Sample analysis device and bottle cap assembly

Abstract

The application discloses a sample analysis device and a bottle cap assembly, and belongs to the technical field of medical devices. The sample analysis device comprises a waste area and a bottle cap assembly. The waste area is used for placing a collection bottle. The bottle cap assembly has an opening position and a closing position relative to the bottle mouth of the collection bottle. The bottle cap assembly comprises a cap body and a sealing piece. The sealing piece has a fixed end and a free end. The fixed end is in sealing connection with the cap body. An end face of the free end is used for being pressed against the bottle mouth. In the closing position, the cap body applies pressure to the sealing piece to press the end face against the bottle mouth. In the opening position, the end face is separated from the bottle mouth. The pressure applied by the cap body to the sealing piece is released. And the distance between the end face and the cap body changes in the process. Through the technical scheme, the structure of the bottle cap assembly can be simplified, and the sealing performance of the bottle cap assembly and the bottle mouth can be ensured.

Description

Technical Field

[0001] This application relates to the field of medical devices, and more particularly to a sample analysis device and a bottle cap assembly. Background Technology

[0002] Sample analysis equipment typically includes waste liquid bottles for collecting waste. Currently, the cap assemblies on these waste liquid bottles suffer from several drawbacks, including poor sealing performance leading to low safety, and complex structures hindering automated cap opening. Utility Model Content

[0003] This application provides a sample analysis device and a bottle cap assembly, which reduces the risk of waste liquid discharge and leakage in the sample analysis device, and improves the degree of full automation of the sample analysis device, thereby at least partially solving the above-mentioned technical problems.

[0004] To achieve the above objectives, embodiments of this application provide a sample analysis device, comprising:

[0005] Waste disposal area for storing containment bottles; and,

[0006] A bottle cap assembly has an open position and a closed position relative to the bottle opening of the receiving bottle. The bottle cap assembly includes a cap body, a sealing element, and a flow guide tube. The cap body has a fluid channel. The sealing element has a fixed end and a free end disposed opposite to each other. The fixed end is sealed to the cap body, and the free end has an end face for pressing against the bottle opening. The sealing element has an opening that penetrates the fixed end and the free end. The flow guide tube is disposed in the opening and connected to the cap body, and communicates with the fluid channel.

[0007] In the closed position, the cap applies pressure to the seal, causing the end face to seal against the bottle opening. In the open position, the end face separates from the bottle opening, and the pressure applied by the cap to the seal is released. In the open position, the distance between the cap and the end face is greater than the distance between the cap and the end face in the closed position.

[0008] This application embodiment also provides a bottle cap assembly for cooperating with the bottle opening of a receiving bottle and having an open position and a closed position relative to the bottle opening, the bottle cap assembly comprising:

[0009] The cover body has a fluid channel inside;

[0010] A sealing element has a fixed end and a free end disposed opposite to each other. The fixed end is sealed to the cap, and the free end has an end face for pressing against the bottle mouth. The sealing element has an opening penetrating the fixed end and the free end. In the closed position, the cap applies pressure to the sealing element, causing the end face to seal against the bottle mouth. In the open position, the end face separates from the bottle mouth, releasing the pressure applied by the cap to the sealing element. The distance between the cap and the end face in the open position is greater than the distance between the cap and the end face in the closed position.

[0011] A flow guide tube is disposed inside the opening and connected to the cover, and communicates with the fluid channel.

[0012] In the sample analysis device and bottle cap assembly of this application embodiment, through the above technical solution, when the bottle cap assembly is in the closed position, the cap body can apply pressure to the sealing element, enabling the sealing element to seal with the bottle opening and avoiding the risk of leakage from the containing bottle. When the bottle cap assembly is in the open position, the pressure applied by the cap body to the sealing element is released. During the switching between the two states of being under force and not under force, the sealing element displaces relative to the cap body. The displacement distance can be set to an appropriate size according to the sealing requirements, thereby achieving a seal and preventing leakage. At the same time, the bottle cap assembly has a relatively simple structure due to the cooperation between the cap body and the sealing element, which facilitates the automated opening and closing of the bottle cap assembly.

[0013] Other features and advantages of this application will be described in detail in the following detailed description section. Attached Figure Description

[0014] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0015] To gain a more complete understanding of this application and its beneficial effects, the following description will be provided in conjunction with the accompanying drawings, wherein the same reference numerals in the following description denote the same parts.

