A mouse minimally invasive uterine exposure device

Abstract

The utility model discloses a mouse minimally invasive uterus exposure device, it includes base, the edge department in the base is installed with the enclosure of one body, and the base and the enclosure form the containing space of combination, and the containing space is provided with anesthetizing module and constant temperature hot plate, and anesthetizing module and constant temperature hot plate are adjacent to set up, the upper cover, the upper cover is capped in containing space, and the upper cover is seted up with upper cover openwork opening, and the upper cover openwork opening is located the top of constant temperature hot plate, and the side of upper cover to base is provided with uterus imaging module, and uterus imaging module includes sliding slot, sliding block, screw hole, nut and U type titanium alloy thin stick, and the sliding slot fixed mounting is in the upper cover and is adjacent to the upper cover openwork opening, and the sliding block is slidably installed in the sliding slot, and the sliding block is seted up with screw hole, and the nut is installed to the screw hole, and the U type titanium alloy thin stick is installed to the sliding block through the nut. The device of the utility model is simple to operate, can conveniently carry out mouse uterus live imaging, and mouse abdominal operation opening is smaller.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, specifically a minimally invasive uterine exposure device for mice. Background Technology

[0002] In the field of medical device technology research and development, experimental animals are selected whenever possible to resemble humans in terms of function, metabolism, structure, and disease characteristics. Rats are the most commonly used animals in experiments, with white mice being a key research subject. White mice are small, making them easy to handle; they are also docile, easy to catch, and generally do not bite, making them easy to raise and manage. Secondly, mice are very sensitive to external stimuli. Furthermore, mice can be provided from the same littermate and different strains, and due to their uniform genetics and small individual differences, experimental results are accurate and reliable. Adult white mice are no more than 15.5 cm in length, with a pointed face and whiskers; erect, semi-circular ears; large eyes; a pointed nose; and a tail length similar to their body length. Observing the uterus of live mice using a fluorescence microscope is of great value for basic biological research and research on reproductive-related diseases. Direct observation based on the autofluorescence of uterine tissue allows for understanding the structure and morphology of the uterus under physiological and pathological conditions; fluorescent labeling of specific uterine tissues and cells allows for observation of disease progression and mechanisms; and the introduction of fluorescently labeled drugs allows for monitoring the distribution, metabolism, and efficacy of the drug in the uterus.

[0003] Currently, corresponding in vivo imaging strategies have been developed for different organs in mice. For example, a dedicated skull fixation mechanism and brain window have been developed for the mouse brain. By tightly securing the mouse skull, interference from heartbeat and respiration can be effectively eliminated, enabling stable observation. For organs in the mouse abdominal cavity, such as the liver, stomach, kidneys, spleen, and uterus, observation can be achieved by constructing a window through an abdominal opening. The classic strategy is as follows: 1. Anesthetize the mouse and fix its limbs in an ventral position, remove hair from the abdomen, and make a surgical incision; 2. Suture a titanium alloy abdominal window with an imaging glass slide along the incision, disinfect postoperatively, and allow the mouse to rest; 3. Inject a fluorescent probe into the tail vein; 4. Anesthetize the mouse and fix it in an ventral position, then observe it through the abdominal window using a fluorescence microscope. The above-mentioned existing technologies can achieve fluorescence in vivo imaging of the mouse uterus to a certain extent; however, a series of problems still exist and need to be improved.

[0004] 1. Existing technology requires making an incision in the mouse's abdomen and suturing a titanium alloy abdominal window, which is a complicated procedure. The risk of infection in mice after surgery is relatively high. In addition, the abdominal window usually occupies more than 1 / 2 of the mouse's abdominal area, and long-term retention may cause pain and foreign body sensation in the mouse.

