A paper tip SERS substrate detection device
Patent Information
- Application Number
- CN202522213313.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-10-20
- Publication Date
- 2026-09-29
- Estimated Expiration
- 2035-10-20
AI Technical Summary
[0004]本实用新型为了解决现有SERS基底使用场景受限，且无法进行现场检测的技术问题，提出了一种纸尖SERS基底检测装置，可以解决上述问题
[0012]与现有技术相比，本实用新型的优点和积极效果是：本实用新型的纸尖SERS基底检测装置，通过采用纸尖SERS基底，其具有一定的柔韧性，能够随着不规则的被测对象的弯曲度进行任意弯折擦拭采集，采集方便灵活，尤其适用于现场原位采集。通过在基座上设置在竖直方向以及水平方向可自由调节的支撑杆，结构简单便携，调节灵活，结合加热模块能够对纸尖SERS基底加热，适用于现场原位采集后的现场测量。此外，基底支撑结构通过设置为支撑环状，纸尖SERS基底支撑在支撑环上时，可利用其锥状结构的倾斜侧边与支撑环的内表面形成的夹紧力进行固定，无需设置另外的固定结构，尤其方便锥状结构的纸尖SERS基底自由取放。
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Figure CN224816191U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to a detection device, specifically, to a paper tip SERS substrate detection device. Background Technology
[0002] Raman spectroscopy provides rich biochemical information through molecular vibrational fingerprints, while surface-enhanced Raman spectroscopy (SERS) amplifies signals by several orders of magnitude on metallic nanostructures, making it the preferred technique for trace analysis. Traditional SERS substrates mostly use rigid carriers such as silicon wafers, relying on electron beam lithography, templates, or self-assembly to obtain periodic nanopatterns. Although these methods offer good repeatability and high enhancement factors, they face three major bottlenecks: fixed shapes, making it difficult to fit curved surfaces and resulting in low on-site sampling efficiency; complex and costly processes, preventing single-use and posing a significant risk of cross-contamination; and in high-salinity seawater systems, rapid salt crystallization quickly covers hot spots, causing a sharp drop in signal and making it difficult to meet the needs of rapid on-site detection.
[0003] The seawater hydrogen production process places higher demands on real-time monitoring: trace poisons such as Cl⁻, Br⁻, and organophosphonic acids in seawater can poison the catalyst, leading to a sharp drop in electrolysis efficiency. Complex substrates, large salinity gradients, and limited sampling space make rigid substrates almost unsuitable. Therefore, developing a flexible, disposable, high-salt-resistant paper-tip SERS substrate detection device has become a key solution for rapidly identifying micro-pollutants, membrane contaminants, and catalyst poisons in complex seawater systems. Summary of the Invention
[0004] To address the technical problem that existing SERS substrates are limited in their application scenarios and cannot be tested on-site, this invention proposes a paper tip SERS substrate testing device, which can solve the above problems.
[0005] To solve the above-mentioned technical problems, the present invention adopts the following technical solution: A paper tip SERS substrate detection device, comprising: Base; A support rod is slidably connected to the base via a slider. The support rod includes a fixed shaft and a movable shaft. The fixed shaft is fixed to the slider and has an upward-facing threaded hole. The lower end of the movable shaft has an external thread that matches the threaded hole. The lower end of the movable shaft is inserted into the threaded hole and is movably connected to the fixed shaft via a thread. A base support structure connected to the movable shaft, the base support structure having a support ring; A paper tip SERS substrate, the bottom of which extends into the support ring and is supported on the support ring; A heating module, which is located below the substrate support structure, is used to heat the paper tip SERS substrate; A Raman spectrometer is mounted on the base and positioned opposite the support rod.
[0006] In some embodiments, the heating module is an electric heating ring coaxial with the support ring. When the paper tip SERS substrate is supported on the support ring, the lower end of the paper tip SERS substrate extends into the electric heating ring and there is a gap between the paper tip SERS substrate and the electric heating ring.
[0007] In some embodiments, the paper tip SERS substrate is a conical structure that is wider at the top and narrower at the bottom.
[0008] In some embodiments, the cone angle of the cone-shaped structure is 12° to 17°.
[0009] In some embodiments, the conical structure is provided with a wax oil sealing layer at a distance of 13 mm to 17 mm from the tip of the cone.
[0010] In some embodiments, the material of the paper tip SERS substrate is laboratory qualitative filter paper.
[0011] In some embodiments, the base is provided with a dovetail groove, the slider matches the dovetail groove, and the slider can slide in the dovetail groove.