[0016] Figure 1 This is a schematic diagram of the structure of a sample analysis device provided in an exemplary embodiment of this application;

[0017] Figure 2 This is a partial structural schematic diagram of the sample analysis device provided in an exemplary embodiment of this application;

[0018] Figure 3yes Figure 2 A cross-sectional view of the structure shown;

[0019] Figure 4 yes Figure 3 A magnified view of the area at point X in the diagram;

[0020] Figure 5 yes Figure 2 A three-dimensional structural diagram of the drive component and the cap component in the structure shown.

[0021] Figure 6 yes Figure 2 Another three-dimensional structural diagram of the bottle cap assembly shown in the diagram;

[0022] Figure 7 yes Figure 6 A cross-sectional view of the structure shown;

[0023] Figure 8 yes Figure 6 Another cross-sectional view of the structure shown;

[0024] Figure 9 yes Figure 6 An exploded view of the structure shown from a first-person perspective.

[0025] Figure 10 yes Figure 6 A second-view exploded diagram of the structure shown.

[0026] Explanation of reference numerals in the attached figures:

[0027] 100. Sample storage component; 200. Nucleic acid extraction component; 300. Amplification and detection component; 400. First loading component; 500. Second loading component;

[0028] 10. Waste disposal area;

[0029] 20. Container bottle; 21. Bottle mouth; 22. Bottle body; 23. Handle;

[0030] 30. Bottle cap assembly; 301. Shaft;

[0031] 31. Cover; 310. Fluid passage; 311. Liquid passage; 312. Gas passage; 313. Fixing groove; 314. Mounting groove;

[0032] 32. Seal; 320. Opening; 321. Fixed end; 322. Intermediate section; 323. Free end; 324. End face; 325. Inner periphery; 326. Outer periphery; 327. Connecting surface;

[0033] 33. Elastic component; 34. Abutment component; 340. Positioning groove; 35. Protective shell; 350. Opening; 351. Guide structure; 352. Mounting component;

[0034] 36. Drainage pipe;

[0035] 40. Driver components. Detailed Implementation

[0036] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of them. All other embodiments obtained by those skilled in the art based on the embodiments of this application without creative effort are within the protection scope of this application.

[0037] Before presenting the technical solution of this application, let's look at some existing technical solutions. One solution involves providing two channels on the waste liquid bottle cap: an inlet channel and a vent channel. These channels are equipped with quick-connect fittings, and a sealing gasket is placed between the bottle cap and the waste liquid container. The gasket is tightened by screwing on a threaded connection. The inventors found that with this solution, when the waste liquid container needs to be replaced, the quick-connect fitting must be disconnected, or the waste liquid bottle cap must be unscrewed, thereby disconnecting the pipeline connecting to the waste liquid container. Both operations are relatively complex and not conducive to automating the opening process.

[0038] Another approach is to cover the waste liquid container with a cap. The inventors found that this method results in a poor seal, posing a risk of leakage of aerosols or gaseous substances from the waste liquid container. Furthermore, the cap lacks a venting channel, allowing excess gas-liquid mixture to escape directly from the bottle opening when the cap is opened, also creating a leakage risk.

[0039] This application provides a sample analysis device and a bottle cap assembly 30 to address the technical problems of high risk of waste liquid discharge and leakage in the sample analysis device, and low degree of automation in the entire process of the sample analysis device.

[0040] Before detailing this application, let me first describe the overall structure of the sample analysis device.

[0041] The sample analysis device can be any kind of sample analysis device used for in vitro testing of samples such as blood, urine, and tissue; this application embodiment does not limit this.

[0042] For example, the sample analysis device can be a molecular diagnostic instrument for nucleic acid detection.

[0043] Please refer to Figure 1 The sample analysis device may include a sample storage component 100, a sample dispensing component, a nucleic acid extraction component 200, a pipetting component, an amplification and detection component 300, and a controller.

[0044] The sample storage component 100 has a receiving position for placing a sample container containing the sample to achieve sample loading.

[0045] The sample dispensing component is used to aspirate at least a portion of the sample from the sample container of the sample storage component 100 and dispense all or part of the aspirated sample into the nucleic acid extraction container.

[0046] The nucleic acid extraction component 200 is used to extract nucleic acids from a liquid in a nucleic acid extraction container that is at least made from a sample, to obtain a nucleic acid extract.

