Mouse skin photoaging test device

Abstract

The utility model relates to medical experimental equipment, especially a mouse skin photoaging experimental device. The mouse skin photoaging experimental device comprises a box body, a box cover and a fixer for limiting the body position of a mouse, the box body is provided with a containing cavity and an opening corresponding to the containing cavity, the fixer is placed in the containing cavity, and the box cover is detachably capped at the opening of the box body; the side of the box cover facing the containing cavity is provided with a lamp set for irradiating the skin of the mouse, the lamp set is provided with a ventilation opening for air circulation; the box body is provided with an air inlet for communicating with the external environment, and the box body is provided with an air filter membrane corresponding to the air inlet; the box cover is provided with a fan, the fan is located on the side of the lamp set away from the containing cavity, and is used for pumping the gas in the containing cavity to the outside of the box body to guide the external air to flow through the containing cavity from the air inlet. The air filter membrane arranged at the air inlet can filter and purify the air entering the containing cavity, and prevent the mouse from being infected by external pollutants.

Description

Technical Field

[0001] This utility model relates to medical experimental equipment, and in particular to a mouse skin photoaging experimental device. Background Technology

[0002] In studies of skin photoaging, mice are typically placed inside a UV lamp chamber for periodic or continuous UV irradiation to induce photoaging pathological changes in their skin, similar to those in human skin. Existing UV lamp chambers often lack temperature control systems, and prolonged exposure to UV light generates significant heat, leading to excessively high internal temperatures. After approximately two hours of continuous irradiation, the temperature inside the chamber significantly exceeds the ambient temperature and surpasses the mice's heat tolerance threshold. At this point, the high temperature environment easily triggers heat stress in the mice, potentially causing heatstroke and death, thus affecting the reliability and reproducibility of experimental data and harming animal welfare.

[0003] Secondly, after repeated or high-intensity ultraviolet radiation, the skin of mice has a decreased immune defense capacity. If the external air enters the chamber directly without purification during the irradiation process, the bacteria, fungi and other microorganisms suspended in the air may increase the risk of infection on the damaged skin surface of the mice, thereby reducing the accuracy of the experimental results. Utility Model Content

[0004] The technical problem to be solved by this utility model is to overcome the defects in the prior art, such as high internal temperature of the box and skin infection of mice caused by microorganisms in the air of the external environment when the lamp group is irradiated for a long time, and to provide a mouse skin photoaging experimental device.

[0005] The present invention solves the above-mentioned technical problems through the following technical solution:

[0006] A mouse skin photoaging experimental device includes a box, a box cover, and a restraint for limiting the position of the mouse. The box has a receiving cavity and an opening corresponding to the receiving cavity. The restraint is placed inside the receiving cavity. The box cover is detachably sealed to the opening of the box. A lamp assembly for irradiating mouse skin is provided on the side of the box cover facing the receiving cavity. The lamp assembly has a vent for air circulation. The box has an air inlet for communicating with the external environment. An air filter membrane is arranged on the box body corresponding to the air inlet. A fan is installed on the box cover. The fan is located on the side of the lamp assembly away from the receiving cavity and is used to extract gas from the receiving cavity to the outside of the box to guide external air to flow through the receiving cavity from the air inlet.

[0007] In this design, a fan guides airflow within the containment chamber, carrying away heat generated by the lamps and thus lowering the temperature. This prevents stress and heatstroke in mice caused by high temperatures, ensures air circulation, maintains oxygen levels, and reduces ammonia buildup. An air filter membrane is installed at the air inlet to filter and purify the air entering the containment chamber while ensuring airflow. This removes suspended particulate matter, bacteria, viruses, and other microorganisms, improving the cleanliness of the containment chamber, preventing infection of mice from external contaminants, and enhancing the accuracy of experimental results. A removable lid seals the opening of the enclosure, facilitating the placement and removal of mice and lamp replacement, thus improving operational convenience.

