An auxiliary device for preparing an animal model of senile dementia

Abstract

The utility model relates to the technical field of animal model, concretely relates to a kind of auxiliary device for preparing senile dementia animal model, including box, the top of box is fixedly connected with ventilation mechanism and gas input mechanism, gas input mechanism is connected with lateral cavity by conveying pipeline, the inside two sides of box are separated and are equipped with two groups of isolation cavity, separation plate is arranged between the two groups of isolation cavity, the inside two ends of box are all set up and are adjacent to lateral cavity of isolation cavity, the front of isolation cavity is fixedly connected with open-close screen, the surface of open-close screen is movably connected with screen door. Through the mechanical linkage system of operating lever, elastic layer and capture cover set in backplate, the user can realize the non-contact type containment and guidance of mouse outside the isolation cavity, and finally take out through the screen door, which greatly reduces the stress and human injury to the mouse during the capture process, thereby ensuring the reliability of experimental data.

Description

Technical Field

[0001] This utility model relates to the technical field of animal models, specifically to an auxiliary device for preparing an animal model of Alzheimer's disease. Background Technology

[0002] The core technical challenge in preparing animal models (such as mouse models) of Alzheimer's disease lies in: Traditional experimental devices use direct hand-grabbing or tool-clamping methods to capture animals, which can easily trigger severe stress responses in animals, leading to fluctuations in physiological indicators directly related to the pathological mechanisms of Alzheimer's disease, such as neuroinflammation and abnormal cortisol levels. This not only disrupts the consistency of the pathological phenotype of the model animals but also seriously interferes with the success rate of model establishment and the accuracy of experimental data for subsequent drug efficacy evaluation. Existing devices lack effective solutions to this core problem and cannot meet the precise requirements for the stability of animal physiological state in the preparation of Alzheimer's disease models. Utility Model Content

[0003] In view of the deficiencies in the existing technology, the present invention provides an auxiliary device for preparing an animal model of Alzheimer's disease, which can solve the above-mentioned technical problems.

[0004] To solve the above-mentioned technical problems, the present invention proposes the following technical solution: An auxiliary device for preparing an animal model of Alzheimer's disease includes a box body. A ventilation mechanism and a gas input mechanism are fixedly connected to the top of the box body. The gas input mechanism is connected to a side cavity via a delivery pipe. Two sets of isolation chambers are separated on both sides of the box body, with a partition plate between them. Side cavities adjacent to the isolation chambers are opened at both ends of the box body. An opening / closing mesh plate is fixedly connected to the front of each isolation chamber, and a mesh door is movably connected to the surface of the opening / closing mesh plate. A bottom layer assembly is provided on the bottom surface of each isolation chamber. A guide plate is fixedly connected to the inner side of each side cavity, and a ventilated grid is fixedly connected to the inner wall of the outer side of each isolation chamber. The enclosure has multiple sets of ventilation grids arranged longitudinally and vertically along the inner wall of the isolation chamber. A back panel is fixedly connected to the back of the enclosure. The back panel has semi-circular operation windows on both sides corresponding to the isolation chamber. An elastic layer is fixedly connected to the inner side of the operation window. A capture cover is fixedly connected to the front of the elastic layer. An operation rod that penetrates the back panel is fixedly connected to the inner side of the capture cover. The bottom component includes a sliding inner mounting frame and a bottom mesh plate. The inner surface of the inner mounting frame has longitudinally arranged feeding troughs and guide grooves respectively. One end of the bottom mesh plate is slidably set in the guide groove. A cleaning frame is embedded in the bottom of the bottom mesh plate.

[0005] Furthermore, the guide plate is inclined downward along the inner wall of the side cavity away from the isolation cavity.

[0006] Furthermore, the surface of the partition is covered with a food-grade PVC buffer layer, and the surface of the partition is pre-set with standardized mounting holes and magnetic attachment points for installing enrichment facilities.

[0007] Furthermore, the surface of the opening and closing mesh plate is equipped with a high-strength tempered glass observation window.

[0008] Furthermore, the inner mounting frame is arranged longitudinally in a trapezoidal shape, and the inner side of the guide groove is provided with ultra-high molecular weight polyethylene wear-resistant strips.

[0009] Furthermore, the cleaning frame slides into the recessed area on the bottom surface of the bottom mesh plate, and a sealing strip is provided on the edge of the cleaning frame.

