A device for separating a polypeptide conjugate

Abstract

The utility model provides a kind of polypeptide conjugated drug synthesis is used to separate liquid device, belong to the technical field of medicine, it solves the overall size of the stirring shaft arranged inside it is small, to possibly not effectively stir solution, lead to reaction mixing uneven, reduce reaction rate and the overall quality of product's technical problem.A kind of polypeptide conjugated drug synthesis is used to separate liquid device, including separating liquid cylinder, separating liquid cylinder top is provided with cylinder cover, separating liquid cylinder inside is provided with two first rotating shafts, two first rotating shafts top are slidably equipped with stirring rod, two stirring rods top are all set with two limit slots, two limit slots inside are all equipped with the rotating mechanism for rotating stirring rod, cylinder cover top is symmetrically set with two first sliding slots, two first sliding slots inside are all equipped with the constraint mechanism for constraining cylinder cover.In the utility model, through the setting of two groups of stirring rods, it can be ensured that solution can be more fully mixed.

Description

Technical Field

[0001] This invention belongs to the field of pharmaceutical technology and relates to liquid separation devices, specifically a liquid separation device for the synthesis of polypeptide-coupled drugs. Background Technology

[0002] A search revealed a Chinese patent with authorization number CN217220278U, which discloses a liquid-liquid separation device for the synthesis of polypeptide-conjugated drugs. The device includes a liquid-liquid separation tank, a cover plate connected to the top of the tank, a first inlet pipe and a second inlet pipe connected to the cover plate, a first liquid-liquid separation pipe connected to the bottom of the tank, and a second liquid-liquid separation pipe connected inside the tank. One end of the second liquid-liquid separation pipe is connected to a delivery pump, and one side of the delivery pump is connected to one end of an outlet pipe. A second collection tank is located below the other end of the outlet pipe. The first collection tank is located below the first liquid-liquid separation pipe. The second liquid-liquid separation pipe passes through a pipe mounting block. The first and second liquid-liquid separation pipes facilitate the separation of the drug solution in the tank. The second liquid-liquid separation pipe is adjusted in height by a lifting cylinder, which raises and lowers the pipe mounting block, thus facilitating the separation of the drug solution.

[0003] The liquid separation device for polypeptide-coupled drug synthesis in the aforementioned patent has an internal stirring shaft that is too small in size, which may prevent it from effectively stirring the solution, resulting in uneven mixing, reduced reaction rate, and lower overall product quality. Therefore, this problem needs to be solved. Utility Model Content

[0004] The purpose of this invention is to address the shortcomings of existing technologies by proposing a liquid separation device for the synthesis of peptide-coupled drugs. The technical problem to be solved by this invention is that the overall size of the internal stirring shaft is too small, which may prevent it from effectively stirring the solution, resulting in uneven mixing of the reaction, reduced reaction rate and overall product quality.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A dispensing device for polypeptide-conjugated drug synthesis includes a dispensing cylinder with a cap at the top. Inside the dispensing cylinder are two first rotating shafts, each with a slidably mounted stirring rod on its top. Each stirring rod has two limiting grooves at its top, and each limiting groove contains a rotating mechanism for rotating the stirring rod. A second dispensing tube is fixedly connected to the surface of the dispensing cylinder near the cap, and an extension tube is fixedly connected to the end of the second dispensing tube near the stirring rod. The bottom of the extension tube has an adjusting mechanism for adjusting the extension tube. The cap has two symmetrically arranged cleaning ports at its top, each with a slidably mounted sealing cap. Each sealing cap has two symmetrically arranged second sliding grooves at its top, each with a fixing mechanism for fixing the sealing cap. The cap also has two symmetrically arranged first sliding grooves at its top, each with a restraining mechanism for constraining the cap. The arrangement of the two sets of stirring rods ensures more thorough mixing of the solution.

[0007] As a further embodiment of this utility model, the rotating mechanism includes a second rotating shaft, which is rotatably connected to the inside of the cylinder cover. A limiting member is fixedly connected to the bottom of the cylinder cover, and the limiting member is slidably connected to the inside of the limiting groove. A motor is fixedly connected to the top of the cylinder cover, and a third rotating shaft is fixedly connected to the output shaft of the motor. A second synchronous wheel is fixedly sleeved on the surface of the third rotating shaft, and a first synchronous wheel is fixedly sleeved on the surface of the second rotating shaft near the second synchronous wheel. The same synchronous belt is sleeved on the surfaces of the first and second synchronous wheels. By setting the synchronous belt, the stirring rod can be rotated.

