A high performance liquid chromatography mixer

Abstract

The utility model discloses a high efficiency liquid chromatogram mixer, include: mixer switching hub, shell, mixer support, the lateral surface of mixer switching hub is provided with optional connecting pipe, optional connecting pipe is provided with two, and two optional connecting pipe all are provided with stainless steel connecting screw, the lateral surface of mixer switching hub is provided with main flow path one, main flow path two, main flow path three away from optional connecting pipe, and is linked together with two optional connecting pipe, main flow path one, main flow path two, main flow path three all include straight pipe flow path and coil flow path, through the stainless steel screw of setting, the pipeline connection is convenient, through optional connecting pipe adjustment mixed flow path's length, change the volume of mixer, to be suitable for the mixed selection of different volume, and through the cooperation of straight pipe flow path and coil flow path in main flow path, increase the time of liquid residence mixer, prolong the time of liquid mixing, promote the liquid more evenly through the mixer.

Description

Technical Field

[0001] This utility model relates to the field of liquid chromatography technology, and more specifically, to a high-performance liquid chromatography mixer. Background Technology

[0002] With the increasing demand and higher requirements for the analysis and detection of substances in modern society, high-performance liquid chromatography (HPLC) has been widely applied in various fields such as food, chemical, pharmaceutical research, environmental analysis, and medical testing due to its characteristics of high resolution, high sensitivity, high speed, reusable columns, wide range of mobile phase selection, and easy collection of eluted components. The infusion pump continuously injects the mobile phase from the reservoir into the liquid circuit system under high pressure, enabling the sample to complete the separation process in the chromatographic column. During the use of HPLC, the composition of the eluent can be continuously changed or gradient changed. Gradient changes offer better adaptability, and gradient changes of two or more mobile phases are an important method to achieve satisfactory separation. In gradient mode, multiple mobile phases exist separately before entering the infusion pump and are mixed together after entering the analytical system. If not intentionally mixed, the multiple mobile phases are not homogeneous, which can cause baseline fluctuations, abnormal peaks, etc., affecting the separation effect, quantitative repeatability, and stability of the sample. Therefore, a mixer is added to address this issue, ensuring the mobile phase is thoroughly mixed before entering the chromatographic column. However, existing static mixers are not convenient for adjusting the length of the mixing flow path, and the liquid remains in the mixer for a relatively long time, resulting in uneven mixing. For example, patent document publication number CN223055435U describes a micro-volume ultra-high performance liquid chromatography mixer, which includes a main body, mixer caps, external components, and a mixing unit. One end of the main body has an inlet, and the other end has an outlet. A mixer cap is installed at both the inlet and outlet, and an external component is installed on each mixer cap. The unit has a main cavity, inside which a mixing unit is installed. The two ends of the mixing unit are connected to the liquid outlet and the liquid inlet, respectively. Both the liquid inlet and the liquid outlet are equipped with a first sieve plate, and the two ends of the mixing unit are respectively attached to the two first sieve plates. The mixing unit includes a mixing module, with an outlet and an inlet at each end. The mixing module has multiple flow paths inside. Through the above structure, it is easy to use. However, in actual use, it still has some disadvantages, such as: it is not easy to change the length of the mixing flow path, and the liquid stays in the mixer for a long time, which makes the liquid uneven during mixing and limits its use. Utility Model Content

[0003] In order to overcome the above-mentioned defects of the prior art, the present invention provides a high-performance liquid chromatography mixer to solve the problems in the prior art that it is not convenient to change the length of the mixing flow path, and the liquid stays in the mixer for a long time, resulting in uneven mixing.

[0004] To solve the above-mentioned technical problems, this utility model provides the following technical solution: a high-performance liquid chromatography mixer, comprising: a mixer switching center, a housing, and a mixer support. The side surface of the mixer switching center is provided with optional connecting pipes, and two optional connecting pipes are provided, each with a stainless steel connecting screw. The side surface of the mixer switching center away from the optional connecting pipes is provided with a main flow path one, a main flow path two, and a main flow path three. The main flow paths one, two, and three have identical structures and are connected to the two optional connecting pipes. Each of the main flow paths one, two, and three includes a straight pipe flow path and a coiled pipe flow path, and the straight pipe flow path and the coiled pipe flow path are connected.