[0047] The pipetting device is used to transfer the nucleic acid extraction solution from the nucleic acid extraction container to the amplification reaction container.

[0048] The amplification and detection component 300 is used to perform amplification reactions and detection on the nucleic acid extract in the amplification reaction container.

[0049] The controller is configured to output the detection results of the sample based on the detection information fed back by the amplification detection unit 300.

[0050] The sample analysis device also includes a first loading component 400. The first loading component 400 is used to load containers to be used, including at least one of an amplification reaction container and a nucleic acid extraction container. The sample analysis device also includes a second loading component 500. The second loading component 500 is used to load reagents to be used, including at least one of extraction reagents and amplification reaction reagents.

[0051] Based on this, in the embodiments of this application, the sample analysis device can obtain a test solution by extracting and amplifying nucleic acid from the sample, and then test the test solution to obtain the test result of the sample, thereby realizing the automatic extraction and detection of nucleic acid from the sample, that is, realizing automatic molecular diagnosis.

[0052] Please see Figure 2 and Figure 3 , Figure 2 This is a partial structural schematic diagram of the sample analysis device provided in an embodiment of this application. Figure 3 for Figure 2 A cross-sectional view of the middle part of the structure shows Figure 2 Some specific structural details of the bottle cap assembly 30 and the receiving bottle 20 that mates with the bottle cap assembly 30 are shown.

[0053] In some embodiments, the sample analysis device further includes a waste area 10 for holding a container bottle 20. The container bottle 20 is used to hold waste liquid generated by the sample analysis device. For example, the waste liquid may be sample liquid after sample extraction, extract liquid extracted from the sample liquid and subjected to amplification reaction and detection, and cleaning waste liquid after cleaning the sample container, nucleic acid extraction container, pipetting component, amplification reaction container, amplification detection component 300, etc.

[0054] In some examples, the containment bottle 20 includes a bottle body 22 and a handle 23 located on top of the bottle body 22. When the waste liquid contained in the containment bottle 20 in the waste area 10 reaches its maximum value, the handle 23 of the containment bottle 20 can be grasped to remove the containment bottle 20 from the waste area 10, and an empty containment bottle 20 can be placed into the waste area 10. The bottle opening 21 of the containment bottle 20 is located on one side of the top of the bottle body 22, and the bottle opening 21 allows waste liquid to enter the bottle body 22 or to be poured out of the bottle body 22. The bottle opening 21 is generally set as a cylindrical tube, but it can also be set as a non-cylindrical shape. The direction of movement of the containment bottle 20 from the bottom of the bottle body 22 to the top of the bottle body 22 can be defined as the direction of movement of the containment bottle 20 leaving the waste area 10. The containment bottle 20 leaves the waste area 10 along this direction of movement and enters the waste area 10 in the opposite direction of movement. The central axis of the bottle opening 21 can form a certain angle with the direction of movement, and the bottle opening 21 is tilted outward toward the top of the bottle body 22 to facilitate the entry and exit of waste liquid into and out of the bottle body 22.

[0055] In some examples, the sample analysis device also includes a cap assembly 30. The cap assembly 30 is configured to engage with the receiving bottle 20 of the waste area 10 and has an open position and a closed position relative to the bottle opening 21 of the receiving bottle 20. Figure 2 As shown, the waste area 10 can have more than one placement position for a containment bottle 20, for example, two placement positions. In one placement position, a containment bottle 20 is placed, and the corresponding bottle cap assembly 30 is in the closed position to form a sealing fit with the containment bottle 20. In the other placement position, no containment bottle 20 is placed, and the corresponding bottle cap assembly 30 is in the open position.

[0056] When the cap assembly 30 is in the open position, the opening 21 of the receiving bottle 20 is exposed. In a specific example, when the cap assembly 30 moves from the closed position to the open position, the direction of movement of the receiving bottle 20 away from the waste area 10 is offset from that of the cap assembly 30. Thus, the cap assembly 30 does not interfere with the receiving bottle 20 leaving or entering the waste area 10, thereby improving the efficiency of the replacement operation of the receiving bottle 20.

[0057] When the cap assembly 30 is in the closed position, the bottle mouth 21 of the receiving bottle 20 is sealed to the cap assembly 30, and the waste liquid generated by the sample analysis device can be guided from the cap assembly 30 to the bottle body 22 of the receiving bottle 20.

