Disposable tangential flow filtration liquid mixing bag

Abstract

The utility model relates to liquid processing and mixing equipment technical field discloses a disposable tangential flow filtration liquid mixing bag, including primary mixing ware, secondary mixing ware and liquid storage bag, the primary mixing ware is located the liquid storage bag outside, the secondary mixing ware is located the liquid storage bag inside, and the primary mixing ware and the secondary mixing ware are perpendicular distribution each other. The utility model discloses a primary mixing ware, including cubic liquid storage sac, Y type joint and three-leaf type agitator and secondary mixing ware, including semicircular pipeline and liquid flow hole, utilize Y type joint to guide tangential flow filtration backflow liquid and liquid supplement liquid to drive three-leaf type agitator to rotate, combine the diameter of semicircular pipeline and the liquid flow hole jet form micro eddy, solved the background art in traditional device of relying on external power leading to the problem of uneven mixing, high energy consumption, at the same time, the full -enclosed structure avoids the mechanical transmission component to introduce the pollution, adapts the sterile, high purity liquid processing scene.

Description

Technical Field

[0001] This utility model relates to the field of liquid treatment and mixing equipment technology, and more specifically, to a disposable tangential flow filtration liquid mixing bag. Background Technology

[0002] In liquid treatment processes such as tangential flow filtration (TFF), the liquid at the return end is prone to concentration gradient differences due to its flow characteristics, and some active substances are prone to adhering and depositing. This not only reduces the treatment efficiency of the filtration system, but may also affect the purity and performance of the final product.

[0003] Traditional mixing devices rely on external power sources such as motors, and their fixed mixing frequency and intensity cannot match the dynamically changing reflux rate of tangential flow filtration systems, easily leading to insufficient mixing in certain areas. Most devices require multi-stage pumping components or complex mechanical transmission structures, increasing manufacturing costs and installation / operation complexity, hindering mass production. When mechanical transmission components come into contact with liquids or are exposed to the external environment, impurities or microorganisms can be introduced, potentially causing product contamination, especially in sterile environments such as biopharmaceuticals. Continuous operation requires external power, limiting their applicability in mobile or temporary outdoor processing scenarios without power supply. Therefore, improvements are needed. Utility Model Content

[0004] To overcome the shortcomings of the prior art, this utility model provides a disposable tangential flow filtration liquid mixing bag, which has the advantages of requiring no external power, having a simplified structure, being pollution-proof, and having excellent mixing effect.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a disposable tangential flow filtration liquid mixing bag, comprising a primary mixer, a secondary mixer, and a storage bag, wherein the primary mixer is disposed outside the storage bag, the secondary mixer is disposed inside the storage bag, and the primary mixer and the secondary mixer are distributed perpendicularly to each other. The primary mixer includes a cubic liquid storage bladder, a Y-shaped connector, and a three-bladed agitator. The Y-shaped connector is vertically installed above the cubic liquid storage bladder, and the three-bladed agitator is connected to the inside of the cubic liquid storage bladder via a fixed shaft. The secondary mixer includes a semi-circular pipe and a flow orifice, with the flow orifice located inside the flow cavity of the semi-circular pipe. A connecting pipe is connected directly below the cubic liquid storage bladder, with one end of the connecting pipe away from the cubic liquid storage bladder connected to a liquid storage bag to form the liquid inlet structure of the liquid storage bag. The bottom of the liquid storage bag has a first outlet and a sampling port, and the two ends of the semi-circular pipe have second outlets that communicate with the internal space of the liquid storage bag.

[0006] As a preferred embodiment of this invention, the fixed shaft is vertically connected to the inner wall of the cubic liquid storage bladder. The installation position satisfies the requirement that the distance from the upper inner wall of the cubic liquid storage bladder is half the side length of the shaft, and the distance from the inner side wall is half the side length of the shaft. The length of the fixed shaft is half the side length of the cubic liquid storage bladder. The blades of the three-bladed agitator are perpendicular to the fixed shaft, and the blade length is one-quarter the side length of the cubic liquid storage bladder. The included angle between adjacent blades is 60°, and the three-bladed agitator is located directly below the Y-shaped connector. The Y-shaped connector connects to the tangential flow filter return liquid pipeline and the replenishment liquid pipeline, respectively. The liquid flowing out through the Y-shaped connector can drive the three-bladed agitator to rotate and stir the liquid inside the cubic liquid storage bladder.

