Solvent management system for a liquid chromatograph and liquid chromatograph

Abstract

The application provides a solvent management system for a liquid chromatograph and the liquid chromatograph, wherein the solvent management system comprises a solvent management module, an automatic liquid supply module, a liquid level sensor and an electric control system, the main solvent management module comprises a main solvent bottle and a first liquid inlet pipeline arranged on the main solvent bottle and used for connecting a constant flow pump; the automatic liquid supply module comprises a supplementary solvent bottle, a matching device installed on the supplementary solvent bottle and matched with the main solvent bottle, and a connecting pipeline used for connecting the matching device and the main solvent bottle; the liquid level sensor is arranged in the main solvent bottle and the supplementary solvent bottle respectively; and the electric control system is in communication connection with the liquid level sensor and the matching device respectively to control the working of the liquid level sensor and the matching device. Through the solvent management system, when the liquid surface of the mobile phase in the main solvent bottle is low, the matching device is used to supplement the solution in the main solvent bottle in time, manual operation is reduced, and the working efficiency of the liquid chromatograph is improved.

Description

Technical Field

[0001] This application relates to the field of liquid chromatography technology, and more particularly to a solvent management system for a liquid chromatograph and a liquid chromatograph. Background Technology

[0002] Conventional liquid chromatography instruments typically have 2-4 mobile phase inlets in their constant flow pump section. The mobile phase usually consists of organic phase solution, buffer solution, water, etc., which can basically meet the automatic preparation requirements for 8-12 hours. However, when liquid chromatography instruments need to perform automated multi-variety detection for a long time, there will be situations where the instrument needs to be stopped midway to manually change the buffer solution or add the mobile phase.

[0003] In view of this, it is necessary to design a solvent management system for a liquid chromatograph and a liquid chromatograph to solve one of the above problems. Utility Model Content

[0004] This application provides a solvent management system for a liquid chromatograph and a liquid chromatograph, which enables automatic switching of buffer solutions and automatic addition of mobile phase.

[0005] To achieve the above objectives, the technical solution provided in this application is as follows: This application provides a solvent management system for a liquid chromatograph, wherein the solvent management system includes: The solvent management module includes a main solvent bottle and a first inlet pipe disposed on the main solvent bottle for connecting a constant flow pump; An automatic liquid supply module includes a replenishing solvent bottle, a mating device connected to the replenishing solvent bottle, and a connecting pipe for connecting the mating device to the main solvent bottle; Liquid level sensors are located in the main solvent bottle and the replenishment solvent bottle, respectively. The electronic control system is communicatively connected to the liquid level sensor and the cooperating device to control their operation.

[0006] Furthermore, the fitting device includes a fixing structure for fixing the connecting pipe, a peristaltic pump disposed on the connecting pipe, a motor for driving the peristaltic pump, and a vent hole penetrating the fixing structure to connect the inside and outside of the replenishment solvent bottle, wherein the motor is mounted on the fixing structure.

[0007] Furthermore, the volume of the replenishing solvent bottle is not less than the volume of the main solvent bottle.

[0008] Furthermore, the connecting pipe has a first end extending to the bottom of the main solvent bottle and a second end extending to the bottom of the replenishment solvent bottle, and the replenishment solvent bottle is provided with a first filter block located directly below the second end.

[0009] Furthermore, the first inlet pipe has a first inlet end extending to the bottom of the main solvent bottle, and the main solvent bottle is provided with a second filter block located directly below the first inlet end.

[0010] Furthermore, the solvent management module also includes at least two buffer solvent bottles, a switching valve connected between the buffer solvent bottles, and a second inlet line for connecting the switching valve and the constant flow pump. The switching valve is communicatively connected to the electronic control system.

[0011] Furthermore, the second inlet pipe has a second inlet end extending to the bottom of the buffer solvent bottle, and the buffer solvent bottle is provided with a third filter block located directly below the second inlet end.

[0012] Furthermore, the solvent management module also includes magnetic stirring devices located at the bottom of the main solvent bottle and the buffer solvent bottle, respectively, and the magnetic stirring devices are communicatively connected to the electronic control system.

