A kit for cardiovascular disease

Abstract

The utility model provides a kit for cardiovascular disease belongs to the technical field of kit, including the fixed between upper box body and lower box body through the pin shaft, the upper box body and lower box body are clamped with NC film, the surface of upper box body is equipped with the drop port and observation port, the inside of upper box body is equipped with protection mechanism still. The utility model solves the structure design of such kit of existing this kind often is not enough to the protection of NC film, and the drop port of kit is as the key passageway of sample addition, and its below directly corresponds the reaction area of NC film, and the drop port and NC film are usually short of effective physical isolation structure between the existing design, lead to the sewage of outside to cause the pollution of NC film easily when using, and then appear the problem of the inaccurate condition of detection result.

Description

Technical Field

[0001] This invention belongs to the field of reagent kit technology, specifically relating to a reagent kit for cardiovascular diseases. Background Technology

[0002] In vitro diagnostic kits serve as crucial tools for the rapid detection of various diseases, including cardiovascular diseases, inflammation, and gastrointestinal dysfunction, playing a key role in clinical diagnosis and health monitoring. Their core detection principle relies on methodologies such as immunofluorescence, chemiluminescence, or colloidal gold. Qualitative or quantitative analysis is achieved through the specific reaction between the sample (e.g., whole blood, plasma, serum) and the reaction system within the kit. The nitrocellulose matrix (NC membrane), as the core carrier of the test strip, is a critical site for antigen-antibody complex diffusion, capture, and signal generation; its integrity directly determines the accuracy of the test results.

[0003] Existing kits of this type often lack adequate protection for the NC membrane. The dropper port of the kit is the key channel for sample addition, and its lower part directly corresponds to the reaction area of ​​the NC membrane. However, existing designs usually lack an effective physical isolation structure between the dropper port and the NC membrane, which makes it easy for external wastewater to contaminate the NC membrane during use, resulting in inaccurate test results. Summary of the Invention

[0004] This invention provides a reagent kit for cardiovascular diseases, which aims to solve the problem that the existing structural design of such reagent kits often fails to adequately protect the NC membrane. The dropper of the reagent kit is the key channel for sample addition, and its lower part directly corresponds to the reaction area of ​​the NC membrane. However, in the existing design, there is usually no effective physical isolation structure between the dropper and the NC membrane, which makes it easy for external sewage to contaminate the NC membrane during use, resulting in inaccurate test results.

[0005] This utility model provides a reagent kit for cardiovascular diseases, including an upper box and a lower box fixed by a pin, an NC membrane sandwiched between the upper box and the lower box, a drip port and an observation port on the surface of the upper box, and a protective mechanism inside the upper box.

[0006] Furthermore, the upper box body has an internal cavity, and the dripping port and the observation port are connected from top to bottom, with the dripping port and the observation port having the same width.

[0007] By adopting the above technical solution, the cavity provides installation and movement space for the protective mechanism, ensuring that the protective components can move flexibly inside the box; the through design of the drip port and the observation port meets the sample dripping requirements and facilitates direct observation of the reaction results on the NC membrane; the fact that both are the same width ensures that the protective mechanism can simultaneously accommodate the shielding requirements of two openings.

[0008] Furthermore, the protective mechanism includes two sliders slidably disposed in the cavity. The two sliders are symmetrical about the drip port and the observation port. Sliding holes are provided at both ends of the upper box. A pressing post slides in the sliding hole. An abutment block is fixed at the end of the pressing post extending into the cavity. The abutment block is inverted trapezoidal. The top of the abutment block is connected to the wall surface of the sliding hole by a first spring. Elastic guides are also provided on both sides of the cavity wall. The elastic guides are connected to the sliders.

