A device for aiding in the detection of viruses

Abstract

This utility model discloses an auxiliary device for naked-eye virus detection, belonging to the field of virus detection technology. This utility model solves the problem in existing technologies of how to avoid the impact on detection accuracy and environmental pollution caused by excessive sample addition on immunochromatographic test strips. This utility model includes a shell and an immunochromatographic structure disposed within the shell. The shell has a sample inlet and an observation port, with a slidable isolation pad at the bottom of the sample inlet. The sample inlet has a groove-shaped structure, and a first overflow port is provided on its inner sidewall. A second overflow port is also provided in the area between the sample inlet and the observation port. The ends of the first overflow ports overlap to form a residual liquid absorption structure that completely surrounds the sample inlet. A liquid storage chamber is disposed around the sample inlet within the shell, and both the first and second overflow ports are connected to the liquid storage chamber. A liquid aspirator is disposed within the liquid storage chamber. This utility model is extremely easy to operate, requires no professional operating skills, and improves the applicability of naked-eye virus detection technology.

Description

Technical Field

[0001] This utility model belongs to the field of virus detection technology, specifically relating to an auxiliary device for naked-eye virus detection. Background Technology

[0002] Virus naked-eye detection is a method that allows for direct visual observation of results to determine whether someone is infected with a virus, without the need for complex instruments. Its core principles include immunochromatography (such as the binding of colloidal gold-labeled antibodies to viral antigens to form visible test lines) and gene fragment recognition technology (such as specific binding to viral gene fragments for naked-eye interpretation). This method has significant advantages such as ease of operation, low cost, and rapid response (suitable for primary healthcare or home testing), and is particularly useful in epidemic control for quickly triaging suspected cases. Applications include virus screening, preliminary diagnosis in resource-limited areas, and home testing.

[0003] In existing technologies, due to operational experience and other issues, overfilling of immunochromatographic test strips is a common occurrence. Overfilling leads to sample overflow, which can cause multiple problems: First, excess sample may dilute the labeled antibody, resulting in insufficient antigen enrichment, a faded or absent T-line, and false negative results. Second, overflowing liquid may contaminate adjacent testing areas or instruments, increasing the risk of cross-contamination. Excessive liquid may also over-wet the test strip, damaging it or blurring the detection area, making it impossible to read the results. Therefore, solving the problem of avoiding overfilling of immunochromatographic test strips, which affects detection accuracy and contaminates the surrounding environment, will further reduce the operational difficulty of naked-eye virus detection, facilitating its widespread adoption and application. Utility Model Content

[0004] To address the problem of how to avoid the impact on detection accuracy and environmental pollution caused by excessive sample addition in existing immunochromatographic test strips, this invention provides an auxiliary device for naked-eye virus detection.

[0005] The technical solution adopted in this utility model is as follows:

[0006] A virus naked-eye detection auxiliary device includes a housing and an immunochromatographic structure disposed within the housing. The housing is provided with a sample dispensing port and an observation port that cooperate with the immunochromatographic structure. An isolation pad is slidably disposed at the bottom of the sample dispensing port.

[0007] The sample inlet has a groove-shaped structure, and a first overflow port is provided on the inner side wall of the sample inlet near the groove opening. The first overflow port is located on the side away from the observation port.

[0008] The top surface of the shell is provided with a second overflow port in the area between the sample inlet and the observation port. The positions of the two ends of the first overflow port overlap with the positions of the two ends of the second overflow port, thereby forming a residual liquid absorption structure that completely surrounds the sample inlet.

[0009] A liquid storage chamber is provided inside the housing surrounding the sample inlet. The first overflow port and the second overflow port are both connected to the liquid storage chamber. A liquid suction device is provided inside the liquid storage chamber.