[0012] Compared with existing technologies, the advantages and positive effects of this utility model are as follows: The paper tip SERS substrate detection device of this utility model, by using a paper tip SERS substrate, has a certain degree of flexibility, and can be bent and wiped to collect data according to the curvature of the irregular test object, making data collection convenient and flexible, especially suitable for in-situ on-site collection. By setting a support rod that can be freely adjusted vertically and horizontally on the base, the structure is simple, portable, and flexible in adjustment. Combined with a heating module, the paper tip SERS substrate can be heated, making it suitable for on-site measurement after in-situ collection. Furthermore, the substrate support structure is set as a support ring. When the paper tip SERS substrate is supported on the support ring, it can be fixed by the clamping force formed by the inclined side of its conical structure and the inner surface of the support ring, eliminating the need for additional fixing structures. This is especially convenient for the free placement and removal of the conical paper tip SERS substrate.
[0013] Other features and advantages of this utility model will become clearer after reading the detailed description of the embodiments of this utility model in conjunction with the accompanying drawings. Attached Figure Description
[0014] Figure 1 This is a schematic diagram of the structure of one embodiment of the paper tip SERS substrate detection device proposed in this utility model; Figure 2 yes Figure 1 A partial structural schematic diagram of the dovetail groove structure of the SERS substrate detection device for the paper tip; Figure 3 This is a schematic diagram of the structure of a paper tip SERS substrate according to an embodiment of the paper tip SERS substrate detection device proposed in this utility model; Figure 4 This is a Raman signal intensity map of different regions on the paper tip SERS substrate 14 in one embodiment of the paper tip SERS substrate detection device proposed in this utility model. Detailed Implementation
[0015] The specific embodiments of this utility model will be described in further detail below with reference to the accompanying drawings.
[0016] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.
[0017] It should be noted that in the description of this invention, terms such as "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," indicating directional or positional relationships, are based on the directional or positional relationships shown in the accompanying drawings. These are merely for ease of description and do not indicate or imply that the device or element must have a specific orientation, or be constructed and operated in a specific orientation; therefore, they should not be construed as limitations on this invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance. In the description of this invention, "a plurality of" means two or more, unless otherwise explicitly specified.
[0018] In this invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.
[0019] Example 1: This example proposes a paper tip SERS substrate detection device, see [link to example]. Figure 1As shown, the system includes a base 11, a support rod 12, a substrate support structure 13, a paper tip SERS substrate 14, a heating module 15, and a Raman spectrometer 16. The support rod 12 is slidably connected to the base 11 via a slider, which allows the support rod 12 to move horizontally on the base 11.
[0020] The support rod 12 includes a fixed shaft 121 and a movable shaft 122. The fixed shaft 121 is fixed to the slider and has an upward-facing threaded hole. The lower end of the movable shaft 122 has an external thread that matches the threaded hole. The lower end of the movable shaft 122 is inserted into the threaded hole and is movably connected to the fixed shaft 121 via the thread. By rotating the movable shaft 122, the depth of the movable shaft 122 inserted into the threaded hole can be adjusted, thereby achieving vertical adjustment of the movable shaft 122.
[0021] In some embodiments, the base support structure 13 is connected to the movable shaft 122, and the base support structure 13 has a support ring 131. When the movable shaft 122 is adjusted in the vertical direction, it can drive the base support structure 13 to move, ultimately realizing the height adjustment of the paper tip SERS base 14 located on it driven by the base support structure 13.
[0022] The Raman spectrometer 16 is mounted on the base 11 and is positioned opposite the support rod 12.
[0023] In some embodiments, the Raman spectrometer 16 is a portable Raman spectrometer, which is small in size and easy to carry and measure on site.
[0024] The bottom of the paper tip SERS substrate 14 extends into the support ring 131 and is supported on the support ring 131.
[0025] Specifically, after sample collection, the paper tip SERS substrate is supported on the support ring 131. The Raman spectrometer 16 emits a 785 nm wavelength laser towards the support rod 12. By adjusting the height of the paper tip SERS substrate 14 and its distance from the Raman spectrometer 16, the laser is directed onto the paper tip SERS substrate 14. The SERS signal at three random detection positions within a 1 mm range from the bottom of the paper tip SERS substrate 14 is measured, and the average value is taken to represent the SERS signal of the paper tip.
[0026] Besides directly wiping the surface of solid samples with the paper-tip SERS substrate 14, samples in liquid conditions require the paper-tip SERS substrate 14 to be dipped in the sample solution for collection. After dipping the paper-tip SERS substrate 14 in the sample solution, it needs to be dried before measurement. To accelerate the drying process, in some embodiments, a heating module 15 is provided, positioned below the substrate support structure 13, for heating the paper-tip SERS substrate 14.