[0007] As a preferred technical solution of this utility model, the inner diameter of the flow cavity of the semi-circular pipe gradually decreases from the middle position to the two liquid outlets at both ends, and the inner diameter of the two liquid outlets at both ends of the semi-circular pipe is 1 / 6-1 / 4 of the inner diameter of the connecting pipe. The flow holes are evenly distributed inside the flow cavity of the semi-circular pipe. The distance between adjacent flow holes is 1 / 10 of the circumference of the semi-circular pipe. The diameter of the flow holes is 1 / 30 to 1 / 20 of the inner diameter of the two outlets at both ends of the semi-circular pipe.

[0008] As a preferred technical solution of this utility model, the Y-type connector is provided with a flow guide cone structure inside, and the cone angle of the flow guide cone is 20°-45°.

[0009] As a preferred technical solution of this utility model, the surface of the blade of the three-blade agitator is provided with a streamlined curved surface, and the radius of curvature R of the streamlined curved surface is 10-20mm; the end of the blade is provided with a spiral groove, and the pitch of the spiral groove is 3-7mm.

[0010] As a preferred technical solution of this utility model, the liquid storage bag is made of a three-layer co-extruded film structure, consisting of an inner layer, a middle layer, and an outer layer from the inside out; the inner layer is a food-grade polyethylene layer or a food-grade polypropylene layer, the middle layer is a high-strength nylon layer or a high-strength polyester layer, and the outer layer is an anti-UV aging layer; the front of the liquid storage bag is provided with a transparent visual observation area to monitor the liquid level, and a three-way valve is installed on the sampling port to control the opening and closing of the sampling operation.

[0011] As a preferred embodiment of this utility model, the top of the cubic liquid storage bladder is provided with a bearing, and the end of the fixed shaft away from the three-blade agitator passes through the bearing and is sealed to the cubic liquid storage bladder; the Y-type connector is fixed to the liquid inlet of the cubic liquid storage bladder by heat fusion connection, and the internal guide cone of the Y-type connector corresponds to the position of the blade of the three-blade agitator; the liquid outlet at the bottom of the liquid storage bag is used to connect to an external filtration system, and the semi-circular pipe is fixed to the inner wall of the liquid storage bag by a connecting structure to maintain a stable position.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows: 1. This utility model solves the problems of uneven mixing and high energy consumption caused by the reliance on external power in traditional devices in the background technology. At the same time, the fully enclosed structure avoids the introduction of contamination by mechanical transmission components, making it suitable for sterile and high-purity liquid processing scenarios.

[0013] 2. This utility model designs the liquid storage bag as a three-layer co-extruded film structure, with an inner layer of PE / PP, a middle layer of PA / PET, and an outer layer of UV-resistant aging protection. It integrates liquid inlet, liquid outlet, and sampling functions, and is equipped with a transparent and visual observation area and a three-way valve for the sampling port. This simplifies the complex structure of multi-stage pumping or mechanical stirring systems in the background technology, reduces equipment costs and operating difficulties; and requires no external power supply, breaking through the application limitations in scenarios without electricity. At the same time, it improves the durability of the device and the safety of liquid handling, and is suitable for the needs of multiple fields such as water treatment and biopharmaceuticals. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the structure of this utility model; Figure 2 This is a vertical cross-sectional view of the present invention; Figure 3 This is a schematic diagram of the semi-circular pipeline of this utility model; Figure 4 This is a schematic diagram of the cubic liquid storage bladder of this utility model; Figure 5 This is a schematic diagram of the Y-type connector of this utility model.