[0058] In some examples, such as Figure 3 and Figure 4 As shown, the cap assembly 30 includes a cap body 31 and a seal 32. A fluid channel 310 is provided within the cap body 31 for the flow of waste liquid and gas. When the cap assembly 30 is in the closed position, waste liquid from the sample analysis device can flow into the receiving bottle 20 through the fluid channel 310, and excess gas within the receiving bottle 20 can also flow out through the fluid channel 310 to an external gas treatment device.

[0059] The sealing element 32 has a fixed end 321 and a free end 323 that are disposed opposite to each other. The fixed end 321 is sealed to the cover 31. For example, the fixed end 321 and the cover 31 can be sealed to each other by interference fit or by heat fusion, which is not limited here.

[0060] The free end 323 has an end face 324, which is used to press against the bottle neck 21 when the cap assembly 30 is in the closed position. The sealing member 32 has an opening 320 that passes through the fixed end 321 and the free end 323. When the cap assembly 30 is in the closed position, the opening 320 connects the fluid passage 310 in the cap body 31 and the bottle neck 21 of the receiving bottle 20.

[0061] When the bottle cap assembly 30 is in the closed position, the cap body 31 applies pressure to the seal 32, causing the end face 324 to seal against the bottle opening 21. When the bottle cap assembly 30 is in the open position, the end face 324 separates from the bottle opening 21, the pressure applied by the cap body 31 to the seal 32 is released, and the distance between the cap body 31 and the end face 324 in the open position is greater than the distance between the cap body 31 and the end face 324 in the closed position.

[0062] Through the above technical solution, when the bottle cap assembly 30 is in the closed position, the cap body 31 can apply pressure to the sealing element 32, enabling the sealing element 32 to seal with the bottle opening 21 and preventing leakage risk from the containing bottle 20. When the bottle cap assembly 30 is in the open position, the pressure applied by the cap body 31 to the sealing element 32 is released. In other words, during the switching between the two states of being under force and not under force, the sealing element 32 is displaced relative to the cap body 31. The displacement distance can be set to an appropriate size according to the sealing force requirements, thus achieving a seal and preventing leakage. At the same time, the bottle cap assembly 30 has a relatively simple structure due to the cooperation between the cap body 31 and the sealing element 32, which facilitates the automatic opening and closing of the bottle cap assembly 30.

[0063] In some examples, such as Figure 2 and Figure 5As shown, the sample analysis device also includes a drive assembly 40, which is disposed in the waste area 10 and is used to drive the bottle cap assembly 30 to switch between an open position and a closed position. The drive assembly 40 enables automated opening and closing of the bottle cap assembly 30. More specifically, the drive assembly 40 can drive the bottle cap assembly 30 to rotate between the open and closed positions. Figure 6 As shown, the bottle cap assembly 30 has a rotating shaft 301 on the cap body 31, which forms a rotatable connection with the drive assembly 40. In some specific examples, the drive assembly 40 may include a worm gear mechanism or other mechanism with a self-locking function. Even in the event of an abnormal power failure, the bottle cap assembly 30 can remain in the closed position without sealing failure. At the same time, the drive assembly 40 with a self-locking function does not require a large drive current to keep the bottle cap assembly 30 in the closed position, reducing the energy consumption and heat generation of the drive assembly 40.

[0064] In some embodiments, the sample analysis device further includes a control unit (not shown) for receiving instructions and controlling the drive assembly 40 to switch the cap assembly 30 between an open position and a closed position. The control unit can further enhance the automation and intelligence of the sample analysis device. For example, combined with… Figure 2 As shown, a container bottle 20 is placed in one of the placement positions, and the control unit can control the corresponding drive component 40 to drive the corresponding bottle cap assembly 30 to maintain it in the closed position. The other placement position does not have a container bottle 20 placed there, and the control unit can control the corresponding drive component 40 to drive the corresponding bottle cap assembly 30 to maintain it in the open position.

[0065] In some embodiments, the seal 32 may be made of a material capable of elastic deformation, so that when the cap assembly 30 switches between an open position and a closed position, the seal 32 can deform, thereby allowing the end face 324 of the seal 32 to easily displace relative to the cap body 31. (Refer to...) Figure 3 and Figure 7 In some examples, the seal 32 also includes an intermediate section 322 disposed between the fixed end 321 and the free end 323. The intermediate section 322 is configured in the shape of a bellows to facilitate the deformation of the seal 32.