[0008] Optionally, the light assembly includes a light diffuser plate and lamp tubes. A plurality of light diffuser plates extend along the length direction of the housing and are spaced apart along the width direction of the housing. The spacing between the plurality of light diffuser plates forms the ventilation opening. A plurality of lamp tubes are disposed corresponding to the light diffuser plates and are detachably connected to at least one of the light diffuser plates or the housing cover.

[0009] In this scheme, the light distribution inside the containment cavity is made more uniform by using a light-diffusing plate, which improves the consistency of experimental results. The lamp tube is detachably connected to at least one of the light-diffusing plate or the cover to allow for the replacement of lamp tubes with different wavelength combinations.

[0010] Optionally, the air filter membrane includes a filter membrane body and a mounting ring. The filter membrane body covers the air inlet and is detachably fixed to the area of ​​the housing corresponding to the air inlet by the mounting ring.

[0011] In this design, the air filter membrane is detachably connected to the housing for easy replacement.

[0012] Optionally, the mouse skin photoaging experimental device further includes a support plate and a lifting mechanism. The support plate is located inside the receiving cavity and is used to support the fixture. The lifting mechanism is used to enable the support plate to move relative to the box body along the height direction of the box body.

[0013] In this design, the lifting mechanism allows the support plate to be moved along the height of the enclosure to adjust the distance between the light group and the mouse inside the fixture, thereby meeting the light intensity requirements of the experiment.

[0014] Optionally, the housing is provided with distance measuring marks along its height direction.

[0015] In this scheme, the distance measuring mark is used to indicate the position of the fixture in the height direction of the housing, which facilitates the adjustment of the distance between the fixture and the light group.

[0016] Optionally, the restraint includes a housing and a cover. The housing is a hollow cylindrical shape with an opening, and the cover selectively seals the opening of the housing. The housing and the cover together form an accommodating space for accommodating a mouse. The housing includes a bottom plate, a top plate, and side plates. The bottom plate and the top plate are connected end-to-end, and the side plates are connected to the side of the bottom plate and the top plate away from the cover. The side plates have multiple ventilation holes, and the cover has a clearance hole for the mouse's tail to pass through.

[0017] In this design, the cover is selectively sealed at the opening of the shell to facilitate the placement of mice and to restrict their position. The side panels have multiple ventilation holes to allow air circulation and ensure that the mice can breathe smoothly.

[0018] Optionally, the area of ​​the box cover corresponding to the fan is covered with a sealing element, the air inlet is located in the lower area of ​​the box body, and the upper area of ​​the box body is provided with an air outlet. The air inlet and the air outlet are respectively used to connect to an external anesthesia system.

[0019] In this design, the air inlet is connected to an external anesthesia system, allowing anesthetic gas to enter the containment chamber. This prevents irradiation deviation caused by mouse positional instability, improving experimental accuracy. The air inlet and outlet are located in the lower and upper parts of the chamber, respectively, allowing the anesthetic gas to enter from the bottom, gradually flow upwards, and replace the air inside the chamber, thus filling the containment chamber more evenly and improving anesthesia efficiency.

[0020] Optionally, the mouse skin photoaging experimental device includes a temperature control module, which includes a controller that is communicatively connected to the fan and a temperature probe that is electrically connected to the controller. The temperature probe is disposed on the inner surface of the fixture and is used to measure the temperature inside the fixture in real time. The controller is used to control the fan to turn on or off.

[0021] In this design, a temperature control probe is placed on the inner surface of the restraint to detect the temperature of the area where the mouse is located. The controller can control the opening and closing of the fan to adjust the temperature inside the containment cavity in real time, preventing the temperature inside the containment cavity from exceeding the mouse's heat tolerance threshold, thereby reducing the risk of stress response and overheating death caused by high temperature in the mouse.

