A sample preparation device for perfluorinated compounds

Abstract

The utility model relates to a kind of sample pretreatment device of perfluorinated compound, small positive pressure solid phase extraction component of volume includes base, each pair of stand respectively is arranged at the both sides position of base;Positive pressure acceleration controller is arranged on stand;The bottom of positive pressure acceleration controller is provided with lifting rod;Extraction block is connected with lifting rod by extraction block support;The bottom both sides of extraction block are provided with connecting side plate, collection frame is arranged below extraction block;Large volume sample loading component includes peristaltic pump, and three-dimensional sample rack is provided with sample bottle, and sample bottle is connected with the liquid inlet of peristaltic pump by sample tube;The liquid outlet of peristaltic pump is connected with extraction column by sample tube;Device is extracted using peristaltic pump to large volume liquid sample, can continuously uninterruptedly sample, applicable to volume more than tens of milliliter sample loading;For small volume sample, using pipette directly add extraction column, as low as 50ul and below biological sample loading, maximum degree avoid the recovery rate of sample loss caused by low.

Description

Technical Field

[0001] This invention belongs to the field of perfluorinated compound sample pretreatment technology, specifically relating to a perfluorinated compound sample pretreatment device. Background Technology

[0002] In analytical testing, sample pretreatment for perfluorinated compounds accounts for a significant portion of the analytical process, and the main analytical errors also originate from this stage. With the continuous emergence of new adsorbents and operational modes, solid-phase extraction (SPE) has become a powerful tool for chemical separation and purification, widely applied in various fields such as food, biomedicine, and environmental monitoring, from trace sample pretreatment to industrial-scale chemical separation. As an emerging pollutant, perfluorinated compounds have received widespread attention in recent years, and analytical method standards for perfluorinated compounds in various fields are gradually being published. Most of these standards employ solid-phase extraction for sample purification. There are two main types of existing solid phase extraction (SPE) equipment: 1. Semi-automatic SPE equipment, which mainly includes glass cylinder negative pressure SPE instruments and gas positive pressure assisted positive pressure SPE instruments. Traditional semi-automatic negative pressure SPE equipment requires a sealed connection between the pipeline and the solid phase extraction column. Large-volume samples are loaded onto the column by negative pressure. The flow rate is adjusted by manually adjusting the knob under each column according to the liquid dripping frequency. This makes it difficult to accurately control the flow rate, and the sealing tube under the knob is prone to deformation, resulting in poor reusability. 2. Fully automated solid-phase extraction (SPE) instruments are primarily designed for loading large-volume samples, but they generally suffer from difficulties and slow loading speeds. Typically, only 4 or 6 samples can be processed at a time, and the use of a syringe pump for large-volume loading results in intermittent sample passage through the column, slow loading, and low processing efficiency. Furthermore, the switching valves on the instrument are prone to clogging by fine particles in the sample, causing malfunctions. Fully automated SPE also has limitations in sample loading capacity, limiting it to either small or large samples. Switching between different sample sizes requires stopping the machine to replace parts, resulting in poor operational flexibility. Therefore, existing equipment cannot optimally accommodate sample loading of varying sizes.

[0003] Furthermore, solid-phase extraction (SPE) equipment employs various sample loading power systems, such as peristaltic pumps, metering pumps, or syringe pumps. Due to limitations in equipment design, these systems can only meet the needs of samples of a specific volume. While syringe pumps can effectively transfer small-volume samples, large-volume samples require multiple reciprocating pumping actions, significantly wasting experimental time. If the water sample contains particulate matter, syringe pump loading presents the problem of particle residue abrasion of the syringe and sealing plug. Using a continuous peristaltic pump for small-volume samples results in sample loss due to the lengthy tubing and valves. In positive pressure SPE, the uniformity of gas pressure and airflow across different channels is crucial for ensuring the parallelism and repeatability of experimental results. Uneven airflow leads to variations in column velocity, reagent-sample contact time, and column dryness across different channels, resulting in inconsistent adsorption and elution efficiencies of the target analyte. Ultimately, this causes deviations in detection results, failing to meet the accuracy requirements for detecting organic residues in agricultural products, environmental samples, and other similar samples. Utility Model Content