[0005] 2. The uterus of mice is small when they are not pregnant (2cm in length and 2mm in diameter). The uterus gradually increases in size after pregnancy. The existing titanium alloy abdominal window technology is more suitable for observing the uterus of mice that are more than 9.5 days pregnant. For the uterus of mice that are not pregnant or in the early to mid-pregnancy stage (0.5-9.5 days), it is difficult to observe because the uterus is small and easily obscured by other organs and tissues.

[0006] 3. When using existing technology to perform fluorescence in vivo imaging of the mouse uterus, the abdominal window is directly sutured to the abdomen, making it difficult to eliminate the shaking caused by the mouse's heartbeat and respiration. The imaging image is difficult to keep stable, which is not conducive to performing fluorescence in vivo imaging that requires a long time (such as three-dimensional reconstruction of thick tissues or time-delayed change imaging at specific locations).

[0007] 4. Current techniques typically involve fixing mice to a constant-temperature heating plate and then placing them directly under a microscope for observation. However, there is room for improvement in maintaining the mice's anesthesia, body temperature, and the cleanliness of the experimental environment. Utility Model Content

[0008] The purpose of this invention is to provide a minimally invasive uterine exposure device for mice to solve the problems mentioned in the background art.

[0009] To achieve the above objectives, this utility model provides the following technical solution:

[0010] A minimally invasive uterine exposure device for mice, comprising:

[0011] The base has an integral enclosure installed at its inner edge. The base and the enclosure together form an accommodating space. The accommodating space is equipped with an anesthesia module and a constant temperature heating plate. The anesthesia module and the constant temperature heating plate are arranged adjacent to each other.

[0012] The upper cover seals the accommodating space and has a perforated opening located above the constant temperature heating plate. A uterine imaging module is disposed on the side of the upper cover facing the base. The uterine imaging module includes a sliding groove, a sliding block, a threaded hole, a nut, and a U-shaped titanium alloy rod. The sliding groove is fixedly installed on the upper cover and adjacent to the perforated opening. The sliding block is slidably installed in the sliding groove and has the threaded hole. The nut is installed in the threaded hole, and the U-shaped titanium alloy rod is installed to the sliding block through the nut.

[0013] Optionally, the base is equipped with a charging indicator light, a battery charging port, a constant temperature heating switch, a temperature adjustment button, and a temperature display screen on its side.

[0014] Optionally, the front and rear ends of the enclosure are respectively provided with a front enclosure opening and a rear enclosure opening in the middle part.

[0015] Optionally, the anesthesia module includes a head receiving slot and a circular hole holder, the head receiving slot being close to the constant temperature heating plate, and the circular hole holder having a circular slot.

[0016] Optionally, the lower area of ​​the base has an inner compartment, in which charging cables, power cables, control cables, and lithium batteries are distributed.

[0017] Optionally, a rack is provided at the upper side of the sliding block, and a control knob is fixedly installed on the upper cover near the rack. The lower end of the control knob is connected to a screw, and a gear is provided at the connection between the screw and the control knob. The gear and the rack are meshed and connected to each other to drive the sliding block to slide along the groove.

[0018] Optionally, a butterfly-shaped plate is installed on the upper end of the nut.

[0019] Optionally, the U-shaped titanium alloy rod is provided with parallel front and rear handles respectively.

[0020] Optionally, the uterine imaging module further includes a receiving guide rail, which is fixedly installed on the upper cover. The hollow opening of the upper cover is located between the receiving guide rail and the sliding groove, wherein the receiving guide rail is used to receive the parallel front end of the U-shaped titanium alloy rod.

[0021] Compared with the prior art, the beneficial effects of this utility model are:

[0022] 1. The device described in this utility model is simple to operate and can conveniently perform live imaging of the mouse uterus without the need for complex window suturing operations. The surgical incision required for the mouse abdomen is small, causing less harm to the mouse. After the observation is completed, the incision can be sutured and the mouse can continue to be fed normally. The uterine imaging module of this utility model can effectively suppress the shaking caused by the mouse's heartbeat and breathing, making it easy to observe with a microscope.