[0022] Optionally, the temperature control module includes a light detection probe disposed on the inner surface of the fixture for detecting the light intensity in the area corresponding to the fixture within the receiving cavity, and the light detection probe is electrically connected to the controller; the temperature control module also includes a timing module, and the timing module is electrically connected to the controller.

[0023] In this protocol, an illumination detection probe is used to ensure experimental accuracy, and a timing module is used to ensure the physiological safety of the mice.

[0024] The positive and progressive effects of this utility model are as follows:

[0025] This novel mouse skin photoaging experimental device utilizes a fan to guide airflow within the containment chamber, carrying away heat generated by the lamp assembly and thus lowering the temperature inside the chamber. This prevents stress and heatstroke in the mice caused by high temperatures. An air filter membrane is installed at the air inlet to ensure airflow while purifying the air entering the containment chamber, removing suspended particulate matter, bacteria, viruses, and other microorganisms. This improves the cleanliness of the containment chamber, preventing infection of the mice by external contaminants and enhancing the reliability of the experiment. A detachable lid seals the opening of the enclosure, facilitating the placement and removal of mice and the replacement of the lamp assembly, thus improving operational convenience. Attached Figure Description

[0026] Figure 1 This is a first-view structural diagram of a mouse skin photoaging experimental apparatus according to an embodiment of the present invention, with part of the side wall of the chamber removed.

[0027] Figure 2 This is a second-view structural diagram of the mouse skin photoaging experimental apparatus according to an embodiment of the present invention, with part of the side wall of the chamber removed.

[0028] Figure 3 This is a schematic diagram of the structure of the box cover and lamp assembly according to an embodiment of the present utility model.

[0029] Figure 4 This is a schematic diagram of the lamp assembly from a first-view perspective according to an embodiment of the present invention.

[0030] Figure 5 This is a structural schematic diagram of a lamp assembly from a second perspective according to an embodiment of the present invention.

[0031] Figure 6 This is a schematic diagram of the structure of a mouse skin photoaging experimental apparatus with part of the side wall of the chamber removed, according to another embodiment of the present invention.

[0032] Explanation of reference numerals in the attached figures:

[0033] Box 1

[0034] Containment cavity 11

[0035] Air inlet 12

[0036] Air outlet 13

[0037] Box lid 2

[0038] Air outlet 21

[0039] Fixture 3

[0040] Casing 3a

[0041] Base plate 31

[0042] Top plate 32

[0043] Side panel 33

[0044] Vent hole 331

[0045] Storage space 34

[0046] Light Group 4

[0047] Ventilation vent 41a

[0048] Homogeneous plate 41

[0049] First homogenization section 411

[0050] Second light distribution section 412

[0051] Third light distribution section 413

[0052] 42 fluorescent tubes

[0053] Air filter membrane 5

[0054] Filter membrane body 51

[0055] Mounting ring 52

[0056] Fan 6

[0057] Bearing plate 7

[0058] Seal 81

[0059] Ice storage box 82 Detailed Implementation

[0060] The present invention will be further illustrated below by way of embodiments, but these embodiments are not intended to limit the scope of the present invention. Based on the description of the present invention, all other embodiments obtained by those skilled in the art without inventive effort are within the scope of protection of the present invention.

[0061] In the description of this utility model, unless otherwise explicitly specified and limited, the terms "connection," "setting," "installation," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can mean that two components are internally connected. For those skilled in the art, the specific meaning of the above terms in this utility model can be understood according to the specific circumstances.

[0062] The terms “upper,” “lower,” “left,” “right,” “front,” “back,” “center,” “top,” “bottom,” “inner,” “outer,” “vertical,” “horizontal,” “axial,” “radial,” and “circumferential” indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product is in use. They are used only for the convenience of description and simplification, and do not indicate or imply that the device or component referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0063] The terms “first”, “second”, etc., are used merely to distinguish components with similar attributes, not to indicate or imply relative importance or a specific order.

[0064] The terms “including,” “comprising,” or any other variations thereof are intended to cover non-exclusive inclusion, which includes not only the elements listed but also other elements not expressly listed.

