Microchannel reactor for sulfonamide continuous amidation reactions

Abstract

The utility model relates to chemical engineering technical field discloses a micro -channel reactor for sulfonamide continuous amidation reaction, including micro -pipeline, the left and right sides of micro -pipeline all are provided with mounting mechanism, the mounting mechanism is used for controlling the amount of liquid in micro -pipeline, the inner wall of micro -pipeline is provided with dismounting mechanism, the dismounting mechanism is used for the dismounting of convenient inside filter equipment, the mounting mechanism includes two fixed rings, the adjacent side of two fixed rings with the left and right sides of micro -pipeline outer wall all are fixedly connected, the side away from of two fixed rings all is provided with hollow shell, the inner wall of hollow shell is provided with transmission assembly. In the utility model, push the push rod and drive the inner tooth ring to rotate, the gear drives fixed column no.

Description

Technical Field

[0001] This invention relates to the field of chemical engineering technology, and in particular to a microchannel reactor for continuous amidation reaction of sulfonamides. Background Technology

[0002] Traditional sulfonamide amidation reactions often employ batch reactors. The operation process includes feeding, reaction, and discharging steps, resulting in long non-production times, long production cycles per batch, and low equipment capacity per unit time. Furthermore, material mixing in batch systems relies on stirring, leading to variations in reaction temperature and concentration distribution between different batches, resulting in significant fluctuations in product yield and making it difficult to meet the stringent quality uniformity requirements of the pharmaceutical and chemical industries. The raw materials commonly used in sulfonamide amidation reactions are highly corrosive and toxic, and the reactions are exothermically intense. In batch reactors, if stirring fails or feeding is too rapid, runaway temperatures, material spills, or even explosions can easily occur. In addition, batch reactions consume large amounts of solvent, generating substantial amounts of waste liquid and residue, requiring significant energy and reagent consumption for subsequent treatment, which does not meet the requirements of green chemistry. Microchannel reactors, on the other hand, have small material channel sizes, enabling complete radial mixing within millisecond ranges. They offer strong heat exchange capabilities, extremely narrow residence times, and large specific surface areas, allowing reactants to mix and exchange heat within micron-sized or even smaller spatial regions, shortening reaction and separation times and reducing the generation of byproducts.

[0003] In chemical production, precise control of liquid flow rate ensures uniform input of raw materials, allows the reaction to proceed according to predetermined stoichiometric relationships, avoids drastic changes in temperature and pressure during the reaction, and thus ensures consistent product quality. Current technologies utilize flow sensors to collect the current flow rate during the raw material delivery process in microreactors. Based on the difference between the current flow rate and the target flow rate, a flow PID control module determines the corrected flow control amount, thereby controlling the delivery flow rate of the servo system to achieve precise flow control in the microchannel reactor. However, this adjustment method requires a high-precision flow sensor, and the cost of a single system is many times that of mechanical adjustment. Furthermore, the sensor requires regular calibration; if the reaction fluid contains corrosive components, it will accelerate the aging of the sensor probe, leading to a shorter calibration cycle and increased maintenance costs. Utility Model Content

[0004] To overcome the above shortcomings, this invention provides a microchannel reactor for the continuous amidation reaction of sulfonamides. It aims to improve upon existing technologies where the control method requires a high-precision flow sensor, resulting in a system cost several times higher than mechanical control. Furthermore, if the reaction fluid contains corrosive components, it will accelerate the aging of the sensor probe, increasing maintenance costs.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: a microchannel reactor for continuous amidation reaction of sulfonamide, comprising a microchannel, wherein an installation mechanism is provided on both the left and right sides of the microchannel, the installation mechanism is used to control the amount of liquid entering the microchannel, and a disassembly mechanism is provided on the inner wall of the microchannel, the disassembly mechanism is used to facilitate the disassembly of the internal filtration equipment. The installation mechanism includes two fixing rings. The adjacent sides of the two fixing rings are fixedly connected to the left and right sides of the outer wall of the micro-channel. The opposite sides of the two fixing rings are provided with hollow shells. The inner wall of the hollow shells is provided with a transmission component. The right side of the transmission component is provided with a sealing component. The bottom of the transmission component is provided with a pushing component.