[0010] With this technical solution, the isolation pad in this invention prevents the sample solution from contacting the immunochromatographic structure below before the liquid addition is completed. The housing has a first overflow port and a second overflow port, and the two ends of the first overflow port overlap with the two ends of the second overflow port to form a residual liquid absorption structure that completely surrounds the sample addition port. When too much liquid is added, the excess liquid flows from the first overflow port into the storage chamber and is absorbed by the suction element inside the storage chamber, preventing overflow. When the liquid addition is too fast, causing the first overflow port to be unable to drain quickly, or when the device is tilted causing liquid to overflow from the other side, the excess liquid enters the second overflow port on the surface of the housing and is absorbed by the suction element inside the storage chamber, preventing liquid from leaving to the outside and causing contamination. This invention effectively solves the problem of excessive liquid addition affecting detection accuracy and polluting the surrounding environment. Using this virus naked-eye detection auxiliary device for virus detection is extremely easy, requiring no professional operating skills, effectively improving the applicability of virus naked-eye detection technology.

[0011] Preferably, the device also includes a transparent cover, the housing being slidably disposed within the transparent cover, one end of the transparent cover having an extension opening for the housing to extend out, and a limiting mechanism for restricting the sliding of the housing being provided between the transparent cover and the housing.

[0012] With this technical solution, virus detection using naked eyes is generally only required under outdoor conditions. However, in existing technologies, immunochromatographic structures are usually directly exposed to the environment. Since various contaminants may exist outdoors, they may contaminate the immunochromatographic structure during the waiting period after sample addition, thus affecting the detection accuracy. To solve this technical problem, this invention also includes a transparent cover. In the unused state, the sample addition port is located outside the transparent cover due to the limitation mechanism, facilitating sample addition. After sample addition, the limitation mechanism can be removed, and by tilting the transparent cover downwards, the shell slides further inwards within the transparent cover, allowing the sample addition port to enter the transparent cover. The protection of the transparent cover reduces the probability of contamination of the immunochromatographic structure in outdoor environments, thereby improving the detection accuracy to some extent.

[0013] Preferably, the transparent cover is provided with a T-shaped groove, and a T-shaped slider is slidably disposed in the T-shaped groove. The T-shaped slider is connected to the end of the housing. The limiting mechanism includes a limiting groove, which is disposed near the end of the T-shaped groove. A communicating groove is provided on the transparent cover at a position corresponding to the limiting groove, communicating with the inside of the transparent cover. A limiting block is movably disposed in the communicating groove, with one end of the limiting block located inside the limiting groove and the other end located outside the transparent cover.

[0014] After adopting this technical solution, the sliding direction of the shell on both sides is limited by the cooperation of the T-shaped groove, the T-shaped slider and the limiting block. The T-shaped groove and the T-shaped slider prevent the shell from sliding outward so that the shell cannot be separated from the transparent cover, while the limiting block prevents the shell from sliding into the transparent cover at will.

[0015] Preferably, when the limiting block is located within the limiting groove and the connecting groove, the sample dispensing port is located outside the transparent cover, and the observation port is located inside the transparent cover.

[0016] With this technical solution, the sample dispensing port is located outside the transparent cover when the limit is applied, which facilitates sample dispensing.

[0017] Preferably, the transparent cover is a white transparent cover.

[0018] Preferably, both the first overflow port and the second overflow port are U-shaped structures.

[0019] With this technical solution, both the first overflow port and the second overflow port are U-shaped structures to achieve full enclosure of the sample dispensing port.

[0020] Preferably, the immunochromatographic structure includes a backplate card, on which a sample pad, a conjugate release pad, an antibody immobilization membrane, and an adsorption pad are sequentially arranged from one end to the other, and the ends of two adjacent structures are overlapped vertically. The antibody immobilization membrane is provided with test lines and control lines.

[0021] The sample application port is aligned with the sample pad, and the observation port is aligned with the antibody immobilization membrane and the test line and control line on the antibody immobilization membrane.

[0022] Preferably, the housing has an installation cavity that communicates with the sample inlet and the observation port. The side wall of the sample inlet on the housing abuts against the sample pad. The liquid storage cavity and the sample inlet are isolated by the side wall of the sample inlet, and the liquid storage cavity is not communicated with the installation cavity.