[0065] Example 1

[0066] See Figure 1 and Figure 2 This invention provides a mouse skin photoaging experimental device, including a box body 1, a box cover 2, a fixture 3, a lamp assembly 4, and a fan 6. Specifically, the box body 1 has a receiving cavity 11, and the top of the box body 1 has an opening communicating with the receiving cavity 11. The box cover 2 is detachably placed on the opening of the box body 1 by means of fastener connection or snap-fit, which facilitates the placement and removal of mice. The fixture 3 is placed inside the receiving cavity 11 to limit the position of the mouse. The lamp assembly 4 is fixed to the side of the box cover 2 facing the receiving cavity 11 by means of fastener connection, snap-fit, or adhesive bonding, that is, the lamp assembly 4 is located above the receiving cavity 11 and is used to irradiate the mouse skin. The lamp assembly 4 can be replaced by removing the box cover 2, which improves the convenience of operation.

[0067] The box 1 is made at least partially of a transparent material that is UV resistant, such as glass or medical engineering plastic. For example, the box 1 is made of medical-grade brown PPSU (Polyphenylsulfone) material, which allows observation of the mouse's condition without opening the box lid 2, making observation and operation convenient, with low manufacturing cost, and is resistant to high temperature and has good tolerance to ultraviolet light.

[0068] Furthermore, the side wall of the housing 1 is provided with an air inlet 12 connecting the receiving cavity 11 and the external environment, and the housing cover 2 is provided with an air outlet 21 penetrating its upper and lower surfaces, and the receiving cavity 11 is connected to the external environment through the air outlet 21. The lamp assembly 4 is provided with a ventilation opening 41a for air circulation (e.g., Figure 4(As shown). The fan 6 is installed in the area corresponding to the air outlet 21 on the cover 2, and is located on the side of the lamp assembly 4 away from the containment cavity 11. It is used to draw the gas in the containment cavity 11 to the outside of the box 1, so as to guide the outside air from the air inlet 12 through the containment cavity 11 and the vent 41a, and exhaust it through the air outlet 21, thereby removing the heat generated by the lamp assembly 4 in the containment cavity 11, thereby reducing the temperature inside the containment cavity 11 and preventing stress response and heatstroke in mice caused by high temperature. In addition, the air circulation in the containment cavity 11 achieved by the fan 6 can reduce the ozone content in the containment cavity 11, which is beneficial to the health of mice.

[0069] The number of air inlets 12 can be one or more, such as Figure 1 As shown, in one embodiment, multiple air inlets 12 are located at the bottom of the side wall of the housing 1 and are spaced apart along the width direction of the housing 1. The location of the air inlets 12 at the bottom of the side wall of the housing 1, and the air outlet 21 located on the housing cover 2, facilitates extending the airflow path of the external environment within the containment cavity 11, thereby improving the cooling effect. It should be noted that this invention does not limit the shape of the air inlets 12; the projection of the air inlet 12 along its extension direction can be square (e.g., ...). Figure 1 (as shown), rectangle or circle (e.g.) Figure 6 (as shown in the image) etc.

[0070] In one embodiment, an air filter membrane 5 is detachably installed in the area of ​​the housing 1 corresponding to the air inlet 12. This ensures airflow while filtering and purifying the air entering the containment cavity 11, removing suspended particulate matter, bacteria, viruses, and other microorganisms from the air, improving the cleanliness of the containment cavity 11, preventing external pollutants from infecting mice, and improving the accuracy of experimental results. Specifically, the air filter membrane 5 includes a filter membrane body 51 and a mounting ring 52. The filter membrane body 51 can be fixedly connected to the mounting ring 52 by means of adhesive bonding, fastener connection, or other methods.

