Bending device for surface plasmon resonance analyzer sample injection needle

Abstract

The utility model relates to a kind of bending device for surface plasmon resonance analyzer sample introduction needle, comprising: first bending mechanism, including first installation part and first bending operation component;Angle adjusting auxiliary assembly, including first adjusting auxiliary structure and second adjusting auxiliary structure;First adjusting auxiliary structure includes angle contrast mark, and second adjusting auxiliary structure includes the stop piece for stopping sample introduction needle at target angle position;First installation part is used to selectively detachable installation one of first adjusting auxiliary structure and second adjusting auxiliary structure. The bending device of the utility model, by configuring angle adjusting auxiliary assembly, can be applicable to the high-precision bending demand of two situations of rapid prototyping and batch stable production, by first installation part selectively detachable installation one of first adjusting auxiliary structure and second adjusting auxiliary structure, convenient operation, it is conducive to the miniaturization design of bending device.

Description

Technical Field

[0001] This utility model relates to the field of bending processing equipment technology, and in particular to a bending device for a sample injection needle of a surface plasmon resonance analyzer. Background Technology

[0002] Surface plasmon resonance (SPR) analyzers are used for detecting biomolecular interactions. The biological samples involved typically include, but are not limited to, proteins, antibodies, antigens, enzymes, receptors, peptides, nucleic acids, polysaccharides, liposomes, small molecule drugs, viral antigens, cytokines, and biological fluids such as serum and plasma. The injection needle is a key component of the SPR analyzer, a precision sub-component within its liquid path system. The needle draws the sample from a 96-well plate and introduces it into the instrument's detection system, playing a crucial role in the precise introduction of minute amounts of sample. Injection needles are typically made of narrow-diameter metal capillaries to achieve accurate transfer of minute sample volumes. Internally, due to space constraints and flow path requirements, the injection needle often requires high-precision bending to ensure its shape accurately matches the position and orientation of the internal flow path interfaces. The bending device is a precision machining tool used for the injection needle.

[0003] Currently, the bending methods for injection needles mainly include the following two methods: (1) Manual bending has the disadvantages of low precision, poor consistency and low bending efficiency; (2) Using large bending equipment makes it difficult to meet the precise bending requirements of injection needles with an outer diameter of millimeters. The equipment is bulky and occupies a lot of space. Utility Model Content

[0004] Based on the aforementioned deficiencies in the existing technology, the purpose of this utility model is to provide a bending device for the injection needle of a surface plasmon resonance analyzer. By configuring an angle adjustment auxiliary component, it can meet the high-precision bending requirements of both rapid prototyping and stable mass production. The first mounting part allows for the selective detachable installation of either the first adjustment auxiliary structure or the second adjustment auxiliary structure, making operation convenient and facilitating the miniaturization design of the bending device.

[0005] Therefore, the present invention provides the following technical solution.

[0006] This invention provides a bending device for a sample injection needle in a surface plasmon resonance (SPR) analyzer, the SPR analyzer being used to analyze biomolecular interactions, and the bending device comprising: The first bending mechanism includes a first mounting part and a first bending operation component, the first bending operation component being used to bend the injection needle in a plane; An angle adjustment auxiliary component includes a first adjustment auxiliary structure and a second adjustment auxiliary structure; the first adjustment auxiliary structure includes an angle reference mark, and the second adjustment auxiliary structure includes a stop member for stopping the injection needle at a target angle position; the first mounting part is used to selectively and detachably install one of the first adjustment auxiliary structure and the second adjustment auxiliary structure.

[0007] Optionally, the first mounting part is a slot structure, used to selectively engage one of the first adjustment auxiliary structure and the second adjustment auxiliary structure.

[0008] Optionally, the second adjustment auxiliary structure further includes a mounting member, the mounting member having a first shaft hole, and the stop member having an eccentric shaft, the eccentric shaft being rotatably connected to the first shaft hole.

[0009] Optionally, the second adjustment auxiliary structure further includes a magnetic component, which is mounted on the stop component; the mounting component is a magnetically attracted element, and the magnetic component is magnetically attracted to the mounting component. And / or, the number of the first shaft holes is multiple, and the multiple first shaft holes are spaced apart.

[0010] Optionally, the first bending mechanism further includes a first limiting structure and a first abutting portion. The first limiting structure is used to restrict the movement of the first end of the injection needle, and the first bending operation component is used to abut the injection needle against the first abutting portion. The first bending operation component is rotatably configured, and the first bending operation component performs the planar bending by rotating.

[0011] Optionally, the first limiting structure includes a square through hole and at least two first threaded holes, the at least two first threaded holes being respectively connected to both sides of the square through hole; the bending device further includes a first fastener, the square through hole being used for insertion of the first end, and the first fastener being used for screwing into the first threaded hole and for pressing against the injection needle; And / or, the outline of the first abutment portion is semi-circular; And / or, the first bending mechanism further includes a protrusion, one end face of which forms the first abutment portion, the first bending operation component is rotatably mounted on the protrusion, and the first mounting portion is located on the side of the protrusion away from the first limiting structure.

[0012] Optionally, the first bending operation assembly includes a first operating arm and a first roller. The first operating arm includes a first rotating arm and a first extension arm. The first rotating arm is rotatably configured, and the first extension arm is used to extend the lever arm length of the first operating arm. The first roller is rotatably connected to the first rotating arm. The first roller is used to press against the injection needle in the direction of the first abutment portion and to squeeze the injection needle during the rotation of the first operating arm so as to cause the injection needle to bend.

[0013] Optionally, the bending device further includes a second bending mechanism, which includes a second mounting part and a second bending operation component. The second mounting part is used to selectively and detachably mount one of the first adjustment auxiliary structure and the second adjustment auxiliary structure. The second bending mechanism is used to perform spatial bending on the injection needle after planar bending.

[0014] Optionally, the number of angle adjustment auxiliary components is two sets, with one set of angle adjustment auxiliary components each matching the first mounting part and the second mounting part; And / or, the second mounting part is a slot structure for selectively engaging one of the first adjustment auxiliary structure and the second adjustment auxiliary structure; And / or, the first bending mechanism further includes a first limiting structure for restricting the movement of the first end of the injection needle; the second bending mechanism further includes a second limiting structure for restricting the movement of one end of the injection needle; the length extension direction of the first end when it is restricted by the first limiting structure is different from the length extension direction of one end of the injection needle when it is restricted by the second limiting structure.