[0004] To address at least one of the problems in the prior art, the purpose of this invention is to provide a sample pretreatment device for perfluorinated compounds. For large-volume liquid samples, a peristaltic pump is used for extraction, allowing for continuous and uninterrupted sample loading, suitable for samples with volumes of tens of milliliters or more. For small-volume samples, a pipette is used to directly add the sample into the extraction column, allowing for the loading of biological samples as low as 50 μL or less without passing through any valves or pipelines, thus minimizing sample loss and avoiding low recovery rates.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: A sample pretreatment device for perfluorinated compounds includes a small-volume positive pressure solid-phase extraction component and a large-volume sample loading component. The small-volume positive pressure solid-phase extraction component includes: Base; The uprights are configured as at least one pair, with each pair of uprights respectively located on both sides of the base; A positive pressure acceleration controller is mounted on the column. Multiple air nozzles are installed at the bottom of the positive pressure acceleration controller. The positive pressure acceleration controller is connected to an external compressed air source through pipelines. A lifting rod is installed at the bottom of the positive pressure acceleration controller. An extraction block is connected to the lifting rod via an extraction block bracket. The extraction block has multiple extraction column placement holes for placing extraction columns. After the lifting rod is raised, the extraction columns can connect to the jet nozzle. Connecting side plates are provided on both sides of the bottom of the extraction block, and sliding grooves are provided on the inner side of the connecting side plates. A collection rack is slidably disposed below the extraction block via the groove. The collection rack is provided with multiple collection tubes, each of which is located directly below the extraction column and is used to collect the sample after it has been processed by the extraction column. Waste liquid tank, replacing the collection rack, is slidably disposed below the extraction block via the chute for collecting waste liquid; The large-volume sample loading assembly includes: A peristaltic pump is located on top of the positive pressure acceleration controller; A three-dimensional sample holder has sample bottles mounted at an angle. The sample bottles can be connected to the inlet of the peristaltic pump via a sample tube. The outlet of the peristaltic pump can be connected to the outlet of the extraction column via a sample tube.

[0006] Preferably, multiple grooves are arranged in parallel vertically.

[0007] Preferably, the extraction column placement holes are arranged in four rows, with eight holes in each row.

[0008] Preferably, there are two peristaltic pumps, which are respectively located on the top two sides of the positive pressure acceleration controller.

[0009] Preferably, a side-fixed combing block is provided on the side wall of the positive pressure acceleration controller, and a sample tube slot is provided on the side-fixed combing block.

[0010] Preferably, a sample tube placement groove is provided below the side-fixed comb block on the side wall of the positive pressure acceleration controller.

[0011] Preferably, a column-mounted folding combing rack is provided on the outer side of the column, and the column-mounted folding combing rack has through holes.

[0012] Preferably, the bottom of the side wall of the waste liquid tank is provided with a drain port, and the drain port is connected to the waste liquid bucket through a drain pipe.

[0013] Preferably, there are two three-dimensional sample holders, which are placed on both sides of the base.

[0014] Preferably, each of the three-dimensional sample racks is provided with eight sample bottle placement slots, and each of the sample bottle placement slots is inclined upwards.

[0015] This utility model has the following advantages due to the adoption of the above technical solution: 1. The sample pretreatment device for fluorine compounds provided by this utility model uses a peristaltic pump to extract large-volume liquid samples, which can continuously and uninterruptedly load samples, and is suitable for loading samples with a volume of tens of milliliters or more; for small-volume samples, a pipette is used to directly add the samples into the extraction column, and biological samples as low as 50 μL or less can be loaded without passing through any valves or pipelines, so as to minimize the loss of samples and avoid low recovery rates.