[0006] As a further description of the above technical solution: The disassembly mechanism includes multiple screws, the outer walls of which are threaded to the outer edge of the fixing ring. A hollow column is fixedly connected to the middle of the inner wall of the micro-channel. Multiple reaction balls are arranged on the inner wall of the hollow column. A reaction component is arranged on the left side of the hollow column, and a pulling component is arranged on the right side of the hollow column.

[0007] As a further description of the above technical solution: The transmission assembly includes an internal gear ring, the outer wall of which is rotatably connected to the middle of the inner wall of the hollow shell, and multiple gears meshing with the inner wall of the internal gear ring. A fixing post is fixedly connected to the left side of each gear.

[0008] As a further description of the above technical solution: The enclosure component includes a second fixed post, the left end of which is fixedly connected to the right side of the gear, and the right end of which is fixedly connected to a sealing plate.

[0009] As a further description of the above technical solution: The pushing assembly includes a pushing rod, the top end of which is fixedly connected to the bottom of the outer wall of the inner toothed ring, and a hollow groove is formed at the bottom of the outer wall of the hollow shell.

[0010] As a further description of the above technical solution: The reaction assembly includes a sliding plate, the outer wall of which is slidably connected to the inner wall of the transmission assembly, and a plurality of filter holes are provided on the left side of the sliding plate.

[0011] As a further description of the above technical solution: The pulling assembly includes a pulling column, the left end of which is fixedly connected to the right side of the sliding plate, and a fixing block is fixedly connected to the right end of the pulling column. A baffle is fixedly connected to the right side of the inner wall of the hollow column.

[0012] As a further description of the above technical solution: The left end of the fixed column is rotatably connected to the left side of the inner wall of the hollow shell, and the inner wall of the baffle is fixedly connected to the outer wall of the pulling column.

[0013] This utility model has the following beneficial effects: 1. In this utility model, when adjusting the flow rate of the amination reaction liquid, the push rod is pushed, which drives the internal gear ring to rotate. The internal gear ring drives the four gears on the inner wall to rotate, and the gears drive the fixed column two and the sealing plate to rotate. Because the fixed position of the fixed column two is off-center from the gear center, the sealing plate opens when the gear rotates, thereby controlling the flow rate of the incoming liquid, preventing excessive liquid from clogging the micro-pipeline, and reducing costs.

[0014] 2. In this invention, if the reaction inside the hollow column requires filtration, the screw is turned, the hollow shell is removed, and then the fixing block is pulled, which moves the pulling column and sliding plate to the right. When the sliding plate moves to the right, it pushes out the reaction ball inside the hollow column, thus achieving complete disassembly and replacement of the reaction ball. This simplifies the disassembly process and improves the practicality and durability of the equipment. Attached Figure Description

[0015] Figure 1 This is a front perspective view of the microchannel reactor for the continuous amidation reaction of sulfonamides proposed in this utility model; Figure 2 This is a side view of the microchannel reactor for the continuous amidation reaction of sulfonamides proposed in this invention. Figure 3 This is a partial structural diagram of the microchannel reactor for the continuous amidation reaction of sulfonamides proposed in this utility model; Figure 4 This is a partial structural diagram of the microchannel reactor for the continuous amidation reaction of sulfonamides proposed in this utility model; Figure 5 This is a partial structural schematic diagram of the microchannel reactor for the continuous amidation reaction of sulfonamides proposed in this utility model.