[0005] The mixer bracket is fixedly connected to the lower surface of the mixer switching hub. The mixer bracket is convex and has a fixing groove.

[0006] The mixer switching hub side surface is provided with a mixer outlet and a mixer inlet, which are located on both sides of the optional connecting pipe.

[0007] The optional connecting pipe is equipped with a stainless steel blade ring.

[0008] The mixer switching hub has two through slots, each containing a cross-shaped pan head screw. The mixer bracket is located between the cross-shaped pan head screw and the mixer switching hub, and a spring washer and a flat washer are provided between the cross-shaped pan head screw and the mixer bracket.

[0009] The outer casing is located on the side of the mixer switching center away from the stainless steel connecting screw, and is located outside the main flow path one, main flow path two, and main flow path three.

[0010] The beneficial effects of the above-mentioned technical solution of this utility model are as follows:

[0011] In the above scheme, the stainless steel screws facilitate pipe connection, and the length of the mixing flow path can be adjusted by the optional connecting pipe to change the volume of the mixer, so as to be suitable for mixing different volumes. Furthermore, the combination of the straight pipe flow path and the coil flow path in the main flow path increases the liquid residence time in the mixer, prolongs the liquid mixing time, and promotes more uniform liquid passing through the mixer. Attached Figure Description

[0012] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0013] Figure 2 This is a schematic diagram of the overall device structure of this utility model;

[0014] Figure 3 This is a schematic diagram of the connection structure of the lifting component of this utility model;

[0015] Figure 4 This is a schematic diagram of the transmission component structure of this utility model.

[0016] [Figure Labels]

[0017] 1. Mixer switching hub; 2. Housing; 3. Mixer bracket; 4. Stainless steel connecting screw; 5. Cross-head pan screw; 6. Spring washer; 7. Flat washer; 8. Stainless steel blade ring; 9. Optional connecting pipe; 10. Mixer outlet; 11. Mixer inlet; 12. Straight pipe flow path; 13. Coil flow path; 14. Main flow path one; 15. Main flow path two; 16. Main flow path three. Detailed Implementation

[0018] To make the technical problems, technical solutions and advantages of this utility model clearer, a detailed description will be given below in conjunction with the accompanying drawings and specific embodiments.

[0019] As attached Figure 1 To be continued Figure 4 An embodiment of this utility model provides a high-performance liquid chromatography mixer, including: a mixer switching center 1, a housing 2, and a mixer support 3. The side surface of the mixer switching center 1 is provided with optional connecting pipes 9, and two optional connecting pipes 9 are provided, each with a stainless steel connecting screw 4. The side surface of the mixer switching center 1 away from the optional connecting pipes 9 is provided with a main flow path 14, a main flow path 25, and a main flow path 36. The main flow paths 14, 25, and 36 have the same structure and are connected to the two optional connecting pipes 9. Each main flow path 14, 25, and 36 includes a straight pipe flow path 12 and a coiled pipe flow path 13, which are connected.

[0020] The mixer bracket 3 is fixedly connected to the lower surface of the mixer switching hub 1. The mixer bracket 3 is convex and has a fixing groove. The side surface of the mixer switching hub 1 is provided with a mixer outlet 10 and a mixer inlet 11. The mixer outlet 10 and the mixer inlet 11 are located on both sides of the optional connecting pipe 9. The optional connecting pipe 9 is provided with a stainless steel blade ring 8. Two through slots are provided through the mixer switching hub 1. A cross-slot pan head screw 5 is provided in the through slot. The mixer bracket 3 is located between the cross-slot pan head screw 5 and the mixer switching hub 1. A spring washer 6 and a flat washer 7 are provided between the cross-slot pan head screw 5 and the mixer bracket 3. The outer shell 2 is located on the side of the mixer switching hub 1 away from the stainless steel connecting screw 4, and is located outside the main flow path one 14, main flow path two 15, and main flow path three 16.

