A reaction apparatus for preparing sodium alginate hydrogel beads

Abstract

The utility model belongs to sodium alginate hydrogel bead preparation technical field discloses a kind of reaction device of preparation sodium alginate hydrogel bead, including cylinder, first horizontal baffle, second horizontal baffle, liquid discharge port, drain, sample box and the communication plate being arranged at the bottom of first horizontal baffle;First horizontal baffle is provided with several first through-holes, and second horizontal baffle is provided with several third through-holes;Sample box is vertically arranged and top is open, and several fourth through-holes are opened in sample box bottom;Two to three notches are opened in cylinder;Communication plate is attached with first horizontal baffle, and communication plate is rotatably connected with cylinder, and several second through-holes are opened in communication plate.The utility model changes the communication between first through-hole and second through-hole and the communication between third through-hole and fourth through-hole by stirring the position of sample box in cylinder, realizes the preparation of sodium alginate-based gel bead, and can realize flushing to sodium alginate-based gel bead.

Description

Technical Field

[0001] This utility model relates to the field of sodium alginate hydrogel bead preparation technology, and in particular to a reaction apparatus for preparing sodium alginate hydrogel beads. Background Technology

[0002] Sodium alginate (SA) is a linear polysaccharide isolated from brown algae, composed of poly-β-1,4-diaminobenzoic acid (M units) and α-1,4-L-glucuronic acid (G units) in varying proportions. Its aqueous solution exhibits strong viscosity. Due to the large number of carboxyl and hydroxyl groups in its molecular structure, sodium alginate possesses high chemical activity, rapidly forming a three-dimensional network hydrogel structure within a relatively mild environment. It is also non-toxic, odorless, and exhibits excellent biocompatibility and eco-friendliness. Sodium alginate can be gelled by direct dropwise addition—the sodium alginate-based mixed solution is directly added to the gelling solution to form "diamond"-shaped gel beads. The direct dropwise addition method offers advantages such as simple operation, rapid gel formation, uniform shape, and no need for molds, making it a commonly used method for gelling sodium alginate.

[0003] The preparation of sodium alginate-based gels via the direct dropwise addition method mainly involves three steps: ① preparing a sodium alginate-based mixed solution; ② adding the solution dropwise to the gelling solution; ③ filtering the solution to obtain gel beads. Currently, there is no integrated equipment for preparing gel beads; each process step requires specific operations, which is cumbersome and inconvenient. Utility Model Content

[0004] To address the problem that the existing methods for preparing sodium alginate hydrogel beads are cumbersome and inconvenient, this invention proposes a reaction apparatus for preparing sodium alginate hydrogel beads, which integrates the preparation steps of sodium alginate-based hydrogel beads, thereby simplifying the preparation steps of sodium alginate-based gel beads.

[0005] This utility model is achieved through the following technical solution: It includes a vertically arranged cylindrical body with an open top, a first horizontal partition and a second horizontal partition disposed inside the body, a drain outlet and a water outlet disposed at the bottom of the body, a cylindrical sample container disposed between the first and second horizontal partitions, and a connecting plate disposed at the bottom of the first horizontal partition; the first and second horizontal partitions are respectively fixedly connected to the body, with the first horizontal partition disposed on the upper part of the body; the first horizontal partition has several first through holes, and the second horizontal partition has several third through holes; the sample container is detachably connected to the body. The sample box is vertically arranged with an open top and several fourth through holes at the bottom. Two to three slots are opened on the cylinder between the first and second horizontal partitions. The connecting plate is attached to the first horizontal partition and is rotatably connected to the cylinder. Several second through holes are opened on the connecting plate, and the positions of the second through holes correspond one-to-one with the positions of the first through holes and are equal in size. The positions of the fourth through holes at the bottom of the sample box correspond one-to-one with the positions of the third through holes on the second horizontal partition and are equal in size. The size of the third through hole on the second horizontal partition is smaller than that of the first through hole on the first horizontal partition.