[0066] In some examples, the cap assembly 30 also includes an elastic element 33. The elastic element 33 is disposed between the cap body 31 and the free end 323. When the cap assembly 30 moves from the open position to the closed position, the elastic element 33 is compressed to generate an elastic force, which causes the end face 324 to seal against the bottle opening 21. In the closed position, the elastic element 33 can provide a force other than the deformation of the sealing element 32 itself, causing the cap body 31 to press the sealing element 32 tightly against the bottle opening 21, ensuring sealing performance. The sealing force applied by the elastic element 33 to the bottle opening 21 can be ensured by properly setting various parameters of the elastic element 33.

[0067] The elastic element 33 can be a tubular spring or a strip-shaped spring, etc.

[0068] In some embodiments, referencing Figure 9 and Figure 10 The bottle cap assembly 30 also includes an abutment 34. The abutment 34 is disposed between the elastic member 33 and the sealing member 32, and is used to transmit the elastic force generated by the elastic member 33 to the sealing member 32. Typically, the elastic member 33 is made of a material with high rigidity, while the sealing member 32 is made of a softer material. The abutment 34 prevents the elastic member 33 from causing physical damage such as puncture to the sealing member 32, and also allows the elastic force of the elastic member 33 to be transmitted more evenly to the sealing member 32.

[0069] More specifically, the abutment 34 is fitted onto the seal 32, and the abutment 34 has a positioning groove 340 for assembling one end of the elastic member 33.

[0070] like Figure 3 , Figure 4 and Figure 7 As shown, the free end 323 of the seal 32 also has a connecting surface 327 opposite to the end face 324. The fixed end 321 and the abutment 34 of the seal 32 are both connected to the side where the connecting surface 327 of the free end 323 is located. The elastic element 33 is sleeved on the outside of the fixed end 321 and disposed between the cover 31 and the abutment 34. In an embodiment where the seal 32 has an intermediate section 322, one end of the intermediate section 322 is connected to the fixed end 321, and the other end of the intermediate section 322 is connected to the connecting surface 327 of the free end 323. The elastic element 33 is sleeved on the outside of the fixed end 321 and the intermediate section 322.

[0071] like Figure 7 As shown, in some examples, the cover 31 is provided with a fixing groove 313, and the fixing end 321 is snapped into the fixing groove 313.

[0072] Also refer to Figure 9 and Figure 10In some examples, the cap assembly 30 also includes a protective shell 35, which is connected to the cap body 31 and houses at least a portion of the sealing element 32. The protective shell 35 has an opening 350, through which the sealing element 32 and other components can be connected to the cap body 31 after the protective shell 35 is connected during assembly. Understandably, during assembly, the sealing element 32, elastic element 33, and other components can be connected to the cap body 31 first, and then the connection between the protective shell 35 and the cap body 31 can be completed. A mounting element 352 is provided at the end of the protective shell 35 opposite to the opening 350, and a corresponding mounting groove 314 is provided on the cap body 31. The protective shell 35 and the cap body 31 can be fixedly connected through the cooperation of the mounting element 352 and the mounting groove 314.

[0073] The protective shell 35 can be made of a highly rigid material to protect the seal 32. It also guides the displacement path when the seal 32 and the cap 31 move relative to each other. That is, the seal 32 can move relative to the cap 31 along the relevant structure within the protective shell 35 to ensure the sealing performance between the seal 32 and the bottle opening 21. For example, as... Figure 9 and Figure 10 As shown, the inner wall of the protective shell 35 and the abutment member 34 form a mutually cooperating guide structure 351. The guide structure 351 is used to guide the abutment member 34 to move relative to the protective shell 35 when the cap assembly 30 switches between the open and closed positions, so as to ensure the accuracy of the displacement of the sealing member 32 and the elastic member 33 relative to the cap body 31. The guide structure 351 can be a mutually cooperating groove structure.

[0074] like Figure 7 As shown, the protective housing 35 can be configured with a suitable height so that when the cap assembly 30 is in the open position, the free end 323 of the seal 32 is at least partially exposed outside the protective housing 35. When the cap assembly 30 is in the closed position, the end face 324, after displacement, can be located within the protective housing 35. In another example, when the cap assembly 30 is in the closed position, the end face 324 may also be flush with the opening 350 of the protective housing 35. Understandably, the relative positional relationship between the end face 324 and the protective housing 35 is not limited here; it is also possible that when the cap assembly 30 is in the closed position, the distance between the end face 324 and the opening 350 of the protective housing 35 is less than the distance between the end face 324 and the opening 350 of the protective housing 35 when the cap assembly 30 is in the open position.