[0015] Optionally, the second bending mechanism further includes two sets of bending mating components, each of which includes a matching second limiting structure, a second abutment portion, and a second shaft hole. The second limiting structure is used to restrict the movement of one end of the injection needle. Two sets of bending mating components are symmetrically arranged about a first axis, and the second bending operation component is selectively rotatably connected to the second shaft hole of one of the two sets of bending mating components; The second bending operation component is used to abut against the injection needle in opposition to the matching second abutment portion, and the second bending operation component performs the spatial bending by rotating.

[0016] Optionally, the second bending operation assembly includes a second operating arm and a second roller, the second roller being rotatably connected to the second operating arm, and the second operating arm being selectively rotatably connected to the second shaft hole of one of the two sets of bending mating assemblies; The second roller is used to abut against the injection needle in opposition to the matching second abutment portion, and to squeeze the injection needle during the rotation of the second operating arm, so as to cause the injection needle to bend. And / or, the second abutment portion has an annular structure, and the annular region of the second abutment portion at least constitutes a partial hole segment of the second shaft hole.

[0017] This utility model has the following technical effects: This invention provides a bending device for a sample injection needle in a surface plasmon resonance analyzer. By configuring an angle adjustment auxiliary component, it assists the operator in determining the bending stop position of the sample injection needle, meeting the high-precision bending requirements of the needle. Furthermore, the angle adjustment auxiliary component includes a first adjustment auxiliary structure and a second adjustment auxiliary structure, making it suitable for both rapid prototyping and stable mass production, thus broadening its application scenarios. In addition, a first mounting part is configured on the first bending mechanism, allowing selective and detachable installation of either the first or second adjustment auxiliary structure. This allows the operator to operate the first bending component from the same workstation without switching operating positions when switching between the first and second adjustment auxiliary structures, simplifying operation. It also simplifies the structure of the first bending mechanism, facilitating its miniaturization and consequently, the miniaturization of the bending device itself.

[0018] The sample introduction device of this invention constitutes an essential actuator for the surface plasmon resonance (SPR) analyzer to realize the sample introduction function. That is, the bending device is an important device for the sample introduction needle to adapt to the surface plasmon resonance (SPR) analyzer. The bending device is used to ensure that the sample introduction needle can accurately align with the position and direction of the internal flow path interface of the surface plasmon resonance (SPR) analyzer, thereby ensuring that an effective sample introduction liquid path can be formed inside the surface plasmon resonance (SPR) analyzer. Attached Figure Description

[0019] Figure 1 This is a three-dimensional structural diagram of the bending device of this utility model. Figure 1 ; Figure 2 This is a schematic diagram of the angle adjustment auxiliary component of this utility model; Figure 3 This is an exploded view of the second adjustment auxiliary structure of this utility model; Figure 4 This is an exploded view of the assembly structure of the first bending mechanism, the first adjustment auxiliary structure, and the injection needle of this utility model. Figure 5 This is a partial structural schematic diagram of the first bending mechanism of this utility model; Figure 6 This is an exploded view of the assembly structure of the first rotating arm, the first roller, the first rotating shaft, and the second fastener of this utility model. Figure 7This is an exploded view of the assembly structure of the second bending mechanism, the first adjustment auxiliary structure, and the injection needle of this utility model. Figure 8 This is a partial structural schematic diagram of the second bending mechanism of this utility model; Figure 9 This is an exploded view of the assembly structure of the first operating arm, the second roller, the second mounting shaft, and the fourth fastener of this utility model. Figure 10 This is a three-dimensional structural diagram of the bending device of this utility model. Figure 2 .

[0020] Explanation of reference numerals in the attached figures 100. Bending device; 1. First bending mechanism; 11. First mounting part; 111. First anti-foolproof groove; 12. First bending operation assembly; 121. First operating arm; 1211. First rotating arm; 12111. First elongated hole; 12112. Second threaded hole; 1212. First extended arm; 12121. Second elongated hole; 1213. First gripping part; 122. First roller; 123. First mounting shaft; 124. Second fastener; 125. First rotating shaft; 13. First limiting structure; 131. Square through hole; 132. First threaded hole; 14. Protrusion; 141. First abutment part; 142. Third shaft hole; 15. First mounting base; 2. Angle adjustment auxiliary components; 21. First adjustment auxiliary structure; 211. Angle comparison mark; 212. Marking plate; 2121. First anti-foolproof protrusion; 22. Second adjustment auxiliary structure; 221. Stopping element; 2211. Eccentric shaft; 222. Mounting element; 2221. First shaft hole; 2222. Second anti-foolproof protrusion; 223. Magnetic element; 3. Second bending mechanism; 31. Second mounting part; 311. Second anti-foolproof groove; 32. Second bending operation assembly; 321. Second operating arm; 3211. Third elongated hole; 3212. Second grip; 322. Second roller; 323. Second mounting shaft; 324. Fourth fastener; 325. Second rotating shaft; 33. Second limiting structure; 331. Limiting plate; 332. Limiting hole; 34. Second abutment part; 341. Second shaft hole; 35. Second mounting base; 351. Slot; 3511. Support platform; 3512. Positioning post; 352. Receiving cavity; 4. Base; 200, Injection needle; 201, First end; 202, Section to be bent. Detailed Implementation

[0021] To make the technical solution and beneficial effects of this utility model more apparent and understandable, a detailed description is provided below by listing specific embodiments. Unless otherwise defined, the technical and scientific terms used herein have the same meanings as those in the technical field to which this application pertains.

[0022] In the description of this utility model, unless otherwise expressly defined, the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "height", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the purpose of simplifying the description of this utility model and do not indicate that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. That is, they should not be construed as limitations on this utility model.

[0023] In this utility model, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating the relative importance of the indicated features or the number of indicated technical features. Therefore, a feature specified as "first" or "second" can explicitly include at least one of that feature. In the description of this utility model, "a plurality of" means at least two; "several" means at least one; unless otherwise expressly defined.

