Material adding metering system for imipenem crude product production

Abstract

The utility model discloses a kind of material adding metering systems for imine penem crude production, including the reaction tank body for carrying out material reaction operation, the reaction tank body has two, two reaction tank body upper is provided with two metering tank body and two metering tank body is correspondingly set with two reaction tank body, two reaction tank body is connected with corresponding metering tank body by flow pipeline respectively, two metering tank body upper is provided with buffer tank body and two metering tank body is all connected with the buffer tank body;Balancing pipe is arranged between the reaction tank body and corresponding metering tank body, and the both ends of balancing pipe are connected with metering tank body top inside, reaction tank body top inside respectively. The entire DIPEA adding process of the material adding metering system is all closed structure, there is no DIPEA volatilization, leakage risk, improves the production operation safety of imine penem.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical chemistry, and in particular to a material addition metering system for the production of crude imipenem. Background Technology

[0002] Imipenem, also known as 6-(1-hydroxyethyl)-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, belongs to the carbapenem β-lactam antibiotic class. It can inhibit the formation of bacterial cell walls when combined with various penicillins, thereby eliminating bacteria that parasitize host cells. It also exhibits strong activity against Gram-positive and Gram-negative aerobic and anaerobic organisms and high stability against β-lactamases. Therefore, it has great market potential and high clinical usage.

[0003] In the production of crude imipenem, the amount of DIPEA added directly affects the product quality, yield, and impurity content. Therefore, it is necessary to control the amount of DIPEA added. Patent No. ZL202021751735.5 discloses a quantitative addition device for injection production, which can realize the material addition operation. However, DIPEA is a flammable, volatile, and toxic liquid. When the above-mentioned device is used for open feeding, there are potential safety risks and it may affect the health of the operators. Therefore, it is necessary to study a material addition metering system for the production of crude imipenem to solve the above problems. Summary of the Invention

[0004] The purpose of this invention is to address the above-mentioned problems by providing a simple and convenient material addition metering system for the production of crude imipenem.

[0005] To achieve the above objectives, the technical solution of this utility model is as follows: A material addition metering system for the production of crude imipenem includes two reaction tanks for material reaction operations. Two metering tanks are positioned above the two reaction tanks, corresponding to each other. Each reaction tank is connected to its corresponding metering tank via a flow pipe. A buffer tank is positioned above each metering tank, and both metering tanks are connected to it. A balance pipe is installed between each reaction tank and its corresponding metering tank, with both ends connected to the top interior of the metering tank and the top interior of the reaction tank, respectively.

[0006] Furthermore, the top of the buffer tank is provided with a material pipeline and is connected to the material storage tank through the material pipeline, and the material pipeline is provided with a feed valve; the bottom of the buffer tank is provided with a metering pipeline with a two-part structure and is connected to two metering tanks respectively through the metering pipeline, and the metering pipeline is provided with metering control valves corresponding to the two metering tanks.

[0007] Furthermore, a flow control valve is installed on the flow pipe, and a balance control valve is installed on the balance pipe.

[0008] Furthermore, a transparent graduation sight glass is provided on the side wall of the metering tank, and the graduation sight glass is set along the height direction of the metering tank; the graduation sight glass is provided with metering scale.

[0009] Furthermore, a pressure gauge is installed at the top of the metering tank for monitoring the internal pressure of the metering tank.

[0010] Furthermore, the bottom of the reaction vessel is provided with a discharge port, and the discharge ports at the bottom of the two reaction vessels are connected by a first three-way pipe with a two-in-one structure. Three discharge control valves are provided in the first three-way pipe, and the three ports of the first three-way pipe are controlled by the three discharge control valves.

[0011] Furthermore, a vacuum port is provided on one side of the top of the reaction vessel. The vacuum ports of the two reaction vessels are connected by a two-in-one three-way pipe. Two ports of the two-in-one three-way pipe are respectively connected to the vacuum ports of the two reaction vessels, and the other port of the two-in-one three-way pipe is connected to a gas storage container through a vacuum pump. A vacuum control valve corresponding to the two reaction vessels is provided on the two-in-one three-way pipe.

[0012] Furthermore, a connecting port is provided on one side wall of the gas storage container and is connected to the second three-way pipe through the connecting port. A connection port is provided on the side wall of the gas storage container, and an elastic rubber pad is provided on the outside of the connection port. The edge of the rubber pad is sealed to the outer wall of the gas storage container so that a sealed cavity is formed inside the gas storage container. The inner wall of the rubber pad and the inner wall of the gas storage container are both coated with an anti-corrosion coating.

