A methyl betacyclodextrin derivative reaction tank

Abstract

The utility model relates to methyl betacyclodextrin technical field, and disclose a kind of methyl betacyclodextrin derivative reaction tank, including jar body, the jar body top is provided with driving motor, the output shaft of driving motor is connected with the main drive gear that intrudes jar body inside.This methyl betacyclodextrin derivative reaction tank, by jar body, driving motor, main drive gear, driven gear, main stirring shaft, outer periphery scraper, main stirring paddle, auxiliary dispersion disc, heat insulating jacket and electric heating coil pipe's cooperation setting, use the composite stirring design of '' inclined blade turbine paddle + dispersion disc '', both can realize the macrocirculation in full tank range, can also to high viscosity material carry out efficient shearing and dispersion, ensure that reactant contact is sufficient, heat transfer is uniform, effectively avoided local overheating and reaction dead angle, to improve the substitution uniformity and purity of product (methyl betacyclodextrin derivative).

Description

Technical Field

[0001] This utility model relates to the field of methyl beta-cyclodextrin technology, specifically a reaction vessel for methyl beta-cyclodextrin derivatives. Background Technology

[0002] Methylbetacyclodextrin and its derivatives are important pharmaceutical excipients and chemical intermediates, and their synthesis typically involves etherification reactions catalyzed by a base. This reaction system is characterized by high material viscosity, intense exothermic reaction, and stringent requirements for temperature and material mixing homogeneity.

[0003] Conventional paddle or anchor mixers are difficult to mix high-viscosity materials efficiently, which can easily lead to uneven mass and heat transfer, causing local overheating or incomplete reaction, affecting the degree of substitution and purity of the product. Therefore, this invention provides a reaction vessel for methyl beta-cyclodextrin derivatives. Utility Model Content

[0004] (a) Technical problems to be solved

[0005] To address the shortcomings of existing technologies, this invention provides a reaction vessel for methyl beta-cyclodextrin derivatives, solving the problems mentioned in the background section.

[0006] (II) Technical Solution

[0007] To achieve the above objectives, this utility model provides the following technical solution: a reaction vessel for methyl beta-cyclodextrin derivatives, comprising a vessel body, a drive motor disposed at the top of the vessel body, an output shaft of the drive motor connected to a drive gear extending into the vessel body, a driven gear meshing with the surface of the drive gear, a main stirring shaft fixedly connected inside the drive gear, an outer peripheral scraper, at least two sets of main stirring paddles and an auxiliary dispersion disc disposed sequentially from top to bottom on the surface of the main stirring shaft, a heat insulation jacket disposed outside the vessel body, an electric heating coil disposed inside the vessel body, and a feeding port disposed at the top of the vessel body, with a premixer fixedly connected to the top of the feeding port.

[0008] Preferably, the main stirring impeller is an inclined blade turbine-type stirring impeller, and the auxiliary dispersing disk is a disc turbine-type structure with a plurality of through holes evenly opened on its surface.

[0009] Preferably, the premixer includes a container body, a container lid, a stirring motor, a premixing roller, and a pull-out clamping plate. The container body and one side of the container lid are rotatably connected by a damping hinge, and the other side of the container body and the container lid are connected by a snap-fit. The stirring motor is fixed to the top of the container lid, and the output shaft of the stirring motor is fixedly connected to the premixing roller. The pull-out clamping plate is snapped to the container body by a sealing ring. The pull-out clamping plate has a handle on its outside, and a limiting rotating plate is movably limited to the outer surface of the pull-out clamping plate. The limiting rotating plate is rotatably connected to the container body through a rotating shaft.

[0010] Preferably, the inner wall of the tank, the driving gear, the driven gear, the main stirring shaft, the scraper, the main stirring paddle, and the auxiliary dispersion disc are all coated with a polytetrafluoroethylene anti-corrosion coating.

[0011] Preferably, the top of the tank is provided with a pressure relief pipe and a safety valve connected to the pressure relief pipe, and a rupture disc device is also connected in series on the pressure relief pipe, and a discharge valve is fixedly connected to the bottom of the tank.

[0012] Preferably, an online pH sensor and an online temperature sensor that extend into the tank are also installed on the side wall of the tank.

[0013] (III) Beneficial Effects

[0014] Compared with the prior art, the present invention provides a reaction vessel for methyl beta-cyclodextrin derivatives, which has the following beneficial effects:

[0015] This methyl beta-cyclodextrin derivative reaction vessel, through the coordinated arrangement of the vessel body, drive motor, drive gear, driven gear, main stirring shaft, outer scraper, main stirring paddle, auxiliary dispersion disc, insulation jacket, and heating coil, employs a composite stirring design of "inclined blade turbine paddle + dispersion disc." This design achieves macroscopic circulation throughout the entire vessel while efficiently shearing and dispersing high-viscosity materials, ensuring sufficient contact of reactants and uniform heat transfer. It effectively avoids localized overheating and reaction dead zones, thereby improving the substitution uniformity and purity of the product (methyl beta-cyclodextrin derivative). Through pre- The coordinated arrangement of the mixer, container body, container lid, stirring motor, premixing roller, and pull-out clamp allows solid catalysts or high-concentration reagents to be pre-dispersed and diluted before entering the main reaction system, fundamentally avoiding side reactions and product decomposition caused by excessively high local concentrations, and further improving product yield and quality. The integrated online pH and temperature sensors enable real-time monitoring of key reaction parameters, providing a foundation for process optimization and automated control, reducing manual intervention, and improving production efficiency and batch stability. Attached Figure Description

[0016] Figure 1This is a schematic diagram of the structure of this utility model;

[0017] Figure 2 This utility model Figure 1 Enlarged view at point A.

