A microfiltration filtering device for preparing a liposome of docetaxel

Abstract

The utility model relates to medicine preparation equipment technical field, a microfiltration filter device for docetaxel liposome preparation, including the barrel main part, the top of barrel main part has the sealing top cover through screw thread connection, the top center of sealing top cover fixed mounting has the delivery pipe, the outside of barrel main part is close to the bottom fixed mounting and has the discharge pipe, the utility model discloses when needing to replace the filter membrane, after putting the filter membrane into the filter drum inside, and put the filter drum into the barrel main part, in the process of rotating sealing top cover and barrel main part screw thread connection, through the fixed mechanism realizes the quick clamping locking of filter drum and filter membrane, and also prolongs the use time of filter membrane through the blowdown mechanism not only increases the stability when filter drum is fixed, this series of conditions greatly reduces the operation difficulty, and only needs to spend short time every time installation and disassembly, and further reduces the overall time cost.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical preparation equipment technology, and in particular to a backup microfiltration device for docetaxel lipid formulation. Background Technology

[0002] Docetaxel liposomes are a drug delivery system that encapsulates the anti-tumor drug docetaxel in liposomes. Liposome technology enhances the water solubility and stability of docetaxel, enabling controlled drug release, improved targeting, and reduced damage to normal cells. This formulation is primarily used to treat malignant tumors such as breast cancer and non-small cell lung cancer, and can reduce adverse reactions such as hair loss and bone marrow suppression caused by traditional formulations, thus improving treatment safety.

[0003] In the preparation process of docetaxel liposomes, microfiltration is a key step. It can effectively remove impurities such as unencapsulated drug crystals and lipid fragments, while also achieving sterilization, thereby ensuring the safety of the formulation.

[0004] However, the filter element needs to be replaced after a period of use. In order to enhance the stability between the filter element and the main body of the device, the connection structure between the two is usually designed to be more complex. During installation, the operator must accurately align multiple parts and then tighten them step by step. Disassembly is also extremely tricky, requiring multiple parts to be disassembled step by step in sequence. This series of situations greatly increases the difficulty of operation, and each installation and disassembly takes a long time, thereby increasing the overall time cost. Utility Model Content

[0005] This utility model addresses the shortcomings of existing technologies by providing the following technical solution: a docetaxel lipid system backup microfiltration device, comprising a cylindrical body, a sealing top cover connected to the top of the cylindrical body by a thread, a delivery pipe fixedly installed at the top center of the sealing top cover, a discharge pipe fixedly installed on the outer side of the cylindrical body close to the bottom end, a filter cylinder arranged inside the cylindrical body, and a filter membrane attached to the inside of the filter cylinder. The cylindrical body and the filter cylinder are slidably arranged in a circular pattern, and a fixing mechanism is provided for convenient and quick locking of the filter cylinder. The bottom of the filter cylinder is fixedly equipped with a sewage discharge mechanism for discharging impurities.

[0006] As an improvement to the above technical solution, the fixing mechanism includes a circular sealing gasket, a horizontal locking block, an arc-shaped clamping block, and a circular guiding block. The inner wall of the top of the sealing top cover has a circular locking groove, which is connected to the conveying pipe. The circular sealing gasket is fixedly installed on the inner wall of the outer side of the circular locking groove. The filter cylinder is movably engaged with the circular sealing gasket. The inner wall of the top of the sealing top cover, located on the outer side of the circular locking groove, has a horizontal locking groove. The horizontal locking block is slidably engaged in the horizontal locking groove. The arc-shaped clamping block is fixedly installed at the bottom end of the horizontal locking block. The circular guiding block is fixedly installed on the inner wall of the cylindrical body close to the top, and the inner wall of the circular guiding block is in contact with the outer side of the arc-shaped clamping block.