[0024] In this utility model, unless otherwise explicitly defined, the terms "installation," "connection," "linking," "fixing," and "setting," etc., should be interpreted broadly. For example, "connection" can be a fixed connection, a detachable connection, or an integral molding; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium; it can also refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0025] In this utility model, unless otherwise explicitly defined, the terms "above," "on top of," "above," "over," "below," "below," "below," or "below" for "first feature above second feature" can refer to direct contact between the first and second features, or indirect contact between the first and second features through an intermediate medium. Furthermore, "above," "above," and "over" for "first feature above second feature" can mean the first feature is directly above or diagonally above the second feature, or simply indicates that the horizontal height of the first feature is higher than the horizontal height of the second feature. Similarly, "below," "below," and "below" for "first feature below second feature" can mean the first feature is directly below or diagonally below the second feature, or simply indicates that the horizontal height of the first feature is lower than the horizontal height of the second feature.

[0026] In this utility model, the terms "front," "rear," "left," "right," "up," and "down" all refer to... Figure 1 and Figure 10 The markings in the text shall prevail.

[0027] The following is based on Figures 1 to 10 This invention provides a detailed description of the bending device.

[0028] In this embodiment, such as Figure 1 , Figure 2 , Figure 4 and Figure 10 As shown, the bending device 100 is used to bend the injection needle 200 of the surface plasmon resonance analyzer. The surface plasmon resonance analyzer is used to analyze the interaction of biomolecules. The injection needle 200 can be a thin-diameter metal capillary tube. The injection needle 200 is used for the injection of biological samples, including but not limited to proteins, antibodies, antigens, enzymes, receptors, peptides, nucleic acids, polysaccharides, liposomes, small molecule drugs, viral antigens, cytokines, and biological fluids such as serum and plasma.

[0029] The bending device 100 includes a first bending mechanism 1 and an angle adjustment auxiliary component 2. The first bending mechanism 1 includes a first mounting part 11 and a first bending operation component 12. The first bending operation component 12 is used to perform planar bending of the injection needle 200. The angle adjustment auxiliary component 2 includes a first adjustment auxiliary structure 21 and a second adjustment auxiliary structure 22. The first adjustment auxiliary structure 21 includes an angle reference mark 211, and the second adjustment auxiliary structure 22 includes a stop member 221, which is used to stop the injection needle 200 at a target angle position. The first mounting part 11 is used to selectively and detachably mount one of the first adjustment auxiliary structure 21 and the second adjustment auxiliary structure 22.

[0030] Specifically, when the first adjustment auxiliary structure 21 is installed on the first mounting part 11, before performing planar bending, the corresponding angle reference mark 211 is determined on the first adjustment auxiliary structure 21 according to the bending angle requirement. For example, if the bending angle requirement is 90°, the angle reference mark 211 corresponding to 90° is found on the first adjustment auxiliary structure 21. Then, the first bending operation component 12 is used to perform planar bending on the injection needle 200 until the injection needle 200 is bent to the position corresponding to the angle reference mark 211, indicating that the bending is in place. The operation of the first bending operation component 12 is then stopped, and the planar bending is completed. In this solution, since the bending stop position of the injection needle 200 needs to be controlled manually according to the angle reference mark 211 during the bending process, and the angle reference mark 211 can provide multiple angle stop position references, this solution is applicable to rapid prototyping and can quickly produce the required bent products during the equipment research and development and debugging stage.

[0031] When the second adjustment auxiliary structure 22 is installed on the first mounting part 11, the first bending operation component 12 is used to bend the injection needle 200 in a plane until it abuts against the stop member 221, indicating that the bending is in place. The operation of the first bending operation component 12 is then stopped, completing the plane bending. In this solution, because the bending operation can be stopped when the needle abuts against the stop member 221, there is no need for manual judgment of the stop position, avoiding or reducing angle errors caused by subjective human factors. Furthermore, the stop member 221 acts as a foolproof mechanism, simplifying the operator's work. This solution is suitable for high-precision forming at specific bending angles, with high accuracy repeatability and high reliability, making it suitable for stable batch production.

[0032] The outer diameter of the injection needle is typically on the order of millimeters. Due to the small diameter of the injection needle, high bending accuracy is required. Therefore, the above-mentioned technical solution of this application, by configuring an angle adjustment auxiliary component 2 to assist the operator in determining the bending stop position of the injection needle 200, can meet the high-precision bending requirements of the injection needle 200. Furthermore, the angle adjustment auxiliary component 2 includes a first adjustment auxiliary structure 21 and a second adjustment auxiliary structure 22, which can be applied to both rapid prototyping and stable mass production, thus broadening its application scenarios. Furthermore, a first mounting part 11 is provided on the first bending mechanism 1. One of the first adjustment auxiliary structure 21 and the second adjustment auxiliary structure 22 can be selectively and detachably mounted on the first mounting part 11. In this way, on the one hand, the operator can operate the first bending operation component 12 at the same workstation without having to switch the operation position when switching the first adjustment auxiliary structure 21 and the second adjustment auxiliary structure 22. On the other hand, the number of first mounting parts 11 can be reduced, simplifying the structure of the first bending mechanism 1 and facilitating the miniaturization design of the first bending mechanism 1, thereby facilitating the miniaturization design of the bending device 100.

[0033] It should be explained that "planar bending" in this article means that during the bending process, the bending path of the injection needle 200 always lies within a single geometric plane, that is, the injection needle 200 extends in two-dimensional space. "Spatial bending" in this article means that after the bending is completed, the axis of the injection needle 200 extends into at least two different planes, that is, the injection needle 200 extends in at least three-dimensional space.

[0034] In one implementation, such as Figure 1 , Figure 4 and Figure 5 As shown, the first mounting part 11 is a slot structure used to selectively engage one of the first adjustment auxiliary structure 21 and the second adjustment auxiliary structure 22. This snap-fit ​​assembly method is simple in structure and allows for convenient disassembly and operation. In one specific embodiment, the first bending mechanism 1 includes a first mounting base 15, with the first mounting part 11 located on the top wall of the first mounting base 15. This facilitates user viewing of the first adjustment auxiliary structure 21 or the second adjustment auxiliary structure 22 installed in the first mounting part 11.