[0016] 2. The sample pretreatment device for fluorine compounds provided by this utility model adopts two eight-channel peristaltic pumps to achieve simultaneous continuous loading and column passage of sixteen samples, resulting in high sample throughput and high efficiency.

[0017] 3. The sample pretreatment device for fluorine compounds provided by this utility model has an accurate and controllable sample loading flow rate. The peristaltic pump column flow rate can be set through a touch screen, and the flow rate of each channel is consistent, ensuring the uniformity of column passage for each sample.

[0018] 4. The sample pretreatment device for fluorinated compounds provided by this utility model adopts continuous sample loading technology for large-volume samples, which can save 3 / 4 of the sample loading time compared with traditional syringe pump sample loading; at the same time, it can accurately control the flow rate, which is beneficial to the development of methods for perfluorinated compounds; in the scenario of large-volume liquid sample loading, the peristaltic pump has a lower maintenance cost and greater durability, and the only vulnerable part is the sample tube hose, which has low operating cost and does not require disassembling the pump body for replacement, making maintenance simple. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the sample pretreatment device for fluorine compounds provided in one embodiment of the present invention.

[0020] Figure 2 This is another schematic diagram of the sample pretreatment device for fluorine compounds provided in this embodiment of the present invention.

[0021] Figure 3 This is a schematic diagram of the waste liquid tank of the sample pretreatment device for fluorine compounds provided in this embodiment of the present invention.

[0022] Figure 4 This is a schematic diagram of the collection rack area provided in this embodiment of the present invention.

[0023] Figure 5 This is a schematic diagram of the side-fixed combing block area provided in this embodiment of the present invention.

[0024] Marked in the attached diagram: 1. Base, 2. Column, 3. Positive pressure acceleration controller, 301. Jet nozzle, 4. Lifting rod, 5. Extraction block, 6. Extraction block support, 7. Extraction column, 8. Connecting side plate, 801. Slide groove, 9. Collection rack, 10. Waste liquid tank, 11. Collection tube, 12. Peristaltic pump, 13. Tray, 14. Three-dimensional sample rack, 15. Sample bottle, 16. Side-fixed combing block, 17. Sample tube placement slot, 18. Column-mounted folding combing rack. Detailed Implementation

[0025] To make the objectives, technical solutions, and advantages of this utility model clearer, the technical solutions of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. All other embodiments obtained by those skilled in the art based on the embodiments of this utility model without creative effort are within the scope of protection of this utility model.

[0026] In the description of this utility model, it should be noted that the terms "upper", "lower", "front", "rear", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the system or component referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0027] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "assembly," "setup," and "connection" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0028] This invention provides a sample pretreatment device for perfluorinated compounds. For large-volume liquid samples, a peristaltic pump is used for extraction, which can continuously and uninterruptedly load samples, suitable for loading samples with volumes of tens of milliliters or more. For small-volume samples, a pipette is used to directly add the samples into the extraction column, suitable for loading biological samples as low as 50 μL or less, without going through any valves or pipelines, thus minimizing the risk of low recovery rates due to sample loss.

[0029] The embodiments of this utility model will now be described in detail with reference to the accompanying drawings.

