Organ mechanical perfusion device

Abstract

The utility model discloses an organ mechanical perfusion device, include: liquid storage container for storing perfusion solution, perfusion pump, perfusion pump is connected with the liquid storage container and the organ in vitro through perfusion pipeline, and the perfusion liquid in the liquid storage container is extracted through the perfusion pump and is carried out one -way perfusion to the organ in vitro through perfusion pipeline. The perfusion device in the utility model can avoid metabolic waste into the organ in vitro, and can greatly simplify the device structure, improve the overall performance such as use safety, stability and portability.

Description

Technical Field

[0001] This utility model relates to the field of medical equipment technology, and more specifically, to an organ mechanical perfusion device. Background Technology

[0002] Limb replantation is an important field of trauma surgery and microsurgery, as well as a crucial technique for battlefield rescue. Currently, ischemic time of a severed limb exceeding 6 hours will lead to irreversible muscle necrosis, nerve degeneration, and vascular endothelial damage, resulting in a replantation failure rate as high as 30%-50%.

[0003] Traditional limb preservation relies on low-temperature static cryopreservation (e.g., ice at 4°C), which can only slow down metabolism but cannot repair tissue damage. Normothermic Machine Perfusion (NMP) technology maintains the metabolic activity of the severed limb by simulating the physiological environment, while also performing repair functions, providing an innovative solution for extending the ischemic time window and improving replantation success rates.

[0004] As early as the 1980s, clinicians attempted to perfuse the arteries of severed limbs with heparinized saline to maintain basal metabolism for 4-6 hours, but this failed to address muscle edema and nerve damage. Due to the lack of tissue-specific support, it was only suitable for simple amputations. In recent years, mechanical circulation perfusion has been commonly used. During perfusion, metabolic waste products re-enter the circulation with the perfusion fluid, leading to drawbacks such as elevated potassium and lactate levels. Furthermore, a dialyzer is required to maintain homeostasis. Simultaneously, it is necessary to prevent tissue fragments or thrombi from entering the perfusion tubing and perfusion fluid during circulation, and an oxygenator is essential to increase the oxygen content of the perfusion fluid.

[0005] It is evident that the circulating perfusion devices in related technologies cannot prevent metabolic waste from entering the circulation, and require the use of multiple devices, resulting in complex device structures and poor flexibility in use. Utility Model Content

[0006] The main objective of this invention is to provide an organ mechanical perfusion device to solve the problems of related technologies, such as the difficulty in preventing metabolic waste from entering the organ, the need to use multiple devices, complex device structure, and poor flexibility of use.

[0007] To achieve the above objectives, this utility model provides an organ mechanical perfusion device, comprising: A liquid storage container used to store the filling fluid; Infusion tubing, used for perfusing organs; The perfusion pump is connected to the storage container and the isolated organ through the perfusion pipeline. The perfusion pump draws perfusion fluid from the storage container and performs unidirectional perfusion on the isolated organ through the perfusion pipeline.

[0008] Optionally, it may also include an organ compartment for accommodating ex vivo organs.

[0009] Optionally, it also includes a temperature control device for controlling the temperature of the perfusion fluid and the isolated organ.

[0010] Optionally, it also includes a control module for controlling the injection pump speed and the temperature control device.

[0011] Optionally, it also includes a waste liquid container, which is connected to the organ chamber and is used to contain waste liquid discharged by one-way perfusion.

[0012] Optionally, the perfusion pump is configured to draw perfusion fluid from the reservoir in stages to perform unidirectional perfusion of the isolated organ.

[0013] Optionally, it also includes an oxygenator, wherein the outlet end of the infusion pump is connected to the infusion fluid inlet of the oxygenator through the infusion pipeline, and the infusion fluid outlet of the oxygenator is connected to the isolated organ through the infusion pipeline.

[0014] Optionally, it also includes an oxygen supply device connected to the oxygen inlet of the oxygenator for supplying oxygen to the oxygenator.

[0015] Optionally, it also includes: Pressure sensor used to detect pressure in the injection line; Flow and bubble sensors are used to detect flow and bubbles in the injection line.

[0016] Optionally, it also includes: Solar power supply devices are used for power supply. Ultraviolet light device is used to sterilize the perfusion fluid.