[0015] In the diagram: 1. Cubic liquid storage bladder; 2. Liquid storage bag; 3. Y-type connector; 4. Connecting pipeline; 5. Outlet 1; 6. Sampling port; 7. Semi-circular pipeline; 8. Outlet 2; 9. Flow hole; 10. Fixed shaft; 11. Three-bladed agitator. Detailed Implementation

[0016] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0017] like Figures 1 to 5As shown, this utility model provides a disposable tangential flow filtration liquid mixing bag, including a primary mixer, a secondary mixer and a liquid storage bag 2. The primary mixer is located outside the liquid storage bag 2, and the secondary mixer is located inside the liquid storage bag 2. The primary mixer and the secondary mixer are distributed perpendicular to each other. The primary mixer includes a cubic liquid storage bladder 1, a Y-type connector 3, and a three-bladed agitator 11. The Y-type connector 3 is vertically installed above the cubic liquid storage bladder 1, and the three-bladed agitator 11 is connected to the inside of the cubic liquid storage bladder 1 via a fixed shaft 10. The secondary mixer includes a semi-circular pipe 7 and a flow hole 9, with the flow hole 9 located inside the flow cavity of the semi-circular pipe 7. A connecting pipe 4 is connected directly below the cubic liquid storage bladder 1. One end of the connecting pipe 4, away from the cubic liquid storage bladder 1, is connected to a liquid storage bag 2, forming the liquid inlet structure of the liquid storage bag 2. The bottom of the liquid storage bag 2 is provided with a first liquid outlet 5 and a sampling port 6. The two ends of the semi-circular pipe 7 are provided with second liquid outlets 8, which are connected to the internal space of the liquid storage bag 2.

[0018] Install the three-bladed agitator 11 inside the cubic liquid storage bladder 1, ensuring that the fixed shaft 10 of the three-bladed agitator 11 is perpendicular to the inner side of the cubic liquid storage bladder 1. The installation position of the fixed shaft 10 must meet the requirements of "half the height of the top half the side length of the cubic liquid storage bladder 1 and half the side length", and the length of the fixed shaft 10 is half the side length of the cubic liquid storage bladder 1. Then, install a bearing at the top of the cubic liquid storage bladder 1 corresponding to the fixed shaft 10, so that the end of the fixed shaft 10 away from the blade passes through the bearing, and use a sealing structure to achieve a sealed connection between the fixed shaft 10 and the cubic liquid storage bladder 1 to prevent liquid leakage. Fix the Y-type connector 3 to the top liquid inlet of the cubic liquid storage bladder 1 using a heat fusion connection. During connection, precise alignment is required to ensure that the guide cone with a cone angle of 20°-45° inside the Y-type connector 3 is directly facing the blade of the three-bladed agitator 11, ensuring that the subsequent liquid is guided by the guide cone and accurately impacts the blade. After the connection is completed, check the sealing of the connection to prevent liquid leakage. To prevent leakage, first fix the semi-circular pipe 7 to the inner wall of the storage bag 2 using heat sealing or special connectors to ensure its stable position within the storage bag 2. Simultaneously confirm that flow holes 9 are evenly spaced inside the flow cavity of the semi-circular pipe 7, with the spacing between adjacent flow holes 9 being 1 / 10 of the circumference of the semi-circular pipe 7 and the hole diameter being 1 / 30-1 / 20 of the inner diameter of the two outlets 8 at both ends of the semi-circular pipe 7. Then, take the connecting pipe 4, with one end connected to the outlet directly below the cubic storage bag 1. Connect one end to the inlet of the storage bag 2 and the other end to the outlet. After connection, check whether the pipeline is unobstructed and free from bends or blockages, and seal the connection to prevent liquid leakage. Install outlet 5 and sampling port 6 at the preset positions at the bottom of the storage bag 2. Outlet 5 must be compatible with the pipeline of the external tangential flow filtration system, and use a standard interface for connection and sealing. Install a three-way valve at sampling port 6 and test the flexibility and sealing of the three-way valve to prevent liquid leakage or external contamination during sampling.