[0035] In one implementation, such as Figure 1 and Figure 2As shown, the first adjustment auxiliary structure 21 includes an indicator plate 212, and an angle reference mark 211 is disposed on the upper surface of the indicator plate 212. The angle reference mark 211 can be a radially distributed scale line, with each scale line pointing to the same center, and the position of each scale line corresponding to a bending angle; the angle reference mark 211 can also be an angle scale mark, with the position of each angle scale corresponding to a bending angle; of course, the angle reference mark 211 can also be other structural forms that can indicate the angle.

[0036] Furthermore, such as Figure 2 and Figure 5 As shown, in order to facilitate the quick assembly of the first mounting part 11 and the first adjustment auxiliary structure 21, at least one side of the first mounting part 11 is provided with a first anti-fooling groove 111, and the marking plate 212 is provided with a first anti-fooling protrusion 2121. When the first adjustment auxiliary structure 21 is installed on the first mounting part 11, the first anti-fooling protrusion 2121 is aligned with the first anti-fooling groove 111 until the first adjustment auxiliary structure 21 is engaged in the first mounting part 11.

[0037] In one implementation, such as Figure 2 and Figure 3 As shown, the second adjustment auxiliary structure 22 also includes a mounting member 222, which has a first shaft hole 2221 and a stop member 221 with an eccentric shaft 2211, which is rotatably connected to the first shaft hole 2221. Specifically, because the outer diameter of the injection needle 200 is small, the injection needle 200 has a certain degree of elasticity. Therefore, after the first bending operation component 12 is used to bend the injection needle 200 to abut against the stop member 221, and the force applied to the injection needle 200 by the first bending operation component 12 is removed, the injection needle 200 may elastically rebound, resulting in the injection needle 200 not being bent to the correct position. In this case, the stop member 221 can be rotated according to the rebound angle of the injection needle 200, so that the stop member 221 rotates around the center line of the eccentric shaft 2211, thereby causing the stop member 221 to deviate from the original stop position. The stop member 221 is then adjusted to the required stop position. By finely adjusting the position of the stop member 221, the angular deviation caused by the rebound of the injection needle 200 can be compensated, thereby ensuring the bending accuracy of the injection needle 200.

[0038] In one implementation, such as Figure 3As shown, the second adjustment auxiliary structure 22 also includes a magnetic component 223 (e.g., a magnet), which is mounted on the stop component 221. The mounting component 222 is a magnetically attractive element (e.g., an iron component). The magnetic component 223 and the mounting component 222 are magnetically attracted to each other. Thus, when the stop component 221 is adjusted to the desired stop position, it can be stably positioned under magnetic attraction, thereby ensuring the stability of the angle adjustment auxiliary function. Furthermore, the magnetic component 223 is mounted on the side of the stop component 221 facing the mounting component 222, and can be installed by snap-fit.

[0039] Of course, magnetic components can also be provided on the mounting component 222, and magnetically adsorbable components can be provided on the stop component 221 to achieve magnetic adsorption.

[0040] In one implementation, such as Figure 2 and Figure 3 As shown, there are multiple first shaft holes 2221, such as two, three, or even more. These multiple first shaft holes 2221 are spaced apart to provide multiple mounting positions for the stop member 221. By configuring a stop member 221, a suitable first shaft hole 2221 can be selected for mounting the stop member 221 according to the bending angle requirements. That is, compared to fine-tuning the position of the stop member 221 by rotating it, this solution can also adjust the position of the stop member 221 on the mounting member 222 to a greater extent, thereby increasing the angle requirements that the second adjustment auxiliary structure 22 can match.

[0041] In one implementation, such as Figure 2 and Figure 3 As shown, the mounting component 222 is plate-shaped and is installed on the first mounting part 11. There is no need to set up an additional plate, which helps to simplify the structure of the second adjustment auxiliary structure 22.

[0042] Furthermore, such as Figure 2 , Figure 3 and Figure 5 As shown, in order to facilitate the quick assembly of the first mounting part 11 and the second adjustment auxiliary structure 22, the mounting part 222 is provided with a second anti-fooling protrusion 2222. When the second adjustment auxiliary structure 22 is installed on the first mounting part 11, the second anti-fooling protrusion 2222 is aligned with the first anti-fooling groove 111 until the second adjustment auxiliary structure 22 is engaged in the first mounting part 11.

[0043] In one implementation, such as Figure 1 , Figure 4 and Figure 5As shown, the first bending mechanism 1 further includes a first limiting structure 13 and a first abutting part 141. The first limiting structure 13 is used to restrict the movement of the first end 201 of the injection needle 200, and the first bending operation component 12 is used to abut the injection needle 200 against the first abutting part 141. The first bending operation component 12 is rotatably configured, and the first bending operation component 12 performs planar bending by rotating. Specifically, when the first bending mechanism 1 is used to perform planar bending of the injection needle 200, the first limiting structure 13 is first used to restrict the first end 201 of the injection needle 200 to prevent the injection needle 200 from moving during the bending process. Then, the first bending operation component 12 is rotated so that the first bending operation component 12 abuts the injection needle 200 against the first abutting part 141, and the first bending operation component 12 is rotated to bend the injection needle 200 to the target angle position, thus completing the planar bending process.

[0044] In one implementation, such as Figure 1 , Figure 4 and Figure 5 As shown, the first limiting structure 13 includes a square through hole 131 and two first threaded holes 132, which are respectively connected to both sides of the square through hole 131. The bending device 100 also includes a first fastener (not shown in the figure). The square through hole 131 is used for the insertion of the first end 201, and the first fastener is used to screw into the first threaded holes 132 and to abut against the injection needle 200. Specifically, during planar bending, the first end 201 of the injection needle 200 is first inserted into the square through hole 131, and then the first fastener is screwed into the first threaded holes 132 until the two first fasteners abut against the injection needle 200 from both sides, thereby restricting the first end 201 of the injection needle 200 in the square through hole 131 and ensuring that the first end 201 of the injection needle 200 cannot move. In this design, by setting a square through hole 131 and a first threaded hole 132, the first limiting structure 13 can be applied to limit injection needles 200 with different outer diameters.