[0006] As a further preferred embodiment, a top cover is provided at the top opening of the cylinder, and a first sample inlet and a first water inlet are respectively opened on the top cover.

[0007] As a further preferred embodiment, the bottom of the top cover is provided with rotating fan blades, a baffle is provided on the side wall of the sample injection area inside the cylinder, and a drive motor is provided on the top of the top cover, the drive motor being connected to the rotating fan blades.

[0008] As a further preferred embodiment, the bottom of the first horizontal partition is provided with a plurality of tapered outlet drippers, the number of which is consistent with the number of the first through holes and their positions correspond one-to-one.

[0009] As a further preferred embodiment, the side wall of the sample container is provided with a second sample inlet and a second water inlet near the top opening, and a flexible tube is connected to each of the second sample inlet and the second water inlet.

[0010] As a further preferred embodiment, a drain pipe is also provided inside the cylinder. The drain pipe is vertically arranged, with one end of the drain pipe fixedly connected to the second horizontal partition and the other end connected to the sample box.

[0011] As a further preferred option, the drain pipe is a retractable structure.

[0012] As a further preferred embodiment, the inner wall of the cylinder between the first horizontal partition and the second horizontal partition is vertically provided with a third channel, and the third channel is provided with a groove, and the sample box is provided with a protrusion at the corresponding position.

[0013] As a further preferred embodiment, the bottom of the first horizontal partition is provided with a first channel along the circumferential direction, and a protrusion is provided at the corresponding position on the connecting plate.

[0014] As a further preferred embodiment, the top of the second horizontal partition is provided with a second channel along the circumferential direction, and the bottom of the sample box is provided with a protrusion at the corresponding position.

[0015] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0016] 1. This invention integrates the preparation steps of sodium alginate-based gel beads, avoiding the use of multiple preparation devices and thus simplifying the preparation steps of sodium alginate-based gel beads.

[0017] 2. This utility model achieves the preparation of sodium alginate-based gel beads by adjusting the position of the sample box inside the cylinder and changing the connection between the first through hole and the second through hole, as well as between the third through hole and the fourth through hole, and can also rinse the sodium alginate-based gel beads.

[0018] 3. In order to facilitate the entry of the solution into the sample inlet area, the present invention provides a first sample inlet and a water inlet on the top cover. The first sample inlet and the water inlet are arranged opposite to each other on the top cover. A drive motor is added to the top cover to drive the rotating fan blades. The rotating fan blades can further mix the solution.

[0019] 4. In this utility model, a groove is formed at the outer circumference edge of the first horizontal partition to form the first groove, which is located at the bottom of the first horizontal partition; this ensures that the connecting plate and the first horizontal partition are always aligned, so that the second through hole on the connecting plate is aligned with the first through hole on the first horizontal partition.

[0020] 5. This utility model features a second channel formed by creating a circumferential groove at the top of the second horizontal partition. This ensures that the sample box is always aligned with the second horizontal partition, facilitating rotation until the fourth through hole on the sample box aligns with the third through hole on the second horizontal partition.

[0021] 6. In this invention, a third channel is vertically provided on the inner wall of the cylinder in the gel bead forming area, and a groove is provided on the third channel. A protrusion is provided at the corresponding position of the sample box to ensure that the sample box is always perpendicular to the second horizontal partition and does not deviate when sliding. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0023] Figure 2 This is a schematic diagram of the sample box of this utility model when it is located in the middle of the cylinder.

[0024] Figure 3This is a schematic diagram of the cylindrical structure of this utility model.

[0025] Figure 4 This is a schematic diagram of the first horizontal partition structure of this utility model.

[0026] Figure 5 This is a schematic diagram of the conical outlet dripper structure of this utility model.

[0027] Figure 6 This is a schematic diagram of the connecting plate structure of this utility model.

[0028] Figure 7 This is a schematic diagram of the second horizontal partition structure of this utility model.

[0029] Figure 8 This is a schematic diagram of the sample box structure of this utility model.