[0071] See Figure 1 and Figure 2 In one embodiment, there are two mounting rings 52, which are stacked and fixedly connected by fasteners. The edge of the filter membrane body 51 is fixedly sandwiched between the two mounting rings 52. In this embodiment, the mounting rings 52 are detachably connected to the air inlet 12 of the housing 1 by means of snap-fit, fastener connection, etc., which facilitates the installation and removal of the air filter membrane 5, thereby facilitating the replacement of the filter membrane body 51.

[0072] See Figure 3 In some embodiments, the lamp assembly 4 includes a diffuser plate 41 and a lamp tube 42, combined with Figure 4Specifically, the lamp tube 42 is set to correspond to the light diffusion plate 41 and is detachably connected to at least one of the light diffusion plate 41 or the box cover 2, so as to facilitate quick replacement of the lamp tube 42 and thus allow the lamp tube 42 with different wavelength combinations to be replaced according to experimental needs.

[0073] In one embodiment, the lamp tube 42 is detachably connected to the light-diffusing plate 41 by a snap-fit ​​connection. Multiple light-diffusing plates 41 extend along the length of the housing 1 and are spaced apart along the width of the housing 1, with the spacing between the multiple light-diffusing plates 41 forming a ventilation opening 41a. The lamp tube 42 includes at least one of UVA and UVB lamps to accommodate experimental requirements of different ultraviolet wavelengths. In one embodiment, the lamp tube 42 includes multiple UVA lamps; in another embodiment, the lamp tube 42 includes multiple UVB lamps; and in yet another embodiment, the lamp tube 42 includes several UVA lamps and several UVB lamps. It should be noted that this invention does not limit the number of lamp tubes 42. The number of lamp tubes 42 can be the same as the number of light-diffusing plates 41, and each light-diffusing plate 41 has a lamp tube 42 located below it. The number of lamp tubes 42 can also be less than the number of light-diffusing plates 41. By increasing or decreasing the number of lamp tubes 42, the light intensity can be adjusted.

[0074] Combination Figure 5 The light-diffusing plate 41 includes a first light-diffusing section 411, a second light-diffusing section 412, and a third light-diffusing section 413. The first light-diffusing section 411 extends along the length of the lamp tube 42. The first light-diffusing section 411 extends outward from its opposite sides in a direction perpendicular to its extension direction to form the second light-diffusing section 412 and the third light-diffusing section 413. The second light-diffusing section 412 and the third light-diffusing section 413 are symmetrically arranged to make the light distribution in the receiving cavity 11 more uniform and reduce the light gradient of "strong in the center and weak at the edge" in the irradiated area. In addition, when there are multiple restraints 3, that is, when multiple mice are placed in the receiving cavity 11, the second light-diffusing section 412 and the third light-diffusing section 413 are inclined relative to the first light-diffusing section 411, making the light distribution more uniform and thus improving the consistency of experimental results.

[0075] In some embodiments, the fixture 3 includes a housing 3a and a cover (not shown). The housing 3a is a hollow column with an opening, made of quartz material, allowing ultraviolet light to pass through. The cover selectively seals the opening of the housing 3a. For example, the cover is connected to the housing 3a by a hinge or slide rail, or the cover is detachably connected to the housing 3a by fasteners or snap-fit, facilitating the placement of the mouse and restricting its position. Specifically, the housing 3a includes a bottom plate 31, a top plate 32, and a side plate 33. The bottom plate 31 and the top plate 32 are connected end to end, and the side plate 33 is connected to the side of the bottom plate 31 and the top plate 32 away from the cover. The top plate 32, the bottom plate 31, and the side plate 33 can be fixedly connected by adhesive, snap-fit, or fasteners. The top plate 32, the bottom plate 31, and the side plate 33 can also be integrally formed. The bottom plate 31, the top plate 32, the side plate 33, and the cover enclose a space for accommodating the mouse, resulting in a simple structure.