[0075] like Figure 4As shown, end face 324 has an inner periphery 325 defining the outline of opening 320, and an outer periphery 326 disposed opposite to the inner periphery 325. The distance between the inner periphery 325 and the outer periphery 326 defines the thickness of end face 324. When the cap assembly 30 is in the closed position, both the inner periphery 325 and the outer periphery 326 are spaced from the bottle opening 21 by a predetermined distance; in other words, the thickness of end face 324 is greater than the thickness d of bottle opening 21. With this configuration, even if misalignment between the sealing element 32 and bottle opening 21 occurs due to assembly errors or movement errors when the cap assembly 30 is switched to the closed position, it will not affect the sealing fit between the sealing element 32 and bottle opening 21. It can be understood that alignment means that the central axis of bottle opening 21 coincides with the central axis of end face 324. Figure 4 As shown, when the seal 32 is aligned with the bottle opening 21, the distance d1 between the inner periphery 325 and the bottle opening 21, and the distance d2 between the outer periphery 326 and the bottle opening 21, are equal. When the seal 32 is not aligned with the bottle opening 21, d1 and d2 are not equal.

[0076] like Figure 7 As shown, when the bottle cap assembly 30 is in the open position, the end face 324 is flat. Figure 4 As shown, when the bottle cap assembly 30 is in the closed position, the portion of the end face 324 that presses against the bottle opening 21 deforms to form a notch, into which the bottle opening 21 can be inserted. In other words, when the bottle cap assembly 30 is in the closed position, the end face 324 deforms from a planar surface into an irregular surface. In other examples, when the bottle cap assembly 30 is in the open position, the end face 324 can also be in other shapes, such as a conical surface, a curved surface, an irregular surface, or any combination of the above shapes. For example, the end face 324 can be a composite surface composed of a planar surface and a conical surface. Near the outer perimeter 326, the end face 324 is planar, while near the inner perimeter 325, it is conical. The smaller end of the conical surface is further away from the cap body 31 than the larger end. When the end face 324 contacts the bottle opening 21, the conical structure allows for a better seal between the end face 324 and the bottle opening 21.

[0077] Also refer to Figure 3 and Figure 7 The cap assembly 30 also includes a flow guide 36. The flow guide 36 is disposed within the opening 320 of the seal 32 and connected to the cap body 31, and communicates with the fluid passage 310. In this case, the flow guide 36 communicates with the fluid passage 310 to form a flow path for the fluid.

[0078] like Figure 3 and Figure 8As shown, in some examples, the fluid channel 310 includes a separate liquid channel 311 and a gas channel 312. The liquid channel 311 guides the waste liquid generated by the sample analysis device into the receiving bottle 20, and the gas channel 312 discharges the gas in the receiving bottle 20 to an external gas handling device. The cap 31 has two channels for the flow of waste liquid and gas, allowing the receiving bottle 20 to be replaced when the cap assembly 30 is in the open position. This arrangement simplifies the replacement of the receiving bottle 20 compared to separately removing the waste liquid and gas channels 312.

[0079] One end of the guide tube 36 is connected to the liquid channel 311, and the other end of the guide tube 36 extends from the opening 320 and protrudes from the free end 323 of the seal 32. The guide tube 36 allows waste liquid to flow and be directly introduced into a deeper position of the receiving bottle 20, which can prevent waste liquid from splashing onto the seal 32 or near the bottle mouth 21, so as to prevent waste liquid leakage when the bottle cap assembly 30 is in the open position.

[0080] In some examples, the cap assembly 30 also includes a gas guide (not shown), which communicates with the gas passage 312 and discharges the gas in the containment bottle 20 to the outside gas handling device. The gas guide can be various pumps or other devices, and can be located in the waste area 10, for example, adjacent to the drive assembly 40, or in other suitable locations, as long as it can communicate with the gas passage 312 and discharge the gas in the containment bottle 20.

[0081] In the above embodiments, the descriptions of each embodiment have different focuses. For parts not described in detail in a certain embodiment, please refer to the relevant descriptions in other embodiments.

[0082] The embodiments, implementation methods, and related technical features of this application can be combined and substituted for each other without conflict.