[0013] Compared with the prior art, the advantages and positive effects of this utility model are: In the production of crude imipenem, this invention first transfers DIPEA from the material storage tank to a metering tank via a material pipeline, and determines the amount added using a graduated sight glass on the outside of the metering tank. Next, the DIPEA in the metering tank flows into the reaction tank through a flow pipe for the crude imipenem reaction. Simultaneously, a balancing pipe ensures gas flow between the metering and reaction tanks during the transfer process, preventing pressure differences from affecting material flow. The entire DIPEA addition process of this material addition metering system is a closed structure, eliminating the risk of DIPEA volatilization or leakage, thus improving the safety of imipenem production and ensuring the health of operators. Furthermore, by using two sets of metering and reaction tanks to alternately add material and perform the reaction, this invention enables continuous and safe addition of DIPEA and continuous production of imipenem, effectively improving production efficiency and further enhancing the overall effectiveness of this invention. Attached Figure Description

[0014] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0015] Figure 1 This is a schematic diagram of the structure of this utility model; Figure 2 This is a cross-sectional view of a gas storage container in its normal state. Figure 3 This is a cross-sectional view of the gas storage container in its expanded state. Detailed Implementation

[0016] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, any modifications, equivalent substitutions, improvements, etc., made by those skilled in the art to all other embodiments obtained without creative effort should be included within the protection scope of the present utility model.

[0017] like Figure 1 , Figure 2 and Figure 3As shown, this embodiment discloses a material addition metering system for the production of crude imipenem, including two reaction tanks 1 for material reaction operations; the bottom of each reaction tank 1 is provided with a discharge port, and the discharge ports at the bottom of the two reaction tanks 1 are connected by a first three-way pipe 10 with a two-in-one structure. Three discharge control valves 1001 are provided in the first three-way pipe 10, and the three ports of the first three-way pipe 10 are controlled by the three discharge control valves 1001; a vacuum port is provided on one side of the top of each reaction tank 1, and the vacuum ports of the two reaction tanks 1 are connected by a second three-way pipe 8 with a two-in-one structure. Two ports of the second three-way pipe 8 are respectively connected to the vacuum ports of the two reaction tanks 1, and the other port of the second three-way pipe 8 is connected to a gas storage container 9 through a vacuum pump 11; a vacuum control valve 801 corresponding to the two reaction tanks 1 is provided on the second three-way pipe 8.

[0018] A connecting port 901 is provided on one side wall of the gas storage container 9, and the connecting port 901 is connected to the second three-way pipe 8. A connection port is provided on the side wall of the gas storage container 9, and an elastic rubber pad 902 is provided on the outside of the connection port. The edge of the rubber pad 902 is sealed to the outer wall of the gas storage container 9, so that a sealed cavity is formed inside the gas storage container 9. The inner wall of the rubber pad 902 and the inner wall of the gas storage container 9 are both coated with an anti-corrosion coating to prevent the material from corroding them.

[0019] Two metering tanks 2 are installed above the two reaction tanks 1, and the two metering tanks 2 are corresponding to the two reaction tanks 1. The two reaction tanks 1 are connected to the corresponding metering tanks 2 through flow pipes 6, and flow control valves 601 are installed on the flow pipes 6. A transparent scale sight glass 201 is installed on the side wall of the metering tank 2, and the scale sight glass 201 is set along the height direction of the metering tank 2. The scale sight glass 201 is provided with metering scale. A pressure gauge 202 for monitoring the internal pressure of the metering tank 2 is installed at the top of the metering tank 2.

[0020] A balance pipe 7 is provided between the reaction vessel 1 and the corresponding metering vessel 2. The two ends of the balance pipe 7 are connected to the inside of the top of the metering vessel 2 and the inside of the top of the reaction vessel 1, respectively. A balance control valve 701 is provided on the balance pipe 7.

[0021] A buffer tank 3 is provided above the two metering tanks 2, and both metering tanks 2 are connected to the buffer tank 3; a material pipeline 4 is provided at the top of the buffer tank 3 and is connected to the material storage tank through the material pipeline 4, and a feed valve 401 is provided on the material pipeline 4; a metering pipeline 5 with a two-part structure is provided at the bottom of the buffer tank 3 and is connected to the two metering tanks 2 respectively through the metering pipeline 5, and a metering control valve 501 corresponding to the two metering tanks 2 is provided on the metering pipeline 5.