[0030] Figure 9 This is a schematic diagram of the third channel structure of this utility model.

[0031] The image shows:

[0032] 1. Cylinder body; 2. First horizontal partition; 3. Rotating fan blade; 4. Connecting plate; 5. Conical outlet dropper; 6. Second horizontal partition; 7. Sample box; 8. Drain pipe; 9. First through hole; 10. Second through hole; 11. Third through hole; 12. Fourth through hole; 13. Top cover; 14. First sample inlet; 15. First water inlet; 16. Baffle plate; 17. Second sample inlet; 18. Second water inlet; 19. Flexible tube; 20. First channel; 21. Second channel; 22. Third channel; 23. Groove; 24. Protrusion; 25. Sample injection area; 26. Gel bead formation area; 27. Drain outlet; 28. Liquid outlet; 29. ​​Groove opening; 30. Drive motor. Detailed Implementation

[0033] The advantages and features of this utility model will be illustrated and explained through the following non-limiting description of preferred embodiments, which are given by way of example only with reference to the accompanying drawings.

[0034] Example 1

[0035] like Figures 1 to 9As shown, this utility model provides a reaction apparatus for preparing sodium alginate hydrogel beads, including a cylindrical body 1, which is vertically arranged and has an opening at the top and a drain outlet 28 and a water outlet 27 at the bottom. Inside the cylindrical body 1, from top to bottom, are a first horizontal partition 2 and a second horizontal partition 6, which are fixedly connected to the cylindrical body 1. Both the first and second horizontal partitions are horizontally arranged, dividing the interior of the cylindrical body 1 into three regions: a sample inlet area 25 at the top, a gel bead formation area 26 between the first and second horizontal partitions 2 and 6, and a drain area at the bottom. The first horizontal partition 2 has several first through holes 9, and the second horizontal partition 6 has several third through holes 11. The gel bead formation area 26 is equipped with a detachable sample container 7, which is cylindrical and vertically arranged, with an opening at the top and several fourth through holes 12 at the bottom. Two to three slots 29 are formed on the cylindrical body 1 between the first horizontal partition 2 and the second horizontal partition 6. These slots 29 are used to install the sample box 7. A connecting plate 4 is provided at the bottom of the first horizontal partition 2. The connecting plate 4 is fitted to the first horizontal partition 2 and rotatably connected to the cylindrical body 1. Several second through holes 10 are formed on the connecting plate 4. The positions of the second through holes 10 correspond one-to-one with the positions of the first through holes 9, and they are of equal size. The position of the fourth through hole 12 at the bottom of the sample box 7 corresponds one-to-one with the position of the third through hole 11 on the second horizontal partition 6, and they are of equal size. To retain the formed sodium alginate hydrogel beads inside the sample box 7 for easy removal, the size of the third through hole 11 on the second horizontal partition 6 is smaller than the size of the first through hole 9 on the first horizontal partition 2.

[0036] In use, rotate the connecting plate 4 to offset the second through hole 10 on the connecting plate 4 from the first through hole 9 on the first horizontal partition 2. Pour water and sodium alginate solution into the sample injection area 25 inside the cylinder 1 from the top opening in a certain proportion for mixing. Since the first through hole 9 and the second through hole 10 are offset, the solution will not flow into the sample loading box 7. After the solution is mixed, add gelling solution to the sample loading box 7, rotate the connecting plate 4 to align the first through hole 9 and the second through hole 10 one by one, and drip the mixed sodium alginate solution into the sample loading box 7 to carry out the gelation reaction and form sodium alginate hydrogel beads. At this time, the fourth through hole 12 at the bottom of the sample loading box 7 is offset from the third through hole 11 on the second horizontal partition 6. After the gelation reaction is complete, rotate the sample box 7 to align the third through hole 11 and the fourth through hole 12 one by one, and let the reacted solution flow into the drainage area at the bottom of the cylinder 1, and then out of the cylinder 1 through the drainage port 28. Rinse the sodium alginate hydrogel beads in the sample box 7 with water, and let the rinsed waste liquid flow into the drainage area and be discharged through the drain port 27. Finally, remove the sample box 7 and take out the sodium alginate hydrogel beads inside.