[0016] Legend: 1. Micro-channel; 2. Installation mechanism; 201. Fixing ring; 202. Hollow shell; 203. Transmission assembly; 2031. Internal gear ring; 2032. Fixing post one; 2033. Gear; 204. Sealing assembly; 2041. Fixing post two; 2042. Sealing plate; 205. Pushing assembly; 2051. Push rod; 2052. Hollow groove; 3. Disassembly mechanism; 301. Screw; 302. Hollow column; 303. Reaction ball; 304. Reaction assembly; 3041. Sliding plate; 3042. Filter hole; 305. Pulling assembly; 3051. Pulling post; 3052. Fixing block; 3053. Baffle. Detailed Implementation

[0017] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0018] Please see the appendix Figure 1 Appendix Figure 2 and attached Figure 3 An embodiment of this utility model is provided: a microchannel reactor for continuous amidation reaction of sulfonamide, including a microchannel 1, with an installation mechanism 2 on both the left and right sides of the microchannel 1. The installation mechanism 2 is used to control the amount of liquid entering the microchannel 1. The inner wall of the microchannel 1 is provided with a disassembly mechanism 3, which is used to facilitate the disassembly of the internal filtration equipment. The mounting mechanism 2 includes two fixing rings 201. The adjacent sides of the two fixing rings 201 are fixedly connected to the left and right sides of the outer wall of the micro-channel 1. Hollow shells 202 are provided on the opposite sides of the two fixing rings 201. A transmission component 203 is provided on the inner wall of the hollow shell 202. A sealing component 204 is provided on the right side of the transmission component 203. A pushing component 205 is provided at the bottom of the transmission component 203. The transmission component 203 includes an internal gear ring 2031. The outer wall of the internal gear ring 2031 is rotatably connected to the middle of the inner wall of the hollow shell 202. Multiple gears 2033 are meshed on the inner wall of the internal gear ring 2031. A fixing post 2032 is fixedly connected to the left side of the gear 2033. Specifically, the main function of the installation mechanism 2 is to precisely control the flow rate of the liquid entering the micro-pipe 1 to ensure the normal operation of the system. It can achieve precise adjustment of the liquid flow rate, thereby ensuring that the flow state of the liquid inside the micro-pipe 1 meets the working requirements of the system. The main function of the disassembly mechanism 3 is to facilitate users to quickly and conveniently disassemble and maintain the filter equipment inside the micro-pipe 1, thereby extending the service life of the equipment and improving the maintenance efficiency of the system. The adjacent side of the retaining ring 201 is fixedly connected to the micro-pipe 1 to ensure the stability of the installation mechanism 2. The fixed ring 201 is fixedly connected to the micro-pipe 1 to prevent loosening or displacement during operation. The transmission component 203 can flexibly adjust the flow rate of liquid entering the micro-pipe 1 according to the system requirements to ensure stable system operation. The sealing component 204 is used to prevent liquid leakage and ensure the system's sealing performance. The sealing component 204 can effectively isolate the liquid and prevent leakage during transmission, ensuring the safe operation of the system. The driving component 205 is used to drive the normal operation of the transmission component 203 and provides stable power. The output ensures that the transmission assembly 203 can work continuously and efficiently. The internal gear ring 2031 is rotatably connected to the hollow shell 202 to ensure the smoothness of the transmission process. The internal gear ring 2031 is fixedly connected to the hollow shell 202 to reduce friction and wear during the transmission process and extend service life. The gear 2033 can withstand a large transmission load to ensure the stability and reliability of the transmission process. The function of the fixing post 2032 is to further stabilize the position of the gear 2033 to ensure the stability and reliability of the entire transmission system. The fixing post 2032 is fixedly connected to the gear 2033 to prevent it from shifting during the transmission process and to ensure the overall stability of the transmission system.