[0022] During the material addition operation, the liquid material in the material storage tank is first transferred to the buffer tank. Then, a vacuum pump is used to extract some of the gas from the reaction tank into the gas storage container. The rubber gasket inside the gas storage container expands under elasticity (e.g., Figure 3 As shown), the reaction vessel is placed under negative pressure. Then, the corresponding metering control valve and balance control valve are opened sequentially, allowing the liquid material in the buffer tank to enter the metering tank under negative pressure. The graduated sight glass on the metering tank is observed; once the designated scale is reached, the metering control valve is closed, and the flow control valve at the bottom of the metering tank is opened, allowing the liquid material in the metering tank to flow into the reaction vessel for reaction. After the material addition is complete, the balance control valve and flow control valve are closed. During product discharge from the reaction vessel, the discharge control valve and vacuum control valve are opened sequentially. The rubber pad inside the gas storage container returns to its original shape under elasticity, allowing the gas inside the gas storage container to enter the reaction vessel and compress the internal material, causing it to be quickly discharged from the discharge port, thus increasing the discharge rate. In addition, when one of the reaction vessels malfunctions during the reaction process, the reaction materials in the malfunctioning reaction vessel can be transferred to another reaction vessel to continue the reaction operation through the cooperation of the first three-way pipe, the second three-way pipe, and the vacuum pump. This avoids the waste of the internal reaction materials when the reaction vessel malfunctions, and further improves the effectiveness of this utility model.

[0023] In the production of crude imipenem, this invention first transfers DIPEA from the material storage tank to a metering tank via a material pipeline, and determines the amount added using a graduated sight glass on the outside of the metering tank. Next, the DIPEA in the metering tank flows into the reaction tank through a flow pipe for the crude imipenem reaction. Simultaneously, a balancing pipe ensures gas flow between the metering and reaction tanks during the transfer process, preventing pressure differences from affecting material flow. The entire DIPEA addition process of this material addition metering system is a closed structure, eliminating the risk of DIPEA volatilization or leakage, thus improving the safety of imipenem production and ensuring the health of operators. Furthermore, by using two sets of metering and reaction tanks to alternately add material and perform the reaction, this invention enables continuous and safe addition of DIPEA and continuous production of imipenem, effectively improving production efficiency and further enhancing the overall effectiveness of this invention.

Claims

1. A material addition metering system for the production of crude imipenem, comprising a reaction vessel for performing material reaction operations, characterized in that: There are two reaction vessels, and two metering vessels are arranged above the two reaction vessels, with the two metering vessels corresponding to the two reaction vessels. The two reaction vessels are connected to the corresponding metering vessels through flow pipes. A buffer tank is arranged above the two metering vessels, and the two metering vessels are connected to the buffer tank. A balance pipe is arranged between the reaction vessels and the corresponding metering vessels, and the two ends of the balance pipe are connected to the inside of the top of the metering vessel and the inside of the top of the reaction vessel, respectively.

2. The material addition metering system for imipenem crude product production as described in claim 1, characterized in that: The top of the buffer tank is equipped with a material pipeline that connects to the material storage tank. The material pipeline is equipped with an inlet valve. The bottom of the buffer tank is equipped with a metering pipeline with a two-part structure that connects to two metering tanks. The metering pipeline is equipped with metering control valves corresponding to the two metering tanks.

3. The material addition metering system for imipenem crude product production as described in claim 1, characterized in that: A flow control valve is installed on the flow pipe, and a balance control valve is installed on the balance pipe.

4. The material addition metering system for imipenem crude product production as described in claim 1, characterized in that: A transparent graduation sight glass is provided on the side wall of the metering tank, and the graduation sight glass is set along the height direction of the metering tank; the graduation sight glass is provided with metering scale.

5. The material addition metering system for imipenem crude product production as described in claim 1, characterized in that: The metering tank is equipped with a pressure gauge at its top for monitoring the internal pressure of the metering tank.

6. The material addition metering system for imipenem crude product production as described in claim 1, characterized in that: The bottom of the reaction vessel is provided with a discharge port. The discharge ports at the bottom of the two reaction vessels are connected by a first three-way pipe with a two-in-one structure. Three discharge control valves are installed in the first three-way pipe and the three ports of the first three-way pipe are controlled by the three discharge control valves.

7. The material addition metering system for imipenem crude product production as described in claim 1, characterized in that: A vacuum port is provided on one side of the top of the reaction vessel. The vacuum ports of the two reaction vessels are connected by a two-in-one three-way pipe. Two ports of the two-in-one three-way pipe are connected to the vacuum ports of the two reaction vessels respectively, and the other port of the two-in-one three-way pipe is connected to a gas storage container through a vacuum pump. A vacuum control valve corresponding to the two reaction vessels is provided on the two-in-one three-way pipe.

8. The material addition metering system for imipenem crude product production as described in claim 7, characterized in that: The gas storage container has a connecting port on one side wall, which is connected to a second three-way pipe. The gas storage container also has a connection port on its side wall, and an elastic rubber pad is provided on the outside of the connection port. The edge of the rubber pad is sealed to the outer wall of the gas storage container to form a sealed cavity inside the gas storage container. The inner wall of the rubber pad and the inner wall of the gas storage container are both coated with an anti-corrosion coating.

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