[0027] In some embodiments, the heating module 15 is an electric heating ring coaxial with the support ring 131. When the paper tip SERS base 14 is supported on the support ring 131, the lower end of the paper tip SERS base 14 extends into the electric heating ring and there is a gap between the paper tip SERS base 14 and the electric heating ring, so as to prevent the paper tip SERS base 14 from directly contacting the electric heating ring and causing damage to the paper tip SERS base 14.
[0028] In some embodiments, the paper-tip SERS substrate 14 has a conical structure that is wider at the top and narrower at the bottom. When collecting samples by dipping, the solution rapidly accumulates at the tip of the paper tip under the combined effects of gravity and the coffee ring effect, thus generating a large number of uniformly distributed SERS hotspots. Simultaneously, the analyte can also accumulate at the tip, achieving good signal amplification for SERS detection. The entire preparation and detection process can be completed within 2 hours. By combining with a portable Raman spectrometer, the paper-tip SERS substrate of this device can achieve on-site quantitative analysis.
[0029] like Figure 3 As shown, in some embodiments, the cone angle α of the cone-shaped structure is 12° to 17°.
[0030] In this embodiment, the preferred cone angle is 15°, as a 15° paper tip can achieve the best signal intensity. This is likely due to the shape-enhanced capillary effect, meaning that a smaller paper tip angle has a stronger capillary effect. Additionally, the rapid evaporation of the solvent at the tip of the small paper tip can lead to the rapid enrichment of the analyte in the tiny test area. Therefore, a paper tip with a 15° angle was chosen for subsequent experiments.
[0031] like Figure 4 As shown, the Raman signal intensity in different regions of the paper tip SERS substrate 14 (regions 1, 2, 3, and 4 are 13 mm, 9 mm, 5 mm, and 1 mm from the paper tip, respectively). In some embodiments, a wax oil sealing layer 141 is provided on the conical structure at a distance of 13 mm to 17 mm from the cone tip. For example, sealing with solid wax oil at a position more than 15 mm from the front end of the paper tip can reduce the upward flow of solvent caused by the coffee ring effect.
[0032] In some embodiments, the material of the paper tip SERS substrate may be, but is not limited to, laboratory qualitative filter paper.
[0033] In some embodiments, such as Figure 2 As shown, a dovetail groove 110 is provided on the base 11, and a slider 17 is set in the dovetail groove 110 to match it, and the slider 17 can slide in the dovetail groove 110.
[0034] Of course, the above description is not intended to limit the present utility model, and the present utility model is not limited to the examples given above. Any changes, modifications, additions or substitutions made by those skilled in the art within the scope of the present utility model should also fall within the protection scope of the present utility model.
Claims
1. A paper tip SERS substrate detection device, characterized in that, include: Base; A support rod is slidably connected to the base via a slider. The support rod includes a fixed shaft and a movable shaft. The fixed shaft is fixed to the slider and has an upward-facing threaded hole. The lower end of the movable shaft has an external thread that matches the threaded hole. The lower end of the movable shaft is inserted into the threaded hole and is movably connected to the fixed shaft via a thread. A base support structure connected to the movable shaft, the base support structure having a support ring; A paper tip SERS substrate, the bottom of which extends into the support ring and is supported on the support ring; A heating module, which is located below the substrate support structure, is used to heat the paper tip SERS substrate; A Raman spectrometer is mounted on the base and positioned opposite the support rod.
2. The paper tip SERS substrate detection device according to claim 1, characterized in that, The heating module is an electric heating ring coaxial with the support ring. When the paper tip SERS substrate is supported on the support ring, the lower end of the paper tip SERS substrate extends into the electric heating ring and leaves a gap between it and the electric heating ring.
3. The paper tip SERS substrate detection device according to claim 1, characterized in that, The paper tip SERS substrate has a conical structure that is wider at the top and narrower at the bottom.
4. The paper tip SERS substrate detection device according to claim 3, characterized in that, The cone angle of the cone-shaped structure is 12° to 17°.
5. The paper tip SERS substrate detection device according to claim 3, characterized in that, The conical structure has a wax oil sealing layer at a distance of 13 mm to 17 mm from the tip of the cone.
6. The paper tip SERS substrate detection device according to claim 1, characterized in that, The material of the paper tip SERS substrate is laboratory qualitative filter paper.
7. The paper tip SERS substrate detection device according to any one of claims 1-6, characterized in that, The base is provided with a dovetail groove, and the slider is matched with the dovetail groove, so that the slider can slide in the dovetail groove.