[0017] In this embodiment of the invention, a storage container is provided to store the perfusion fluid; a perfusion pump is connected to the storage container and the isolated organ via a perfusion pipeline. The perfusion pump draws the perfusion fluid from the storage container and performs unidirectional perfusion of the isolated organ through the perfusion pipeline. After unidirectional perfusion of the isolated organ, the perfusion fluid that has passed through the isolated organ does not recirculate back into the isolated organ, thus preventing metabolic waste generated during perfusion from re-entering the isolated organ. Furthermore, after unidirectional perfusion, there are no defects such as elevated potassium ions or lactic acid levels in the perfusion fluid, eliminating the need for a dialyzer to maintain internal environmental stability. Simultaneously, since the perfusion fluid does not recirculate back into the isolated organ, it avoids the re-entry of tissue fragments or thrombi carried by the perfusion fluid into the isolated organ, eliminating the need for filtration structures such as embolus filters. Additionally, since the perfusion fluid does not recirculate back into the isolated organ, an additional oxygenator is not required during perfusion; only pre-oxygenated perfusion fluid needs to be stored in the storage container. Therefore, the perfusion device of this invention can prevent metabolic waste from entering isolated organs, and can greatly simplify the device structure and improve the overall performance such as safety, stability and portability. Attached Figure Description

[0018] The accompanying drawings, which form part of this utility model, are used to provide a further understanding of the utility model, making other features, objects, and advantages of the utility model more apparent. The illustrative embodiments of the utility model and their descriptions are used to explain the utility model and do not constitute an undue limitation of the utility model. In the drawings: Figure 1 This is a schematic diagram of the infusion device according to an embodiment of the present utility model; Figure 2 This is a simplified schematic diagram of the infusion device connection according to an embodiment of this utility model; The components include: 1. Liquid storage container; 2. Infusion pipeline; 3. Infusion pump; 4. Waste liquid container; 5. Organ compartment; 6. Ex vivo organ; 7. Oxygenator; 8. Oxygen supply device; 9. Central control system; 10. Micro pump; 11. Temperature control device; 12. Ultraviolet light; 13. Pressure sensor; and 14. Flow and bubble sensor. Detailed Implementation

[0019] To enable those skilled in the art to better understand the present invention, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort should fall within the protection scope of the present invention.

[0020] It should be noted that the terms "first," "second," etc., used in the specification, claims, and accompanying drawings of this utility model are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. It should be understood that such data can be interchanged where appropriate for the embodiments of this utility model described herein.

[0021] In this invention, the terms "upper," "lower," "inner," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. These terms are primarily for the purpose of better describing this invention and its embodiments, and are not intended to limit the indicated device, element, or component to having a specific orientation, or to be constructed and operated in a specific orientation.

[0022] Furthermore, in addition to indicating direction or positional relationship, some of the aforementioned terms may also have other meanings. For example, the term "above" may also be used in some cases to indicate a certain dependency or connection relationship. Those skilled in the art can understand the specific meaning of these terms in this utility model according to the specific circumstances.

[0023] Furthermore, the terms "set up," "equipped with," "connected," and "fixed" should be interpreted broadly. For example, "connected" can be a fixed connection, a detachable connection, or an integral structure; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, or it can be an internal connection between two devices, components, or parts. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0024] In addition, the term "multiple" should mean two or more.

[0025] It should be noted that, where there is no conflict, the embodiments and features in the embodiments of this utility model can be combined with each other. The present utility model will now be described in detail with reference to the accompanying drawings and embodiments.

[0026] To solve related technical problems, such as Figure 1 As shown, this utility model embodiment provides an ex vivo organ perfusion device, including: a liquid storage container 1 for storing perfusion fluid; a perfusion pump 3, which is connected to the liquid storage container 1 and the ex vivo organ 6 through a perfusion pipeline 2. The perfusion pump 3 draws the perfusion fluid from the liquid storage container 1 and performs unidirectional perfusion on the ex vivo organ 6 through the perfusion pipeline 2.

[0027] In this embodiment, the ex vivo organ 6 perfusion device is mainly used to preserve vascularized tissue complexes such as severed limbs and skin flaps, as well as low-flow organs such as kidneys, uterus, and pancreas. The storage container 1 can pre-store a certain amount of perfusion fluid. The storage container 1 can be a storage bag or a storage tank, etc., and its capacity can be set according to actual needs. Different capacities of storage containers 1 can be used to adapt to different perfusion requirements of the ex vivo organ 6. The inlet end of the perfusion pump 3 is connected to the storage container 1 via the perfusion pipeline 2, and the outlet end of the perfusion pump 3 is connected to the ex vivo organ 6 via the perfusion pipeline 2, for example, to the artery of the ex vivo severed limb. The perfusion pump 3 draws perfusion fluid from the storage container 1, which flows along the perfusion pipeline 2 into the artery of the ex vivo severed limb and flows out from the vein of the ex vivo severed limb. The perfusion fluid flowing out of the excised limb no longer flows back to the storage container 1 or other equipment for perfusion fluid circulation through the perfusion pipeline 2, but is directly discharged as waste fluid. Therefore, the excised organ perfusion device in this embodiment can perform unidirectional perfusion of the excised organ 6.

