An induced pluripotent stem cell preservation device

Abstract

The utility model belongs to the field of medical apparatus and instruments, concretely relates to a kind of induced pluripotent stem cell storage device, including storage box, and the inside fixed mounting of storage box has storage rack, and the top of storage box is movably connected with sealing plate, and the both sides of the front side of sealing plate bottom are uniformly fixedly connected with mounting lug.The utility model is equipped with storage rack etc. structure on storage box, can provide stable load support for the storage container (such as cryopreservation tube, culture dish etc.) of induced pluripotent stem cell, avoid the collision, dumping of container due to device movement, shaking in the storage process, effectively protect the integrity of stem cell sample, reduce the risk of sample pollution or injury;Meanwhile, the adaptive design of the movable connection structure cooperation mounting lug and structure cavity of sealing plate and storage box, form multiple sealing protection, reduce the air circulation inside and outside the box, help to maintain the low temperature, sterile etc. stable storage environment inside storage box, extend the storage period of stem cell sample.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, specifically to an induced pluripotent stem cell preservation device. Background Technology

[0002] According to patent publication number CN117461628A, an induced pluripotent stem cell storage device is disclosed, relating to the field of medical device technology. Its key technical features include a protective box, a base plate fixedly connected to the lower surface of the protective box, a push-out plate slidably connected to the surface of the base plate, an outer cover rotatably connected to the surface of the protective box away from the push-out plate, and a sealing cap fixedly connected to the inner surface of the outer cover. In this induced pluripotent stem cell storage device, when a worker inserts cryopreservation tubes containing stem cells into the slots, and liquid nitrogen is injected after the storage tank is sealed by the sealing cap, the liquid nitrogen is injected from the center of the sealing cap, causing the liquid nitrogen storage component to diffuse outwards from the center. Therefore, the downward flow of liquid nitrogen during injection pushes the rotating block to rotate, causing the rotating shaft to rotate. This causes the extension plate on the outer side of the rotating shaft to rotate the fixed block, increasing the contact area between the cryopreservation tubes and the liquid nitrogen. This facilitates the addition and replacement of internal liquid nitrogen during use, reducing the waste of liquid nitrogen resources.

[0003] However, there are problems with the existing technology: the sealing cap and the protective box lack a secure fastening effect. When the protective box is being carried, the sealing cap on top is prone to loosening and opening, causing the test tubes inside to fall out easily, which reduces the safety of the sealing cap and the protective box. Utility Model Content

[0004] The purpose of this invention is to provide an induced pluripotent stem cell preservation device that solves the problem of insufficient fastening between the sealing cap and the protective box. When the protective box is being carried, the sealing cap on top is prone to loosening and opening, causing the test tubes inside to fall out easily, which reduces the safety of the sealing cap and the protective box.

[0005] To achieve the above objectives, this utility model provides the following technical solution: an induced pluripotent stem cell preservation device, comprising a preservation box, a storage rack fixedly installed inside the preservation box, a sealing plate movably connected to the top of the preservation box, mounting ears fixedly connected to both sides of the bottom front side of the sealing plate, a structural cavity provided on the front side of the preservation box, the bottom of the mounting ears penetrating into the interior of the structural cavity, slots provided on both sides of the inner wall of the structural cavity, and a fixing mechanism provided inside the structural cavity.

[0006] Preferably, the fixing mechanism includes a pin located inside the slot. A movable plate is fixedly connected to the other side of the pin, and a tension spring is fixedly connected to the inner side of the movable plate. The other side of the tension spring is fixedly connected to the inner wall of the structural cavity. The mounting ear is located on the surface of the pin. Through the tension spring, the elastic force of the tension spring can push the movable plate to keep the pin in a tight state against the mounting ear, ensuring the sealing and firmness of the connection between the sealing plate and the storage box, and preventing the sealing plate from loosening due to vibration or collision. At the same time, when it is necessary to open the sealing plate, the pin can be disengaged from the mounting ear simply by overcoming the tension spring force and pulling the movable plate. The operation is simple and labor-saving, requiring no additional tools. This not only ensures the reliability of the fixing but also improves the convenience of the device operation. Moreover, the structure is simple, the failure rate is low, and the maintenance cost of the device is reduced.