[0010] Furthermore, the elastic layer is designed with an accordion bellows structure and is made of medical-grade silicone rubber.

[0011] Furthermore, the capture cover and the semi-circular baffle connected to its inner side are both made of transparent medical-grade PC material, and the operating lever is a multi-section telescopic linkage.

[0012] Furthermore, the mesh door and the opening / closing mesh panel are magnetically connected, and the mesh surface is made of stainless steel woven mesh.

[0013] As can be seen from the above technical solution, the beneficial effects of this utility model are: 1. This utility model, through a mechanical linkage system consisting of an operating rod, an elastic layer, and a capture cover set on the back plate, allows users to achieve non-contact containment and guidance of mice outside the isolation chamber, and finally remove them through the mesh door. This structure greatly reduces stress and human harm to mice during the capture process, thereby ensuring the reliability of experimental data.

[0014] 2. This utility model, through the mechanical combination of a side cavity, a downwardly inclined guide plate, and a longitudinally distributed permeable grid, enables the drug gas entering from the gas input mechanism to diffuse smoothly and evenly throughout the entire isolation cavity, ensuring the consistency of drug concentration at various points within the cavity, thereby improving the uniformity and accuracy of modeling and drug testing.

[0015] 3. In this utility model, the bottom component adopts a sliding sleeve structure of inner mounting frame, bottom mesh plate and cleaning frame, and integrates feeding trough. This modular design allows the operation of cleaning feces, changing bedding and adding feed to be completed in one go. The entire component can be pulled out from the front, which greatly improves maintenance efficiency and can effectively keep the experimental environment clean.

[0016] 4. In this utility model, the mounting holes and magnetic points on the partition plate provide an installation base for enrichment facilities, improving animal welfare. At the same time, the tempered glass observation window on the openable and closed mesh plate facilitates direct observation of animal behavior without opening the mesh door, reducing disturbance to the animals. Attached Figure Description

[0017] To more clearly illustrate the specific embodiments of this utility model or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. In all the drawings, similar elements or parts are generally identified by similar reference numerals. In the drawings, the elements or parts are not necessarily drawn to scale.

[0018] Figure 1 This is an exploded view of the overall structure of this utility model; Figure 2 This is a schematic diagram of the internal structure connection of the box in this utility model; Figure 3 This is a schematic diagram of the connection of the bottom-level components in this utility model; Figure 4 In this utility model Figure 2 Enlarged view of the structure at point A in the middle.

[0019] Figure label: 1. Housing; 2. Ventilation mechanism; 3. Gas input mechanism; 4. Isolation chamber; 5. Side chamber; 6. Opening and closing mesh panel; 7. Mesh door; 8. Bottom layer assembly; 9. Back panel; 10. Operation window; 11. Elastic layer; 12. Snap-on cover; 13. Operating lever; 14. Inner mounting frame; 15. Feed trough; 16. Guide trough; 17. Bottom mesh panel; 18. Cleaning frame; 19. Flow deflector; 20. Ventilation grid. Detailed Implementation

[0020] The embodiments of the present invention will now be described in detail with reference to the accompanying drawings. These embodiments are merely illustrative of the present invention and should not be construed as limiting the scope of protection of the present invention.

[0021] See Figure 1-4 As shown, an auxiliary device for preparing an animal model of Alzheimer's disease includes a box 1. A ventilation mechanism 2 and a gas input mechanism 3 are fixedly connected to the top of the box 1. Two sets of isolation chambers 4 are separated on both sides of the inside of the box 1. Side chambers 5 adjacent to the isolation chambers 4 are opened at both ends of the inside of the box 1. An opening and closing mesh plate 6 is fixedly connected to the front of the isolation chamber 4. A mesh door 7 is movably connected to the surface of the opening and closing mesh plate 6. A bottom layer component 8 is provided on the bottom surface of the inside of the isolation chamber 4. A guide plate 19 is fixedly connected to the inner side of the side chamber 5. A breathable grid 20 is fixedly connected to the inner wall of the outer side of the isolation chamber 4. A back plate 9 is fixedly connected to the back of the housing 1. The back plate 9 has semi-circular operation windows 10 on both sides of the surface corresponding to the isolation cavity 4. An elastic layer 11 is fixedly connected to the inner side of the operation window 10. A capture cover 12 is fixedly connected to the front of the elastic layer 11. An operation rod 13 that penetrates the back plate 9 is fixedly connected to the inner side of the capture cover 12. The bottom component 8 includes an inner mounting frame 14 that is movably fitted and a bottom mesh plate 17. The inner side surface of the inner mounting frame 14 is provided with a longitudinally arranged feeding trough 15 and a guide groove 16 respectively. One end of the bottom mesh plate 17 is simultaneously slidably fitted with the guide groove 16, and a cleaning frame 18 is embedded in the bottom of the bottom mesh plate 17.