[0023] With this technical solution, the mounting cavity and the liquid storage cavity are isolated from each other to prevent excess liquid from reaching the immunochromatographic structure through the liquid storage cavity.

[0024] Preferably, the liquid-absorbing component is an absorbent sponge block.

[0025] After adopting this technical solution, excess liquid is absorbed and fixed by the water-absorbing sponge block, and the liquid in the storage chamber is prevented from flowing back from the first overflow port and the second overflow port to the sample dispensing port during the movement of the device.

[0026] In summary, due to the adoption of the above technical solution, the beneficial effects of this utility model are:

[0027] 1. In this invention, a first overflow port and a second overflow port are provided on the shell of the immunochromatographic structure. The two ends of the first overflow port and the two ends of the second overflow port are respectively overlapped to form a residual liquid absorption structure that completely surrounds the sample application port. The space between the isolation pad and the first overflow port forms a sample liquid quantitative chamber. When too much liquid is added, the excess liquid flows from the first overflow port into the storage chamber and is absorbed by the liquid aspirator in the storage chamber to prevent overflow. When the liquid is added too quickly, causing the first overflow port to be unable to drain quickly, or when the device is tilted and the liquid overflows from the other side, the excess liquid enters the second overflow port provided on the surface of the shell and is absorbed by the liquid aspirator in the storage chamber to prevent the liquid from leaving to the outside and causing pollution. This invention can effectively solve the problem of affecting the detection accuracy and polluting the surrounding environment caused by excessive liquid addition. The operation difficulty of using this virus naked-eye detection auxiliary device is extremely low, requiring no professional operating skills, and effectively improving the applicability of virus naked-eye detection technology.

[0028] 2. This utility model also includes a transparent cover. When not in use, the sample dispensing port is located outside the transparent cover due to the limitation of the limiting mechanism, which facilitates sample dispensing. After the sample dispensing is completed, the limitation of the limiting mechanism can be removed. By tilting the transparent cover downward, the shell can slide further inward inside the transparent cover, allowing the sample dispensing port to enter the transparent cover. The protection of the transparent cover can reduce the probability of contamination of the immunochromatographic structure in outdoor environments, thereby improving the accuracy of detection to a certain extent. Attached Figure Description

[0029] This utility model will be described by way of example and with reference to the accompanying drawings, wherein:

[0030] Figure 1 This is a schematic diagram of the external structure of the present invention in one embodiment when the transparent cover is not provided;

[0031] Figure 2 This is a schematic diagram of the internal structure of the present invention in one embodiment without a transparent cover;

[0032] Figure 3 yes Figure 2 A magnified view of a section at point A in the middle;

[0033] Figure 4This is a schematic diagram of the external structure of the present invention when a transparent cover is provided in one embodiment;

[0034] Figure 5 This is a schematic diagram of the limiting mechanism in one embodiment of the present invention when a transparent cover is provided;

[0035] Figure 6 This is a schematic diagram showing the positional relationship between the isolation pad and the sample application port in one embodiment;

[0036] Wherein: 1-shell, 2-second overflow port, 3-sample dispensing port, 4-first overflow port, 5-observation port, 6-installation cavity, 7-sample pad, 8-conjugate release pad, 9-antibody fixation membrane, 10-adsorption pad, 11-backplate card, 12-liquid aspiration piece, 13-transparent cover, 14-limiting block, 15-limiting groove, 16-T-shaped slide, 17-T-shaped slider, 18-isolation pad. Detailed Implementation

[0037] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. The components of the embodiments of this application described and shown in the accompanying drawings can generally be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of this application provided in the accompanying drawings is not intended to limit the scope of the claimed application, but merely represents selected embodiments of this application. All other embodiments obtained by those skilled in the art based on the embodiments of this application without inventive effort are within the scope of protection of this application.

[0038] In the description of the embodiments of this application, it should be noted that the terms "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the utility model product is in use. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application. In addition, the terms "first," "second," and "third," etc., are only used to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0039] The following is combined Figures 1-6 This utility model will be described in detail.