[0045] Of course, the number of first threaded holes 132 is not limited to two; it can also be three, four, or even more. Multiple first fasteners can be used to abut the injection needle 200 from multiple directions. Preferably, such as... Figure 1 and Figure 4 As shown, in order to reduce the number of parts and simplify operation, there are two first threaded holes 132. Furthermore, in order to ensure the stability of the limiting effect of the first limiting structure 13 on the injection needle 200, the two first threaded holes 132 are perpendicular in axis. In this way, the two first fasteners cooperate to press the first end 201 of the injection needle 200 against one of the corners of the square through hole 131.

[0046] In one implementation, such as Figure 4, Figure 5 and Figure 10 As shown, the outline of the first contact part 141 is semi-circular. In this way, when the first contact part 141 abuts against the injection needle 200, the semi-circular outline allows the injection needle 200 to bend smoothly during the bending process, reducing scratches on the injection needle 200.

[0047] In one implementation, such as Figure 4 and Figure 5 As shown, the first bending mechanism 1 also includes a protrusion 14, one end face of which forms a first abutment portion 141. The first bending operation component 12 is rotatably mounted on the protrusion 14, and the first mounting portion 11 is located on the side of the protrusion 14 away from the first limiting structure 13. In this way, the various structures in the first bending mechanism 1 are arranged compactly, which is conducive to the miniaturization design of the first bending mechanism 1.

[0048] In one implementation, such as Figure 1 , Figure 4 and Figure 10 As shown, the first bending operation assembly 12 includes a first operating arm 121 and a first roller 122. The first operating arm 121 includes a first rotating arm 1211 and a first extended arm 1212. The first rotating arm 1211 is rotatably arranged, and the first extended arm 1212 is used to extend the lever arm length of the first operating arm 121, thereby making it easier for the user to rotate the first operating arm 121. Of course, the number of first extended arms 1212 can be one, two or even more, and the number of first extended arms 1212 can be adjusted according to the need for saving effort and the space conditions of the application site of the device.

[0049] The first roller 122 is rotatably connected to the first rotating arm 1211. The first roller 122 is used to abut against the injection needle 200 facing the first abutment part 141, and to squeeze the injection needle 200 during the rotation of the first operating arm 121, so that the injection needle 200 bends. Specifically, when performing planar bending, the user rotates the first operating arm 121, the first roller 122 abuts against the injection needle 200 facing the first abutment part 141, the first roller 122 squeezes the injection needle 200, so that the injection needle 200 bends, and due to the friction between the first roller 122 and the injection needle 200, the first roller 122 will rotate, so as to reduce the frictional force generated between the first roller 122 and the injection needle 200, thereby reducing scratches on the injection needle 200.

[0050] In one implementation, such as Figure 1 , Figure 4 and Figure 6As shown, the first bending operation assembly 12 also includes a first mounting shaft 123 and a second fastener 124. The first rotating arm 1211 has a first elongated hole 12111. The first roller 122 is rotatably mounted on the first mounting shaft 123. The second fastener 124 passes through the first elongated hole 12111 and is screwed to the first mounting shaft 123. The cap of the second fastener 124 abuts against the surface wall of the first rotating arm 1211, thereby mounting the first mounting shaft 123 onto the first rotating arm 1211. The first roller 122 is located below the first rotating arm 1211. In this solution, by setting the first elongated hole 12111, the minimum distance between the first roller 122 and the first abutment part 141 can be adjusted by adjusting the installation position of the second fastener 124 in the length direction of the first elongated hole 12111, thus making it suitable for planar bending processing of injection needles 200 with different outer diameters.

[0051] In one implementation, such as Figure 4 and Figure 6 As shown, the first extended arm 1212 is provided with a second elongated hole 12121, and the first rotating arm 1211 is provided with a second threaded hole 12112. A third fastener (not shown in the figure) passes through the second elongated hole 12121 and is screwed into the second threaded hole 12112 to install the first extended arm 1212 onto the first rotating arm 1211. In this solution, based on the labor-saving requirements and the space conditions of the application site, the relative position of the first rotating arm 1211 and the first extended arm 1212 can be adjusted by adjusting the installation position of the third fastener in the length direction of the second elongated hole 12121, thereby adjusting the lever arm length of the first operating arm 121.

[0052] In one implementation, such as Figure 1 and Figure 4 As shown, the first operating arm 121 also includes a first grip portion 1213, which is connected to the end of the first extended arm 1212 away from the first rotating arm 1211. The first grip portion 1213 is used for the operator to grip so as to rotate the first operating arm 121.

[0053] In one implementation, such as Figure 1 , Figure 4 and Figure 5 As shown, the protrusion 14 is provided with a third shaft hole 142, and the end of the first rotating arm 1211 away from the first extended arm 1212 is connected to a first rotating shaft 125. The first rotating shaft 125 is rotatably connected to the third shaft hole 142, and the first roller 122 is located between the first rotating shaft 125 and the first extended arm 1212.

[0054] In one implementation, such as Figure 1 , Figure 2 , Figure 7 and Figure 10As shown, the bending device 100 also includes a second bending mechanism 3, which includes a second mounting part 31 and a second bending operation component 32. The second mounting part 31 is used to selectively and detachably mount one of the first adjustment auxiliary structure 21 and the second adjustment auxiliary structure 22. The second bending mechanism 3 is used to perform spatial bending on the injection needle 200 after planar bending.

[0055] Specifically, when the first adjustment auxiliary structure 21 is installed on the second mounting part 31, the angle comparison mark 211 can be used by the operator for reference during the spatial bending process, so as to accurately determine the bending stop position of the injection needle 200. It can be used for rapid prototyping and can quickly produce the required bent products during the equipment research and development and debugging stage.

[0056] When the second adjustment auxiliary structure 22 is installed on the second mounting part 31, during the spatial bending process, the bending operation can be stopped when the injection needle 200 bends to abut against the stop member 221. It is suitable for high-precision forming at a specific bending angle, with high precision repeatability and high reliability, and is suitable for stable batch production.