[0076] In one embodiment, the base plate 31 is rectangular and flat, allowing the restrainer 3 to be placed more stably on the support plate 7. The top plate 32, projected along the axial direction of the restrainer 3, is arc-shaped, adapting to the mouse's body shape and facilitating the restraint of the mouse's position. Furthermore, the side plate 33 has multiple ventilation holes 331 for air circulation, ensuring smooth breathing for the mouse, and the cover has clearance holes for the mouse's tail to pass through. It should be noted that this invention does not limit the number of restrainers 3, such as... Figure 6 As shown, there are multiple restraints 3, which can be used to conduct experiments on multiple mice at the same time, thus improving experimental efficiency.

[0077] In one embodiment, the lamp tube 42 includes a plurality of UVA lamp tubes and a plurality of UVB lamp tubes, and the UVA and UVB lamp tubes are arranged alternately or at intervals on the side of the box cover 2 facing the box body 1. In this embodiment, the bottom plate 31 and the top plate 32 of the fixture 3 extend in a direction perpendicular to the length direction of the lamp tube 42, so that the ultraviolet rays of different wavelengths emitted by the UVA lamp tubes and UVB lamp tubes can be fully superimposed and mixed when they irradiate the mouse skin, avoiding excessive UVA or UVB intensity in local areas due to the setting position of the fixture 3.

[0078] In some embodiments, a sealing ring is sandwiched between the lid 2 and the body 1. The sealing ring is made of silicone or rubber material and is used to improve the sealing between the lid 2 and the body 1 to prevent gas exchange between the containment cavity 11 and the external environment.

[0079] See Figure 1The mouse skin photoaging experimental device of this utility model also includes a support plate 7 and a lifting mechanism (not shown in the figure). The support plate 7 is located in the receiving cavity 11 and is used to support the fixation device 3. The lifting mechanism can be a linkage mechanism or telescopic rod in the prior art, which is used to enable the support plate 7 to move relative to the box 1 along the height direction of the box 1, thereby adjusting the distance between the fixation device 3 and the lamp group 4. By adjusting the distance between the lamp group 4 and the back of the mouse, the light intensity required for the experiment is met.

[0080] In the above embodiment, the housing 1 is provided with distance measuring marks along its height direction to indicate the position of the fixture 3 in the height direction of the housing 1, facilitating the adjustment of the distance between the fixture 3 and the lamp assembly 4. Compared with relying on the operator's experience, this improves the adjustment accuracy and thus enhances the reliability of experimental data. Specifically, the distance measuring marks are linear scale marks with equal spacing extending along the height direction of the housing 1. The distance measuring marks are set on the surface of the side wall of the housing 1, for example, on the edge area of ​​the side wall of the housing 1, to avoid obstructing the observation field of the housing 1. The distance measuring marks can be fixed to the side wall of the housing 1 by adhesive bonding or snap-fitting, or they can be integrally formed on the side wall of the housing 1 by screen printing, laser etching, etc., improving the convenience of experimental operation.

[0081] In one embodiment, the fixture 3 is provided with a light-shielding layer, which can be made of opaque materials such as tin foil or cardboard. Specifically, the light-shielding layer is installed in the fixture 3 by means of adhesion or embedding to block ultraviolet rays from irradiating the non-irradiated areas, thus limiting the irradiated area of ​​the mouse skin. This allows for the construction of experimental and control groups on the skin of the same mouse, thereby avoiding the influence of individual differences on the experimental and control group results and improving the accuracy of the experimental results.

[0082] In one embodiment, the mouse skin photoaging experimental device includes a temperature control module. The module includes a controller communicatively connected to a fan 6 and a temperature probe electrically connected to the controller. The temperature probe is disposed on the inner surface of the fixture 3 to detect the temperature inside the fixture 3. The controller controls the opening and closing of the fan 6, thereby adjusting the temperature inside the containment cavity in real time to ensure animal welfare. Since the heat tolerance threshold of mice is typically 32-35°C, the mouse skin photoaging experimental device of this invention lowers the temperature inside the containment cavity 11 through the fan 6, preventing the temperature inside the containment cavity 11 from exceeding the heat tolerance threshold of the mice, thereby reducing the risk of stress response and overheating death caused by high temperatures in the mice.