[0019] After assembly, check the sealing and stability of all connections, including Y-connector 3 to cube-shaped reservoir 1, connecting pipe 4 to cube-shaped reservoir 1 and reservoir bag 2, outlet 5 to external system, and sampling port 6 three-way valve, to ensure there is no looseness or leakage. Simultaneously observe the transparent area of ​​reservoir bag 2, which is a three-layer co-extruded film structure (inner layer PE / PP, middle layer PA / PET, outer layer UV-resistant aging layer), confirming no damage to ensure normal liquid level monitoring later. Connect the tangential flow filter return liquid pipeline and replenishment liquid. The body pipes are connected to the two inlets of the Y-type connector 3. Turning on the liquid delivery switch allows the two liquids to enter the Y-type connector 3 at a certain flow rate. Inside the Y-type connector 3, the liquids are guided by a guide cone and impact the blades of the three-blade agitator 11 at a tangential velocity. The blades have streamlined curved surfaces with a radius of curvature R = 10-20 mm and helical grooves with a pitch of 3-7 mm at the ends, driving the three-blade agitator 11 to rotate around the fixed shaft 10. The rotation speed is adaptively adjusted according to the liquid flow rate, thus radially and axially agitating the liquid inside the cubic liquid reservoir 1. Stirring completes the first stage of mixing. The liquid after the first stage of mixing enters the semi-circular pipe 7 inside the storage bag 2 through the connecting pipe 4. Because the inner diameter of the flow cavity in the semi-circular pipe 7 gradually decreases from the middle towards the two outlets 8 (the inner diameter is 1 / 6 to 1 / 4 of the inner diameter of the connecting pipe 4), the liquid flow velocity increases during the flow process. Simultaneously, it is ejected through the flow holes 9 on the inner side of the flow cavity of the semi-circular pipe 7, forming a multi-scale vortex field within the storage bag 2, performing fine micro-mixing of the liquid and completing the second stage of mixing. The liquid after the second stage of mixing is stored in the storage bag. Inside the storage bag 2, the outlet 5 at the bottom is connected to the external tangential flow filtration system. The liquid enters the filtration system through the outlet 5 for processing. The filtered liquid is then returned to the Y-type connector 3 as reflux liquid, forming a "filtration-reflux-mixing-re-filtration" cycle. During operation, the staff monitors the liquid level in the bag in real time through the transparent visual observation area of ​​the storage bag 2. When it is necessary to monitor the liquid mixing quality, the three-way valve of the sampling port 6 is opened to extract a liquid sample for analysis. After sampling, the three-way valve is closed to ensure continuous sealed operation of the device.

[0020] The fixed shaft 10 is vertically connected to the inner wall of the cube-shaped liquid storage bladder 1. The installation position is such that the height from the upper inner wall of the cube-shaped liquid storage bladder 1 is 1 / 2 of its side length, and the distance from the inner wall of the side is 1 / 2 of its side length. The length of the fixed shaft 10 is 1 / 2 of the side length of the cube-shaped liquid storage bladder 1. The blades of the three-blade agitator 11 are perpendicular to the fixed shaft 10. The blade length is 1 / 4 of the side length of the cube-shaped liquid storage bladder 1. The included angle between adjacent blades is 60°. The three-blade agitator 11 is located directly below the Y-type connector 3. The Y-type connector 3 is connected to the tangential flow filter return liquid pipeline and the replenishment liquid pipeline, respectively. The liquid flowing out through the Y-type connector 3 can drive the three-blade agitator 11 to rotate and agitate the liquid in the cube-shaped liquid storage bladder 1.

[0021] The precise installation position and size of the fixed shaft 10 ensure that the three-blade agitator 11 is located in the center of the cubic liquid storage bladder 1, and the 60° angled blades maximize the mixing coverage and avoid dead corners. Relying on the liquid drive of the Y-type connector 3, no external power is required, which reduces energy consumption and adapts to the dynamic backflow characteristics of tangential flow filtration, effectively improving the uniformity of liquid mixing.