[0030] Example like Figures 1 to 5As shown, this embodiment provides a sample pretreatment device for perfluorinated compounds, characterized in that it includes a small-volume positive pressure solid-phase extraction component and a large-volume sample loading component. Small-volume positive pressure solid-phase extraction components include: Base 1 is a square flat plate with four support feet at the four corners of the bottom of the plate. The uprights 2 are set as at least one pair; each pair of uprights is set on both sides of the base; Specifically, the column 2 is provided with two pairs, which can more stably support the positive pressure acceleration controller 3; A positive pressure acceleration controller 3 is mounted on the column 2. Multiple jet nozzles 301 are installed at the bottom of the positive pressure acceleration controller 3. The positive pressure acceleration controller 3 is connected to an external compressed air source through pipelines. A lifting rod 4 is installed at the bottom of the positive pressure acceleration controller 3. Specifically, the positive pressure acceleration controller 3 has a control panel on its front side. The control panel includes a lifting button for controlling the raising and lowering of the lifting rod 4 and a gas positive pressure acceleration switch for controlling the jet nozzle 301. The jet nozzle 301 is connected to an external compressed air source via a pipeline equipped with an electrically controlled valve. This valve is connected to a control module within the positive pressure acceleration controller 3, and the control module is connected to the gas positive pressure acceleration switch. The lifting rod 4 is connected to the control module via a cylinder, and the control module is connected to the lifting button. A pressure gauge on the control panel can detect the air pressure in the pipeline. An elastic sealing ring is installed at the nozzle 301's nozzle opening. When the nozzle 301 is connected to the inlet of the extraction column 7, the elastic sealing ring ensures a tight seal between the contact surfaces. The lifting rod 4 can be a pneumatic lifting rod.

[0031] The extraction block 5 is connected to the lifting rod 4 via the extraction block support 6. The extraction block 5 is provided with multiple extraction column placement holes for placing extraction columns 7. After the lifting rod 4 is raised, the extraction column 7 can be connected to the jet nozzle 301. The bottom sides of the extraction block 7 are provided with connecting side plates 8, and the inner side of the connecting side plates 8 is provided with a sliding groove 801.

[0032] Specifically, the extraction block 5 is a square plate with four rows of extraction column placement holes, eight in each row, evenly arranged on the extraction block 5. The extraction column placement holes have different diameters to accommodate extraction columns 7 of different sizes, such as 1mL / 3mL / 6mL / 12ml. The extraction columns 7 are commercially available solid-phase extraction columns, and different types of extraction columns 7 can be used to aspirate impurities or extracts from the sample. There are two extraction block supports 6, one on each side of the extraction block 5. The top of the extraction block support 6 is connected to the lifting rod 4, and the bottom is connected to the extraction block 5. The connecting side plate 8 is used to connect to the collection rack 9 or the waste liquid tank 10. Multiple sliding grooves 801 are arranged parallel to each other vertically. In actual applications, four sliding grooves 801 are provided. By inserting different sliding grooves 801 into the top of the collection rack 9 or the waste liquid tank 10, the distance between the collection tube 11 and the extraction column 7 can be adjusted. In practical applications, the extraction block 5 can move back and forth within the slide of the extraction block support 6. When the extraction block 5 moves to the front of the support 6, it facilitates the loading and unloading of the extraction column 7 and the addition of solvent or sample into the extraction column 7, enabling operations such as activation, sample loading, rinsing, and elution in solid-phase extraction. When the extraction block 5 is pushed to the rear of the support 6, the lifting button can be flipped upwards via the positive pressure acceleration controller 3, provided that a gas connection is established. The extraction block 5 rises with the support 6 and contacts the elastic sealing ring at the bottom of the positive pressure acceleration controller 3, sealing the top of the extraction block 5 with the nozzle 301 of the positive pressure acceleration controller 3. Depending on the placement of the extraction block 5, the corresponding row of positive pressure gas acceleration switches can be turned on. The positive pressure gas accelerates the liquid flow rate through the column or is used to dry the inside of the extraction column 7.

[0033] The collection rack 9 is slidably positioned below the extraction block 5 via the slide groove 801. The collection rack 9 is equipped with multiple collection tubes 11, each of which is located directly below the extraction column 7 and is used to collect the sample after it has been processed by the extraction column.

[0034] Specifically, the collection rack 9 has three layers of flat plates connected by connecting columns. The upper two plates have holes for placing collection tubes 11, and the bottom plate supports the collection tubes 11. The opening of the collection tube 11 is located directly below the outlet of the extraction column 7, which allows for better collection of the sample after processing by the extraction column 7.