[0019] Please see the appendix Figure 4 and attached Figure 5 The disassembly mechanism 3 includes multiple screws 301, the outer walls of the multiple screws 301 are threaded to the outer edge of the fixing ring 201, a hollow column 302 is fixedly connected to the middle of the inner wall of the micro-channel 1, multiple reaction balls 303 are provided on the inner wall of the hollow column 302, a reaction component 304 is provided on the left side of the hollow column 302, a pulling component 305 is provided on the right side of the hollow column 302, the reaction component 304 includes a sliding plate 3041, the outer wall of the sliding plate 3041 is slidably connected to the inner wall of the transmission component 203, and multiple filter holes 3042 are opened on the left side of the sliding plate 3041; Specifically, screw 301 is threadedly connected to retaining ring 201 to ensure structural stability; reaction ball 303 is used for specific chemical reactions; sliding plate 3041 is slidably connected to transmission assembly 203, allowing sliding plate 3041 to slide freely inside transmission assembly 203; filter hole 3042 is used to filter impurities in fluid or gas; and pulling assembly 305 is used to control the movement of sliding plate 3041, thereby achieving precise control of the reaction process and ensuring the stability and efficiency of the system.

[0020] Please see the appendix Figure 1 Appendix Figure 2 and attached Figure 3The closing component 204 includes a second fixing post 2041, the left end of which is fixedly connected to the right side of the gear 2033, and the right end of the second fixing post 2041 is fixedly connected to a closing plate 2042. The pushing component 205 includes a pushing rod 2051, the top end of which is fixedly connected to the bottom of the outer wall of the internal gear ring 2031. A hollow groove 2052 is provided at the bottom of the outer wall of the hollow shell 202. Specifically, the fixed column 2041 is fixedly connected to the gear 2033, ensuring that the relative position between the two is stable and not easily displaced. The fixed column 2041 is fixedly connected to the enclosed plate 2042, aiming to form a complete enclosed space to ensure the stability and safety of the internal structure. The push rod 2051 is fixedly connected to the internal gear ring 2031, which can ensure that the push rod 2051 can effectively transmit power during the movement, thereby achieving precise control of the internal gear ring 2031. The hollow groove 2052 not only provides the necessary space for the movement of the push rod 2051, but also provides more flexibility and operability for the structural layout of the entire system.

[0021] Please see the appendix Figure 1 Appendix Figure 2 and attached Figure 3 The pulling assembly 305 includes a pulling column 3051. The left end of the pulling column 3051 is fixedly connected to the right side of the sliding plate 3041. A fixing block 3052 is fixedly connected to the right end of the pulling column 3051. A baffle 3053 is fixedly connected to the right side of the inner wall of the hollow column 302. The left end of the fixing column 2032 is rotatably connected to the left side of the inner wall of the hollow shell 202. The inner wall of the baffle 3053 is fixedly connected to the outer wall of the pulling column 3051. Specifically, the pulling column 3051 is fixedly connected to the sliding plate 3041 to ensure that the two can move synchronously and in coordination. The fixed block 3052 is fixedly connected to the pulling column 3051 to provide stability and support. The main function of the baffle 3053 is to prevent the internal objects from shifting during movement. The fixed column 2032 is rotatably connected to the hollow shell 202, allowing the fixed column 2032 to rotate flexibly within a certain range. The baffle 3053 is fixedly connected to the pulling column 3051 to ensure that all parts of the entire pulling assembly 305 can work together during operation to achieve the expected functions and effects.

[0022] Working principle: When it is necessary to adjust the flow rate of the amination reaction liquid, push the push rod 2051. The push rod 2051 will drive the internal gear ring 2031 to rotate. The push rod 2051 will slide along the inner wall of the hollow groove 2052. During the rotation of the internal gear ring 2031, it will drive the four gears 2033 on the inner wall to rotate. The gears 2033 will further drive the fixed column 2041 and the closing plate 2042 to rotate. Since the fixed position of the fixed column 2041 is off from the center of the gears 2033, the closing plate 2042 will open when the gears 2033 rotate. By controlling the sliding distance of the push rod 2051, the opening size of the closing plate 2042 can be controlled, thereby realizing the control of the inflow of liquid, preventing excessive liquid volume from causing internal blockage of the micro-pipeline 1, reducing the operating cost of the equipment, and eliminating concerns about corrosion. If the reaction inside the hollow column 302 requires filtration, screwing the screw 301 will disassemble the hollow shell 202. Then, pulling the fixing block 3052 will cause the pulling column 3051 and the sliding plate 3041 to move to the right. During the movement to the right, the sliding plate 3041 will push out the reaction balls 303 inside the hollow column 302 and disassemble and replace all the reaction balls 303. This realizes the disassembly and replacement of the equipment, simplifies the disassembly steps, and improves the practicality and durability of the equipment.