[0009] By adopting the above technical solution, the protective mechanism forms a set of linked mechanical protection systems. Under normal conditions, the force of the elastic guide causes the two sliders to move closer together, blocking the drip port and observation port. After the packaging bag is opened, it prevents external liquid from splashing onto the drip port and observation port or from being intentionally contaminated by others, which could lead to inaccurate test results. When it is necessary to add a sample or observe the results, pressing the pressing posts at both ends moves the contact block upward into the box. The inverted trapezoidal contact block pushes the two sliders to slide to the sides through the inclined plane, exposing the drip port and observation port. After releasing the pressing posts, the first spring drives the contact block to reset, and the elastic guide drives the sliders to close again, restoring the protective state and avoiding the problem that the NC membrane is easily contaminated or scratched due to the lack of a targeted isolation structure.

[0010] Furthermore, the slider includes a main body adapted to the cavity, and two ends of the two main bodies on opposite sides are provided with inclined surfaces, which are adapted to the inverted trapezoidal abutment blocks. The opposite side of the main body is also provided with a convex plate, and the width of the two convex plates is adapted to the width of the drip port and the observation port.

[0011] By adopting the above technical solution, the fit between the main body and the cavity ensures that the slider slides smoothly and avoids deviation; the cooperation between the inclined surface and the inverted trapezoidal contact block converts the longitudinal pressure of the pressing column into the lateral sliding force of the slider, realizing efficient force transmission; the width of the convex plate is adapted to the drip port and the observation port, ensuring that the slider can completely cover the two openings when closed, forming a tight protection to prevent external liquids or impurities from seeping into the contact NC membrane from the openings. At the same time, when the slider is opened, the convex plate completely leaves the opening area, without affecting the sample dripping and result observation.

[0012] Furthermore, the elastic guide includes guide grooves on both sides of the slider, and a guide rod extending toward the guide groove is fixed on the wall of the cavity. The bottom of the guide groove and the top of the guide rod are connected by a second spring.

[0013] By adopting the above technical solution, the cooperation between the guide groove and the guide rod provides precise guidance for the sliding of the slider, avoiding tilting or jamming of the slider during movement; the elastic force of the second spring always pushes the slider towards the center, ensuring that the convex plate can tightly cover the drip port and observation port under normal conditions, forming a stable protection; when the slider is pushed away by the abutment block, the second spring is compressed. After the pressing column is released, the second spring is released, causing the slider to quickly return to its original position. At the same time, the first spring also changes from a stretched state back to a normal state, thereby causing the pressing column to rebound upward, ensuring the immediate restoration of the protective function.

[0014] Furthermore, the depth of the guide groove is greater than the length of the guide rod, and the sliding distance of the slider from both sides to the middle is less than the length of the guide rod.

[0015] By adopting the above technical solution, the depth of the guide groove is greater than the length of the guide rod, which provides sufficient space for the slider to slide to both sides and avoids the guide rod from obstructing the slider from opening; the sliding distance of the slider to the middle is less than the length of the guide rod, which ensures that the guide rod will not detach from the guide groove when the slider is closed, thus ensuring the structural stability of the elastic guide and the continuous effectiveness of the guiding function.

[0016] Furthermore, a limiting plate is integrally formed at the bottom of the inclined surface.

[0017] By adopting the above technical solution, the limiting plate can restrict the downward movement of the contact block, preventing the contact block from separating from the inclined surface of the slider due to excessive pressing, thereby ensuring the reliability of the protective mechanism and its service life.

[0018] The beneficial effects of this utility model are as follows:

[0019] 1. The present invention provides a cavity for the installation and movement of the protective mechanism, ensuring that the protective components can move flexibly inside the box.

[0020] 2. Through the design of the protective mechanism, this utility model forms a set of linked mechanical protection systems. Under normal conditions, it can shield the drip port and the observation port, thereby shielding the internal NC membrane. When adding samples, the protection is opened by pressing the pressing block to facilitate dripping and observation operations. After releasing the pressing block, the slider closes again under external action, restoring the protective state. This avoids the problem of inaccurate test results caused by external contamination of the NC membrane due to the lack of a targeted isolation structure.