[0023] 2. The uterine imaging module in this invention exposes the uterus in a semi-suspended manner, which can effectively reduce the interference caused by the mouse's breathing and heartbeat, and improve the stability of fluorescence in vivo imaging. This device can be used to observe the uterus of mice in non-pregnant state as well as the uterine state throughout the entire pregnancy (0.5-20 days).

[0024] 3. The semi-enclosed structure of this invention helps maintain the mouse's body temperature and anesthesia state, and also helps keep the experimental environment clean, avoiding damage or contamination of the instrument due to leakage of mouse hair or body fluids. When mice are anesthetized by intraperitoneal injection of anesthetic, the fixation device has no external tubing, making operation more convenient during microscope imaging. Attached Figure Description

[0025] Figure 1This is a schematic diagram of the base structure of this utility model.

[0026] Figure 2 This is a schematic diagram of the anesthesia module structure of this utility model.

[0027] Figure 3 This is a schematic diagram of the inner structure of the base of this utility model.

[0028] Figure 4 This is a schematic diagram of the upper cover structure of this utility model.

[0029] Figure 5 This is a schematic diagram of the uterine imaging module of this utility model.

[0030] Figure 6 This is a schematic diagram of the U-shaped titanium alloy rod installation structure of this utility model.

[0031] Figure 7 This is a cross-sectional structural diagram of the nut installation of this utility model.

[0032] Figure 8 This is a schematic cross-sectional view of the U-shaped titanium alloy rod installation structure of this utility model.

[0033] Figure 9 This is a schematic diagram of the sliding block structure of this utility model.

[0034] Figure 10 This is a schematic diagram of the control knob structure of this utility model.

[0035] Figure 11 This is a schematic diagram of the nut and sliding block installation structure of this utility model.

[0036] Figure 12 This is a side view of the nut structure of this utility model.

[0037] Figure 13 This is a schematic diagram of the U-shaped titanium alloy rod structure of this utility model.

[0038] In the diagram: 1. Base; 101. Enclosure; 102. Constant temperature heating plate; 104. Front enclosure opening; 105. Charging indicator light; 106. Battery charging port; 107. Constant temperature heating switch; 108. Temperature adjustment button; 109. Temperature display screen; 110. Rear enclosure opening;

[0039] 2. Anesthesia module; 201. Head receiving slot; 202. Round hole holder;

[0040] 3. Base inner compartment; 301. Charging cable; 302. Power cord; 303. Control cable; 304. Lithium battery;

[0041] 4. Top cover; 401. Top cover enclosure; 402. Hollowed-out opening;

[0042] 5. Uterine imaging module; 501. Slide groove; 502. Sliding block; 503. Threaded hole; 504. Rack;

[0043] 6. Nut; 601. Disc;

[0044] 7. We undertake the supply of guide rails;

[0045] 8. Control knob; 801. Screw; 802. Gear;

[0046] 10. U-shaped titanium alloy thin rod; 1001. Parallel front end; 1002. Tail end handle. Detailed Implementation

[0047] To make the technical means, creative features, objectives and effects of this utility model easier to understand, the present utility model will be further described below in conjunction with specific embodiments.

[0048] In the description of this utility model, it should be noted that the terms "upper," "lower," "inner," "outer," "front end," "rear end," "both ends," "one end," and "the other end," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model. In addition, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0049] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installed," "equipped with," and "connected," etc., should be interpreted broadly. For example, "connected" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be a connection within two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0050] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0051] Please see Figure 1-13This utility model provides a minimally invasive uterine exposure device for mice, comprising a base 1 and an upper cover 4, wherein:

[0052] An integral enclosure 101 is installed at the inner edge of the base 1. The base 1 and the enclosure 101 together form an accommodating space. The accommodating space is equipped with an anesthesia module 2 and a constant temperature heating plate 102. The anesthesia module 2 and the constant temperature heating plate 102 are arranged adjacent to each other.