[0007] Preferably, a pull rope is fixedly connected to the inner side of the movable plate, and a winding reel is fixedly connected to the inner side of the pull rope. The front side of the winding reel extends to the front side of the storage box. With the pull rope and winding reel, the operator can rotate the winding reel to retract the pull rope, thereby driving the movable plate to move synchronously. There is no need to directly reach into the structural cavity to operate, avoiding hand contact with the internal components of the structural cavity and causing contamination. It also facilitates precise control of the movement distance of the pin, ensuring that the pin is completely disengaged or accurately inserted into the slot. The design of the winding reel extending to the front side of the storage box makes the operation position more intuitive and easy to access, simplifies the opening and fixing process of the sealing plate, and improves the flexibility and efficiency of operation, especially suitable for scenarios that require frequent opening and closing of the sealing plate.

[0008] Preferably, a stabilizing rod is provided at the bottom of the movable plate. The surface of the stabilizing rod is fixedly connected to the inner wall of the structural cavity. By setting the stabilizing rod, the offset and tilt of the movable plate during the movement can be limited, ensuring that the movable plate always slides smoothly in the horizontal direction. This ensures the linearity and accuracy of the pin movement and avoids the pin failing to accurately insert into the slot or detaching from the mounting ear due to misalignment of the movable plate. At the same time, the stabilizing rod can distribute the tensile and elastic forces on the movable plate, reducing deformation and damage caused by uneven force on the movable plate, extending the service life of the movable plate and the pin, ensuring the long-term stable operation of the fixing mechanism, and improving the structural reliability and durability of the entire storage device.

[0009] Preferably, a limiting plate is fixedly connected to the inner side of the stabilizing rod. The limiting plate is located inside the moving plate. By setting the limiting plate, it can effectively prevent the moving plate from moving beyond its limit due to excessive pulling of the rope or excessive tension of the spring. When the moving plate moves inward to contact the limiting plate, the limiting plate will block its continued movement, avoiding excessive stretching of the spring and loss of elasticity, or violent collision between the moving plate and the inner wall of the structural cavity, which could cause damage to the components. At the same time, the limiting plate can ensure that the pin remains in a reasonable position when it is in the open state, preventing the pin from completely detaching from the structural cavity or getting stuck with other components, ensuring the operational stability and safety of the fixing mechanism, and extending the service life of the device.

[0010] Preferably, a knob is fixedly connected to the front side of the winding reel. The knob is located on the front side of the storage box. The knob increases the gripping area and friction of the winding reel, allowing the operator to rotate the reel more easily and stably, avoiding slippage during rotation, and improving the feel and accuracy of operation. The visual design of the knob makes the operation position more conspicuous, making it convenient for the operator to quickly locate the operating parts. Especially when operating in low-temperature environments while wearing gloves, the operator can still efficiently complete the rotation of the winding reel, further optimizing the operating experience and reducing the risk of sample storage and retrieval delays due to inconvenient operation.

[0011] Preferably, a reinforcing block is fixedly connected to the surface of the pull rope, and the surface of the reinforcing block is fixedly connected to the surface of the moving plate. With the setting of the reinforcing block, the connection between the pull rope and the moving plate is prone to wear and breakage due to concentrated tension during long-term winding and unwinding and stress. The reinforcing block increases the connection contact area, disperses the tensile load, reduces stress concentration at the connection between the pull rope and the moving plate, effectively prevents the pull rope from falling off or breaking, and ensures the stability and continuity of tensile force transmission. At the same time, the reinforcing block can also protect the connection part of the moving plate, avoid friction of the pull rope causing wear on the surface of the moving plate, extend the service life of the moving plate and the pull rope, improve the overall reliability of the fixing mechanism, and ensure the long-term stable operation of the device.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0013] 1. This utility model, by adding storage racks and other structures to the preservation box, can provide stable support for the preservation containers (such as cryovials, culture dishes, etc.) of induced pluripotent stem cells, avoiding collisions and tipping of containers due to device movement or shaking during preservation, effectively protecting the integrity of stem cell samples and reducing the risk of sample contamination or damage; at the same time, the movable connection structure between the sealing plate and the preservation box, combined with the fitting design of the mounting ears and the structural cavity, forms multiple layers of sealing protection, reducing air circulation inside and outside the box, helping to maintain a stable preservation environment such as low temperature and sterility inside the preservation box, and extending the preservation period of stem cell samples.