[0083] The above are merely preferred embodiments of this application and are not intended to limit this application in any way. Any simple modifications, equivalent changes, and alterations made to the above embodiments based on the technical essence of this application without departing from the scope of the technical solution of this application shall still fall within the scope of the technical solution of this application.

Claims

1. A sample analysis device, characterized in that, include: Waste area (10) for storing containment bottles (20); and, The bottle cap assembly (30) has an open position and a closed position relative to the bottle opening (21) of the receiving bottle (20). The bottle cap assembly (30) includes a cap body (31), a sealing element (32), and a flow guide tube (36). The cap body (31) is provided with a fluid channel (310). The sealing element (32) has a fixed end (321) and a free end (323) arranged opposite to each other. The fixed end (321) is sealed to the cap body (31). The free end (323) has an end face (324) for pressing against the bottle opening (21). The sealing element (32) is provided with an opening (320) that penetrates the fixed end (321) and the free end (323). The flow guide tube (36) is disposed in the opening (320) and connected to the cap body (31), and communicates with the fluid channel (310). In the closed position, the cover (31) applies pressure to the seal (32), causing the end face (324) to seal against the bottle mouth (21). In the open position, the end face (324) separates from the bottle mouth (21), and the pressure applied by the cover (31) to the seal (32) is released. In the open position, the distance between the cover (31) and the end face (324) is greater than the distance between the cover (31) and the end face (324) in the closed position.

2. The sample analysis device according to claim 1, characterized in that, The cap assembly (30) further includes an elastic element (33) disposed between the cap body (31) and the free end (323). When the cap assembly (30) moves from the open position to the closed position, the elastic element (33) is compressed to generate an elastic force, which causes the end face (324) to seal and press against the bottle mouth (21).

3. The sample analysis device according to claim 2, characterized in that, The bottle cap assembly (30) further includes an abutment (34) disposed between the elastic member (33) and the sealing member (32), the abutment (34) being used to transmit the elastic force generated by the elastic member (33) to the sealing member (32).

4. The sample analysis device according to claim 3, characterized in that, The abutment (34) is sleeved on the seal (32), and a positioning groove (340) is formed on the abutment (34) for assembling one end of the elastic member (33).

5. The sample analysis device according to claim 4, characterized in that, The free end (323) also has a connecting surface (327) opposite to the end face (324). The fixed end (321) and the abutting member (34) are both connected to the side where the connecting surface (327) is located. The elastic member (33) is sleeved on the outside of the fixed end (321) and is disposed between the cover (31) and the abutting member (34).

6. The sample analysis device according to claim 3, characterized in that, The cap assembly (30) further includes a protective shell (35) connected to the cap body (31), the protective shell (35) housing at least a portion of the seal (32).

7. The sample analysis device according to claim 6, characterized in that, When the bottle cap assembly (30) is in the open position, the free end (323) is at least partially exposed outside the protective shell (35); When the bottle cap assembly (30) is in the closed position, the relative positional relationship between the end face (324) and the protective shell (35) is one of the following: the end face (324) is located inside the protective shell (35); or the end face (324) is flush with the opening (350) of the protective shell (35); or the distance between the end face (324) and the opening (350) of the protective shell (35) when the bottle cap assembly (30) is in the closed position is less than the distance between the end face (324) and the opening (350) of the protective shell (35) when the bottle cap assembly (30) is in the open position.

8. The sample analysis device according to claim 6, characterized in that, The inner wall of the protective shell (35) and the abutment (34) form a mutually cooperating guide structure (351), the guide structure (351) is used to guide the abutment (34) to move relative to the protective shell (35) when the bottle cap assembly (30) switches between the open position and the closed position.

9. The sample analysis device according to claim 1, characterized in that, The fluid channel (310) includes an independent liquid channel (311) and a gas channel (312). The liquid channel (311) is used to guide the waste liquid generated by the sample analysis device to the receiving bottle (20). The waste liquid generated by the sample analysis device includes cleaning waste liquid and / or sample liquid after sampling. The gas channel (312) is used to discharge the gas in the receiving bottle (20) to an external gas treatment device.

10. The sample analysis device according to claim 9, characterized in that, One end of the guide tube (36) is connected to the liquid channel (311), and the other end of the guide tube (36) extends from the opening (320) and protrudes from the free end (323) of the seal (32); and / or The bottle cap assembly (30) also includes a gas guide that is connected to the gas channel (312) and is a gas handling device that discharges the gas in the receiving bottle (20) to the outside.