[0053] The upper cover 4 seals the receiving space. The upper cover 4 has a hollow opening 402, which is located above the constant temperature heating plate 102. The upper cover 4 has a uterine imaging module 5 on the side facing the base 1. The uterine imaging module 5 includes a sliding groove 501, a sliding block 502, a threaded hole 503, a nut 6, and a U-shaped titanium alloy rod 10. The sliding groove 501 is fixedly installed on the upper cover 4 and adjacent to the hollow opening 402. The sliding block 502 is slidably installed in the sliding groove 501. The sliding block 502 has a threaded hole 503. The nut 6 is installed in the threaded hole 503. The U-shaped titanium alloy rod 10 is installed to the sliding block 502 through the nut 6.

[0054] The device described in this invention is simple to operate, requiring no complex window suturing. The surgical incision in the mouse abdomen is small, causing minimal harm to the mouse. After observation, the incision can be sutured, and the mouse can continue normal feeding. The uterine imaging module of this invention effectively suppresses the shaking caused by the mouse's heartbeat and respiration, facilitating observation under a microscope. The uterine imaging module exposes the uterus in a semi-suspended manner, effectively reducing interference from the mouse's respiration and heartbeat, and improving the stability of fluorescence in vivo imaging. This device can be used to observe the uterus of non-pregnant mice as well as the uterine condition throughout pregnancy (0.5-20 days). The semi-enclosed structure of this invention helps maintain the mouse's body temperature and anesthesia state, and also helps maintain a clean experimental environment, preventing damage or contamination of the instrument due to leakage of mouse hair or body fluids. When mice are anesthetized by intraperitoneal injection of anesthetic, the fixation device has no external tubing, making operation more convenient during microscope imaging.

[0055] In this embodiment, an integral enclosure 101 is installed at the inner edge of the base 1.

[0056] Optionally, the front and rear ends of the enclosure 101 are respectively provided with a front enclosure opening 104 and a rear enclosure opening 110. The outlet of the anesthetic gas hose can enter and be limited through the front enclosure opening 104 on the base 1, and can be removed through the rear enclosure opening 110 for tail vein injection of drugs or fluorescent probes.

[0057] Optionally, the anesthesia module 2 includes a head receiving slot 201 and a round hole holder 202. The head receiving slot 201 is close to the constant temperature heating plate 102, and the round hole holder 202 has a round opening.

[0058] In this embodiment, the anesthesia module 2 is provided with a head receiving groove 201 and a round hole holder 202. The outlet of the anesthetic gas hose enters through the front enclosure opening 104 on the base 1 and is fixed in the round hole holder 202. The position of the outlet of the anesthetic gas hose is adjusted to connect with the mouse's mouth and nose to maintain the mouse's anesthesia.

[0059] In this embodiment, an upper cover enclosure 401 is provided at the edge of the upper cover 4. The upper cover 4 and the upper cover enclosure 401 are an integral structure. An upper cover hollow opening 402 is provided on the upper cover 4. The enclosure 401 can be closed with the base 1 to form a semi-closed heat-insulating chamber. The upper cover hollow opening 402 is provided on the top of the upper cover 4, which is located above the abdomen of the anesthetized mouse on the constant temperature heating plate 102 of the base 1, which facilitates the operation and subsequent imaging of the mouse uterus. The left and right sides of the hollow opening 402 of the upper cover 4 are uterine imaging modules 5, which are used to expose and fix the mouse uterus during fluorescence in vivo imaging.

[0060] In this embodiment, the uterine imaging module 5 includes a slide groove 501, a sliding block 502, a threaded hole 503, and a rack 504. The slide groove 501 is fixedly installed on the upper cover 4. The sliding block 502 is nested and slides within the slide groove 501. The threaded hole 503 is provided on the upper surface of the sliding block 502. The rack 504 is provided at the upper end of the side of the sliding block 502. A nut 6 is provided in the threaded hole 503.