[0013] Furthermore, the solvent management module also includes gas regulating valves located on the upper part of the main solvent bottle and the buffer solvent bottle for balancing the internal and external gas pressure.

[0014] This application also provides a liquid chromatograph, wherein the liquid chromatograph includes the solvent management system described above for a liquid chromatograph.

[0015] Compared with related technologies, the beneficial effects of this application are as follows: by utilizing the solvent management system for liquid chromatographs of this application, the solvent management module and the automatic liquid supply module can replenish the solution in the main solvent bottle in a timely manner when the solution level in the main solvent bottle is low, thereby reducing manual operation and improving the working efficiency of the liquid chromatograph. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of the solvent management system of one embodiment of the solvent management system for liquid chromatographs according to this application.

[0017] Among them, 10-solvent management module, 11-main solvent bottle, 111-second filter block, 12-first liquid inlet pipe, 121-first liquid inlet end, 13-buffer solvent bottle, 131-third filter block, 14-switching valve, 15-second liquid inlet pipe, 151-main pipe, 152-branch pipe, 153-second liquid inlet end, 16-magnetic stirring device, 17-gas regulating valve, 20-automatic liquid supply module, 21-replenishing solvent bottle, 211-first filter block, 22-cooperating device, 221-fixed structure, 222-peristaltic pump, 223-motor, 224-vent, 23-connecting pipe, 231-first end, 232-second end, 30-liquid level sensor. Detailed Implementation

[0018] To enable those skilled in the art to better understand the technical solutions in this application, the technical solutions in the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without creative effort should fall within the scope of protection of this application.

[0019] It should be noted that the terms "upper" and "lower" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only to simplify the description of this application and do not indicate or imply that the device referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limiting the scope of protection of this application.

[0020] In the various figures of this application, for ease of illustration, certain dimensions of structures or parts may be exaggerated relative to other structural parts; therefore, they are only used to illustrate the basic structure of the subject matter of this application.

[0021] This application provides a solvent management system for a liquid chromatograph and a liquid chromatograph, wherein the solvent management system is used to coordinate the injection settings of the mobile phase and the buffer solution.

[0022] like Figure 1 As shown, the solvent management system includes a solvent management module 10, an automatic liquid supply module 20, a liquid level sensor 30, and an electronic control system (not shown). Through the cooperation of the electronic control system and the liquid level sensor 30, the automatic liquid supply module 20 is controlled to replenish solvent to the solvent management module 10, reducing manual operation, achieving the purpose of automatic liquid supply, and improving the working efficiency of the liquid chromatograph.

[0023] The solvent management module 10 includes a main solvent bottle 11 and a first inlet pipe 12 provided on the main solvent bottle 11 for connecting a constant flow pump. The main solvent bottle 11 contains an organic phase solution and needs to continuously supply the solution to the sample injection system of the liquid chromatograph.

[0024] The first liquid inlet pipe 12 has a first liquid inlet end 121 extending to the bottom of the main solvent bottle 11, which facilitates the absorption of the solution at the bottom of the main solvent bottle 11. The main solvent bottle 11 is provided with a second filter block 111 located directly below the first liquid inlet end 121, which is used to filter impurities in the organic phase solution in the main solvent bottle 11 and prevent impurities from entering the constant flow pump.

[0025] The solvent management module 10 also includes at least two buffer solvent bottles 13, a switching valve 14 connected between the buffer solvent bottles 13, and a second inlet line 15 for connecting the switching valve 14 and the constant flow pump. The switching valve 14 is communicatively connected to the electronic control system. The buffer solvent bottles 13 contain buffer solutions. The main solvent bottle 11 and the buffer solvent bottles 13 work together in the entire solvent management system to provide different mobile phase solutions for the constant flow pump.

[0026] In this application, the switching valve 14 can be a parallel electrically controlled switching valve or a rotary switching valve, both of which facilitate switching the passage to another buffer solvent bottle. The switching time of the switching valve 14 can be set in advance to switch the flow path.

[0027] When multiple buffer solvent bottles are provided, the second liquid inlet line 15 includes a main line 151 connecting the switching valve 14 and the constant flow pump, and a branch line 152 connecting the switching valve 14 and extending into the buffer solvent bottle 13.