[0008] As a further embodiment of this utility model, the adjusting mechanism includes a piston chamber, which is fixedly connected to one side of the dispensing cylinder. Two piston cylinders are fixedly connected to the surface of the piston chamber near the second dispensing tube. A connecting column is slidably connected inside each of the two piston cylinders. The same fixing plate is fixedly connected to the bottom of the two connecting columns. The fixing plate is fixedly connected to the bottom of the extension tube. A piston disc is fixedly connected to the top of each of the two connecting columns, and the piston disc and piston cylinder are mutually coordinated. Two electric push rods are fixedly connected to the surface of the dispensing cylinder near the piston chamber. The output ends of the two electric push rods are fixedly connected to the same connecting plate. A piston plate is fixedly connected to the top of the connecting plate, and the piston plate and piston chamber are mutually coordinated. By setting the piston disc, the length of the extension tube can be adjusted.

[0009] As a further embodiment of this utility model, the fixing mechanism includes two support rods, both of which are fixedly connected inside the second slide groove. The same adjusting plate is slidably sleeved on the surface of the two support rods. A first spring is sleeved on the surface of each of the two support rods. One end of each of the two first springs is fixedly connected to one side of the second slide groove, and the other end of each of the two first springs is fixedly connected to one side of the adjusting plate. Two second locking pins are fixedly connected to the surface of the adjusting plate away from the first springs. The two second locking pins are slidably connected to one side of the sealing cover. A second locking hole is opened on the surface of the cleaning port near the two second locking pins. The second locking pins and the second locking holes are configured to cooperate with each other. The sealing cover can be fixed by the setting of the second locking pins.

[0010] As a further embodiment of this utility model, the constraint mechanism includes two first locking holes, both of which are located at the top of the dispensing cylinder. A first receiving groove is provided on the top of the first slide groove near the two first locking holes. A first locking post is slidably connected inside each of the two first receiving grooves, and the first locking post cooperates with the first locking hole. A squeezing disc is fixedly connected to the top of each of the two first locking posts. Two third springs are sleeved on the surface of each of the two first locking posts. The bottom ends of each of the two third springs are fixedly connected to the inside of the first receiving groove, and the top ends of each of the two third springs are fixedly connected to the bottom of the squeezing disc. Two second receiving grooves are symmetrically provided on the surface of the cylinder cover near the first slide groove. A sliding rod is slidably connected inside each of the two second receiving grooves. The surface of the two sliding rods away from the first slide groove... The two slide rods are fixedly connected to the same pull plate. The other ends of the two slide rods are fixedly connected to a limiting plate. The surfaces of the two slide rods are fitted with second springs. One end of each second spring is fixedly connected to one side of the limiting plate, and the other end of each second spring is fixedly connected to one side of the inside of the second receiving groove. A clamping plate is fixedly connected to the surface of the pull plate near the liquid separator, and the clamping plate and the liquid separator are mutually coordinated. A squeezing plate is fixedly connected to the surface of the pull plate near the squeezing plate, and the squeezing plate and the squeezing plate are mutually coordinated. Two liquid inlet pipes are symmetrically opened on the surface of the liquid separator away from the second liquid separator. The bottom of the liquid separator is respectively provided with a first liquid separator and a cleaning pipe. The surfaces of the first liquid separator and the cleaning pipe near the liquid separator are provided with solenoid valves. The cylinder cover can be constrained by the setting of the first locking pin.

[0011] The beneficial effects of this utility model are as follows:

[0012] 1. This utility model employs a technical solution of stirring the solution using two sets of stirring rods, ensuring more thorough mixing of the solution. This effectively solves the problem of insufficient stirring shaft size, which could lead to uneven mixing, reduced reaction rate, and lower overall product quality. The separatory cylinder contains two stirring rods occupying most of its space, ensuring more complete mixing of the solution. A cap is installed at the top of the separatory cylinder, and a motor is mounted on top of the cap. The motor starts when the stirring rods rotate. Two synchronous belts are installed on the motor's output shaft, connected to limiting components at the top of the two stirring rods. Thus, when the motor rotates, both stirring rods rotate, achieving the purpose of stirring the solution. Attached Figure Description

[0013] Figure 1 This is a schematic diagram of the overall structure of a liquid-liquid separator for the synthesis of polypeptide-coupled drugs proposed in this utility model;

[0014] Figure 2 This is a schematic diagram of the internal structure of a liquid-liquid separator for the synthesis of polypeptide-coupled drugs proposed in this utility model;