[0021] Other features and advantages of this invention will be set forth in the description which follows, and will be apparent in part from the description, or may be learned by practicing the invention. The objects and other advantages of this invention can be realized and obtained by means of the structures particularly pointed out in the description and the drawings. Attached Figure Description

[0022] The accompanying drawings are provided to further illustrate the present invention and form part of the specification. They are used together with the embodiments of the present invention to explain the present invention, but do not constitute a limitation thereof. In the drawings:

[0023] Figure 1 This is a schematic diagram of the overall structure of an embodiment of the present utility model;

[0024] Figure 2 This is a front view of the protective mechanism according to an embodiment of the present invention;

[0025] Figure 3 This is a schematic diagram of the closed front view structure of the protective mechanism according to an embodiment of the present utility model;

[0026] Figure 4 This is a schematic diagram of the cross-sectional structure of the protective mechanism according to an embodiment of the present utility model;

[0027] Figure 5 This is a schematic cross-sectional view of the protective mechanism in an embodiment of the present invention.

[0028] Figure 6 This is an enlarged structural diagram of point a in an embodiment of the present invention;

[0029] Figure 7 This is an enlarged structural diagram of section b in an embodiment of the present invention;

[0030] Figure 8 This is an enlarged structural diagram of point c in an embodiment of the present invention;

[0031] Figure 9 This is an enlarged structural diagram of point d in an embodiment of the present invention;

[0032] Reference numerals: 1. Upper box; 11. Cavity; 2. Lower box; 3. NC membrane; 4. Drip port; 5. Observation port; 6. Protective mechanism; 61. Slider; 611. Main body; 612. Inclined surface; 6121. Limiting plate; 613. Protruding plate; 62. Sliding hole; 63. Pressing post; 64. Abutting block; 65. First spring; 66. Elastic guide; 661. Guide groove; 662. Guide rod; 663. Second spring. Detailed Implementation

[0033] To make the objectives, technical solutions, and advantages of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. The same reference numerals in the drawings represent the same components. It should be noted that the described embodiments are only some, not all, of the embodiments of this utility model. All other embodiments obtained by those skilled in the art based on the described embodiments of this utility model without creative effort are within the scope of protection of this utility model.

[0034] Reference Figures 1-9 This utility model provides a reagent kit for cardiovascular diseases, comprising an upper box 1 and a lower box 2 fixed together by a pin, with an NC membrane 3 sandwiched between the upper box 1 and the lower box 2. The surface of the upper box 1 is provided with a drop port 4 and an observation port 5, and the interior of the upper box 1 is provided with a cavity 11. The drop port 4 and the observation port 5 are through-holes from top to bottom, and the drop port 4 and the observation port 5 have the same width. The cavity 11 provides installation and movement space for a protective mechanism 6, ensuring that the protective mechanism 6 can move flexibly inside the box. The through-hole design of the drop port 4 and the observation port 5 meets the sample addition requirements and facilitates direct observation of the reaction results on the NC membrane 3. The fact that both are the same width ensures that the protective mechanism 6 can simultaneously accommodate the shielding requirements of two openings.