[0028] The second liquid inlet pipe 15 has a second liquid inlet end 153 extending to the bottom of the buffer solvent bottle 13, that is, the second liquid inlet end 153 is the end of the branch pipe 152. The buffer solvent bottle 13 is provided with a third filter block 131 located directly below the second liquid inlet end 153, which is used to filter impurities in the buffer solution in the buffer solvent bottle 131 to prevent impurities from entering the constant flow pump.

[0029] The buffer solvent bottle 13 is equipped with a liquid level sensor 30 that is connected to the electronic control system. The liquid level sensor 30 is used to detect the liquid level in the buffer solvent bottle 13 and transmit it to the electronic control system. The electronic control system then issues a command to control the switching valve 14 to switch the buffer solvent bottle 13 or an alarm command.

[0030] The solvent management module 10 also includes a magnetic stirring device 16 located at the bottom of the main solvent bottle 11 and the buffer solvent bottle 13, respectively, and the magnetic stirring device 16 is communicatively connected to the electronic control system.

[0031] Specifically, after the electronic control system controls the automatic liquid supply module 20 to replenish the mobile phase to the main solvent bottle 10, it simultaneously controls the magnetic stirrer 16 to start, causing it to rotate at a set speed and for a set time to stir the mobile phase in the main solvent bottle 11, thereby homogenizing the mobile phase in the main solvent bottle 11. Similarly, after the electronic control system controls the switching valve 14 to switch, it simultaneously controls the magnetic stirrer 16 to start, thereby homogenizing the buffer solution in the buffer solvent bottle 13.

[0032] The magnetic stirring device 16 in this application includes a magnetic stir bar 161 disposed on the inner side of the bottom of the main solvent bottle 11 and the buffer solvent bottle 13, and a magnetic stirrer 162 disposed on the outer side of the bottom. The magnetic stirrer 162 is communicatively connected to the electronic control system. The magnetic stirring device 16 is disposed in the middle position of the main solvent bottle 11 or the buffer solvent bottle 13.

[0033] Furthermore, the solvent management module 10 also includes gas regulating valves 17 respectively disposed on the main solvent bottle 11 and the buffer solvent bottle 13 for balancing the internal and external gas pressure. One gas regulating valve 17 is disposed on the upper part of the main solvent bottle 11 and spaced apart from the first liquid inlet pipe 12, and the other gas regulating valve 17 is disposed on the upper part of the buffer solvent bottle 13 and spaced apart from the second liquid inlet pipe 15.

[0034] The automatic liquid supply module 20 includes a replenishing solvent bottle 21, a matching device 22 installed on the replenishing solvent bottle 21 and the main solvent bottle 11, and a connecting pipe 23 for connecting the matching device 22 and the main solvent bottle 11. The matching device 22 is communicatively connected to the electronic control system.

[0035] The fitting device 22 includes a fixing structure 221 for fixing the connecting pipe 23, a peristaltic pump 222 disposed on the connecting pipe 23, a motor 223 for driving the peristaltic pump 222, and a vent 224 penetrating the fixing structure 221 to connect the inside and outside of the replenishment solvent bottle 21. The motor 223 is mounted on the fixing structure 221. The electrical control system is communicatively connected to the motor 223 to control its operation.

[0036] The connecting pipe 23 has a first end 231 extending to the bottom of the main solvent bottle 11 and a second end 232 extending to the bottom of the replenishment solvent bottle 21, so that the organic phase solution in the replenishment solvent bottle 21 can be better mixed with the organic phase solution in the main solvent bottle 11 when it enters the main solvent bottle 11.

[0037] The replenishment solvent bottle 21 is provided with a first filter block 211 located directly below the second end 232, which is used to filter impurities in the replenishment solvent and prevent impurities from entering the main solvent bottle 11.

[0038] The replenishment solvent bottle 21 is equipped with a liquid level sensor 30 that is connected to the electronic control system. The liquid level sensor 30 is used to detect the liquid level in the replenishment solvent bottle 21 and transmit it to the electronic control system. If the electronic control system receives a message that the solution level in the replenishment solvent bottle 21 is insufficient, the electronic control system will issue an alarm command.