[0021] Specifically, the stainless steel connecting screw 4, paired with the stainless steel blade ring 11, connects the optional connecting pipe 9 to the mixer switching center 1. Main flow path one 14, main flow path two 15, and main flow path three 16 are connected to the optional connecting pipe 9 through the mixer switching center 1, forming a passageway. The outer shell 2 is connected to the mixer switching center 1 using epoxy resin adhesive. In use, the optional connecting pipe 9 is removed from the mixer, and one of its ports is used as the mixer's outlet. Similarly, the other optional connecting pipe 9 is removed, and the port connected to that optional connecting pipe 9 is used as the mixer's outlet. The mixing volume is now twice the previous volume. If the mixing volume is adjusted during use, the unused connection hole is plugged with a dustproof plastic plug. After the liquid enters from the mixer inlet 11, it merges through the three-way structure in the mixer switching center and first enters the straight pipe flow path 12 of the mixer, and then enters the coil flow path 13. The liquid changes its flow direction multiple times in the coil flow path 13, continuously circulating and mixing the liquid radially. Then it enters the next section of the straight pipe flow path 12, thus circulating and extending the mixing time of the liquid in the flow path. Finally, the liquid flows out from the mixer outlet 10, completing the mixing.

[0022] The working process of this utility model is as follows: After the liquid enters from the mixer inlet 11, it merges through the three-way structure in the mixer switching center and first enters the straight pipe flow path 12 of the mixer, and then enters the coil flow path 13. The liquid changes its flow direction multiple times in the coil flow path 13, and continuously performs radial circulation mixing on the liquid. Then it enters the next section of the straight pipe flow path 12, and so on, thus extending the mixing time of the liquid in the flow path. Finally, the liquid flows out from the mixer outlet 10, completing the mixing.

[0023] Finally, the following points should be noted: First, in the description of this application, it should be noted that, unless otherwise specified and limited, the terms "installation", "connection", and "linkage" should be interpreted broadly, and can be mechanical or electrical connections, or internal connections between two components, or direct connections. "Up", "down", "left", "right", etc. are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may change.

[0024] Secondly: The accompanying drawings of the embodiments disclosed in this utility model only involve the structures involved in the embodiments disclosed in this utility model. Other structures can refer to the general design. In the absence of conflict, the same embodiment and different embodiments of this utility model can be combined with each other.

[0025] Finally: The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A high-performance liquid chromatography mixer, characterized in that, include: The mixer switching hub (1), the outer shell (2), and the mixer bracket (3) are provided with optional connecting pipes (9) on the side surface of the mixer switching hub (1). There are two optional connecting pipes (9), and each of the two optional connecting pipes (9) is provided with a stainless steel connecting screw (4). The side surface of the mixer switching hub (1) away from the optional connecting pipes (9) is provided with main flow path one (14), main flow path two (15), and main flow path three (16). The main flow path one (14), main flow path two (15), and main flow path three (16) have the same structure and are connected to the two optional connecting pipes (9). The main flow path one (14), main flow path two (15), and main flow path three (16) all include a straight pipe flow path (12) and a coil flow path (13). The straight pipe flow path (12) and the coil flow path (13) are connected.

2. The high-performance liquid chromatography mixer according to claim 1, characterized in that, The mixer bracket (3) is fixedly connected to the lower surface of the mixer switching hub (1). The mixer bracket (3) is convex and has a fixing groove.

3. The high-performance liquid chromatography mixer according to claim 1, characterized in that, The mixer switching hub (1) has a mixer outlet (10) and a mixer inlet (11) on its side surface, and the mixer outlet (10) and the mixer inlet (11) are located on both sides of the optional connecting pipe (9).

4. The high-performance liquid chromatography mixer according to claim 1, characterized in that, The optional connecting pipe (9) is provided with a stainless steel blade ring (8).

5. A high-performance liquid chromatography mixer according to claim 1, characterized in that, Two through slots are provided on the mixer switching hub (1), and a cross-slot pan head screw (5) is provided in the through slot. The mixer bracket (3) is located between the cross-slot pan head screw (5) and the mixer switching hub (1), and a spring washer (6) and a flat washer (7) are provided between the cross-slot pan head screw (5) and the mixer bracket (3).

6. A high-performance liquid chromatography mixer according to claim 1, characterized in that, The outer casing (2) is located on the side of the mixer switching hub (1) away from the stainless steel connecting screw (4), and is located outside the main flow path one (14), main flow path two (15), and main flow path three (16).

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