems, this invention provides a multifunctional mouse sleep deprivation experimental device.

[0006] This invention is implemented as follows: A multifunctional mouse sleep deprivation experimental device includes a cold box with a traditional refrigerator structure, mainly comprising a compressor, condenser, filter, capillary tube, and evaporator. The evaporator is located inside the cold box and absorbs heat during operation, providing a temperature environment of 0-4℃ through control. The cold box is equipped with a door and ventilation openings. Inside the cold box are an interference lamp, an interference rod mechanism, and a reciprocating circulation mechanism. The interference lamp provides light interference. A mouse feces collection tray is located at the bottom of the cold box, with a grid-like base plate above it. During the experiment, the mice are placed on the grid-like base plate. The interference rod mechanism includes a horizontal sweeping rod and a vertical rod. One end of the vertical rod is connected to the horizontal sweeping rod. The length of the horizontal sweeping rod is approximately equal to the width of the cold box. For example, when the width of the cold box is 30cm, the length of the horizontal sweeping rod can be set to 28-29cm to ensure that the horizontal sweeping rod can interfere with all the experimental mice inside the cold box. The horizontal sweeping rod extends approximately 1cm above the grid-like base plate to ensure effective interference. The connection between the horizontal sweeping bar and the vertical bar can be achieved using traditional connection methods such as plug-in connection or threaded connection, ensuring a reliable and secure connection. The reciprocating circulation mechanism includes a fixed beam, a driving wheel, and a driven wheel. The fixed beam is located at the top of the cold storage box. The driving wheel and the driven wheel are fixedly located at both ends of the fixed beam. The driving wheel is connected to a motor, which provides power to the driving wheel. A transmission chain is provided between the driving wheel and the driven wheel. The fixed beam is equipped with a slide rail, which has a side-inverted "U" structure. A through groove is provided on the fixed beam below the slide rail. A slider is installed inside the slide rail. The other end of the vertical bar passes through the through groove and connects to the bottom of the slider. A threaded hole can be provided at the center of the bottom of the slider. An external thread is provided on the top of the vertical bar, corresponding to the threaded hole. The vertical bar is screwed into the threaded hole. A connecting shaft is provided on the side of the slider, extending out of the opening of the slide rail. A connecting piece is provided on the connecting shaft, and the connecting piece is fixedly connected to an outer chain plate on the transmission chain.

[0007] During operation, the driving wheel rotates under the drive of the motor, causing the transmission chain to circulate between the driving and driven wheels. An outer chain plate on the transmission chain is fixedly connected to a connecting piece, which in turn is connected to a slider, which in turn is connected to an interference mechanism. As the connecting piece reciprocates between the driving and driven wheels following the transmission chain, it drives the interference mechanism to also reciprocate within the groove between the driving and driven wheels. When the connecting piece reaches the position of the driving or driven wheel, it rotates 180° along the connecting shaft on the slider. The center of the connecting shaft coincides with the center of the driving or driven wheel when it reaches it. The total length of the connecting piece and the outer chain plate on the transmission chain is equal to the radius of the driving or driven wheel, and the radii of the driving and driven wheels are the same.

[0008] The transmission chain includes several outer chain plates, inner chain plates, pins, sleeves, and rollers. The difference from the general structure of the transmission chain is that, preferably, the connecting member and one of the outer chain plates are an integral structure to ensure the reliability of the connection between the connecting member and the transmission chain.

[0009] A side baffle is provided at the opening of the slide rail, and the side baffle is fixedly connected to the fixed beam by screws.

[0010] Two limiting rings are provided on the connecting shaft, and the connecting member is positioned between the two limiting rings. When the connecting member rotates with the connecting shaft, the position of the connecting member is guaranteed not to shift, which is conducive to the smooth operation of the connecting member.

[0011] Preferably, a fixed connecting seat is provided at the bottom of the vertical rod, and the fixed connecting seat is provided with a threaded hole. The horizontal sweeping rod is also provided with a corresponding threaded hole. The fixed seat and the horizontal sweeping rod are firmly connected together by screws. When the horizontal sweeping rod and the vertical rod are fixedly connected, the above connection method is safe and reliable and can achieve quick installation.