[0035] Waste liquid tank 10, replacement collection rack 9, is slidably set below extraction block 5 via slide groove 801 for collecting waste liquid; Specifically, when loading large-volume samples, the waste liquid tank 10 is hung on the connecting side plate 8. After the sample is absorbed by the extraction column 7, the waste liquid flows from the bottom of the extraction column 7 into the waste liquid tank 10. A drain port is provided at the bottom of the side wall of the waste liquid tank 10. The drain port can be connected to the waste liquid tank through a drain pipe to directly discharge the waste liquid into the waste liquid tank.

[0036] The collection rack 9 or waste liquid tank 10 can move together with the extraction block 5 to realize the waste discharge or collection operation of the liquid passing through the column.

[0037] Large-volume sample loading components include: The peristaltic pump 12 is located on top of the positive pressure acceleration controller 3; Specifically, a tray 13 can be installed on the top of the positive pressure acceleration controller 3, with a waste discharge port at the bottom rear of the tray. The waste discharge port is connected to a waste liquid tank via a waste discharge pipe. A peristaltic pump 12 is installed inside the tray 13. In case of leakage, the liquid can be collected in the tray 13 and discharged through the waste discharge port along the pipeline, preventing contamination of components below the unit inside the tray. Two peristaltic pumps 12 are installed, one on each side of the tray 13 on top of the positive pressure acceleration controller 3. The peristaltic pump 12 is a prior art product, and a control panel is installed on it to set its operating parameters.

[0038] A three-dimensional sample holder 14 is inclinedly mounted on which a sample bottle 15 is mounted. The sample bottle 15 can be connected to the inlet of the peristaltic pump 12 through a sample tube. The outlet of the peristaltic pump 12 can be connected to the outlet of the extraction column 7 through a sample tube.

[0039] Specifically, two three-dimensional sample racks 14 are provided, placed on either side of the base 1, adjacent to the peristaltic pump 12. Each three-dimensional sample rack 14 has eight sample bottle placement slots, each tilted upwards at an angle ranging from 30° to 50°. When a sample bottle 15 is placed in a slot, its opening tilts upwards, ensuring a small contact area and high liquid level for the last small amount of sample inside, allowing for complete extraction. The three-dimensional sample rack 14 occupies minimal space, and the sample bottle placement slots are neatly arranged vertically, facilitating sample observation and organization. The sample tubes are connected to the pump tubes of the peristaltic pump 12 via a two-way valve, and each channel is distinguished by a different color label. The sample tubes use 3603 silicone tubing for the analysis of perfluorinated compounds. This silicone is specifically designed to resist bending fatigue and wear, can handle almost all organic chemicals found in the laboratory, and has lower permeability than rubber tubing. The smooth inner wall helps prevent buildup and facilitates cleaning. It also has excellent chemical resistance, is non-oxidizing, and non-polluting. In this embodiment, a side-fixing comb block 16 is provided on the side wall of the positive pressure acceleration controller 3, and a sample tube slot is provided on the side-fixing comb block 16. The sample tube can be stuck in the slot, making the tubing neater. The sample tube is connected to the inlet end of the peristaltic pump 12, and a suitable length in the middle of the sample tube is fixed in the slot by pressing. This achieves combing and fixing of the sample tube to the inlet end of the pump tube. The outlet end of the peristaltic pump 12 is connected to the sample tube by a two-way sealing connection.

[0040] In this embodiment, a sample tube placement slot 17 is provided below the fixed comb block 16 on the upper side wall of the positive pressure acceleration controller 3. When the sample tube is not connected to the sample bottle 15, its free end can be placed in the sample tube placement slot 17.

[0041] In practical applications, the sample tube connected to the sample vial 15 has a sinker at its sample inlet end. When no sample loading operation is being performed, the inlet end of the sample tube connected to the peristaltic pump 12 is placed in the sample tube placement slot 17 on the same side as the peristaltic pump 12. When a sample loading operation is being performed, the sample inlet end of the sample tube is placed in the sample vial 15. Under the gravity of the sinker, the tube sinks to the bottom of the vial. Combined with the three-dimensional sample rack 14 with the inclined sample vial placement slot, it can be ensured that all samples can be removed.