[0015] Figure 3 This is a schematic diagram of the adjustment mechanism of a liquid dispensing device for polypeptide-coupled drug synthesis proposed in this utility model;

[0016] Figure 4 for Figure 3 Enlarged structural diagram at point A in the diagram;

[0017] Figure 5 This is a schematic diagram of the rotating mechanism of a liquid-liquid separator for the synthesis of polypeptide-coupled drugs proposed in this utility model;

[0018] Figure 6 for Figure 5 Enlarged structural diagram at point B in the diagram;

[0019] Figure 7 This is a schematic diagram of the fixing mechanism of a liquid-liquidation device for polypeptide-coupled drug synthesis proposed in this utility model;

[0020] Figure 8 for Figure 7 Enlarged structural diagram at point C;

[0021] Figure 9 This is a schematic diagram of the constraint mechanism of a liquid-liquidation device for synthesizing polypeptide-coupled drugs proposed in this utility model;

[0022] Figure 10 for Figure 9 A magnified structural diagram at point D in the diagram.

[0023] In the diagram: 1. Separating cylinder; 2. Piston chamber; 3. Motor; 4. Cylinder cover; 5. Sealing cover; 6. Pull plate; 101. Inlet pipe; 102. First rotating shaft; 103. First separating pipe; 104. Cleaning pipe; 105. Solenoid valve; 106. First locking hole; 107. Second separating pipe; 108. Extension pipe; 201. Piston cylinder; 202. Connecting column; 203. Piston disc; 204. Fixing plate; 205. Piston plate; 206. Connecting plate; 207. Electric push rod; 301. Stirring rod; 302. Limiting groove; 303. Limiting component; 304. Second... 305. Rotating shaft; 306. First synchronous pulley; 307. Third rotating shaft; 308. Second synchronous pulley; 309. Synchronous belt; 401. Cleaning port; 402. Second locking hole; 403. First sliding groove; 404. First storage groove; 405. Second storage groove; 501. Second sliding groove; 502. Support rod; 503. First spring; 504. Adjusting plate; 505. Second locking post; 601. Clamping plate; 602. Sliding rod; 603. Second spring; 604. Limiting plate; 605. Extrusion plate; 606. First locking post; 607. Third spring; 608. Extrusion plate. Detailed Implementation

[0024] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments.

[0025] Reference Figure 1 - Figure 10A dispensing device for synthesizing peptide-conjugated drugs includes a dispensing cylinder 1 with a cap 4 on top. Inside the dispensing cylinder 1 are two first rotating shafts 102, each with a slidably mounted stirring rod 301 on its top. Each stirring rod 301 has two limiting grooves 302 on its top, and each limiting groove 302 contains a rotating mechanism for rotating the stirring rod 301. A second dispensing tube 107 is fixedly connected to the surface of the dispensing cylinder 1 near the cap 4. An extension tube 108 is fixedly connected to the end of the second dispensing tube 107 near the stirring rod 301. The bottom of the extension tube 108 has a function for adjusting the extension tube. The adjusting mechanism of 108 has two symmetrical cleaning ports 401 at the top of the cylinder cover 4. Each cleaning port 401 is slidably connected to a sealing cover 5. The cleaning ports 401 allow for cleaning of the inside of the separator 1. Each of the two sealing covers 5 has two symmetrical second sliding grooves 501 at the top. Each of the two second sliding grooves 501 has a fixing mechanism for fixing the sealing cover 5. Each of the two cylinder cover 4 has two symmetrical first sliding grooves 403 at the top. Each of the two first sliding grooves 403 has a restraining mechanism for restraining the cylinder cover 4. The two sets of stirring rods 301 ensure that the solution can be mixed more thoroughly.

[0026] Preferably, the rotating mechanism includes a second rotating shaft 304, which is rotatably connected to the inside of the cylinder cover 4. A limiting member 303 is fixedly connected to the bottom of the cylinder cover 4, and the limiting member 303 is slidably connected to the inside of the limiting groove 302. A motor 3 is fixedly connected to the top of the cylinder cover 4. The setting of the limiting member 303 can ensure that the stirring rod 301 can be easily picked up. A third rotating shaft 306 is fixedly connected to the output shaft of the motor 3. A second synchronous wheel 307 is fixedly sleeved on the surface of the third rotating shaft 306. A first synchronous wheel 305 is fixedly sleeved on the surface of the second rotating shaft 304 near the second synchronous wheel 307. The same synchronous belt 308 is sleeved on the surface of the first synchronous wheel 305 and the second synchronous wheel 307. The stirring rod 301 can be rotated by the setting of the synchronous belt 308.