[0018] In the diagram: 1. Tank body; 2. Drive motor; 3. Driven gear; 4. Driven gear; 5. Main stirring shaft; 6. Outer scraper; 7. Main stirring paddle; 8. Auxiliary dispersing disc; 9. Insulation jacket; 10. Heating coil; 11. Feed port; 12. Online temperature sensor; 13. Premixer; 131. Container body; 132. Container lid; 133. Stirring motor; 134. Premixing roller; 135. Pull-out clamp; 14. Pressure relief pipe; 15. Online pH sensor. Detailed Implementation

[0019] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0020] Please see Figure 1-2This utility model provides a technical solution: a reaction vessel for methyl beta-cyclodextrin derivatives, comprising a vessel body 1. Through the coordinated arrangement of the vessel body 1, a drive motor 2, a driving gear 3, a driven gear 4, a main stirring shaft 5, an outer scraper 6, a main stirring paddle 7, an auxiliary dispersion disc 8, a heat insulation jacket 9, and an electric heating coil 10, a composite stirring design of "inclined blade turbine paddle + dispersion disc" is used. This design achieves macroscopic circulation throughout the entire vessel and efficiently shears and disperses high-viscosity materials, ensuring sufficient contact of reactants and uniform heat transfer. It effectively avoids localized overheating and reaction dead zones, thereby improving the substitution uniformity and purity of the methyl beta-cyclodextrin derivative product. The drive motor 2 is located at the top of the vessel body 1, and the output shaft of the drive motor 2 is connected to a component extending into the vessel body. The tank 1 contains an internal drive gear 3, with a driven gear 4 meshing on its surface. A main stirring shaft 5 is fixedly connected inside the drive gear 3. From top to bottom, the main stirring shaft 5 is equipped with an outer scraper 6, at least two sets of main stirring paddles 7, and an auxiliary dispersion disc 8. The tank 1 has an external insulation jacket 9, and an electric heating coil 10 inside. A feeding port 11 is located at the top of the tank 1, with a premixer 13 fixedly connected to its top. Through the coordinated arrangement of the premixer 13, the container body 131, the container cover 132, the stirring motor 133, the premixing roller 134, and the pull-out clamping plate 135, solid catalysts or high-concentration reagents are pre-dispersed and diluted before entering the main reaction system, fundamentally avoiding localized concentration issues. To mitigate side reactions and product decomposition caused by excessive heat, the product yield and quality are further improved. The main stirring paddle 7 is a slanted blade turbine-type stirring paddle, and the auxiliary dispersion disc 8 is a disc turbine-type structure with several through holes evenly distributed on its surface. The premixer 13 includes a container body 131, a container cover 132, a stirring motor 133, a premixing roller 134, and a pull-out clamping plate 135. The container body 131 and the container cover 132 are rotatably connected on one side by a damping hinge, and the container body 131 and the container cover 132 are connected on the other side by a snap-fit. The stirring motor 133 is fixed to the top of the container cover 132, and the output shaft of the stirring motor 133 is fixedly connected to the premixing roller 134. The pull-out clamping plate 135 is clamped to the container body 131 by a sealing ring. The tank is equipped with an external handle. A limit plate is connected to the external surface of the pull-out plate 135, and the limit plate is rotatably connected to the container body 131 via a rotating shaft. The inner wall of the tank 1, the driving gear 3, the driven gear 4, the main stirring shaft 5, the scraper 6, the main stirring paddle 7, and the auxiliary dispersion disc 8 are all coated with a polytetrafluoroethylene anti-corrosion coating. The top of the tank 1 is equipped with a pressure relief pipe 14 and a safety valve connected to it. A rupture disc device is also connected in series on the pressure relief pipe 14. A discharge valve is fixedly connected to the bottom of the tank 1. An online pH sensor 15 and an online temperature sensor 12 are installed on the side wall of the tank 1, extending into it. Through the coordinated arrangement of the online pH sensor 15 and the online temperature sensor 12, online pH and temperature sensors are integrated.It enables real-time monitoring of key reaction parameters, providing a foundation for process optimization and automated control, reducing manual intervention, and improving production efficiency and batch stability.