[0022] In this embodiment of the utility model, the ventilation mechanism 2 includes an air intake unit and an air exhaust unit. In order to facilitate air volume control, it integrates an adjustable speed fan and is equipped with an air volume sensor. The bottom surface of the ventilation mechanism 2 is equipped with a lighting system. All of the above are existing public technologies, so they will not be described in detail here. The gas input mechanism 3 includes a precision diaphragm pump and a quick-connect Luer connector, and also has a gas mixing chamber with an electric heating mechanism. The gas input mechanism 3 is connected to a delivery pipe with an integrated gas mass flow control mechanism, and the outer end of the delivery pipe is connected to the side chamber 5. The isolation chamber 4 is a rectangular chamber with two adjacent openings. A partition plate with a food-grade PVC surface is set between the two sets of isolation chambers 4. The surface of the partition plate is also pre-set with standardized installation holes and magnetic attachment points to facilitate the installation and replacement of mouse toys. The side chamber 5 is located on the outside of the isolation chamber 4. A small drainage hole with a plug is opened at the lowest point of its bottom. The surface of the opening and closing mesh plate 6 is also provided with a high-strength tempered glass observation window.

[0023] The guide plate 19 is inclined downward along the inner wall of the side cavity 5 on the outer side. The ventilated grid 20 is arranged longitudinally along the inner wall of the isolation cavity 4, and multiple sets are vertically distributed. The inner mounting frame 14 is trapezoidal in shape and is arranged longitudinally along the bottom of the inner wall of the isolation cavity 4 on the outer side. The feeding trough 15 is trapezoidal and concave. The guide groove 16 is rectangular and longitudinally penetrates through. The inner side of the guide groove 16 is provided with ultra-high molecular weight polyethylene wear-resistant strips corresponding to the bottom mesh plate 17. The bottom mesh plate 17 is a rectangular mesh plate with a rectangular concave bottom surface. The cleaning frame 18 is a rectangular frame that slides into the rectangular concave bottom surface of the bottom mesh plate 17. The edge of the cleaning frame 18 is provided with a sealing strip. The cleaning frame 18 is lined with a replaceable absorbent pad.

[0024] The elastic layer 11 is set as an accordion bellows type and is made of medical grade silicone rubber. The capture cover 12 is set as a semi-circular cover. On the inner side of its front, there is another set of semi-circular baffles connected to the operating rod 13. The operating rod 13 is set as a multi-section telescopic connecting rod. The capture cover 12 is set as a horizontal pleated layer. Both the capture cover 12 and the semi-circular baffle on its inner side are made of transparent medical grade PC. The operating window 10 and the capture cover 12 are located at the center of the bottom surface of the back plate 9. The mesh gate 7 and the opening / closing mesh plate 6 are magnetically connected. Both the gate and the opening / closing mesh plate 6 are made of stainless steel, and the mesh surface is made of stainless steel woven mesh.

[0025] When using this device, the user prepares a certain number of mice, randomly divides them into a model group and a control group, and places them in the two isolation chambers 4. When it is necessary to capture the mice for injection or other treatment, the user controls the capture cover 12 to extend and retract and adjust its angle within the isolation chamber 4 using the operating lever 13, so that the capture cover 12 surrounds the mice in the isolation chamber 4. Then, the user pushes the capture cover 12 with the operating lever 13 to push the surrounded mice to the mesh door 7. At this time, the user opens the mesh door 7 and takes out the mice for treatment. When drug testing is required on mice, gaseous drug testing involves introducing drug gas into the side chamber 5 through the gas input mechanism 3. Under the action of the guide plate 19 and the ventilated grid 20, the drug gas enters the isolation chamber 4 and comes into contact with the mice. The feces produced by the mice are collected in the cleaning frame 18 through the bottom mesh plate 17. When cleaning, the user can remove the opening and closing mesh plate 6, pull out the entire bottom component 8 from the isolation chamber 4, and then clean and feed the mice. When capturing mice, the elastic layer 11 allows the capture cover 12 to be adjusted and moved at multiple angles, and the capture cover 12 itself can be adjusted longitudinally under the control of the operating lever 13, so as to effectively capture mice. Ventilation mechanism 2 is responsible for ensuring air circulation within isolation chamber 4. When drug gas needs to be introduced, the ventilation interface in gas input mechanism 3 is connected to an external input device to introduce drug gas into isolation chamber 4.