[0027] Preferably, the adjusting mechanism includes a piston chamber 2, which is fixedly connected to one side of the dispensing cylinder 1. Two piston cylinders 201 are fixedly connected to the surface of the piston chamber 2 near the second dispensing pipe 107. A connecting column 202 is slidably connected inside each of the two piston cylinders 201. The same fixing plate 204 is fixedly connected to the bottom of the two connecting columns 202. The fixing plate 204 is fixedly connected to the bottom of the extension pipe 108. A piston disc 203 is fixedly connected to the top of each of the two connecting columns 202. The piston disc 203 and the piston cylinder 201 are configured to cooperate with each other. Two electric push rods 207 are fixedly connected to the surface of the dispensing cylinder 1 near the piston chamber 2. The output ends of the two electric push rods 207 are fixedly connected to the same connecting plate 206. A piston plate 205 is fixedly connected to the top of the connecting plate 206. The piston plate 205 and the piston chamber 2 are configured to cooperate with each other. The length of the extension pipe 108 can be adjusted by the setting of the piston disc 203. The piston disc 203 can be moved by the setting of the piston chamber 2.

[0028] Preferably, the fixing mechanism includes two support rods 502, both of which are fixedly connected inside the second slide groove 501. The same adjusting plate 504 is slidably sleeved on the surface of the two support rods 502. A first spring 503 is sleeved on the surface of each of the two support rods 502. One end of each of the two first springs 503 is fixedly connected to one side of the second slide groove 501, and the other end of each of the two first springs 503 is fixedly connected to one side of the adjusting plate 504. Two second locking pins 505 are fixedly connected to the surface of the adjusting plate 504 away from the first springs 503. The two second locking pins 505 are slidably connected to one side of the sealing cover 5. The first springs 503 can constrain the adjusting plate 504. The cleaning port 401 has a second locking hole 402 on the surface near the two second locking pins 505. The second locking pins 505 and the second locking holes 402 are configured to cooperate with each other. The second locking pins 505 can fix the sealing cover 5.

[0029] Preferably, the constraint mechanism includes two first locking holes 106, both of which are located at the top of the dispensing cylinder 1. A first receiving groove 404 is provided on the top of the first sliding groove 403 near the two first locking holes 106. A first locking post 606 is slidably connected inside each of the two first receiving grooves 404, and the first locking post 606 cooperates with the first locking hole 106. A squeezing plate 605 is fixedly connected to the top of each of the two first locking posts 606. Two third springs 607 are sleeved on the surface of each of the two first locking posts 606. The bottom ends of each of the two third springs 607 are fixedly connected to the inside of the first receiving groove 404, and the top ends of each of the two third springs 607 are fixedly connected to the bottom of the squeezing plate 605. Two second receiving grooves 405 are symmetrically provided on the surface of the cylinder cover 4 near the first sliding groove 403. A sliding rod 602 is slidably connected inside each of the two second receiving grooves 405. The same pull plate 6 is fixedly connected to the surface of each sliding rod 602 away from the first sliding groove 403. The other ends of each sliding rod 602 are... A limiting disk 604 is fixedly connected. Two slide rods 602 are each fitted with a second spring 603. One end of each second spring 603 is fixedly connected to one side of the limiting disk 604, and the other end is fixedly connected to one side inside the second receiving groove 405. A clamping plate 601 is fixedly connected to the surface of the pull plate 6 near the dispensing cylinder 1, and the clamping plate 601 cooperates with the dispensing cylinder 1. A squeezing plate 608 is fixedly connected to the surface of the pull plate 6 near the squeezing disk 605. The 608 and the squeezing plate 605 are configured to cooperate with each other. The squeezing plate 608 can be used to adjust the first locking post 606. Two inlet pipes 101 are symmetrically opened on the surface of the liquid separator 1 away from the second liquid separator 107. The bottom of the liquid separator 1 is respectively provided with the first liquid separator 103 and the cleaning pipe 104. Solenoid valves 105 are provided on the surface of the first liquid separator 103 and the cleaning pipe 104 near the liquid separator 1. The first locking post 606 can be used to constrain the cylinder cover 4.