[0028] Therefore, after unidirectional perfusion of the isolated organ 6, the perfusion fluid passing through the isolated organ 6 does not circulate back into the isolated organ 6. Thus, metabolic waste generated during perfusion will not re-enter the isolated organ 6. Furthermore, after unidirectional perfusion, there are no defects such as elevated potassium ions or lactic acid levels in the perfusion fluid, eliminating the need for a dialyzer to maintain internal environmental stability. Simultaneously, since the perfusion fluid does not circulate back into the isolated organ 6, tissue fragments or thrombi carried by the perfusion fluid during its passage through the isolated organ 6 can be prevented from re-entering the isolated organ 6, eliminating the need for filtration structures such as embolus filters. Additionally, since the perfusion fluid does not circulate back into the isolated organ 6, an additional oxygenator 7 is not required during perfusion; only pre-oxygenated perfusion fluid needs to be stored in the reservoir 1. Therefore, the perfusion device of this invention can prevent metabolic waste from entering the isolated organ 6 and can greatly simplify the device structure, improving overall performance such as safety, stability, and portability.

[0029] In one implementation, such as Figure 2 As shown, the perfusion pump 3 can be integrated into the main unit. Besides the perfusion pump 3, the main unit can also house corresponding sensors (pressure sensor 13, flow and bubble sensor 14, temperature sensor 15), power supply, and other equipment. For example, the pressure sensor 13 can be installed in the main unit to detect the pressure of the perfusion fluid flowing into and out of the main unit. The temperature sensor 15 can also be installed to detect the temperature of the perfusion fluid and the isolated organ 6. The organ mechanical perfusion device can also include a temperature control device 11 and a control module 9. The temperature control device 11 controls the temperature of the perfusion fluid and the isolated organ 6; the control module 9 controls the rotational speed of the perfusion pump 3 and controls the temperature control device 11.

[0030] In some embodiments, the temperature control device 11 may include a heat exchanger, through which the perfusion fluid delivered by the perfusion pump 3 first exchanges heat before flowing to the organ. The temperature control device 11 may also include an infrared heating device, capable of non-contact radiant heating of the organ within the organ compartment. The control module 9 is a conventional circuit module capable of control, which can control the start / stop and speed of the perfusion pump 3, and also control the temperature of the temperature control device 11, for example, by controlling the power of the heat source in the heat exchanger, or the power of the infrared heating device, etc.

[0031] In addition, to precisely adjust the perfusion fluid flow rate, one can also... Figure 2 Set up a micro-pump 10.

[0032] The main unit can be equipped with an infusion fluid inlet and an outlet, which are connected to the storage container 1 and the excised organ 6 respectively via infusion pipeline 2. The infusion fluid inlet and outlet correspond to the inlet and outlet ends of the infusion pump 3, respectively. The storage container 1 can be a structure that is detachably installed on the main unit, or it can be a separate component; this embodiment does not impose any restrictions on it.

[0033] Depending on the perfusion requirements, the perfusion pump 3 is configured to periodically extract perfusion fluid from the storage container 1 to perform unidirectional perfusion of the isolated organ 6. Specifically, the perfusion pump can perform unidirectional perfusion of the isolated organ 6 in stages. For example, it can be divided into stages according to time, such as dividing 24 hours into multiple stages, with the perfusion pump starting during some stages to perform unidirectional perfusion of the isolated organ, and shutting down during others to stop perfusion of the isolated organ 6. It can also be divided into stages according to temperature. For example, when the isolated organ is at a low temperature (e.g., the perfusion device along with the isolated organ 6 can be placed in a refrigeration device), the perfusion pump is turned off. When the isolated organ is at room temperature (e.g., the isolated organ can be heated using an external heating device, or the organ can be placed in a room temperature environment to allow it to naturally return to room temperature), the perfusion pump 3 is started.