[0007] As an improvement to the above technical solution, the sewage discharge mechanism includes a sewage discharge pipe, a fixing ring, and a bottom plate. The sewage discharge pipe is fixedly installed at the bottom of the cylindrical body, and the top of the sewage discharge pipe penetrates the inner wall of the bottom of the cylindrical body and extends into the interior of the cylindrical body. The fixing ring is fixedly installed on the outer side of the sewage discharge pipe extending into the interior of the cylindrical body, close to the top. The bottom plate is fixedly installed on the inner wall of the filter cylinder and located below the filter membrane. The top center of the bottom plate has a through-hole opening, and the through-hole is movably engaged with the fixing ring.

[0008] As an improvement to the above technical solution, the inner wall of the circular guide block is designed with rounded corners close to the top.

[0009] As an improvement to the above technical solution, the inner wall of the interface is designed with rounded corners close to the bottom.

[0010] The beneficial effects of this utility model are as follows: When the filter membrane needs to be replaced, the filter membrane is placed inside the filter cylinder, and then the filter cylinder is placed inside the cylindrical body. During the process of rotating the sealing top cover and connecting it to the cylindrical body by thread, the fixing mechanism quickly clamps and locks the filter cylinder and filter membrane. At the same time, the sewage discharge mechanism not only increases the stability of the filter cylinder when it is fixed, but also extends the service life of the filter membrane. All these factors greatly reduce the difficulty of operation. Each installation and disassembly only takes a short time, thereby reducing the overall time cost. Attached Figure Description

[0011] Figure 1 This is a front view of the microfiltration device of this utility model; Figure 2 This is a cross-sectional view of the internal structure of this utility model; Figure 3 This utility model Figure 2 Enlarged view of the structure at point A in the middle; Figure 4 This utility model Figure 2 Enlarged view of the structure at point B in the middle.

[0012] Reference numerals: 1. Main body of the cylindrical barrel; 2. Sealed top cover; 21. Conveying pipe; 3. Discharge pipe; 4. Filter cylinder; 41. Filter membrane; 5. Circular groove; 51. Circular sealing gasket; 52. Horizontal groove; 53. Horizontal locking block; 54. Arc-shaped clamping block; 55. Circular guide block; 6. Sewage pipe; 61. Fixing ring; 62. Bottom plate; 63. Connecting interface. Detailed Implementation

[0013] To make the objectives, technical solutions, and advantages of this utility model clearer, the following provides a more detailed description of the utility model. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the scope of the utility model.

[0014] Reference Appendix Figure 1 ,exist Figure 1 In the diagram, 'a' points to the front view and 'b' points to the right-side view. These views are only used to understand the scheme.

[0015] Please see Figure 1-4 This utility model provides a technical solution: a docetaxel lipid system standby microfiltration device, including a cylindrical body 1, a sealing top cover 2 connected to the top of the cylindrical body 1 by a thread, a conveying pipe 21 fixedly installed at the top center of the sealing top cover 2, a discharge pipe 3 fixedly installed on the outside of the cylindrical body 1 close to the bottom end, a filter cylinder 4 is provided inside the cylindrical body 1, and a filter membrane 41 is attached to the inside of the filter cylinder 4. A fixing mechanism for convenient and quick locking of the filter cylinder 4 is provided between the cylindrical body 1 and the filter cylinder 4 in a circular arrangement. The bottom of the filter cartridge 4 is fixedly equipped with a sewage discharge mechanism for discharging impurities.

[0016] In this implementation scheme, when the filter membrane 41 needs to be replaced, the filter membrane 41 is placed inside the filter cylinder 4, and then the filter cylinder 4 is placed inside the cylindrical body 1. During the process of rotating the sealing top cover 2 and threadedly connecting it to the cylindrical body 1, the filter cylinder 4 and the filter membrane 41 are quickly clamped and locked by the fixing mechanism. At the same time, the sewage discharge mechanism not only increases the stability of the filter cylinder 4 when it is fixed, but also extends the service life of the filter membrane 41. All these factors greatly reduce the difficulty of operation, and each installation and disassembly only takes a short time, thereby reducing the overall time cost.