[0030] Working principle: Two stirring rods 301 are installed inside the separatory cylinder 1, occupying most of the cylinder's position to ensure thorough mixing of the solution. A cylinder cover 4 is installed on top of the separatory cylinder 1, and a motor 3 is mounted on top of the cover 4. When the stirring rods 301 rotate, the motor 3 is activated. Two synchronous belts 308 are installed on the output shaft of the motor 3, and these belts are connected to limiting members 303 at the top of the two stirring rods 301. Thus, when the motor 3 rotates, both stirring rods 301 rotate, achieving the purpose of stirring the solution. A second dispensing pipe 107 is provided on one side of the solution, and an extension pipe 108 is provided at the bottom of the second dispensing pipe 107. After the solution has settled, the electric push rod 207 on one side of the second dispensing pipe 107 is activated. A piston chamber 2 is also provided on one side of the second dispensing pipe 107, and the piston chamber 2 is connected to the electric push rod 207 via a piston plate 205. When the electric push rod 207 moves, the piston plate 205 compresses the gas inside the piston chamber 2, thereby causing it to move. Two piston cylinders 201 are provided on one side of the piston chamber 2, and each piston cylinder 201 has a piston disc 203 inside. When the piston plate 205 moves, the piston disc 203 moves. During movement, the two piston discs 203 also move accordingly. A fixing plate 204 is provided at the bottom of the extension tube 108, and the fixing plate 204 is connected to the piston discs 203 via a connecting post 202. Therefore, when the piston discs 203 move downwards, the fixing plate 204 will drive the bottom end of the extension tube 108 to move downwards synchronously, ensuring that the upper layer of liquid can be extracted. A first separating pipe 103 is provided at the bottom of the separating cylinder 1. After the upper layer of liquid is extracted, the lower layer of liquid is extracted through the first separating pipe 103. When the separating cylinder 1 needs to be cleaned, the cleaning pipe 104 at the bottom of the separating cylinder 1 is first opened, then... Then, the adjusting plate 504 on the top of the cylinder cover 4 is pulled. Two second locking pins 505 are installed on one side of the adjusting plate 504, and both second locking pins 505 are connected to the cylinder cover 4 to achieve the purpose of restraining the sealing cover 5. Thus, when the adjusting plate 504 is pulled, the second locking pins 505 can be released from restraint on the cylinder cover 4. After the restraint is released, the sealing cover 5 can be removed. Two cleaning ports 401 are symmetrically opened on the top of the cylinder cover 4. The sealing cover 5 initially closes the cleaning ports 401. Thus, after the sealing cover 5 is removed, the inside of the separator 1 and the stirring rod 301 can be cleaned through the cleaning ports 401.

[0031] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A dispensing device for the synthesis of polypeptide-conjugated drugs, comprising a dispensing cylinder (1), wherein a cap (4) is provided on the top of the dispensing cylinder (1), characterized in that, The separator (1) is equipped with two first rotating shafts (102) inside. A stirring rod (301) is slidably fitted onto the top of each of the two first rotating shafts (102). Two limiting grooves (302) are opened on the top of each of the two stirring rods (301). A rotating mechanism for rotating the stirring rod (301) is provided inside each of the two limiting grooves (302). A second separator tube (107) is fixedly connected to the surface of the separator (1) near the cover (4). An extension tube (108) is fixedly connected to the end of the second separator tube (107) near the stirring rod (301). The extension tube (108) 108) The bottom is provided with an adjustment mechanism for adjusting the extension tube (108). The top of the cylinder cover (4) has two cleaning ports (401) symmetrically connected. The two cleaning ports (401) are slidably connected with sealing caps (5). The top of the two sealing caps (5) is symmetrically provided with two second sliding grooves (501). The two second sliding grooves (501) are provided with a fixing mechanism for fixing the sealing caps (5). The top of the cylinder cover (4) is symmetrically provided with two first sliding grooves (403). The two first sliding grooves (403) are provided with a restraining mechanism for restraining the cylinder cover (4).

2. The dispensing apparatus for polypeptide-conjugated drug synthesis according to claim 1, characterized in that, The rotating mechanism includes a second rotating shaft (304), which is rotatably connected to the inside of the cylindrical cover (4). A limiting member (303) is fixedly connected to the bottom of the cylindrical cover (4). The limiting member (303) is slidably connected to the inside of the limiting groove (302). A motor (3) is fixedly connected to the top of the cylindrical cover (4). A third rotating shaft (306) is fixedly connected to the output shaft of the motor (3). A second synchronous pulley (307) is fixedly sleeved on the surface of the third rotating shaft (306). A first synchronous pulley (305) is fixedly sleeved on the surface of the second rotating shaft (304) near the second synchronous pulley (307). The same synchronous belt (308) is sleeved on the surfaces of the first synchronous pulley (305) and the second synchronous pulley (307).