[0042] In this embodiment, a column-mounted folding combing rack 18 is provided on the outer side of the column 2, and the column-mounted folding combing rack 18 has through holes.

[0043] Specifically, two sets of on-column folding combers 18 are fixed to the left and right columns 2 respectively. The on-column folding combers 18 are provided with sample tube channels, so that after the on-column folding combers 18 are unfolded, the sample tubes passing through each channel and the column sealing caps at their ends are positioned above the extraction block 5 in the pull-out position. The column sealing caps correspond one-to-one with the first two rows of extraction columns 7 in the extraction block 5. After sealing the column sealing caps to the extraction columns 7 respectively, the sample loading operation can be performed. After the sample processing is completed, the column sealing caps are removed, the on-column folding combers 21 are retracted, and other solid phase extraction operations can be performed without hindrance.

[0044] The sample pretreatment device for perfluorinated compounds in this embodiment requires the following steps during sample processing: activation: First, the extraction column 7 needs to be activated. Hang the waste liquid tank 10 on the connecting side plate 8, placing it below the extraction block 5. The waste liquid tank 10 is connected to the waste liquid bucket through a waste liquid pipe. Select the extraction column 7 according to the extraction requirements and place 16 solid phase extraction columns 7 in the two rows of extraction column placement holes outside the corresponding extraction block 5. According to the solid phase extraction method, use a pipette or other pipetting device to load the activation reagent into the solid phase extraction column 7. The activation reagent flows downward under the action of gravity, wets the packing material in the extraction column 7, and then flows out of the tail end of the extraction column 7 and drips into the waste liquid tank 10. The activation reagent is generally two or more types. During the activation process, ensure that the packing material of the solid phase extraction column 7 is not exposed to the air and keep the liquid level slightly higher than the column bed before loading the reagent or sample into the extraction column 7. Sample loading: For loading large-volume samples, after the final activation reagent is loaded onto the extraction column 7, open the column folding comb 18 and seal the column caps connecting the extraction column 7 to the hanging sample tubes one by one. According to the color labels on the tubing, place the inlet end of the sample tube with the corresponding color-coded sink into the corresponding sample bottle 15 in the three-dimensional sample holder 14. Pull up the peristaltic pump tubing clamp, set the pump flow rate and sample volume on the peristaltic pump touchscreen, and start the pump. The sample will be delivered to the extraction column 7 at the set flow rate, and the waste liquid will flow into the waste liquid container through the waste liquid tank 10. After loading, remove the column cap connecting the sample tube to the extraction column 7 and retract the column folding comb 18.

[0045] Rinsing, drying and elution: Continuing with the activation procedure, the extraction column 7 is rinsed with a pipette. If positive pressure acceleration is required to speed up liquid flow or dry the column, the extraction block 5 needs to be pushed to the innermost part of the extraction block holder 6. With the external gas source connected, the lifting button is turned upwards via the control panel of the positive pressure acceleration controller 3. The extraction block holder 6 rises and connects to the jet nozzle 301 at the bottom of the positive pressure acceleration controller 3, and the top of the extraction column 7 is sealed to the positive pressure acceleration controller 3 via an elastic sealing ring. Depending on the placement of the extraction column 7, the corresponding first two rows of positive pressure gas acceleration switches are turned on. The positive pressure gas accelerates the liquid flow through the column or is used to dry the inside of the column. After accelerated flow or column drying, the lifting button is turned downwards, the extraction block holder 6 descends, and the extraction block 5 is pulled out to the front of the extraction block holder 6. Before elution, the collection rack 9 containing the collection tube 11 replaces the waste liquid tank 10 hanging on the connecting side plate 8. The elution reagent is loaded into the extraction column 7 using a pipette or other pipetting device. The eluent flows downwards under gravity, wetting the packing material inside the column before dripping from the tail end of extraction column 7 into collection tube 11. If accelerated elution is required, the positive pressure acceleration process can be repeated. Once elution is complete, the entire solid-phase extraction process is finished.