[0023] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A microchannel reactor for continuous amidation reaction of sulfonamides, comprising microchannels (1), characterized in that: The micro-pipe (1) is provided with an installation mechanism (2) on both the left and right sides. The installation mechanism (2) is used to control the amount of liquid entering the micro-pipe (1). The inner wall of the micro-pipe (1) is provided with a disassembly mechanism (3). The disassembly mechanism (3) is used to facilitate the disassembly of the internal filtration device. The installation mechanism (2) includes two fixing rings (201). The adjacent sides of the two fixing rings (201) are fixedly connected to the left and right sides of the outer wall of the micro-channel (1). Hollow shells (202) are provided on the opposite sides of the two fixing rings (201). A transmission assembly (203) is provided on the inner wall of the hollow shell (202). A sealing assembly (204) is provided on the right side of the transmission assembly (203). A pushing assembly (205) is provided at the bottom of the transmission assembly (203).

2. The microchannel reactor for continuous amidation reaction of sulfonamides according to claim 1, characterized in that: The disassembly mechanism (3) includes multiple screws (301), the outer walls of the multiple screws (301) are threaded to the outer edge of the fixing ring (201), a hollow column (302) is fixedly connected to the middle of the inner wall of the micro-channel (1), multiple reaction balls (303) are provided on the inner wall of the hollow column (302), a reaction component (304) is provided on the left side of the hollow column (302), and a pulling component (305) is provided on the right side of the hollow column (302).

3. The microchannel reactor for continuous amidation reaction of sulfonamides according to claim 2, characterized in that: The transmission assembly (203) includes an internal gear ring (2031), the outer wall of which is rotatably connected to the middle of the inner wall of the hollow shell (202), and a plurality of gears (2033) are meshed on the inner wall of the internal gear ring (2031), and a fixing post (2032) is fixedly connected to the left side of the gear (2033).

4. The microchannel reactor for continuous amidation reaction of sulfonamides according to claim 3, characterized in that: The enclosure component (204) includes a second fixing post (2041), the left end of which is fixedly connected to the right side of the gear (2033), and the right end of which is fixedly connected to a closing plate (2042).

5. The microchannel reactor for continuous amidation reaction of sulfonamides according to claim 3, characterized in that: The pushing assembly (205) includes a pushing rod (2051), the top end of which is fixedly connected to the bottom of the outer wall of the inner toothed ring (2031), and a hollow groove (2052) is provided on the bottom of the outer wall of the hollow shell (202).

6. The microchannel reactor for continuous amidation reaction of sulfonamides according to claim 3, characterized in that: The reaction assembly (304) includes a sliding plate (3041), the outer wall of which is slidably connected to the inner wall of the transmission assembly (203), and a plurality of filter holes (3042) are provided on the left side of the sliding plate (3041).

7. The microchannel reactor for continuous amidation reaction of sulfonamides according to claim 6, characterized in that: The pulling assembly (305) includes a pulling column (3051), the left end of which is fixedly connected to the right side of the sliding plate (3041), and a fixing block (3052) is fixedly connected to the right end of the pulling column (3051). A baffle (3053) is fixedly connected to the right side of the inner wall of the hollow column (302).

8. The microchannel reactor for continuous amidation reaction of sulfonamides according to claim 7, characterized in that: The left end of the fixed column (2032) is rotatably connected to the left side of the inner wall of the hollow shell (202), and the inner wall of the baffle (3053) is fixedly connected to the outer wall of the pulling column (3051).

Images