[0022] The inner diameter of the flow cavity of the semi-circular pipe 7 gradually decreases from the middle position to the two outlets 8 at both ends, and the inner diameter of the two outlets 8 at both ends of the semi-circular pipe 7 is 1 / 6 to 1 / 4 of the inner diameter of the connecting pipe 4; the flow holes 9 are evenly distributed inside the flow cavity of the semi-circular pipe 7, the distance between adjacent flow holes 9 is 1 / 10 of the circumference of the semi-circular pipe 7, and the diameter of the flow holes 9 is 1 / 30 to 1 / 20 of the inner diameter of the two outlets 8 at both ends of the semi-circular pipe 7.

[0023] The tapered inner diameter structure accelerates liquid flow and enhances kinetic energy. The specific proportion of the inner diameter of the outlet 8 prevents splashing due to excessive flow rate or inefficiency due to excessively slow flow rate. The uniformly distributed and appropriately sized flow holes 9 enable the liquid to form multi-scale jet flow and micro-vortex, solving the problem of insufficient local mixing in traditional devices and further optimizing the mixing effect.

[0024] Among them, the Y-type connector 3 has a flow guide cone structure inside, and the flow guide cone angle is 20°-45°.

[0025] The 20°-45° guide cone can precisely guide the tangential flow of filtered return liquid, impacting the blades of the three-blade agitator 11 at tangential velocity, reducing kinetic energy loss, significantly improving the conversion efficiency of liquid kinetic energy into agitator rotational kinetic energy, ensuring stable rotation of the three-blade agitator 11, providing reliable power for primary mixing, and ensuring stable mixing effect.

[0026] Among them, the blade surface of the three-blade agitator 11 is provided with a streamlined curved surface with a curvature radius R of 10-20mm; the blade end is provided with a spiral groove with a spiral groove pitch of 3-7mm.

[0027] The streamlined curved surface with a curvature radius of 10-20mm reduces the resistance of liquid flowing through the blades, reduces energy loss, and makes the liquid flow more smoothly; the spiral groove with a pitch of 3-7mm enhances the interaction between the liquid and the blades, improves the kinetic energy conversion efficiency, and can also promote the formation of a spiral flow of liquid, strengthen the stirring effect, and further improve the mixing uniformity.

[0028] The liquid storage bag 2 is made of a three-layer co-extruded film structure, consisting of an inner layer, a middle layer, and an outer layer from the inside out. The inner layer is a food-grade polyethylene layer or a food-grade polypropylene layer, the middle layer is a high-strength nylon layer or a high-strength polyester layer, and the outer layer is an anti-UV aging layer. The front of the liquid storage bag 2 is provided with a transparent and visual observation area to monitor the liquid level, and a three-way valve is installed on the sampling port 6 to control the opening and closing of the sampling operation.

[0029] In the three-layer co-extruded membrane structure, the inner layer ensures the safety and non-contamination of the liquid and is suitable for various types of liquids; the middle layer improves the durability of the storage bag 2 and prevents rupture; the outer layer extends the service life and avoids the influence of ultraviolet rays; the transparent observation area facilitates real-time monitoring of the liquid level, and the three-way valve makes sampling convenient and prevents contamination, reducing the difficulty of operation and improving work efficiency.

[0030] The cube-shaped liquid storage bladder 1 has a bearing at the top, and the end of the fixed shaft 10 away from the three-blade agitator 11 passes through the bearing and is sealed to the cube-shaped liquid storage bladder 1. The Y-type connector 3 is fixed to the liquid inlet of the cube-shaped liquid storage bladder 1 by heat fusion connection, and the internal guide cone of the Y-type connector 3 corresponds to the position of the blade of the three-blade agitator 11. The liquid outlet 5 at the bottom of the liquid storage bag 2 is used to connect to the external filtration system, and the semi-circular pipe 7 is fixed to the inner wall of the liquid storage bag 2 by the connection structure to maintain a stable position.