[0037] In some embodiments, such as Figure 1 and Figure 2 As shown, to prevent dust and other impurities from contaminating the sodium alginate solution during mixing, a top cover 13 can be installed at the top opening of the cylinder 1. A first sample inlet 14 and a first water inlet 15 are respectively opened on the top cover 13. The first sample inlet 14 is used to introduce sodium alginate solution or sodium alginate material, and the first water inlet 15 is used to introduce solvents such as water. To accelerate the mixing of the sodium alginate solution, a rotating fan blade 3 can be installed at the bottom of the top cover 13, a baffle plate 16 can be installed on the side wall of the sample inlet area 25 inside the cylinder 1, and a drive motor 30 can be installed at the top of the top cover 13. The drive motor 30 is connected to the rotating fan blade 3 and is used to drive the rotating fan blade 3 to rotate.

[0038] In some embodiments, such as Figure 5 As shown, in order to improve the forming effect of sodium alginate hydrogel beads, a number of conical outlet droppers 5 can be set at the bottom of the first horizontal partition 2. The number of conical outlet droppers 5 is the same as the number of first through holes 9 and their positions correspond one-to-one.

[0039] In some embodiments, such as Figure 2 and Figure 8 As shown, the sample container 7 has a second sample inlet 17 and a second water inlet 18 located on the side wall near the top opening. The second sample inlet 17 is used to introduce the gelling solution, and the second water inlet 18 is used to introduce water to rinse the formed sodium alginate hydrogel beads. A flexible tube 19 is connected to both the second sample inlet 17 and the second water inlet 18. The other end of the flexible tube 19 on the second sample inlet 17 is connected to the gelling solution, and the other end of the flexible tube 19 on the second water inlet 18 is connected to water.

[0040] In some embodiments, such as Figure 2 , Figure 8 and Figure 9As shown, a drain pipe 8 is also provided inside the cylinder 1. The drain pipe 8 is vertically arranged and can be opened and closed as needed. One end of the drain pipe 8 is fixedly connected to the second horizontal partition 6, and the other end is connected to the sample box 7. Corresponding positions on the second horizontal partition 6 and the sample box 7 are provided with through holes to facilitate the flow of liquid in the drain pipe 8 into the drainage area. The drain pipe 8 is a telescopic structure. A third channel 22 is vertically arranged on the inner wall of the cylinder 1 in the gel bead formation area. A groove 23 is provided on the third channel 22, and a protrusion 24 is provided at the corresponding position on the sample box 7. The sample box 7 can slide up and down along the third channel 22 and is limited by the cooperation of the protrusion 24 and the groove 23. The protrusion 24 is elastic and can slide along the third channel 22 without interference. The third channel 22 can ensure that the sample box 7 is always perpendicular to the second horizontal partition 6 and does not deviate when sliding. That is, the sample box 7 is installed inside the cylinder 1 through the slot 29 on the cylinder 1. When it is necessary to change the working state, the sample box 7 is manually moved and slides along the third channel 22 towards the middle of the cylinder 1. When it reaches the designated position, the protrusion 24 inside the sample box 7 is stuck in the groove 23 in the third channel 22, thereby limiting the position of the sample box 7.

[0041] In some embodiments, such as Figure 4 , Figure 6 and Figure 7 As shown, to ensure that the connecting plate 4 remains in contact with the first horizontal partition 2 during rotation and does not shift, a first channel 20 can be provided along the circumferential direction at the bottom of the first horizontal partition 2. Correspondingly, a protrusion is provided at a corresponding position on the connecting plate 4. The protrusion on the connecting plate 4, in conjunction with the first channel 20, ensures that the connecting plate 4 and the first horizontal partition 2 are always concentrically aligned, facilitating the alignment of the first through hole 9 and the second through hole 10 during rotation. Similarly, to ensure that the sample box 7 remains in contact with the second horizontal partition 6 during rotation and does not shift, a second channel 21 can be provided along the circumferential direction at the top of the second horizontal partition 6. Correspondingly, a protrusion is provided at a corresponding position at the bottom of the sample box 7. The protrusion at the bottom of the sample box 7, in conjunction with the second channel 21, ensures that the sample box 7 and the second horizontal partition 6 are always concentric, facilitating the alignment of the third through hole 11 and the fourth through hole 12 during rotation.