[0057] The above technical solution, by setting a second bending mechanism 3, can meet the spatial bending requirements of the injection needle 200. Furthermore, the second bending mechanism 3 is equipped with a second mounting part 31, through which one of the first adjustment auxiliary structure 21 and the second adjustment auxiliary structure 22 can be selectively and detachably installed. This satisfies the high-precision spatial bending requirements for both rapid prototyping and stable mass production, without requiring switching the operating position of the second bending operation component 32 when switching between the first and second adjustment auxiliary structures 21 and 22. This simplifies the structure of the second bending mechanism 3 and facilitates its miniaturization. In addition, the angle adjustment auxiliary component 2 can be used in both the first bending mechanism 1 and the second bending mechanism 3, which helps reduce processing costs. The bending device 100 of this solution can meet the high-precision bending requirements of biological sample injection needles, satisfying both planar bending and spatial bending processing needs, to match the position and orientation of the internal flow path interface of the analytical instrument.

[0058] In one implementation, such as Figure 1 and Figure 10 As shown, there are two sets of angle adjustment auxiliary components 2. The first mounting part 11 and the second mounting part 31 are each matched with a set of angle adjustment auxiliary components 2, which reduces the disassembly and assembly process of the angle adjustment auxiliary components 2 and helps to improve bending efficiency.

[0059] In one implementation, such as Figure 1 and Figure 7As shown, the second mounting part 31 is a slot structure used to selectively engage one of the first adjustment auxiliary structure 21 and the second adjustment auxiliary structure 22. This snap-fit ​​assembly method is simple in structure and allows for convenient disassembly and operation. In one specific embodiment, the second bending mechanism 3 includes a second mounting base 35, with the second mounting part 31 located on the top wall of the second mounting base 35. This facilitates user viewing of the first adjustment auxiliary structure 21 or the second adjustment auxiliary structure 22 installed in the second mounting part 31.

[0060] Furthermore, such as Figure 1 , Figure 2 , Figure 7 and Figure 8 As shown, in order to facilitate the quick assembly of the second mounting part 31 with the first adjustment auxiliary structure 21 or the second adjustment auxiliary structure 22, at least one side of the second mounting part 31 is provided with a second anti-fooling groove 311. The second anti-fooling groove 311 is used to align and insert with the first anti-fooling protrusion 2121 of the marking plate 212, or to align and insert with the second anti-fooling protrusion 2222 of the mounting member 222.

[0061] In one implementation, such as Figure 1 and Figure 7 As shown, the second bending mechanism 3 also includes a second limiting structure 33, which restricts the movement of one end of the injection needle 200 to prevent the injection needle 200 from shifting during the bending process. Furthermore, the extension direction of the first end 201 when it is restricted by the first limiting structure 13 is different from the extension direction of the injection needle 200 when one end is restricted by the second limiting structure 33. This allows the section 202 to be bent in both the planar bending stage and the spatial bending stage to be arranged to extend in the same plane, facilitating the bending operation.

[0062] In one implementation, such as Figure 1 and Figure 7 As shown, the second bending mechanism 3 further includes two sets of bending mating components. Each bending mating component includes a matching second limiting structure 33, a second abutment portion 34, and a second shaft hole 341. The second limiting structure 33 restricts movement at one end of the injection needle 200. The two sets of bending mating components are symmetrically arranged about the first axis. The second bending operation component 32 is selectively rotatably connected to the second shaft hole 341 of one of the two sets of bending mating components. The second bending operation component 32 abuts against the injection needle 200 in opposition to the matching second abutment portion 34, and performs spatial bending by rotating.

[0063] Because the two sets of bending engagement components are symmetrically arranged about the first axis, when the second bending operation component 32 is rotatably connected to one of the second shaft holes 341, the second bending operation component 32 rotates counterclockwise, pressing the injection needle 200 counterclockwise to bend it in the counterclockwise direction. When the second bending operation component 32 is rotatably connected to the other second shaft hole 341, the second bending operation component 32 rotates clockwise, pressing the injection needle 200 clockwise to bend it in the clockwise direction. This solution, by setting two sets of bending engagement components symmetrically arranged about the first axis, can achieve bending processes in two opposite directions, enriching the bending functionality.

[0064] Furthermore, such as Figure 7 , Figure 8 and Figure 10 As shown, the second abutment portion 34 is disposed on the second mounting base 35. The second abutment portion 34 has an annular structure, and its outer periphery is used to abut the injection needle 200. The annular region of the second abutment portion 34 at least constitutes a partial segment of the second shaft hole 341, which is beneficial for structural compactness. The annular region of the second abutment portion 34 can constitute the entire segment of the second shaft hole 341, or it can constitute a partial segment of the second shaft hole 341. Preferably, since the second abutment portion 34 needs to abut the injection needle 200, it is a protruding structure. To facilitate the miniaturization design of the second bending mechanism 3, the protrusion height of the second abutment portion 34 will not be too high. Furthermore, to improve the stability of the rotational connection of the second bending operation assembly 32, the annular region of the second abutment portion 34 can constitute a partial segment of the second shaft hole 341, and the remaining segment of the second shaft hole 341 is formed on the second mounting base 35.

[0065] In one implementation, such as Figure 8 and Figure 10 As shown, the second mounting part 31 is provided with two sets of second anti-mistake grooves 311, and one set of bending fitting components matches one set of second anti-mistake grooves 311. Specifically, the user selects the corresponding bending fitting components and second anti-mistake grooves 311 according to the bending direction requirements, and adjusts the installation position of the angle adjustment auxiliary component 2 in the second mounting part 31 so that the angle adjustment auxiliary component 2 can meet the auxiliary determination of the bending stop position in both counterclockwise and clockwise bending situations.

[0066] In one implementation, such as Figure 1 , Figure 7 and Figure 10As shown, the second bending operation assembly 32 includes a second operating arm 321 and a second roller 322. The second roller 322 is rotatably connected to the second operating arm 321. The second operating arm 321 is selectively rotatably connected to the second shaft hole 341 of one of the two sets of bending mating assemblies via a second rotating shaft 325. The second roller 322 is used to abut against the injection needle 200 in opposite directions with the matching second abutment portion 34, and to squeeze the injection needle 200 during the rotation of the second operating arm 321, so that the injection needle 200 bends. Specifically, during spatial bending, the user rotates the second operating arm 321, and the second roller 322 and the matching second abutment part 34 abut against the injection needle 200. The second roller 322 squeezes the injection needle 200, causing it to bend. Furthermore, due to the friction between the second roller 322 and the injection needle 200, the second roller 322 rotates, reducing the frictional force between them and thus minimizing scratches on the injection needle 200. The second operating arm 321 can consist of only one rotating arm, or it can be a structure with a rotating arm and an extension arm, with the extension arm added as needed for labor-saving purposes.