[0040] like Figure 1 and Figure 2The illustrated device for naked-eye virus detection includes a housing 1 and an immunochromatographic structure disposed within the housing 1. It should be noted that the specific structure of the immunochromatographic structure is prior art, referring to the specific structure for achieving lateral chromatographic assay (LFA). The contents of the structure are determined according to the virus being detected, and are all prior art; this invention does not contain any improvements. The housing 1 is provided with a sample dispensing port 3 and an observation port 5 that cooperate with the immunochromatographic structure. In this embodiment, both the sample dispensing port 3 and the observation port 5 have a structure that is wider at the top and narrower at the bottom. The sample dispensing port 3 is for containing the sample solution, and the observation port 5 is for displaying the test results. An isolation pad 18 is slidably disposed at the bottom of the sample dispensing port 3, specifically as shown below. Figure 6 As shown, the housing 1 has a receiving groove, one end of which is connected to the outside and the other end is connected to the sample dispensing port 3. The isolation pad 18 is disposed in the receiving groove to isolate the sample dispensing port 3 from the immunochromatographic structure. The isolation pad 18 extends outside the receiving groove, and can be pulled upward by hand to slide out of the receiving groove. The isolation pad 18 can be made of a flexible plastic plate that can slide within the receiving groove. The function of the isolation pad 18 is to prevent the sample solution from contacting the immunochromatographic structure below before the liquid dispensing is completed, thus avoiding the sample solution flowing away before the liquid dispensing is completed and making it impossible to calculate the liquid dispensing volume, resulting in excessive liquid dispensing.

[0041] like Figure 3 As shown, the sample inlet 3 has a groove-shaped structure, and a first overflow port 4 is provided on the inner side wall of the sample inlet 3 near the groove opening. The first overflow port 4 is located on the side away from the observation port 5.

[0042] The top surface of the housing 1, in the area between the sample inlet 3 and the observation port 5, is also provided with a second overflow port 2. The positions of the two ends of the first overflow port 4 overlap with the positions of the two ends of the second overflow port 2, thereby forming a residual liquid absorption structure that completely surrounds the sample inlet 3 from the top. It should be noted that, from Figure 1 It can be seen that the overlap between the two ends of the so-called first overflow port 4 and the two ends of the second overflow port 2 is not a strict overlap. It means that the residual liquid receiving area formed by the first overflow port 4 and the residual liquid receiving area formed by the second overflow port 2 intersect, and the two together surround the sample inlet 3.

[0043] A liquid storage chamber is provided inside the housing 1 surrounding the sample inlet 3. The first overflow port 4 and the second overflow port 2 are both connected to the liquid storage chamber. A liquid suction member 12 is provided inside the liquid storage chamber. In a preferred case, the volume of the liquid storage chamber is larger than the volume of the liquid suction member 12, so as to provide sufficient expansion space for the liquid suction member 12 to fully absorb the remaining liquid.

[0044] The method of using this utility model is as follows:

[0045] Remove the virus naked-eye detection auxiliary device from the packaging bag, align the sampling liquid with the sampling port 3, and add the sample liquid into the sampling port 3. Due to the obstruction of the isolation pad 18, the liquid will not come into contact with the immunochromatographic structure before the liquid addition is completed. When the liquid level reaches the first overflow port 4, the excess liquid will flow into the storage chamber and be absorbed by the aspirator 12. The space between the isolation pad 18 and the first overflow port 4 forms a sample liquid quantitative chamber, thereby avoiding the effect of adding too much sample and preventing excess sample liquid from overflowing. If the liquid addition is too fast, causing the first overflow port 4 to be unable to drain quickly, or if the device is tilted and the liquid overflows from the other side, the excess liquid enters the second overflow port 2 set on the surface of the housing 1, and then enters the storage chamber and is absorbed by the aspirator 12 in the storage chamber, preventing the liquid from flowing to the outside and causing contamination. After the liquid addition is completed, pull the isolation pad 18 to make the sample liquid come into contact with the immunochromatographic structure below and undergo subsequent detection reaction with the immunochromatographic structure. Observe the detection results through the observation port 5.