[0035] Reference Figures 1-9The upper box 1 also has a protective mechanism 6 inside. The protective mechanism 6 includes two sliders 61 that are slidably disposed in the cavity 11. The two sliders 61 are symmetrical about the drip port 4 and the observation port 5. There are sliding holes 62 at both ends of the upper box 1. A pressing post 63 slides in the sliding hole 62. A contact block 64 is fixed at the end of the pressing post 63 extending to the cavity 11. The contact block 64 is in the shape of an inverted trapezoid. The slider 61 includes a main body 611 that fits into the cavity 11. There are inclined surfaces 612 at both ends of the two main bodies 611 on opposite sides. The inclined surfaces 612 fit into the inverted trapezoidal contact block 64. The top of the contact block 64 is flush with the wall of the sliding hole 62. Connected by the first spring 65, elastic guides 66 are also provided on both sides of the cavity 11. The elastic guides 66 are connected to the sliders 61, and the protective mechanism 6 forms a set of linked mechanical protection systems. Under normal conditions, the force of the elastic guides 66 causes the two sliders 61 to move closer to each other, blocking the drip port 4 and the observation port 5. After the packaging bag is opened, it prevents external liquid from being spilled onto the drip port 4 and the observation port 5 or from being intentionally contaminated by others, which would lead to inaccurate test results. A convex plate 613 is also provided on the opposite side of the main body 611. The width of the two convex plates 613 is adapted to the width of the drip port 4 and the observation port 5. The main body 611 and the cavity 11 are connected by a spring 65. The fit of cavity 11 ensures smooth sliding of slider 61 and avoids deviation; the cooperation between inclined surface 612 and inverted trapezoidal contact block 64 converts the longitudinal pressure of pressing column 63 into the lateral sliding force of slider 61, achieving efficient force transmission; the width of convex plate 613 is adapted to the drip port 4 and observation port 5, ensuring that slider 61 can completely cover drip port 4 and observation port 5 when closed, forming a tight protection to prevent external liquid or impurities from seeping into contact NC membrane 3 from drip port 4 and observation port 5. At the same time, when slider 61 is open, convex plate 613 is completely removed from the opening area, without affecting sample addition and result observation. When it is necessary to add sample or observe results, press the two ends of the push button. The pressing column 63 drives the contact block 64 to move upward into the box 1. The inverted trapezoidal contact block 64 pushes the two sliders 61 to slide to both sides through the inclined surface 612, exposing the drip port 4 and the observation port 5. After the pressing column 63 is released, the first spring 65 drives the contact block 64 to reset, and the elastic guide 66 drives the slider 61 to close again, restoring the protective state. This avoids the problem that the NC membrane 3 is easily contaminated or scratched due to the lack of a targeted isolation structure. The surfaces of the two convex plates 613 that are in contact with each other are provided with sealing gaskets. When the convex plates 613 are tightly fitted, they can achieve a sealing effect and improve the isolation effect between the internal NC membrane 3 and the outside world.

[0036] Reference Figures 1-9The elastic guide 66 includes guide grooves 661 on both sides of the slider 61. A guide rod 662 extending towards the guide grooves 661 is fixed on the wall of the cavity 11. The bottom of the guide groove 661 and the top of the guide rod 662 are connected by a second spring 663. The depth of the guide groove 661 is greater than the length of the guide rod 662. The sliding distance of the slider 61 from both sides to the middle is less than the length of the guide rod 662. The greater depth of the guide groove 661 provides sufficient space for the slider 61 to slide to both sides, preventing the guide rod 662 from obstructing the opening of the slider 61. The less-than-length sliding distance of the slider 61 to the middle ensures that the guide rod 662 will not detach from the guide groove 661 when the slider 61 is closed, thus ensuring the structural stability and continuous effectiveness of the guiding function of the elastic guide 66. The cooperation between the guide groove 661 and the guide rod 662 provides precise guidance for the sliding of the slider 61, preventing the slider 61 from tilting or getting stuck during movement. The elastic force of the second spring 663... The slider 61 is constantly pushed towards the center to ensure that the convex plate 613 can tightly cover the drip port 4 and the observation port 5 under normal conditions, forming a stable protection. When the slider 61 is pushed away by the abutment block 64, the second spring 663 is compressed. After the pressing column 63 is released, the second spring 663 is released, causing the slider 61 to quickly return to its original position. At the same time, the first spring 65 also returns to its normal state from the stretched state, which in turn causes the pressing column 63 to rebound upward, ensuring the immediate restoration of the protective function. The slider 61 can also be made of transparent material, so that the observation port 5 can be observed without pressing the pressing column 63 after the test is completed. The principle of the entire NC membrane 3 detection is the rapid quantitative immunofluorescence detection technology. The probe, reaction buffer and blood sample are mixed. ST2 in the blood sample combines with ST2 antibody in the detection buffer to form an antigen-antibody complex. The mixed sample is added to the sample well of the reaction plate and diffuses on the test band of the nitrocellulose matrix through capillary action. The complex is captured by another ST2 antibody on the test band. Therefore, the more ST2 in the blood, the more complex accumulates on the test band. The intensity of the fluorescence signal reflects the amount of ST2 captured. With the help of a matching immunofluorescence analyzer, the concentration of ST2 in whole blood / plasma / serum can be quantitatively detected.