[0042] The operation process of this utility model is as follows:

[0043] Step S1: Install the sample box 7 inside the cylinder 1 through the slot 29 on the cylinder 1 along the third channel 22, with the bottom of the sample box 7 in contact with the second horizontal partition 6.

[0044] Step S2: Before the sodium alginate-based gel bead reaction, the second through hole 10 on the connecting plate 4 is offset from the first through hole 9 of the first horizontal partition 2 in the sample injection area 25.

[0045] Step S3: Introduce sodium alginate solution or sodium alginate material into the sample injection area 25 through the first sample inlet 14; introduce water into the sample injection area 25 through the first water inlet 15; introduce gelling solution into the sample loading box 7 through the hose 19 and the second sample inlet 17, and then remove the hose 19.

[0046] Step S4: Start the drive motor 30 and turn on the rotating fan blades 3 to further mix the sodium alginate solution in the sample injection zone 25. After a set period of time, turn off the rotating fan blades 3.

[0047] Step S5: Rotate the connecting plate 4 to align the second through hole 10 on the connecting plate 4 with the first through holes 9 of the first horizontal partition 2 in the sample injection area 25, and offset the fourth through holes 12 at the bottom of the sample box 7 with the third through holes 11 on the second horizontal partition 6. Then close the drain pipe 8.

[0048] When the second through holes 10 on the connecting plate 4 are aligned one by one with the first through holes 9 on the first horizontal partition 2 in the sample injection area 25, the sodium alginate-based solution in the sample injection area 25 will drip into the lower conical outlet dropper 5, and then the sodium alginate-based solution will drip from the conical outlet dropper 5 into the gelling solution in the sample loading box 7 to form a gel.

[0049] Step S6: Rotate the connecting plate 4 to offset the second through hole 10 on the connecting plate 4 from the first through holes 9 of the first horizontal partition 2 in the sample injection area 25. Align the fourth through holes 12 at the bottom of the sample box 7 with the third through holes 11 on the second horizontal partition 6 one by one.

[0050] When the fourth through holes 12 at the bottom of the sample box 7 are aligned with the third through holes 11 on the second horizontal partition 6, the gelling solution in the sample box 7 flows into the bottom of the cylinder 1 and then is discharged from the drain port 28.

[0051] Step S7: Manually move the sample box 7. The sample box 7 slides along the third channel 22 towards the middle of the cylinder 1. When it reaches the designated position, the protrusion 24 of the sample box 7 is locked in the groove 23 in the third channel 22, thereby limiting the position of the sample box 7. Open the drain pipe 8 and introduce water into the sample box 7 through the second water inlet 18 to rinse the sodium alginate-based gel beads in the sample box 7. After rinsing for a period of time, take out the sample box 7 to remove the sodium alginate hydrogel beads. The rinsing waste liquid is discharged from the drain pipe 8 to the drain outlet 27.

[0052] It should be noted that the hole spacing in the accompanying drawings of this utility model is only a simplified illustration; the actual requirement is that the spacing between adjacent holes must be consistent.

[0053] In addition to the above embodiments, the present invention may have other implementation methods. All technical solutions formed by equivalent substitution or equivalent transformation fall within the protection scope claimed by the present invention.