[0039] When the liquid level sensor 30 detects that the liquid in the main solvent bottle 21 is insufficient, the electronic control system controls the motor 223 of the cooperating device 22 to start the peristaltic pump 222, which pumps the mobile phase in the replenishing solvent bottle 21 into the main solvent bottle 11 at a preset flow rate and volume. At the same time, the magnetic stirring device 16 is started to rotate at a preset speed for a preset time.

[0040] The volume of the replenishment solvent bottle 21 is not less than the volume of the main solvent bottle 11, so as to ensure that there is enough replenishment organic phase solution in the replenishment solvent bottle 21.

[0041] This application also provides a liquid chromatograph, wherein the liquid chromatograph includes the solvent management system described above for a liquid chromatograph.

[0042] In summary, the solvent management system for liquid chromatographs of this application, through the solvent management module 10 and the automatic liquid supply module 20, can promptly replenish the solution in the main solvent bottle 11 when the liquid level of the mobile phase in the main solvent bottle 11 is low using the matching device 22, thereby reducing manual operation and improving the working efficiency of the liquid chromatograph.

[0043] It should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This way of describing the specification is only for clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

[0044] The detailed descriptions listed above are merely specific illustrations of feasible embodiments of this application and are not intended to limit the scope of protection of this application. All equivalent embodiments or modifications made without departing from the spirit of the art of this application should be included within the scope of protection of this application.

Claims

1. A solvent management system for a liquid chromatograph, characterized in that, The solvent management system includes: The solvent management module includes a main solvent bottle and a first inlet pipe disposed on the main solvent bottle for connecting a constant flow pump; An automatic liquid supply module includes a replenishing solvent bottle, a mating device connected to the replenishing solvent bottle, and a connecting pipe for connecting the mating device to the main solvent bottle; Liquid level sensors are located in the main solvent bottle and the replenishment solvent bottle, respectively. The electronic control system is communicatively connected to the liquid level sensor and the cooperating device to control their operation.

2. The solvent management system for a liquid chromatograph as described in claim 1, characterized in that, The fitting device includes a fixing structure for fixing the connecting pipe, a peristaltic pump disposed on the connecting pipe, a motor for driving the peristaltic pump, and a vent hole penetrating the fixing structure to connect the inside and outside of the replenishment solvent bottle, wherein the motor is mounted on the fixing structure.

3. The solvent management system for a liquid chromatograph as described in claim 1, characterized in that, The volume of the replenishment solvent bottle is not less than the volume of the main solvent bottle.

4. The solvent management system for a liquid chromatograph as described in claim 1, characterized in that, The connecting pipe has a first end extending to the bottom of the main solvent bottle and a second end extending to the bottom of the replenishment solvent bottle. The replenishment solvent bottle is provided with a first filter block located directly below the second end.

5. The solvent management system for a liquid chromatograph as described in claim 1, characterized in that, The first inlet pipe has a first inlet end extending to the bottom of the main solvent bottle, and the main solvent bottle is provided with a second filter block located directly below the first inlet end.

6. The solvent management system for a liquid chromatograph as described in any one of claims 1 to 5, characterized in that, The solvent management module also includes at least two buffer solvent bottles, a switching valve connected between the buffer solvent bottles, and a second inlet line for connecting the switching valve and the constant flow pump. The switching valve is communicatively connected to the electronic control system.

7. The solvent management system for a liquid chromatograph as described in claim 6, characterized in that, The second inlet pipe has a second inlet end extending to the bottom of the buffer solvent bottle, and the buffer solvent bottle is provided with a third filter block located directly below the second inlet end.

8. The solvent management system for a liquid chromatograph as described in claim 6, characterized in that, The solvent management module also includes magnetic stirring devices located at the bottom of the main solvent bottle and the buffer solvent bottle, respectively, and the magnetic stirring devices are communicatively connected to the electronic control system.

9. The solvent management system for a liquid chromatograph as described in claim 6, characterized in that, The solvent management module also includes gas regulating valves located on the top of the main solvent bottle and the buffer solvent bottle, respectively, for balancing the internal and external gas pressure.

10. A liquid chromatograph, characterized in that, Including the solvent management system for a liquid chromatograph as described in any one of claims 1 to 9.

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