[0083] The temperature control module also includes a light detection probe, which is set on the inner surface of the fixture 3 and is used to detect the light intensity of the area corresponding to the fixture 3 in the receiving cavity 11. The light detection probe is electrically connected to the controller to ensure that the light intensity requirements of the experiment are met.

[0084] The temperature control module includes a button and a timing module. The timing module is electrically connected to the controller. The button is used to control the opening and closing of the lamp group 4. The timing module can turn off the lamp tube 42 when the irradiation time reaches a preset value to ensure the physiological safety of the mice.

[0085] The working principle of the mouse skin photoaging experimental device of this utility model is as follows: When the temperature probe of the temperature control module detects that the temperature inside the fixation device 3 exceeds the set value, the controller controls the fan 6 to turn on to reduce the temperature inside the containment cavity 11, and controls the lamp tube 42 of the lamp group 4 to turn off to prevent the temperature inside the containment cavity 11 from continuing to rise. At the same time, the controller also controls the timing module to stop working to pause the cumulative irradiation time.

[0086] When the temperature probe detects that the temperature inside the fixture 3 has dropped below the set value, the temperature control module turns on the lamp 42 through the controller and controls the timing module to continue accumulating time. When the accumulated irradiation time reaches the preset value, the controller turns off the lamp 42 to ensure the physiological safety of the mice.

[0087] Example 2

[0088] See Figure 6 The main difference between this embodiment and Embodiment 1 is that the receiving cavity 11 of the box 1 is used to connect with an external anesthesia system, allowing anesthetic gas to enter the receiving cavity 11, thereby preventing irradiation deviation caused by the unstable position of the mouse and improving the accuracy of the experiment. Specifically, the air inlet 12 on the box 1 is used to connect with the anesthesia system, allowing anesthetic gas to enter the receiving cavity 11 from the anesthesia system through the air inlet 12.

[0089] In this embodiment, the housing 1 is also provided with an air outlet 13, and the air inlet 12 and the air outlet 13 are arranged at different height positions of the housing 1. For example, the air inlet 12 is located in the lower region of the housing 1, and the air outlet 13 is located in the upper region of the housing 1, and are respectively connected to the anesthesia system. Since the density of anesthetic gas is greater than that of air, by setting the air inlet 12 in the lower region of the housing 1, the anesthetic gas enters from the bottom of the housing 1, gradually flows upward and replaces the air in the housing 1, thereby filling the containment cavity 11 more evenly and improving the anesthesia efficiency.

[0090] Furthermore, a sealing element 81 is provided on the area of ​​the cover 2 corresponding to the fan 6 (i.e., the air outlet 21 area). During anesthesia, the fan 6 is in the off state, and the sealing element 81 can selectively cover and seal the air outlet 21 to block the airflow path between the containment cavity 11 and the external environment, preventing the anesthetic gas in the containment cavity 11 from escaping to the external environment. In one embodiment, the sealing element 81 can be a flexible sealing blanket made of elastic materials such as plastic or rubber. In another embodiment, the sealing element 81 can also be a sealing plate made of hard materials such as metal, which can selectively cover the air outlet 21 by means of buckles, fasteners, or magnetic attraction to achieve a sealing effect.

[0091] In this embodiment, an ice storage box 82 is also provided inside the receiving cavity 11 of the box 1. The ice storage box 82 is used to hold pre-frozen ice. During anesthesia, the melting of the ice in the ice storage box 82 absorbs heat from the receiving cavity 11, thereby reducing the temperature inside the receiving cavity 11 and reducing the stress response of mice caused by high temperature. Specifically, the ice storage box 82 is located on the side wall and bottom of the box 1, such as... Figure 6 The ice storage box is placed at the bottom of the box 1 for easy replacement and maintenance.