Claims

1. A reaction apparatus for preparing sodium alginate hydrogel beads, characterized in that: The device includes a vertically arranged cylindrical body (1) with an open top, a first horizontal partition (2) and a second horizontal partition (6) inside the body (1), a drain outlet (28) and a drain outlet (27) at the bottom of the body (1), a cylindrical sample box (7) between the first horizontal partition (2) and the second horizontal partition (6), and a connecting plate (4) at the bottom of the first horizontal partition (2); the first horizontal partition (2) and the second horizontal partition (6) are fixedly connected to the body (1) respectively, and the first horizontal partition (2) is located on the upper part of the body (1). The first horizontal partition (2) is provided with a plurality of first through holes (9), and the second horizontal partition (6) is provided with a plurality of third through holes (11); The sample box (7) is detachably connected to the cylinder (1). The sample box (7) is vertically arranged and has an opening at the top. The bottom of the sample box (7) is provided with several fourth through holes (12). Two to three slots (29) are opened on the cylinder (1) between the first horizontal partition (2) and the second horizontal partition (6). The connecting plate (4) is attached to the first horizontal partition (2) and the connecting plate (4) is rotatably connected to the cylinder (1). Several second through holes (10) are opened on the connecting plate (4). The positions of the second through holes (10) correspond one-to-one with the positions of the first through holes (9) and are equal in size. The position of the fourth through hole (12) at the bottom of the sample box (7) corresponds one-to-one with the position of the third through hole (11) provided on the second horizontal partition (6) and is equal in size. The size of the third through hole (11) on the second horizontal partition (6) is smaller than that of the first through hole (9) on the first horizontal partition (2).

2. The reaction apparatus for preparing sodium alginate hydrogel beads according to claim 1, characterized in that: A top cover (13) is provided at the top opening of the cylinder (1), and a first sample inlet (14) and a first water inlet (15) are respectively opened on the top cover (13).

3. The reaction apparatus for preparing sodium alginate hydrogel beads according to claim 2, characterized in that: The bottom of the top cover (13) is provided with a rotating fan blade (3), a baffle plate (16) is provided on the side wall of the sample injection area (25) inside the cylinder (1), and a drive motor (30) is provided on the top of the top cover (13). The drive motor (30) is connected to the rotating fan blade (3).

4. The reaction apparatus for preparing sodium alginate hydrogel beads according to claim 1, characterized in that: The bottom of the first horizontal partition (2) is provided with a number of conical outlet drippers (5), the number of which is the same as the number of the first through holes (9) and their positions correspond one-to-one.

5. The reaction apparatus for preparing sodium alginate hydrogel beads according to claim 1, characterized in that: The sample container (7) has a second sample inlet (17) and a second water inlet (18) on its side wall near the top opening. A flexible tube (19) is connected to both the second sample inlet (17) and the second water inlet (18).

6. The reaction apparatus for preparing sodium alginate hydrogel beads according to claim 1, characterized in that: The cylinder (1) is also equipped with a drain pipe (8), which is vertically arranged. One end of the drain pipe (8) is fixedly connected to the second horizontal partition (6), and the other end is connected to the sample box (7).

7. The reaction apparatus for preparing sodium alginate hydrogel beads according to claim 6, characterized in that: The drain pipe (8) is a retractable structure.

8. The reaction apparatus for preparing sodium alginate hydrogel beads according to claim 7, characterized in that: The inner wall of the cylinder (1) between the first horizontal partition (2) and the second horizontal partition (6) is vertically provided with a third channel (22), and a groove (23) is provided on the third channel (22). The sample box (7) is provided with a protrusion (24) at the corresponding position.

9. The reaction apparatus for preparing sodium alginate hydrogel beads according to claim 1, characterized in that: The bottom of the first horizontal partition (2) is provided with a first channel (20) along the circumferential direction, and a protrusion is provided at the corresponding position on the connecting plate (4).

10. The reaction apparatus for preparing sodium alginate hydrogel beads according to claim 1, characterized in that: The top of the second horizontal partition (6) is provided with a second channel (21) along the circumferential direction, and the bottom of the sample box (7) is provided with a protrusion at the corresponding position.

Images