[0017] Specifically, the fixing mechanism includes a circular sealing gasket 51, a horizontal clamping block 53, an arc-shaped clamping block 54, and a circular guide block 55. The inner wall of the top of the sealing top cover 2 is provided with a circular groove 5, which is connected to the conveying pipe 21. The circular sealing gasket 51 is fixedly installed on the inner wall of the outer side of the circular groove 5. The filter cylinder 4 is movably engaged with the circular sealing gasket 51. The inner wall of the top of the sealing top cover 2, located on the outer side of the circular groove 5, is provided with a horizontal groove 52. The horizontal clamping block 53 is slidably engaged in the horizontal groove 52. The arc-shaped clamping block 54 is fixedly installed at the bottom end of the horizontal clamping block 53. The circular guide block 55 is fixedly installed on the inner wall of the cylindrical body 1 close to the top, and the inner wall of the circular guide block 55 is in contact with the outer side of the arc-shaped clamping block 54.

[0018] In this embodiment, the filter cylinder 4 and the filter membrane 41 are quickly fastened and locked by the cooperation of the internal structure of the fixing mechanism.

[0019] Specifically, the sewage discharge mechanism includes a sewage pipe 6, a fixing ring 61, and a bottom plate 62. The sewage pipe 6 is fixedly installed at the bottom of the cylindrical body 1, and the top of the sewage pipe 6 penetrates the bottom inner wall of the cylindrical body 1 and extends into the interior of the cylindrical body 1. The fixing ring 61 is fixedly installed on the outer side of the sewage pipe 6 that extends into the interior of the cylindrical body 1, close to the top. The bottom plate 62 is fixedly installed on the inner wall of the filter cylinder 4 and located below the filter membrane 41. The top center of the bottom plate 62 has a through-hole opening 63, which is movably engaged with the fixing ring 61.

[0020] In this embodiment, the coordination of the internal structure of the sewage discharge mechanism not only increases the stability of the filter cylinder 4 when it is fixed, but also extends the service life of the filter membrane 41.

[0021] Specifically, the inner wall of the circular guide block 55 has a rounded corner design close to the top.

[0022] In this embodiment, it is further convenient for the arc-shaped clamping block 54 to engage with the circular guide block 55 when it moves downward.

[0023] Specifically, the inner wall of interface 63 has rounded corners close to the bottom.

[0024] In this embodiment, it is further convenient for the interface 63 to be locked on the outside of the fixed ring 61 when it moves downward.

[0025] In use, the filter membrane 41 is placed into the filter cylinder 4, and the filter cylinder 4 is snapped into the annular groove 5. The deformation of the annular sealing gasket 51 achieves initial fixation of the filter cylinder 4. Then, the filter cylinder 4 is inserted into the cylindrical body 1, and the sealing top cover 2 is rotated so that the sealing top cover 2 is threadedly connected to the outer side of the cylindrical body 1. As the sealing top cover 2 rotates downward, the sealing top cover 2 drives the arc-shaped clamping block 54 to move downward during the rotation through the horizontal groove 52 and the horizontal clamping block 53. The arc-shaped clamping block 54 moves downward and intersects with the annular guide block 55. The filter cylinder 4 is brought into contact with the circular guide blocks 55 and moves towards the filter cylinder 4 under mutual pressure. Similarly, the other arc-shaped clamping blocks 54 move downwards and towards the center of the circle, working on the same principle. This allows multiple arc-shaped clamping blocks 54 to move towards the center of the circle during their downward movement, synchronously clamping and fixing the filter cylinder 4, thereby achieving a tight lock on the filter cylinder 4. At the same time, as the filter cylinder 4 moves downwards, it drives the bottom plate 62 to move downwards. The bottom plate 62 drives the interface 63 to move downwards and lock onto the outside of the fixing ring 61. At this time, the drain pipe 6 and the filter cylinder 4 are in contact. The internal connection of membrane 41, via the fixing ring 61 and the interface 63, not only increases the stability of filter cartridge 4 but also facilitates the discharge of impurities. During docetaxel liposome filtration, the discharge pipe 3 is opened and the drain pipe 6 is closed. The top of the delivery pipe 21 is connected to an external negative pressure infusion pipe, allowing the liquid to enter the filter membrane 41 through the delivery pipe 21 under pressure and gravity. At this time, the liquid flows outwards from the filter cartridge 4 due to pressure, and the filter membrane 41 filters impurities from the liquid. The filtered docetaxel liposomes then pass through… When it is necessary to clean the impurities inside the filter membrane 41, the top of the delivery pipe 21 is connected to the external negative pressure water supply pipe. The discharge pipe 3 is closed and the drain pipe 6 is opened. Under the action of pressure and gravity, the water flow quickly enters the filter membrane 41. The impurities adsorbed on the inner wall of the filter membrane 41 are washed away by the flowing water and discharged through the drain pipe 6, thereby extending the service life of the filter membrane 41. This series of situations greatly reduces the difficulty of operation. Each installation and disassembly only takes a short time, thereby reducing the overall time cost.