11. The sample analysis device according to claim 1, characterized in that, The sample analysis device also includes a drive component (40) disposed in the waste area (10) for driving the cap assembly (30) to switch between the open position and the closed position.

12. The sample analysis device according to claim 11, characterized in that, It also includes at least one of the following: The drive assembly (40) includes a worm gear mechanism; The container bottle (20) includes a bottle body (22) and a handle (23) disposed on the top of the bottle body (22). The bottle mouth (21) is disposed on one side of the top of the bottle body (22). The direction of movement of the container bottle (20) leaving the waste area (10) is defined as the direction of movement of the line connecting the bottom of the bottle body (22) to the top of the bottle body (22). The drive assembly (40) drives the bottle cap assembly (30) to rotate. When the bottle cap assembly (30) is rotated from the closed position to the open position, the direction of movement of the container bottle (20) leaving the waste area (10) is offset from that of the bottle cap assembly (30). It also includes a control unit for receiving instructions and controlling the drive assembly (40) to drive the cap assembly (30) to switch between the open position and the closed position.

13. The sample analysis device according to any one of claims 1 to 12, characterized in that, It also includes at least one of the following: The end face (324) has an inner periphery (325) that defines the outline of the opening (320) and an outer periphery (326) that is disposed opposite to the inner periphery (325). When the cap assembly (30) is in the closed position, both the inner periphery (325) and the outer periphery (326) are spaced at a predetermined distance from the bottle mouth (21). When the bottle cap assembly (30) is in the open position, the end face (324) is one or a combination of more than one of the following: a plane, a conical surface, and a curved surface; The sealing element (32) also includes an intermediate section (322) disposed between the fixed end (321) and the free end (323), wherein the intermediate section (322) is a bellows.

14. The sample analysis device according to any one of claims 1 to 12, characterized in that, Also includes: A sample storage component (100) has a receiving position for placing a sample container containing a sample to load the sample. A sample dispensing component, the sample dispensing component being used to aspirate at least a portion of the sample from the sample container from the sample storage component (100) and dispense all or part of the aspirated sample into a nucleic acid extraction container; Nucleic acid extraction component (200), the nucleic acid extraction component (200) is used to extract nucleic acid from a liquid made of at least the sample in the nucleic acid extraction container to obtain a nucleic acid extract; A pipetting component for transferring the nucleic acid extraction solution from the nucleic acid extraction container to the amplification reaction container; An amplification detection component (300) is used to perform an amplification reaction and detection on the nucleic acid extract in the amplification reaction vessel; and The controller is configured to output the detection result of the sample based on the detection information fed back by the amplification detection unit (300).

15. A bottle cap assembly (30) for engaging with the mouth (21) of a receiving bottle (20) and having an open position and a closed position relative to said mouth (21), characterized in that, The bottle cap assembly (30) includes: A cover (31) is provided with a fluid channel (310) inside the cover (31); A sealing element (32) has a fixed end (321) and a free end (323) disposed opposite to each other. The fixed end (321) is sealed to the cap body (31). The free end (323) has an end face (324) for pressing against the bottle mouth (21). The sealing element (32) has an opening (320) that penetrates the fixed end (321) and the free end (323). When the bottle cap assembly (30) is in the closed position, the cap body (31) presses against the sealing element. (32) Apply pressure to seal the end face (324) with the bottle mouth (21). When the bottle cap assembly (30) is in the open position, the end face (324) separates from the bottle mouth (21), the pressure applied by the cap body (31) to the seal (32) is released, and the distance between the cap body (31) and the end face (324) of the bottle cap assembly (30) in the open position is greater than the distance between the cap body (31) and the end face (324) of the bottle cap assembly (30) in the closed position; and A flow guide (36) is disposed in the opening (320) and connected to the cover (31), and communicates with the fluid channel (310).

16. The bottle cap assembly (30) according to claim 15, characterized in that, It also includes an elastic element (33) disposed between the cap body (31) and the free end (323). When the cap assembly (30) moves from the open position to the closed position, the elastic element (33) is compressed to generate an elastic force, which causes the end face (324) to seal against the bottle mouth (21). It also includes an abutment (34) disposed between the elastic element (33) and the sealing element (32). The abutment (34) is used to transmit the elastic force generated by the elastic element (33) to the sealing element (32).

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