[0037] Reference Figures 1-9 The bottom of the inclined surface 612 is integrally formed with a limiting plate 6121. The limiting plate 6121 can limit the downward movement of the contact block 64, and prevent the contact block 64 from disengaging from the inclined surface 612 of the slider 61 due to excessive pressing, thereby ensuring the reliability of the operation and service life of the protective mechanism 6.

[0038] The specific implementation method is as follows: When the packaging bag is opened for use, the protective mechanism 6 is in a closed state. Under the action of the second spring 663, the two sliders 61 move towards the center, and the convex plate 613 completely covers the drip port 4 and the observation port 5, forming a physical barrier to protect the NC membrane 3 from external contamination or scratches. At this time, the pressing column 63 is located at the top of the sliding hole 62 under the action of the first spring 65, and the contact block 64 does not contact the inclined surface 612 of the slider 61. When it is necessary to add a sample, the operator presses the pressing columns 63 at both ends, causing them to move down along the sliding hole 62 and stretch the first spring 65, driving the contact block 64 towards the center. The downward displacement of the trapezoidal contact block 64 converts the longitudinal force into a lateral thrust through the inclined plane 612, pushing the slider 61 to slide along the guide rod 662 to both sides and compress the second spring 663. The convex plate 613 gradually disengages from the opening, exposing the dripping port 4 and the observation port 5 for sample addition. After releasing the pressing column 63 again, the first spring 65 and the second spring 663 reset, and the slider 61 closes again to block the dripping port 4 and the observation port 5. After the sample reaction is complete, the results can be observed through the observation port 5. The limiting plate 6121 can prevent excessive pressing from causing the contact block 64 to disengage from the inclined plane 612.

[0039] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claims. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A reagent kit for cardiovascular diseases, characterized in that, The upper box (1) and the lower box (2) are fixed together by a pin. An NC membrane (3) is sandwiched between the upper box (1) and the lower box (2). The surface of the upper box (1) is provided with a drip port (4) and an observation port (5). The interior of the upper box (1) is also provided with a protective mechanism (6). The protective mechanism (6) includes two sliders (61) slidably disposed in the cavity (11). The two sliders (61) are symmetrical about the drip port (4) and the observation port (5). The upper box (1) is provided with sliding holes (62) at both ends. A pressing column (63) slides in the sliding hole (62). A contact block (64) is fixed at the end of the pressing column (63) extending into the cavity (11). The contact block (64) is in the shape of an inverted trapezoid. The top of the contact block (64) is connected to the wall of the sliding hole (62) by a first spring (65). The two side walls of the cavity (11) are also provided with elastic guides (66). The elastic guides (66) are connected to the sliders (61).

2. The cardiovascular disease reagent kit according to claim 1, characterized in that: The upper box (1) has a cavity (11) inside. The drip port (4) and the observation port (5) are connected from top to bottom. The width of the drip port (4) and the observation port (5) are the same.

3. A cardiovascular disease reagent kit according to claim 2, characterized in that: The slider (61) includes a main body (611) adapted to the cavity (11). The two ends of the two main bodies (611) on opposite sides are provided with inclined surfaces (612). The inclined surfaces (612) are adapted to the inverted trapezoidal abutment block (64). The opposite side of the main body (611) is also provided with a convex plate (613). The width of the two convex plates (613) is adapted to the width of the drip port (4) and the observation port (5).

4. A reagent kit for cardiovascular diseases according to claim 3, characterized in that: The elastic guide (66) includes guide grooves (661) on both sides of the slider (61), and a guide rod (662) extending toward the guide groove (661) is fixed on the wall of the cavity (11). The bottom of the guide groove (661) and the top of the guide rod (662) are connected by a second spring (663).

5. A reagent kit for cardiovascular diseases according to claim 4, characterized in that: The depth of the guide groove (661) is greater than the length of the guide rod (662), and the sliding distance of the slider (61) from both sides to the middle is less than the length of the guide rod (662).

6. A reagent kit for cardiovascular diseases according to claim 5, characterized in that: The bottom of the inclined surface (612) is integrally formed with a limiting plate (6121).

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