[0067] In one implementation, such as Figure 1 and Figure 7 As shown, the second limiting structure 33 includes a limiting plate 331 and multiple limiting holes 332 with different diameters provided on the limiting plate 331. One end of the injection needle 200 is inserted into the limiting hole 332 to restrict movement of one end of the injection needle 200. This solution, by configuring multiple limiting holes 332 with different diameters, can be applied to restricting injection needles 200 with different outer diameters. Of course, the second limiting structure 33 can also adopt the structure of the first limiting structure 13.

[0068] In one implementation, such as Figure 1 , Figure 7 and Figure 8 As shown, the second mounting base 35 has two slots 351, which are symmetrically arranged about the first axis. The limiting plate 331 is engaged with one of the two slots 351. The slots 351 have two opposing support platforms 3511, and the limiting plate 331 is placed on the support platforms 3511. The second mounting base 35 also has a receiving cavity 352, which communicates with the slots 351 and is used to receive the portion of the injection needle 200 that protrudes from the limiting hole 332.

[0069] Furthermore, such as Figure 7 and Figure 8As shown, the limiting plate 331 is square in shape, and positioning posts 3512 are respectively provided on the two support platforms 3511 of the slot 351. For the two positioning posts 3512 on the same slot 351, one positioning post 3512 is set near the first diagonal of the limiting plate 331, and the other positioning post 3512 is set near the second diagonal of the limiting plate 331. The first diagonal and the second diagonal are on the same diagonal line. The limiting plate 331 is provided with two positioning holes (not shown in the figure). The two positioning holes are matched and inserted into the two positioning posts 3512 one by one. In this way, on the one hand, it plays a positioning role in the process of snapping the limiting plate 331 into the slot 351, which is conducive to rapid assembly. On the other hand, the two positioning posts 3512 can also improve the stability of the snapping between the limiting plate 331 and the slot 351.

[0070] In one implementation, such as Figure 7 and Figure 9 As shown, the second bending operation assembly 32 also includes a second mounting shaft 323 and a fourth fastener 324. The second operating arm 321 has a third elongated hole 3211. The second roller 322 is rotatably mounted on the second mounting shaft 323. The fourth fastener 324 passes through the third elongated hole 3211 and is screwed to the second mounting shaft 323. The cap of the fourth fastener 324 abuts against the surface wall of the second operating arm 321, thereby mounting the second mounting shaft 323 onto the second operating arm 321. The second roller 322 is located below the second operating arm 321. In this solution, by providing the third elongated hole 3211, the minimum distance between the second roller 322 and the second abutment portion 34 can be adjusted by adjusting the installation position of the fourth fastener 324 in the length direction of the third elongated hole 3211, thereby enabling spatial bending processing suitable for injection needles 200 with different outer diameters.

[0071] In one implementation, such as Figure 1 and Figure 7 As shown, the second operating arm 321 also includes a second grip 3212, which is used by the operator to grip and rotate the second operating arm 321.

[0072] Specifically, with Figure 1 The orientational relationship of the components of the bending device 100 is illustrated using an example, such as... Figure 1 and Figure 7 As shown, the two second shaft holes 341 are spaced apart in the front-to-back direction. When the second operating arm 321 is rotatably connected to the second shaft hole 341 located on the front side, the second bending operation component 32 rotates counterclockwise so that the injection needle 200 bends in the counterclockwise direction. When the second operating arm 321 is rotatably connected to the second shaft hole 341 located on the rear side, the second bending operation component 32 rotates clockwise so that the injection needle 200 bends in the clockwise direction.

[0073] In one implementation, such as Figure 1 and Figure 2 As shown, the bending device 100 also includes a base 4, and the first mounting base 15 and the second mounting base 35 are respectively mounted on the base 4 by corresponding fasteners.

[0074] In the process of detecting biomolecular interactions using a surface plasmon resonance (SPR) analyzer, when injecting sample using the injection needle 200, the bending device 100 of this application is used to bend the injection needle 200 according to the position and orientation of the internal flow path interface of the SPR analyzer. It should be understood that the bending device 100 constitutes an essential actuator for the SPR analyzer to achieve its sample injection function; that is, the bending device 100 is a crucial device for adapting the injection needle 200 to the SPR analyzer. The bending device 100 ensures that the injection needle 200 can accurately align with the position and orientation of the internal flow path interface of the SPR analyzer, thereby ensuring the formation of an effective sample injection path within the SPR analyzer.

[0075] In one specific embodiment, the working principle of the bending device 100 is as follows: When performing bending processing using the bending device 100, the first bending mechanism 1 and the angle adjustment auxiliary component 2 are used to insert the first end 201 of the injection needle 200 into the square through hole 131. The first fastener is screwed into the corresponding first threaded hole 132 and presses against the injection needle 200, so that the first end 201 of the injection needle 200 is locked in the square through hole 131. Then, the first operating arm 121 is rotated so that the first roller 122 and the first abutting part 141 abut against each other. The first roller 122 presses the injection needle 200 to cause it to bend in a plane. After the plane bending is completed, the injection needle 200 is transferred to the second bending mechanism 3. One end of the injection needle 200 is inserted into the corresponding limiting hole 332. Then, the second operating arm 321 is rotated so that the second roller 322 and the second abutment part 34 abut against the injection needle 200. The second roller 322 presses the injection needle 200 to cause it to bend in space until it is bent to the corresponding bending angle, thus completing the spatial bending.

[0076] It should be understood that in this article, SPR is an abbreviation for Surface Plasmon Resonance.

[0077] It should be understood that the above embodiments are exemplary and are not intended to encompass all possible implementations included in the claims. Various modifications and changes can be made to the above embodiments without departing from the scope of this disclosure. Similarly, the various technical features of the above embodiments can be arbitrarily combined to form other embodiments of this utility model that may not be explicitly described. Therefore, the above embodiments only illustrate several implementations of this utility model and do not limit the scope of protection of this utility model patent.