[0034] In one implementation, such as Figure 1 As shown, it also includes an organ compartment 5 and a waste liquid container 4. The organ compartment 5 is used to store the excised organ 6. Waste liquid container 4 is connected to organ compartment 5 via a pipeline.

[0035] Specifically, in this embodiment, the excised organ 6 is preserved through the organ compartment 5, which facilitates organ preservation and provides space to accommodate the perfusion fluid flowing through the organ. The waste fluid container 4 is used to collect the perfusion fluid flowing through the organ, and it is connected to the organ compartment 5 through a pipeline. The organ compartment 5 has different structural forms depending on the different excised organs 6, and no limitation is made here.

[0036] The infusion device may or may not include an oxygenator 7. When the oxygenator 7 is not included, the infusion fluid needs to be pre-charged with oxygen. When the oxygenator 7 is included, pre-charging of the infusion fluid with oxygen is not required, and the setting can be adjusted according to actual needs. Regardless of whether the infusion device includes an oxygenator 7, artificial oxygen-carrying agents and other components can be added to the infusion fluid.

[0037] In one embodiment, the infusion device includes an oxygenator 7, the outlet end of the infusion pump 3 is connected to the infusion fluid inlet of the oxygenator 7 through the infusion pipeline 2, and the infusion fluid outlet of the oxygenator 7 is connected to the isolated organ 6 through the infusion pipeline 2.

[0038] Specifically, the oxygenator can be integrated with the injection pump 3 into the main unit. The injection pump 3 draws the injection fluid into the oxygenator 7, and the oxygen content can be increased after the injection fluid flows through the oxygenator 7.

[0039] To be used in conjunction with the oxygenator, the filling device also includes an oxygen supply device 8, which is connected to the oxygen inlet of the oxygenator 7 and is used to supply oxygen to the oxygenator 7. The oxygen supply device can be an oxygen generator or an oxygen cylinder, and the oxygenator 7 can be a membrane oxygenator.

[0040] Optionally, the perfusion device may also include a solar power supply device to power electronic components such as the perfusion pump 3, enabling power supply in field mobile scenarios. Additionally, an ultraviolet (UV) device 12 may be installed to sterilize the perfusion fluid and the isolated organ 6, reducing the risk of infection.

[0041] The above description is merely a preferred embodiment of this utility model and is not intended to limit the scope of this utility model. Various modifications and variations can be made to this utility model by those skilled in the art. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. An organ mechanical perfusion device, characterized in that, include: A liquid storage container used to store the filling fluid; Infusion tubing, used for perfusing organs; The perfusion pump is connected to the storage container and the isolated organ through the perfusion pipeline. The perfusion pump draws perfusion fluid from the storage container and performs unidirectional perfusion on the isolated organ through the perfusion pipeline.

2. The organ mechanical perfusion device according to claim 1, characterized in that, It also includes an organ compartment for accommodating ex vivo organs.

3. The organ mechanical perfusion device according to claim 1, characterized in that, It also includes a temperature control device for controlling the temperature of the perfusion fluid and the excised organ.

4. The organ mechanical perfusion device according to claim 3, characterized in that, It also includes a control module, which is used to control the injection pump speed and the temperature control device.

5. The organ mechanical perfusion device according to claim 2, characterized in that, It also includes a waste liquid container, which is connected to the organ chamber and is used to contain waste liquid discharged by one-way perfusion.

6. The organ mechanical perfusion device according to claim 1, characterized in that, The perfusion pump is configured to draw perfusion fluid from the storage container in stages to perform unidirectional perfusion of the isolated organ.

7. The organ mechanical perfusion device according to claim 1, characterized in that, It also includes an oxygenator, the outlet of the infusion pump is connected to the infusion fluid inlet of the oxygenator through the infusion pipeline, and the infusion fluid outlet of the oxygenator is connected to the isolated organ through the infusion pipeline.

8. The organ mechanical perfusion device according to claim 7, characterized in that, It also includes an oxygen supply device, which is connected to the oxygen inlet of the oxygenator and is used to supply oxygen to the oxygenator.

9. The organ mechanical perfusion device according to claim 1, characterized in that, Also includes: Pressure sensor used to detect pressure in the injection line; Flow and bubble sensors are used to detect flow and bubbles in the injection line.

10. The organ mechanical perfusion device according to claim 1, characterized in that, Also includes: Solar power supply devices are used for power supply. Ultraviolet light device is used to sterilize the perfusion fluid.

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