[0012] When installing and connecting the interference rod mechanism and the reciprocating circulation mechanism, first screw the end of the vertical rod with external threads into the threaded hole at the bottom of the slider. The other end of the vertical rod is equipped with a fixed connecting seat. Then, firmly fix the horizontal sweeping rod to the fixed connecting seat with screws. The whole process is quick and reliable. The length of the vertical rod and the horizontal sweeping rod can be modularly customized and adjusted according to the height and width of the cold storage box.

[0013] The beneficial effects of this utility model are: 1. This utility model uses a reciprocating cyclic interference rod method to interfere with the sleep of experimental mice. The structure is ingenious and easy to install; 2. It integrates light and low temperature cooling interference functions, which makes it convenient to study the sleep interference of experimental mice under long-term light exposure and low temperature. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0015] Figure 2 This is a schematic diagram of the connecting component structure of this utility model;

[0016] Figure 3 This is a schematic diagram of the connection structure between the vertical rod and the horizontal sweeping rod of this utility model;

[0017] Figure 4 The structural block diagram of the circulating refrigeration principle of the cold storage box of this utility model;

[0018] In the diagram: 1-Cold storage box, 2-Box door, 3-Ventilation vent, 4-Interference lamp, 5-Interference rod mechanism, 501-Horizontal sweeping rod, 502-Vertical rod, 6-Reciprocating circulation mechanism, 601-Driving wheel, 602-Driven wheel, 603-Transmission chain, 6031-Outer chain plate, 6032-Inner chain plate, 6033-Pin, 6034-Sleeve, 6035-Roller, 604-Fixed beam, 6041-Side baffle, 6042-Screw, 6043-Through groove, 605-Slide rail, 606-Slider, 607-Connecting shaft, 608-Connector, 7-Feces collection tray. Detailed Implementation

[0019] To better understand the technical solution of this utility model, the following description, in conjunction with the accompanying drawings, further illustrates this utility model.

[0020] like Figure 1-4 The multifunctional mouse sleep deprivation experimental device shown includes a cold storage box 1, which has a traditional refrigerator structure. The main refrigeration components and their working principle are as follows: Figure 4 As shown, the cold box 1 is equipped with a door 2 for convenient placement of experimental mice, and a ventilation opening 3 to facilitate air circulation within the cold box 1. The cold box 1 contains an interference lamp 4, an interference rod mechanism 5, and a reciprocating circulation mechanism 6. The interference rod mechanism 5 includes a horizontal sweeping rod 501 and a vertical rod 502. One end of the vertical rod 502 is connected to the horizontal sweeping rod 501, as shown in the specific connection method. Figure 3 As shown, a fixed connecting seat 5021 is provided at the bottom end of the vertical rod, and the fixed connecting seat is provided with a threaded hole. The top of the horizontal sweeping rod 501 is also provided with a matching threaded hole. The horizontal sweeping rod 501 is firmly fixed to the fixed connecting seat 5021 by screws. The fixed connecting seat can be rectangular or circular. The fixed connecting seat 5021 facilitates the quick connection of the horizontal sweeping rod 501 and the vertical rod 502. The reciprocating circulation mechanism 6 includes a fixed beam 604, a driving wheel 601, and a driven wheel 602. The driving wheel 601 rotates under the drive of a motor. Figure 1 Although the motor is not explicitly labeled, it is easy to understand that the connection structure between the motor and the drive wheel is a conventional connection method. The motor is mounted on, for example,... Figure 2 On one side of the standard indicated by the middle arrow, the fixed beam 604 is located on the upper part of the cold storage box 1. The driving wheel 601 and the driven wheel 602 are fixedly located at both ends of the fixed beam 604. A transmission chain 603 is provided between the driving wheel 601 and the driven wheel 602. The fixed beam 604 is provided with a slide rail 605, which has a sideways "U" structure, as shown below. Figure 2As shown, a through groove 6043 is provided on the fixed beam below the slide rail 605. A slider 606 is provided inside the slide rail. The other end of the vertical rod 502 passes through the through groove 6043 and connects to the bottom of the slider 606. The specific connection method is as follows: a threaded hole is provided at the center of the bottom of the slider 606, and an external thread is provided at the top of the vertical rod corresponding to the threaded hole. The vertical rod 502 is screwed into the threaded hole. A connecting shaft 607 is provided on the side of the slider 606. The connecting shaft 607 is located on the side of the slider 606 facing the opening of the slide rail 605. A connecting member 608 is provided on the connecting shaft 607. Two limiting rings 6071 are provided on the connecting shaft 607, and the connecting member 608 is located between the two limiting rings 6071. The connecting member 608 is fixedly connected to one of the outer chain plates on the transmission chain 603. Specifically, the connecting member 608 and one of the outer chain plates 6031 are an integral structure. The transmission chain 603 includes several outer chain plates 6031, inner chain plates 6032, pins 6033, sleeves 6034, and rollers 6035. This is the general structure of the transmission chain 603. The difference from a typical transmission chain lies in the fact that the connecting member 608 and one of the outer chain plates 6031 are integrally formed. The center of the connecting shaft 607 coincides with the center of the driving wheel 601 or driven wheel 602 when it reaches them. The sum of the lengths d of the connecting member 607 and the outer chain plates 6031 on the transmission chain 603 (this sum of lengths d is the sum of the distances along the central axis as shown in the figure) is equal to the radius of the driving wheel or driven wheel. The radii of the driving wheel and driven wheel are the same. The fixed beam 604 is positioned at the center of the upper part of the cold storage box 1. The vertical rod 502 connects to the midpoint of the horizontal sweeping rod 501. The length of the horizontal sweeping rod 501 is approximately equal to the width of the cold storage box 1. A side baffle 6041 is provided at the opening of the slide rail 605. The side baffle is fixedly connected to the fixed beam 4 by screws 6042. The side baffle 6041 can install the slider 606 inside the slide rail 605, ensuring smooth operation and preventing it from falling off the slide rail when the slider 606 reciprocates inside the slide rail 605.