[0026] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this utility model, and not to limit it. Although the utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of this utility model, and they should all be covered within the scope of the claims and specification of this utility model.

Claims

1. An auxiliary device for preparing an animal model of Alzheimer's disease, comprising a box (1), characterized in that: The top of the box (1) is fixedly connected to a ventilation mechanism (2) and a gas input mechanism (3), and the gas input mechanism (3) is connected to the side cavity (5) through a delivery pipe; The inner sides of the box (1) are separated by two sets of isolation chambers (4), and a partition plate is provided between the two sets of isolation chambers (4). The inner ends of the box (1) are each provided with a side chamber (5) adjacent to the isolation chamber (4). An opening and closing mesh plate (6) is fixedly connected to the front of the isolation cavity (4), and a mesh door (7) is movably connected to the surface of the opening and closing mesh plate (6). A bottom layer component (8) is provided on the inner bottom surface of the isolation cavity (4). A guide plate (19) is fixedly connected to the inner side of the side cavity (5), and a breathable grid (20) is fixedly connected to the inner wall of the outer side of the isolation cavity (4). The breathable grid (20) is arranged longitudinally along the inner wall of the isolation cavity (4) and is vertically distributed in multiple sets. A back plate (9) is fixedly connected to the back of the box (1). The back plate (9) has semi-circular operation windows (10) on both sides of the surface corresponding to the isolation cavity (4). An elastic layer (11) is fixedly connected to the inner side of the operation window (10). A capture cover (12) is fixedly connected to the front of the elastic layer (11). An operation rod (13) that penetrates the back plate (9) is fixedly connected to the inner side of the capture cover (12). The bottom component (8) includes a sliding inner mounting frame (14) and a bottom mesh plate (17). The inner side surface of the inner mounting frame (14) is provided with a longitudinally arranged feeding trough (15) and a guide groove (16) respectively. One end of the bottom mesh plate (17) is slidably disposed in the guide groove (16), and a cleaning frame (18) is embedded in the bottom of the bottom mesh plate (17).

2. The auxiliary device for preparing an animal model of Alzheimer's disease according to claim 1, characterized in that: The guide plate (19) is inclined downward along the inner wall of the side cavity (5) away from the isolation cavity (4).

3. The auxiliary device for preparing an animal model of Alzheimer's disease according to claim 1, characterized in that: The surface of the partition is covered with a food-grade PVC buffer layer, and the surface of the partition is pre-set with standardized mounting holes and magnetic attachment points for installing enrichment facilities.

4. The auxiliary device for preparing an animal model of Alzheimer's disease according to claim 1, characterized in that: The surface of the opening and closing mesh plate (6) is provided with a high-strength tempered glass observation window.

5. The auxiliary device for preparing an animal model of Alzheimer's disease according to claim 1, characterized in that: The inner mounting frame (14) is arranged in a trapezoidal longitudinal shape, and the inner side of the guide groove (16) is provided with a wear-resistant strip of ultra-high molecular weight polyethylene.

6. The auxiliary device for preparing an animal model of Alzheimer's disease according to claim 1, characterized in that: The cleaning frame (18) is slidably embedded in the recessed part of the bottom surface of the bottom mesh plate (17), and the edge of the cleaning frame (18) is provided with a sealing strip.

7. The auxiliary device for preparing an animal model of Alzheimer's disease according to claim 1, characterized in that: The elastic layer (11) is configured as an accordion bellows structure and is made of medical-grade silicone rubber.

8. The auxiliary device for preparing an animal model of Alzheimer's disease according to claim 1, characterized in that: The capture cover (12) and the semi-circular baffle connected to its inner side are both made of transparent medical-grade PC material, and the operating lever (13) is a multi-section telescopic link.

9. The auxiliary device for preparing an animal model of Alzheimer's disease according to claim 1, characterized in that: The mesh door (7) and the opening and closing mesh plate (6) are magnetically connected, and the mesh surface is made of stainless steel woven mesh.

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