[0021] In summary, this methyl beta-cyclodextrin derivative reaction vessel, through the coordinated arrangement of the vessel body 1, drive motor 2, driving gear 3, driven gear 4, main stirring shaft 5, outer scraper 6, main stirring paddle 7, auxiliary dispersion disc 8, insulation jacket 9, and heating coil 10, employs a composite stirring design of "inclined blade turbine paddle + dispersion disc." This design achieves macroscopic circulation throughout the entire vessel and efficiently shears and disperses high-viscosity materials, ensuring sufficient contact of reactants and uniform heat transfer. It effectively avoids localized overheating and reaction dead zones, thereby improving the substitution uniformity and purity of the product (methyl beta-cyclodextrin derivative). Through premixing... The coordinated arrangement of the apparatus 13, container body 131, container lid 132, stirring motor 133, premixing roller 134, and pull-out clamp 135 allows solid catalysts or high-concentration reagents to be pre-dispersed and diluted before entering the main reaction system, fundamentally avoiding side reactions and product decomposition caused by excessively high local concentrations, and further improving product yield and quality. The integrated online pH sensor 15 and online temperature sensor 12 enable real-time monitoring of key reaction parameters, providing a foundation for process optimization and automated control, reducing manual intervention, and improving production efficiency and batch stability.

[0022] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installed," "equipped with," "sleeved / connected," "connected," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can be a connection within two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0023] In the description of this utility model, it should also be noted that the device structure and drawings of this utility model mainly describe the principle of this utility model. In terms of the technical aspects of this design principle, the setting of the power mechanism, power supply system and control system of the device is not fully described. However, under the premise that those skilled in the art understand the principle of the above utility model, the specific details of its power mechanism, power supply system and control system can be clearly understood. The control method in the application document is automatic control through a controller. The control circuit of the controller can be implemented by those skilled in the art through simple programming.

[0024] In the description of this utility model, it should also be noted that all standard parts used can be purchased from the market, and can be customized according to the description and drawings. The specific connection methods of each part adopt conventional methods such as bolts, rivets, and welding that are mature in the prior art. The machinery, parts and equipment adopt conventional models in the prior art, and the structure and principle of the components known to those skilled in the art can be learned by those skilled in the art through technical manuals or conventional experimental methods.

[0025] It should also be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0026] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A reaction vessel for methyl beta-cyclodextrin derivatives, comprising a vessel body (1), characterized in that: The top of the tank (1) is provided with a drive motor (2), the output shaft of the drive motor (2) is connected to a drive gear (3) that extends into the tank (1), the surface of the drive gear (3) is meshed with a driven gear (4), the inside of the drive gear (3) is fixedly connected with a main stirring shaft (5), the surface of the main stirring shaft (5) is provided with an outer peripheral scraper (6), at least two sets of main stirring paddles (7) and an auxiliary dispersion disc (8) from top to bottom, the outside of the tank (1) is provided with a heat insulation jacket (9), the inside of the tank (1) is provided with an electric heating coil (10), the top of the tank (1) is also provided with a feeding port (11), the top of the feeding port (11) is fixedly connected with a premixer (13).

2. The reaction vessel for a methylbetacyclodextrin derivative according to claim 1, characterized in that: The main stirring paddle (7) is an inclined blade turbine stirring paddle, and the auxiliary dispersion disk (8) is a disc turbine structure with several through holes evenly opened on its surface.

3. The reaction vessel for a methylbetacyclodextrin derivative according to claim 1, characterized in that: The premixer (13) includes a container body (131), a container cover (132), a stirring motor (133), a premixing roller (134), and a pull-out plate (135). The container body (131) and one side of the container cover (132) are rotatably connected by a damping hinge, and the other side of the container body (131) and the container cover (132) are connected by a snap fastener. The stirring motor (133) is fixed to the top of the container cover (132), and the output shaft of the stirring motor (133) is fixedly connected to the premixing roller (134). The pull-out plate (135) is snapped to the container body (131) by a sealing ring. The pull-out plate (135) is provided with a handle on the outside. The outer surface of the pull-out plate (135) is movably limited by a limiting rotating plate, and the limiting rotating plate is rotatably connected to the container body (131) through a rotating shaft.

4. The reaction vessel for a methylbetacyclodextrin derivative according to claim 1, characterized in that: The inner wall of the tank (1), the driving gear (3), the driven gear (4), the main stirring shaft (5), the scraper (6), the main stirring paddle (7), and the auxiliary dispersion disc (8) are all coated with a polytetrafluoroethylene anti-corrosion coating.

5. The reaction vessel for a methylbetacyclodextrin derivative according to claim 1, characterized in that: The top of the tank (1) is provided with a pressure relief pipe (14) and a safety valve connected to the pressure relief pipe (14). A rupture disc device is also connected in series on the pressure relief pipe (14). A discharge valve is fixedly connected to the bottom of the tank (1).

6. The reaction vessel for a methylbetacyclodextrin derivative according to claim 1, characterized in that: The tank (1) is also equipped with an online pH sensor (15) and an online temperature sensor (12) that extend into its interior.

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