[0031] The bearing and seal connection reduces the rotational friction of the fixed shaft 10 and prevents liquid leakage; the heat fusion connection ensures that the Y-type connector 3 and the cubic liquid storage bladder 1 are firmly and sealed, and the precise alignment of the guide cone ensures power transmission; the liquid outlet 5 connects to the external system to form a circulation, and the semi-circular pipeline 7 is fixed to avoid displacement, thus improving the overall sealing and stability of the device, reducing the risk of contamination, and ensuring continuous and stable circulation filtration and mixing.

[0032] Working principle and usage process of this utility model: After assembly, check the sealing and stability of all connections, including Y-connector 3 to cube-shaped reservoir 1, connecting pipe 4 to cube-shaped reservoir 1 and reservoir bag 2, outlet 5 to external system, and sampling port 6 three-way valve, to ensure there is no looseness or leakage. Simultaneously, observe the transparent area of ​​reservoir bag 2 (a three-layer co-extruded film structure: inner layer PE / PP, middle layer PA / PET, and outer layer UV-resistant aging layer) to confirm there is no damage, ensuring normal liquid level monitoring later. Connect the tangential flow filter return liquid pipeline and the replenishment liquid... The pipelines are connected to the two inlets of the Y-type connector 3. The liquid delivery switch is turned on, allowing the two liquids to enter the Y-type connector 3 at a certain flow rate. Inside the Y-type connector 3, the liquids are guided by a guide cone and impact the blades of the three-blade agitator 11 at a tangential velocity (the blades have a streamlined curved surface with a radius of curvature R=10-20mm and a spiral groove with a pitch of 3-7mm at the end). This drives the three-blade agitator 11 to rotate around the fixed shaft 10, with the rotation speed adaptively adjusted according to the liquid flow rate, thus radially and axially agitating the liquid within the cubic liquid storage bladder 1. Stirring completes the first stage of mixing. The liquid after the first stage of mixing enters the semi-circular pipe 7 inside the storage bag 2 through the connecting pipe 4. Because the inner diameter of the flow cavity in the semi-circular pipe 7 gradually decreases from the middle towards the two outlets 8 (the inner diameter is 1 / 6 to 1 / 4 of the inner diameter of the connecting pipe 4), the liquid flow velocity increases during the flow process. Simultaneously, it is ejected through the flow holes 9 on the inner side of the flow cavity of the semi-circular pipe 7, forming a multi-scale vortex field within the storage bag 2, performing fine micro-mixing of the liquid and completing the second stage of mixing. The liquid after the second stage of mixing is stored in the storage bag. Inside the storage bag 2, the outlet 5 at the bottom is connected to the external tangential flow filtration system. The liquid enters the filtration system through the outlet 5 for processing. The filtered liquid is then returned to the Y-type connector 3 as reflux liquid, forming a "filtration-reflux-mixing-re-filtration" cycle. During operation, the staff monitors the liquid level in the bag in real time through the transparent visual observation area of ​​the storage bag 2. When it is necessary to monitor the liquid mixing quality, the three-way valve of the sampling port 6 is opened to extract a liquid sample for analysis. After sampling, the three-way valve is closed to ensure continuous sealed operation of the device.

[0033] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0034] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A disposable tangential flow filtration liquid mixing bag, comprising a primary mixer, a secondary mixer, and a storage bag (2), characterized in that: The primary mixer is located outside the liquid storage bag (2), and the secondary mixer is located inside the liquid storage bag (2), with the primary mixer and the secondary mixer being perpendicular to each other. The primary mixer includes a cubic liquid storage bladder (1), a Y-type connector (3), and a three-bladed stirrer (11). The Y-type connector (3) is vertically installed above the cubic liquid storage bladder (1), and the three-bladed stirrer (11) is connected to the inside of the cubic liquid storage bladder (1) via a fixed shaft (10). The secondary mixer includes a semi-circular pipe (7) and a flow hole (9). The flow hole (9) is opened inside the flow cavity of the semi-circular pipe (7). A connecting pipe (4) is connected directly below the cubic liquid storage bladder (1). The end of the connecting pipe (4) away from the cubic liquid storage bladder (1) is connected to the liquid storage bag (2) and forms the liquid inlet structure of the liquid storage bag (2). The bottom of the liquid storage bag (2) is provided with a liquid outlet (5) and a sampling port (6). The two ends of the semi-circular pipe (7) are provided with liquid outlets (8) and are connected to the internal space of the liquid storage bag (2) through the liquid outlets (8).