[0092] While specific embodiments of this utility model have been described above, those skilled in the art should understand that these are merely illustrative examples, and the scope of protection of this utility model is defined by the appended claims. Those skilled in the art can make various changes or modifications to these embodiments without departing from the principles and essence of this utility model, but all such changes and modifications fall within the scope of protection of this utility model.

Claims

1. A mouse skin photoaging experimental device, characterized in that, The device includes a box body, a box lid, and a restraint for limiting the position of a mouse. The box body has a receiving cavity and an opening corresponding to the receiving cavity. The restraint is placed inside the receiving cavity. The box lid is detachably sealed to the opening of the box body. The box cover is provided with a lamp assembly for irradiating mouse skin on the side facing the receiving cavity, and the lamp assembly is provided with a vent for air circulation; The enclosure is provided with an air inlet for communicating with the external environment, and an air filter membrane is arranged on the enclosure corresponding to the air inlet; The cover is equipped with a fan located on the side of the lamp assembly away from the receiving cavity. The fan is used to extract the gas in the receiving cavity to the outside of the box, so as to guide the outside air from the air inlet through the receiving cavity.

2. The mouse skin photoaging experimental apparatus as described in claim 1, characterized in that, The light assembly includes a light diffuser plate and a light tube. Multiple light diffuser plates extend along the length of the housing and are spaced apart along the width of the housing. The spacing between the multiple light diffuser plates forms the ventilation opening. Multiple lamps are disposed corresponding to the light diffuser plate and are detachably connected to at least one of the light diffuser plate or the cover.

3. The mouse skin photoaging experimental apparatus as described in claim 1, characterized in that, The air filter membrane includes a filter membrane body and a mounting ring. The filter membrane body covers the air inlet and is detachably fixed to the area of ​​the housing corresponding to the air inlet by the mounting ring.

4. The mouse skin photoaging experimental apparatus as described in claim 1, characterized in that, It also includes a support plate and a lifting mechanism. The support plate is located inside the receiving cavity and is used to support the fixture. The lifting mechanism is used to enable the support plate to move relative to the box body along the height direction of the box body.

5. The mouse skin photoaging experimental apparatus as described in claim 4, characterized in that, The box is marked with distance measuring marks along its height.

6. The mouse skin photoaging experimental apparatus as described in claim 1, characterized in that, The fixation device includes a shell and a cover. The shell is a hollow column with an opening, and the cover selectively seals the opening of the shell. The shell and the cover together form an accommodating space for accommodating a mouse.

7. The mouse skin photoaging experimental apparatus as described in claim 6, characterized in that, The housing includes a bottom plate, a top plate, and a side plate. The bottom plate and the top plate are connected end to end, and the side plate is connected to the bottom plate and the top plate on the side away from the cover. The side panel has multiple ventilation holes, and the cover has a clearance hole for the mouse's tail to pass through.

8. The mouse skin photoaging experimental apparatus as described in claim 1, characterized in that, The area of ​​the box cover corresponding to the fan is covered with a sealing element. The air inlet is located in the lower part of the box body, and the air outlet is located in the upper part of the box body. The air inlet and the air outlet are respectively used to connect to an external anesthesia system.

9. The mouse skin photoaging experimental apparatus as described in claim 1, characterized in that, The device includes a temperature control module, which includes a controller that is communicatively connected to the fan and a temperature probe that is electrically connected to the controller. The temperature probe is disposed on the inner surface of the fixture and is used to measure the temperature inside the fixture in real time. The controller is used to control the fan to turn on or off.

10. The mouse skin photoaging experimental apparatus as described in claim 9, characterized in that, The temperature control module includes a light detection probe, which is disposed on the inner surface of the fixture and is used to detect the light intensity in the area corresponding to the fixture within the receiving cavity. The light detection probe is electrically connected to the controller. The temperature control module also includes a timing module, which is electrically connected to the controller.

Images