[0046] In one embodiment, such as Figure 4-5 As shown, it also includes a transparent cover 13. The housing 1 is slidably disposed inside the transparent cover 13. One end of the transparent cover 13 is provided with an extension port for the housing 1 to extend out. A limiting mechanism is provided between the transparent cover 13 and the housing 1 to restrict the sliding of the housing 1. In the unused state, the sample dispensing port 3 is located outside the transparent cover 13 due to the limitation of the limiting mechanism, so as to facilitate sample dispensing. After the sample dispensing is completed, the limitation of the limiting mechanism can be removed. By tilting the transparent cover 13 downward, the housing 1 slides further inward inside the transparent cover 13, allowing the sample dispensing port 3 to enter the transparent cover 13. The protection of the transparent cover 13 can reduce the probability of contamination of the immunochromatographic structure in the outdoor environment, thereby improving the accuracy of detection to a certain extent. In a more preferred case, the transparent cover 13 is a white transparent structure, specifically made of white transparent acrylic sheet material, so as to facilitate the observation of the detection results at the observation port 5.

[0047] In one embodiment, a T-shaped groove 16 is provided inside the transparent cover 13, and a T-shaped slider 17 is slidably disposed within the T-shaped groove 16. The T-shaped slider 17 is connected to the end of the housing 1. The limiting mechanism includes a limiting groove 15, which is disposed near the end of the T-shaped groove 16. A communicating groove is provided on the transparent cover 13 at a position corresponding to the limiting groove 15, communicating with the inside of the transparent cover 13. A limiting block 14 is movably disposed within the communicating groove, with one end of the limiting block 14 located inside the limiting groove 15 and the other end located outside the transparent cover 13. The limiting block 14 can be manually squeezed and pulled out. After being pulled out, since there is no obstruction from the limiting block 14, the T-shaped slider 17 can slide backward, thereby moving the sample dispensing port 3 into the transparent cover 13.

[0048] In one embodiment, when the limiting block 14 is located in the limiting groove 15 and the communicating groove, the sample dispensing port 3 is located outside the transparent cover 13, and the observation port 5 is located inside the transparent cover 13.

[0049] In one embodiment, both the first overflow port 4 and the second overflow port 2 are U-shaped structures. The U-shaped structures of the first overflow port 4 and the second overflow port 2 thus achieve complete enclosure of the sample dispensing port 3.

[0050] In one embodiment, the immunochromatographic structure includes a backplate card 11, on which a sample pad 7, a conjugate release pad 8, an antibody immobilization membrane 9, and an adsorption pad 10 are sequentially disposed from one end to the other, with the ends of adjacent structures overlapping. The antibody immobilization membrane 9 is provided with test lines and control lines.

[0051] The sample application port 3 is aligned with the sample pad 7, and the observation port 5 is aligned with the antibody immobilization membrane 9 and the test lines and control lines on the antibody immobilization membrane 9. The immunochromatographic structure is existing technology, and the cooperation of each structure enables lateral chromatography assay.

[0052] In one embodiment, the housing 1 has a mounting cavity 6, which communicates with the sample application port 3 and the observation port 5. The side wall end of the sample application port 3 on the housing 1 abuts against the sample pad 7. The liquid storage cavity and the sample application port 3 are isolated by the side wall of the sample application port 3, and the liquid storage cavity is not connected to the mounting cavity 6. The mounting cavity 6 and the liquid storage cavity are isolated from each other to prevent excess liquid from reaching the immunochromatographic structure through the liquid storage cavity.

[0053] In one embodiment, the liquid-absorbing element 12 is an absorbent sponge block. The absorbent sponge block absorbs and retains excess liquid, and prevents liquid in the storage chamber from flowing back from the first overflow port 4 and the second overflow port 2 into the sample application port 3 during device movement.