[0021] This invention employs a reciprocating cyclic interference rod method to disrupt the sleep of experimental mice. It integrates light and low-temperature cooling interference functions, making it convenient to study the sleep disturbance of experimental mice under prolonged light and low temperature conditions. The structure is ingenious and easy to install.

[0022] The above description is only a preferred embodiment of the present utility model. Therefore, all equivalent changes or modifications made to the structure, features and principles described in the claims of the present utility model patent application are included in the scope of the present utility model patent application.

Claims

1. A multifunctional mouse sleep deprivation experimental device, comprising a cold storage box, wherein the cold storage box is provided with a door and a ventilation opening, and the cold storage box is provided with an interference lamp, an interference rod mechanism, and a reciprocating circulation mechanism, characterized in that, The interference rod mechanism includes a horizontal sweeping rod and a vertical rod. One end of the vertical rod is connected to the horizontal sweeping rod. The reciprocating circulation mechanism includes a fixed beam, a driving wheel, and a driven wheel. The fixed beam is located at the top of the cold storage box. The driving wheel and the driven wheel are fixedly located at both ends of the fixed beam. A transmission chain is provided between the driving wheel and the driven wheel. The fixed beam is provided with a slide rail. The slide rail has a side-inverted "U" structure. A through groove is provided on the fixed beam below the slide rail. A slider is provided inside the slide rail. The other end of the vertical rod passes through the through groove and is connected to the bottom of the slider. A connecting shaft is provided on the side of the slider. A connecting piece is provided on the connecting shaft. The connecting piece is fixedly connected to an outer chain plate on the transmission chain.

2. The multifunctional mouse sleep deprivation experimental device according to claim 1, characterized in that, The fixed beam is located at the center of the upper part of the cold storage box, the vertical rod is connected to the midpoint of the horizontal sweeping rod, and the length of the horizontal sweeping rod is approximately equal to the width of the cold storage box.

3. The multifunctional mouse sleep deprivation experimental device according to claim 1, characterized in that, The transmission chain includes several outer chain plates, inner chain plates, pins, sleeves, and rollers, and the connecting member is an integral structure with one of the outer chain plates.

4. The multifunctional mouse sleep deprivation experimental device according to claim 1, characterized in that, A side baffle is provided at the opening of the slide rail, and the side baffle is fixedly connected to the fixed beam by screws.

5. The multifunctional mouse sleep deprivation experimental device according to claim 1, characterized in that, The connecting shaft is provided with two limiting rings, and the connecting member is disposed between the two limiting rings.

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