[0061] Optionally, a charging indicator light 105, a battery charging port 106, a constant temperature heating switch 107, a temperature adjustment button 108, and a temperature display screen 109 are sequentially installed on the side of the base 1.

[0062] Optionally, the lower area of ​​the base 1 has an inner compartment 3, in which a charging cable 301, a power cable 302, a control cable 303, and a lithium battery 304 are distributed.

[0063] In this embodiment, the constant temperature heating plate 102 draws electrical energy from the internal lithium battery through the power cord 302. When the rechargeable battery is charging, the current flows through the charging cord 301. The charging indicator light 105 is used to indicate the charging status. There is no light when it is not charging. A red light indicates that it is charging and a green light indicates that it is fully charged. The constant temperature heating switch 107 can control the opening and closing of the constant temperature heating plate 102. The temperature adjustment button 108 can set the temperature of the constant temperature heating plate 102. The set temperature is displayed on the temperature display screen 109 as "SET + set temperature value". When the temperature adjustment button 108 is not operated, the temperature display screen 109 displays the current temperature as "RT + temperature value". The buttons on the control panel and the constant temperature heating plate 102 exchange and transmit commands and signals through the control line 303.

[0064] Optionally, a rack 504 is provided at the upper side of the sliding block 502, and a control knob 8 is fixedly installed on the upper cover 4 close to the rack 504. The lower end of the control knob 8 is connected to a screw 801, and a gear 802 is provided at the connection between the screw 801 and the control knob 8. The gear 802 and the rack 504 are meshed and connected to each other to drive the sliding block 502 to slide along the slide groove 501.

[0065] Optionally, a butterfly-shaped plate 601 is installed on the upper end of the nut 6. Tightening the butterfly-shaped plate 601 causes the nut 6 to rotate, thereby achieving its tightening operation.

[0066] Optionally, the U-shaped titanium alloy rod 10 is provided with a parallel front end 1001 and a tail end handle 1002.

[0067] Optionally, the uterine imaging module 5 also includes a receiving guide rail 7, which is fixedly installed on the upper cover 4. The upper cover has a hollow opening 402 located between the receiving guide rail 7 and the sliding groove 501. The receiving guide rail 7 is used to receive the parallel front end 1001 of the U-shaped titanium alloy rod 10.

[0068] In this embodiment, a control knob 8 is fixedly installed on the upper cover 4 near the rack 504. The lower end of the control knob 8 is connected to a screw 801, and a gear 802 is provided at the connection between the screw 801 and the control knob 8. The gear 802 and the rack 504 are meshed together. Rotating the control knob 8 can drive the sliding block 502 to move smoothly along the slide groove 501. A U-shaped titanium alloy rod 10 is provided between the nut 6 and the upper surface of the sliding block 502. Pushing and pulling the tail end of the U-shaped titanium alloy rod 10 controls its parallel front end to extend. The U-shaped titanium alloy rod 10, extending through the tissue beneath the mouse uterus and reaching the receiving guide 7 on the left side of the perforated opening 402, exposes and fixes the mouse uterus. Parallel front ends 1001 and tail handles 1002 are respectively provided on the U-shaped titanium alloy rod 10. The U-shaped titanium alloy rod 10 is made of titanium alloy, which has good biocompatibility and corrosion resistance. The edges of the two parallel front ends 1001 are polished to a smooth finish, which helps improve the smoothness of passing through the tissue beneath the uterus and reduces damage to organs and tissues. The tail handle 1002 is frosted, which facilitates push-pull control during fixation of the mouse uterus.