Claims

1. A bending device for a sample injection needle in a surface plasmon resonance (SPR) analyzer, the SPR analyzer being used to analyze the interactions of biomolecules, characterized in that, The bending device (100) includes: The first bending mechanism (1) includes a first mounting part (11) and a first bending operation assembly (12), the first bending operation assembly (12) being used to perform planar bending on the injection needle (200); An angle adjustment auxiliary component (2) includes a first adjustment auxiliary structure (21) and a second adjustment auxiliary structure (22); the first adjustment auxiliary structure (21) includes an angle reference mark (211), and the second adjustment auxiliary structure (22) includes a stop member (221) for stopping the injection needle (200) at a target angle position; the first mounting part (11) is used to selectively and detachably mount one of the first adjustment auxiliary structure (21) and the second adjustment auxiliary structure (22).

2. The bending device for the injection needle of a surface plasmon resonance analyzer according to claim 1, characterized in that, The first mounting part (11) is a slot structure, which is used to selectively engage one of the first adjustment auxiliary structure (21) and the second adjustment auxiliary structure (22).

3. The bending device for the injection needle of a surface plasmon resonance analyzer according to claim 1, characterized in that, The second adjustment auxiliary structure (22) further includes a mounting component (222), which has a first shaft hole (2221) and a stop component (221) which has an eccentric shaft (2211) rotatably connected to the first shaft hole (2221).

4. The bending device for the injection needle of a surface plasmon resonance analyzer according to claim 3, characterized in that, The second adjustment auxiliary structure (22) further includes a magnetic element (223), which is installed on the stop element (221); the mounting element (222) is a magnetically attracted element, and the magnetic element (223) is magnetically attracted to the mounting element (222); And / or, the number of the first shaft holes (2221) is multiple, and the multiple first shaft holes (2221) are spaced apart.

5. The bending device for the injection needle of a surface plasmon resonance analyzer according to any one of claims 1-4, characterized in that, The first bending mechanism (1) further includes a first limiting structure (13) and a first abutting part (141). The first limiting structure (13) is used to restrict the movement of the first end (201) of the injection needle (200). The first bending operation component (12) is used to abut the injection needle (200) against the first abutting part (141). The first bending operation component (12) is rotatably arranged, and the first bending operation component (12) performs the planar bending by rotating.

6. The bending device for the injection needle of a surface plasmon resonance analyzer according to claim 5, characterized in that, The first limiting structure (13) includes a square through hole (131) and at least two first threaded holes (132), the at least two first threaded holes (132) being respectively connected to both sides of the square through hole (131); the bending device (100) also includes a first fastener, the square through hole (131) being used for the insertion of the first end (201), the first fastener being used for screwing into the first threaded hole (132) and for abutting against the injection needle (200). And / or, the outline of the first abutment (141) is semi-circular; And / or, the first bending mechanism (1) further includes a protrusion (14), one end face of which forms the first abutment portion (141), the first bending operation component (12) is rotatably mounted on the protrusion (14), and the first mounting portion (11) is located on the side of the protrusion (14) away from the first limiting structure (13).

7. The bending device for the injection needle of a surface plasmon resonance analyzer according to claim 5, characterized in that, The first bending operation assembly (12) includes a first operating arm (121) and a first roller (122). The first operating arm (121) includes a first rotating arm (1211) and a first extension arm (1212). The first rotating arm (1211) is rotatably arranged, and the first extension arm (1212) is used to extend the lever arm length of the first operating arm (121). The first roller (122) is rotatably connected to the first rotating arm (1211). The first roller (122) is used to abut against the injection needle (200) in the opposite direction of the first abutment part (141) and to squeeze the injection needle (200) during the rotation of the first operating arm (121) so that the injection needle (200) bends.

8. The bending device for the injection needle of a surface plasmon resonance analyzer according to any one of claims 1-4, characterized in that, The bending device (100) further includes a second bending mechanism (3), which includes a second mounting part (31) and a second bending operation component (32). The second mounting part (31) is used to selectively and detachably mount one of the first adjustment auxiliary structure (21) and the second adjustment auxiliary structure (22). The second bending mechanism (3) is used to perform spatial bending on the injection needle (200) after planar bending.

9. The bending device for the injection needle of a surface plasmon resonance analyzer according to claim 8, characterized in that, The number of angle adjustment auxiliary components (2) is two sets, with the first mounting part (11) and the second mounting part (31) each matching one set of the angle adjustment auxiliary components (2). And / or, the second mounting part (31) is a slot structure for selectively engaging one of the first adjustment auxiliary structure (21) and the second adjustment auxiliary structure (22); And / or, the first bending mechanism (1) further includes a first limiting structure (13) for limiting the movement of the first end (201) of the injection needle (200); the second bending mechanism (3) further includes a second limiting structure (33) for limiting the movement of one end of the injection needle (200); the length extension direction of the first end (201) when it is limited by the first limiting structure (13) is different from the length extension direction of one end of the injection needle (200) when it is limited by the second limiting structure (33).

10. The bending device for the injection needle of a surface plasmon resonance analyzer according to claim 8, characterized in that, The second bending mechanism (3) also includes two sets of bending mating components. The bending mating components include a matching second limiting structure (33), a second abutment part (34), and a second shaft hole (341). The second limiting structure (33) is used to restrict the movement of one end of the injection needle (200). Two sets of bending fitting components are symmetrically arranged about the first axis, and the second bending operation component (32) is selectively rotatably connected to the second shaft hole (341) of one of the two sets of bending fitting components. The second bending operation component (32) is used to abut against the injection needle (200) in opposition to the matching second abutment (34), and the second bending operation component (32) performs the spatial bending by rotating.

11. The bending device for the injection needle of a surface plasmon resonance analyzer according to claim 10, characterized in that, The second bending operation assembly (32) includes a second operating arm (321) and a second roller (322), the second roller (322) being rotatably connected to the second operating arm (321), and the second operating arm (321) being selectively rotatably connected to the second shaft hole (341) of one of the two sets of bending mating assemblies; The second roller (322) is used to abut against the injection needle (200) in opposition to the matching second abutment (34), and to squeeze the injection needle (200) during the rotation of the second operating arm (321) so that the injection needle (200) bends. And / or, the second abutment portion (34) has an annular structure, and the annular region of the second abutment portion (34) at least constitutes a partial hole segment of the second shaft hole (341).

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