[0026] The above embodiments are only used to illustrate the technical solution of this utility model, and are not intended to limit it.

Claims

1. A microfiltration device for docetaxel lipid system, comprising a cylindrical body (1), characterized in that: The top of the cylindrical body (1) is connected to a sealing top cover (2) by a thread. A conveying pipe (21) is fixedly installed at the center of the top of the sealing top cover (2). A discharge pipe (3) is fixedly installed on the outside of the cylindrical body (1) close to the bottom. A filter cylinder (4) is provided inside the cylindrical body (1). A filter membrane (41) is attached to the inside of the filter cylinder (4). The cylindrical body (1) and the filter cylinder (4) are arranged in a circular pattern and are slidably provided with a fixing mechanism for convenient and quick locking of the filter cylinder (4); The filter cylinder (4) is fixedly provided with a sewage discharge mechanism for discharging impurities at its inner bottom.

2. The docetaxel lipid system backup microfiltration device according to claim 1, characterized in that: The fixing mechanism includes a circular sealing gasket (51), a horizontal locking block (53), an arc-shaped clamping block (54), and a circular guide block (55). The inner wall of the top of the sealing top cover (2) is provided with a circular locking groove (5), and the circular locking groove (5) is connected to the conveying pipe (21). The circular sealing gasket (51) is fixedly installed on the inner wall of the outer side of the circular locking groove (5). The filter cylinder (4) is movably locked with the circular sealing gasket (51). The inner wall of the top of the sealing top cover (2) and the outer side of the circular locking groove (5) are provided with a horizontal locking groove (52). The horizontal locking block (53) is slidably locked in the horizontal locking groove (52). The arc-shaped clamping block (54) is fixedly installed at the bottom end of the horizontal locking block (53). The circular guide block (55) is fixedly installed on the inner wall of the cylindrical body (1) close to the top, and the inner wall of the circular guide block (55) is in contact with the outer side of the arc-shaped clamping block (54).

3. The docetaxel lipid system backup microfiltration device according to claim 1, characterized in that: The sewage discharge mechanism includes a sewage pipe (6), a fixed ring (61), and a bottom plate (62). The sewage pipe (6) is fixedly installed at the bottom of the cylindrical body (1), and the top of the sewage pipe (6) penetrates the bottom inner wall of the cylindrical body (1) and extends into the interior of the cylindrical body (1). The fixed ring (61) is fixedly installed on the outer side of the sewage pipe (6) that extends into the interior of the cylindrical body (1) and close to the top. The bottom plate (62) is fixedly installed on the inner wall of the filter cylinder (4) and located below the filter membrane (41). The top center of the bottom plate (62) is provided with a through-hole interface (63), and the through-hole interface (63) is movably engaged with the fixed ring (61).

4. A docetaxel lipid system backup microfiltration device according to claim 2, characterized in that: The inner wall of the circular guide block (55) is designed with rounded corners close to the top.

5. A docetaxel lipid system backup microfiltration device according to claim 3, characterized in that: The inner wall of the interface (63) is rounded at the bottom.

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