[0069] In this embodiment, a receiving guide rail 7 is connected to the U-shaped titanium alloy rod 10 away from the nut 6. The receiving guide rail 7 is fixed to the upper cover 4. In use, loosening the butterfly plate 601 raises the nut 6, inserting the U-shaped titanium alloy rod 10 along both sides of the nut, and tightening the butterfly plate 601 lowers the nut 6 and clamps the U-shaped titanium alloy rod 10 on the surface of the sliding block 502.

[0070] The mouse is first anesthetized and fixed to the base 1. After the top cover 4 is closed, the butterfly plate 601 is loosened and the nut 6 is raised. The handle 1002 at the tail end of the U-shaped titanium alloy rod 10 is pulled so that the parallel front end 1001 is away from the hollow opening 402 of the top cover 4. The mouse is then opened through the hollow opening 402 of the top cover 4. The mouse uterus is gently lifted from the opening with forceps. The control knob 8 is rotated to drive the sliding block 502 to move steadily so that the nut 6 is aligned with the mouse uterus. The handle 1002 at the tail end of the U-shaped titanium alloy rod 10 is pushed so that the parallel front end 1001 of the U-shaped titanium alloy rod 10 passes through the gap under the mouse uterus and reaches the receiving guide rail 7 on the left side of the hollow opening 402. The butterfly plate 601 is tightened and the nut 6 is lowered so that the U-shaped titanium alloy rod 10 is clamped on the surface of the sliding block 502, thereby exposing and fixing the mouse uterus.

[0071] The working principle of this invention is as follows: Laboratory mice are anesthetized in a gas anesthesia machine, and hair removal cream is used to remove hair from their abdomens. Then, the constant temperature heating switch 107 of the base 1 is turned on, and the anesthetized mouse is placed on the constant temperature heating plate 102 of the base 1, with its abdomen facing upwards. The limbs and tail are fixed with medical tape, and the head is fixed to the head receiving slot 201 of the anesthesia module 2. The outlet of the anesthetic gas hose is fixed to the circular slot in front of the circular hole holder 202, and the position of the outlet is adjusted so that it just connects with the mouse's mouth and nose. Anesthetic gas is then introduced to maintain the mouse's anesthesia.

[0072] Alternatively, if anesthesia is maintained in mice via intraperitoneal injection, there is no need to introduce anesthetic gas; the head of the anesthetized mouse can simply be fixed in the head receiving slot 201. The entire device has no external tubing, which improves maneuverability during in vivo imaging.

[0073] Optionally, if it is necessary to inject fluorescent dye or drugs into the tail vein, the mouse tail can be removed through the rear enclosure opening 110, and after injection, the mouse tail can be moved back into the enclosure and fixed again with medical tape.

[0074] Close the top cover 4, forming a semi-enclosed space with the base 1. Loosen the butterfly plate 601 and pull the handle 1002 at the tail end of the U-shaped titanium alloy rod 10, so that the parallel front end 1001 is away from the hollow opening 402. Use surgical scissors to make a 5mm incision on the left (right) side of the middle of the mouse's lower abdomen through the hollow opening 402 of the top cover 4. Use forceps to grasp the uterus and gently lift it. Loosen the butterfly plate 601 on the sliding block 502 and push the U-shaped titanium alloy rod 10 through the gap below the uterus. The parallel front end 1001 of the rod reaches the receiving guide rail 7 on the left side of the hollow opening. Tighten the butterfly plate 601 to fix the U-shaped titanium alloy rod 10, thus simultaneously exposing and fixing the mouse's uterus. Place the entire minimally invasive uterine exposure device with the mouse on the microscope stage. Rotate the control knob 8 to drive the U-shaped titanium alloy rod 10 on the sliding block 502 to move stably, thereby exposing different areas of the mouse's uterus. Adjust the position of the mouse's uterus to be observed and use the microscope for fluorescence in vivo imaging.