3. The dispensing apparatus for polypeptide-conjugated drug synthesis according to claim 1, characterized in that, The adjusting mechanism includes a piston chamber (2), which is fixedly connected to one side of the dispensing cylinder (1). Two piston cylinders (201) are fixedly connected to the surface of the piston chamber (2) near the second dispensing pipe (107). A connecting column (202) is slidably connected inside the two piston cylinders (201). The same fixing plate (204) is fixedly connected to the bottom of the two connecting columns (202). The fixing plate (204) is fixedly connected to the bottom of the extension pipe (108). A piston disc (203) is fixedly connected to the top of the two connecting columns (202).

4. The dispensing apparatus for polypeptide-coupled drug synthesis according to claim 3, characterized in that, The piston disc (203) and piston cylinder (201) are configured to cooperate with each other. Two electric push rods (207) are fixedly connected to the surface of the liquid separator (1) near the piston chamber (2). The output ends of the two electric push rods (207) are fixedly connected to the same connecting plate (206). The top of the connecting plate (206) is fixedly connected to a piston plate (205), and the piston plate (205) and piston chamber (2) are configured to cooperate with each other.

5. The dispensing apparatus for polypeptide-coupled drug synthesis according to claim 1, characterized in that, The fixing mechanism includes two support rods (502), both of which are fixedly connected inside the second slide groove (501). The same adjusting plate (504) is slidably sleeved on the surface of the two support rods (502). A first spring (503) is sleeved on the surface of the two support rods (502). One end of each of the two first springs (503) is fixedly connected to one side of the second slide groove (501), and the other end of each of the two first springs (503) is fixedly connected to one side of the adjusting plate (504).

6. The dispensing apparatus for polypeptide-coupled drug synthesis according to claim 5, characterized in that, Two second locking pins (505) are fixedly connected to the surface of the adjusting plate (504) away from the first spring (503). The two second locking pins (505) are slidably connected to the side of the sealing cover (5). The surface of the cleaning port (401) near the two second locking pins (505) is provided with a second locking hole (402). The second locking pins (505) and the second locking holes (402) are configured to cooperate with each other.

7. The dispensing apparatus for polypeptide-coupled drug synthesis according to claim 1, characterized in that, The constraint mechanism includes two first locking holes (106), both of which are located on the top of the liquid separator (1). The top of the first slide groove (403) near the two first locking holes (106) is provided with a first receiving groove (404). The two first receiving grooves (404) are slidably connected with first locking pins (606), and the first locking pins (606) and the first locking holes (106) are mutually matched. The tops of the two first locking pins (606) are fixedly connected with a squeezing plate (605). The surfaces of the two first locking pins (606) are fitted with two third springs (607). The bottom ends of the two third springs (607) are fixedly connected to the inside of the first receiving groove (404), and the top ends of the two third springs (607) are fixedly connected to the bottom of the squeezing plate (605).

8. The dispensing apparatus for polypeptide-conjugated drug synthesis according to claim 7, characterized in that, The cylindrical cover (4) has two symmetrically arranged second storage slots (405) on the surface near the first slide groove (403). Each of the two second storage slots (405) has a sliding rod (602) slidably connected inside. The surface of each sliding rod (602) away from the first slide groove (403) is fixedly connected to the same pull plate (6). The other end of each sliding rod (602) is fixedly connected to a limit plate (604). Each sliding rod (602) has a second spring (603) sleeved on its surface. The two second springs (603...) One end of each of the two second springs (603) is fixedly connected to one side of the limiting plate (604), and the other end of each of the two second springs (603) is fixedly connected to one side of the inside of the second storage groove (405). A card plate (601) is fixedly connected to the surface of the pull plate (6) near the liquid separator (1), and the card plate (601) and the liquid separator (1) are mutually cooperated. A squeezing plate (608) is fixedly connected to the surface of the pull plate (6) near the squeezing plate (605), and the squeezing plate (608) and the squeezing plate (605) are mutually cooperated.

9. The dispensing apparatus for polypeptide-conjugated drug synthesis according to claim 1, characterized in that, Two inlet pipes (101) are symmetrically opened on the surface of the liquid separator (1) away from the second liquid separator (107). The bottom of the liquid separator (1) is provided with a first liquid separator (103) and a cleaning pipe (104). Solenoid valves (105) are provided on the surface of the first liquid separator (103) and the cleaning pipe (104) near the liquid separator (1).

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