[0054] The embodiments described above merely illustrate specific implementation methods of this application, and while the descriptions are detailed and specific, they should not be construed as limiting the scope of protection of this application. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the technical solution of this application, and these modifications and improvements all fall within the scope of protection of this application.

Claims

1. A device for assisting in the naked-eye detection of viruses, characterized in that: It includes a housing (1) and an immunochromatographic structure disposed within the housing (1). The housing (1) is provided with a sample dispensing port (3) and an observation port (5) that cooperate with the immunochromatographic structure. An isolation pad (18) is slidably disposed at the bottom of the sample dispensing port (3). The sample inlet (3) has a groove-shaped structure, and a first overflow port (4) is provided on the inner side wall of the sample inlet (3) near the groove opening. The first overflow port (4) is located on the side away from the observation port (5). The top surface of the shell (1) is provided with a second overflow port (2) in the area between the sample inlet (3) and the observation port (5). The positions of the two ends of the first overflow port (4) overlap with the positions of the two ends of the second overflow port (2) to form a residual liquid absorption structure that completely surrounds the sample inlet (3). A liquid storage chamber is provided inside the housing (1) surrounding the sample inlet (3). The first overflow port (4) and the second overflow port (2) are both connected to the liquid storage chamber. A liquid suction device (12) is provided inside the liquid storage chamber.

2. The virus naked-eye detection auxiliary device according to claim 1, characterized in that: It also includes a transparent cover (13), the housing (1) is slidably disposed inside the transparent cover (13), one end of the transparent cover (13) is provided with an extension port for the housing (1) to extend out, and a limiting mechanism for restricting the sliding of the housing (1) is provided between the transparent cover (13) and the housing (1).

3. The virus naked-eye detection auxiliary device according to claim 2, characterized in that: The transparent cover (13) is provided with a T-shaped groove (16), and a T-shaped slider (17) is slidably provided in the T-shaped groove (16). The T-shaped slider (17) is connected to the end of the housing (1). The limiting mechanism includes a limiting groove (15), which is located near the end of the T-shaped groove (16). A communicating groove is provided on the transparent cover (13) at a position corresponding to the limiting groove (15) and communicating with the inside of the transparent cover (13). A limiting block (14) is movably provided in the communicating groove. One end of the limiting block (14) is located in the limiting groove (15), and the other end is located outside the transparent cover (13).

4. The virus naked-eye detection auxiliary device according to claim 3, characterized in that: When the limiting block (14) is located in the limiting groove (15) and the connecting groove, the sample dispensing port (3) is located outside the transparent cover (13), and the observation port (5) is located inside the transparent cover (13).

5. A virus naked-eye detection auxiliary device according to any one of claims 1-4, characterized in that: Both the first overflow port (4) and the second overflow port (2) are U-shaped structures.

6. A virus naked-eye detection auxiliary device according to any one of claims 1-4, characterized in that: The immunochromatographic structure includes a backplate card (11), on which a sample pad (7), a conjugate release pad (8), an antibody immobilization membrane (9) and an adsorption pad (10) are arranged sequentially from one end to the other, and the ends of two adjacent structures are arranged overlapping vertically. The antibody immobilization membrane (9) is provided with test lines and control lines. The sample application port (3) is aligned with the sample pad (7), and the observation port (5) is aligned with the antibody immobilization membrane (9) and the test line and control line on the antibody immobilization membrane (9).

7. The virus naked-eye detection auxiliary device according to claim 6, characterized in that: The housing (1) is provided with an installation cavity (6), which is connected to the sample inlet (3) and the observation port (5). The side wall end of the sample inlet (3) on the housing (1) abuts against the sample pad (7). The liquid storage cavity and the sample inlet (3) are isolated by the side wall of the sample inlet (3). The liquid storage cavity is not connected to the installation cavity (6).

8. A virus naked-eye detection auxiliary device according to any one of claims 1-4, characterized in that: The liquid-absorbing component (12) is a water-absorbing sponge block.

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