[0075] After completing in vivo imaging, the entire minimally invasive uterine exposure device containing the mouse is transferred out of the microscope area and placed on the experimental table. The butterfly plate 601 is loosened, and the U-shaped titanium alloy rod 10 is gently pulled out, detaching it from the uterus. The mouse uterus is then pushed back into the abdominal cavity using forceps. The abdominal wound can be sutured for continued feeding. Finally, the constant temperature heating plate 102 is turned off and cleaned.

[0076] The above description is merely an embodiment of this utility model, and common knowledge regarding specific structures and characteristics is not described in detail here. It will be apparent to those skilled in the art that this utility model is not limited to the details of the above exemplary embodiments, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of this utility model. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of this utility model is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this utility model. No reference numerals in the claims should be construed as limiting the scope of the claims.

Claims

1. A minimally invasive uterine exposure device for mice, characterized in that, It includes: A base (1) is provided with an integral enclosure (101) installed at the inner edge of the base (1). The base (1) and the enclosure (101) together form an accommodating space. The accommodating space is provided with an anesthesia module (2) and a constant temperature heating plate (102). The anesthesia module (2) and the constant temperature heating plate (102) are arranged adjacent to each other. The upper cover (4) covers the accommodating space. The upper cover (4) has a hollow opening (402) located above the constant temperature heating plate (102). A uterine imaging module (5) is provided on the side of the upper cover (4) facing the base (1). The uterine imaging module (5) includes a sliding groove (501), a sliding block (502), a threaded hole (503), a nut (6), and a U-shaped titanium alloy rod (10). The sliding groove (501) is fixedly installed on the upper cover (4) and adjacent to the hollow opening (402). The sliding block (502) is slidably installed in the sliding groove (501). The sliding block (502) has the threaded hole (503). The nut (6) is installed in the threaded hole (503). The U-shaped titanium alloy rod (10) is installed to the sliding block (502) through the nut (6).

2. The mouse minimally invasive uterine exposure device according to claim 1, characterized in that: The base (1) is equipped with a charging indicator light (105), a battery charging port (106), a constant temperature heating switch (107), a temperature adjustment button (108), and a temperature display screen (109) on its side.

3. The mouse minimally invasive uterine exposure device according to claim 1, characterized in that: The front and rear ends of the enclosure (101) are respectively provided with a front enclosure opening (104) and a rear enclosure opening (110).

4. The mouse minimally invasive uterine exposure device according to claim 1, characterized in that: The anesthesia module (2) includes a head receiving slot (201) and a round hole holder (202). The head receiving slot (201) is close to the constant temperature heating plate (102), and the round hole holder (202) has a round opening.

5. The mouse minimally invasive uterine exposure device according to claim 1, characterized in that: The lower part of the base (1) has an inner compartment (3), and a charging cable (301), a power cable (302), a control cable (303) and a lithium battery (304) are distributed in the inner compartment (3).

6. The mouse minimally invasive uterine exposure device according to claim 1, characterized in that: A rack (504) is provided at the upper side of the sliding block (502). A control knob (8) is fixedly installed on the upper cover (4) close to the rack (504). A screw (801) is connected to the lower end of the control knob (8), and a gear (802) is provided at the connection between the screw (801) and the control knob (8). The gear (802) and the rack (504) are meshed and connected to each other to drive the sliding block (502) to slide along the groove (501).

7. The mouse minimally invasive uterine exposure device according to claim 1, characterized in that: A butterfly plate (601) is installed on the upper end of the nut (6).

8. The mouse minimally invasive uterine exposure device according to claim 1, characterized in that: The U-shaped titanium alloy rod (10) is provided with a parallel front end (1001) and a tail end handle (1002).

9. The mouse minimally invasive uterine exposure device according to claim 8, characterized in that: The uterine imaging module (5) also includes a receiving guide rail (7), which is fixedly installed on the upper cover (4). The hollow opening (402) of the upper cover is located between the receiving guide rail (7) and the slide groove (501). The receiving guide rail (7) is used to receive the parallel front end (1001) of the U-shaped titanium alloy rod (10).

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