2. The disposable tangential flow filtration liquid mixing bag according to claim 1, characterized in that: The fixed shaft (10) is vertically connected to the inner wall of the cubic liquid storage bladder (1). The installation position satisfies that the height from the upper inner wall of the cubic liquid storage bladder (1) is 1 / 2 of its side length and the distance from the inner wall of the side is 1 / 2 of its side length. The length of the fixed shaft (10) is 1 / 2 of the side length of the cubic liquid storage bladder (1). The blades of the three-blade agitator (11) are perpendicular to the fixed shaft (10). The length of the blades is 1 / 4 of the side length of the cubic liquid storage bladder (1). The included angle between adjacent blades is 60°. The three-blade agitator (11) is located directly below the Y-type connector (3). The Y-type connector (3) is connected to the tangential flow filter return liquid pipeline and the replenishment liquid pipeline respectively. The liquid flowing out through the Y-type connector (3) can drive the three-blade agitator (11) to rotate to agitate the liquid in the cubic liquid storage bladder (1).

3. The disposable tangential flow filtration liquid mixing bag according to claim 1, characterized in that: The inner diameter of the flow cavity of the semi-circular pipe (7) gradually decreases from the middle position to the two liquid outlets (8) at both ends, and the inner diameter of the two liquid outlets (8) at both ends of the semi-circular pipe (7) is 1 / 6 to 1 / 4 of the inner diameter of the connecting pipe (4). The flow holes (9) are evenly distributed inside the flow cavity of the semi-circular pipe (7). The distance between adjacent flow holes (9) is 1 / 10 of the circumference of the semi-circular pipe (7). The diameter of the flow holes (9) is 1 / 30-1 / 20 of the inner diameter of the two outlets (8) at both ends of the semi-circular pipe (7).

4. The disposable tangential flow filtration liquid mixing bag according to claim 1, characterized in that: The Y-type connector (3) has a flow guide cone structure inside, and the flow guide cone has a cone angle of 20°-45°.

5. The disposable tangential flow filtration liquid mixing bag according to claim 1, characterized in that: The blade surface of the three-blade agitator (11) is provided with a streamlined curved surface, and the radius of curvature R of the streamlined curved surface is 10-20mm; the end of the blade is provided with a spiral groove, and the pitch of the spiral groove is 3-7mm.

6. The disposable tangential flow filtration liquid mixing bag according to claim 1, characterized in that: The liquid storage bag (2) is made of a three-layer co-extruded film structure, consisting of an inner layer, a middle layer, and an outer layer from the inside out; the inner layer is a food-grade polyethylene layer or a food-grade polypropylene layer, the middle layer is a high-strength nylon layer or a high-strength polyester layer, and the outer layer is an anti-ultraviolet aging layer; the front of the liquid storage bag (2) is provided with a transparent visual observation area to monitor the liquid level, and a three-way valve is installed on the sampling port (6) to control the opening and closing of the sampling operation.

7. The disposable tangential flow filtration liquid mixing bag according to claim 1, characterized in that: The cube-shaped liquid storage bladder (1) is provided with a bearing at the top. The end of the fixed shaft (10) away from the three-blade agitator (11) passes through the bearing and is sealed to the cube-shaped liquid storage bladder (1). The Y-type connector (3) is fixed to the liquid inlet of the cube-shaped liquid storage bladder (1) by heat fusion connection, and the internal guide cone of the Y-type connector (3) corresponds to the position of the blade of the three-blade agitator (11). The liquid outlet (5) at the bottom of the liquid storage bag (2) is used to connect to the external filtration system. The semi-circular pipe (7) is fixed to the inner wall of the liquid storage bag (2) through the connection structure to maintain a stable position.

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