[0046] For loading small-volume samples, after the activation step, the sample is dropped into the extraction column 7 using a pipette or other pipetting device. The sample flows through the extraction column 7, and the waste liquid generated flows into the waste liquid tank 10. The solid-phase extraction process is then completed through rinsing, drying, and elution steps.

[0047] The sample pretreatment device for perfluorinated compounds in this embodiment can load both large-volume liquid samples and small-volume samples within the same device, improving flexibility and efficiency.

[0048] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this utility model, and not to limit it. Although this utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this utility model.

Claims

1. A sample pretreatment device for perfluorinated compounds, characterized in that, Including small-volume positive pressure solid-phase extraction components and large-volume sample loading components; The small-volume positive pressure solid-phase extraction component includes: Base; The uprights are configured as at least one pair, with each pair of uprights respectively located on both sides of the base; A positive pressure acceleration controller is mounted on the column. Multiple air nozzles are installed at the bottom of the positive pressure acceleration controller. The positive pressure acceleration controller is connected to an external compressed air source through pipelines. A lifting rod is installed at the bottom of the positive pressure acceleration controller. An extraction block is connected to the lifting rod via an extraction block bracket. The extraction block has multiple extraction column placement holes for placing extraction columns. After the lifting rod is raised, the extraction columns can connect to the jet nozzle. Connecting side plates are provided on both sides of the bottom of the extraction block, and sliding grooves are provided on the inner side of the connecting side plates. A collection rack is slidably disposed below the extraction block via the groove. The collection rack is provided with multiple collection tubes, each of which is located directly below the extraction column and is used to collect the sample after it has been processed by the extraction column. Waste liquid tank, replacing the collection rack, is slidably disposed below the extraction block via the chute for collecting waste liquid; The large-volume sample loading assembly includes: A peristaltic pump is located on top of the positive pressure acceleration controller; A three-dimensional sample holder has sample bottles mounted at an angle. The sample bottles can be connected to the inlet of the peristaltic pump via a sample tube. The outlet of the peristaltic pump can be connected to the outlet of the extraction column via a sample tube.

2. The sample pretreatment apparatus for perfluorinated compounds according to claim 1, characterized in that, Multiple slides are arranged parallel to each other vertically.

3. The sample pretreatment apparatus for perfluorinated compounds according to claim 1, characterized in that, The extraction column placement holes are arranged in four rows, with eight holes in each row.

4. The sample pretreatment apparatus for perfluorinated compounds according to claim 1, characterized in that, Two peristaltic pumps are provided, one on each side of the top of the positive pressure acceleration controller.

5. The sample pretreatment apparatus for perfluorinated compounds according to claim 1, characterized in that, The positive pressure acceleration controller has a side-fixed combing block on its side wall, and the side-fixed combing block has a sample tube slot.

6. The sample pretreatment apparatus for perfluorinated compounds according to claim 5, characterized in that, A sample tube placement slot is provided below the side-fixed comb block on the side wall of the positive pressure acceleration controller.

7. The sample pretreatment apparatus for perfluorinated compounds according to claim 1, characterized in that, A column-mounted folding combing rack is provided on the outer side of the column, and the column-mounted folding combing rack has through holes.

8. The sample pretreatment apparatus for perfluorinated compounds according to claim 1, characterized in that, The waste liquid tank has a drain outlet at the bottom of its side wall, and the drain outlet is connected to the waste liquid bucket through a drain pipe.

9. The sample pretreatment apparatus for perfluorinated compounds according to claim 1, characterized in that, Two three-dimensional sample holders are provided, placed on either side of the base.

10. The sample pretreatment apparatus for perfluorinated compounds according to claim 9, characterized in that, Each of the three-dimensional sample racks is provided with eight sample bottle placement slots, and each of the sample bottle placement slots is inclined upwards.

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