[0014] 2. This utility model, by adding a sealing plate and other structures to the storage box, combined with the internal fixing mechanism, not only ensures the firmness of the sealing plate after installation, but also simplifies the opening and closing operation of the sealing plate, making it convenient for staff to quickly store and retrieve stem cell samples, and improving the efficiency of experimental or clinical operations; in addition, the fixed installation design of the storage rack can be reasonably arranged according to the specifications and quantity of stem cell storage containers, adapting to the storage needs of samples of different sizes and types, and improving the versatility and practicality of the device. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the structure of this utility model;

[0016] Figure 2 This is a perspective view of the storage rack of this utility model;

[0017] Figure 3 This is a perspective view of the winding reel of this utility model;

[0018] Figure 4 This is a three-dimensional view of the structural cavity of this utility model.

[0019] In the diagram: 1. Storage box; 2. Storage rack; 3. Sealing plate; 4. Mounting ear; 5. Structural cavity; 6. Slot; 71. Pin; 72. Moving plate; 73. Tension spring; 74. Pull rope; 75. Rewind reel; 76. Stabilizing bar; 77. Limiting plate; 78. Knob; 79. Reinforcing block. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0021] Please see Figure 1 An induced pluripotent stem cell preservation device includes a preservation box 1, a storage rack 2 fixedly installed inside the preservation box 1, a sealing plate 3 movably connected to the top of the preservation box 1, mounting ears 4 fixedly connected to both sides of the bottom front side of the sealing plate 3, a structural cavity 5 provided on the front side of the preservation box 1, the bottom of the mounting ears 4 penetrating into the interior of the structural cavity 5, slots 6 provided on both sides of the inner wall of the structural cavity 5, and a fixing mechanism provided inside the structural cavity 5.

[0022] Please see Figure 3The fixing mechanism includes a pin 71, which is located inside the slot 6. A movable plate 72 is fixedly connected to the other side of the pin 71. A tension spring 73 is fixedly connected to the inner side of the movable plate 72. The other side of the tension spring 73 is fixedly connected to the inner wall of the structural cavity 5. The mounting ear 4 is located on the surface of the pin 71.

[0023] Furthermore, through the setting of the tension spring 73, the elastic force of the tension spring 73 can push the moving plate 72 to drive the pin 71 to always keep it in a tight state against the mounting ear 4, ensuring the sealing and firmness of the connection between the sealing plate 3 and the storage box 1, and preventing the sealing plate 3 from loosening due to vibration or collision; at the same time, when it is necessary to open the sealing plate 3, it is only necessary to overcome the elastic force of the tension spring 73 to pull the moving plate 72 to make the pin 71 disengage from the mounting ear 4. The operation is simple and labor-saving, without the need for additional tools. It not only ensures the reliability of the fixation, but also improves the convenience of the device operation. Moreover, the structure is simple, the failure rate is low, and the maintenance cost of the device is reduced.

[0024] Please see Figure 3 A pull rope 74 is fixedly connected to the inner side of the movable plate 72, and a winding reel 75 is fixedly connected to the inner side of the pull rope 74. The front side of the winding reel 75 extends to the front side of the storage box 1.

[0025] Furthermore, with the pull rope 74 and the take-up reel 75, the operator can retract or extend the pull rope 74 by rotating the take-up reel 75, thereby driving the moving plate 72 to move synchronously. This eliminates the need to directly reach into the structural cavity 5 for operation, avoiding contact between the hands and the internal components of the structural cavity 5, which could cause contamination. It also facilitates precise control of the movement distance of the pin 71, ensuring that the pin 71 is completely disengaged or accurately inserted into the slot 6. The design of the take-up reel 75 extending to the front of the storage box 1 makes the operation position more intuitive and easily accessible, simplifying the opening and fixing process of the sealing plate 3, and improving the flexibility and efficiency of operation. It is especially suitable for scenarios that require frequent opening and closing of the sealing plate 3.

[0026] Please see Figure 3 A stabilizing rod 76 is provided at the bottom of the movable plate 72, and the surface of the stabilizing rod 76 is fixedly connected to the inner wall of the structural cavity 5.

[0027] Furthermore, the stabilizing rod 76 restricts the offset and tilt of the moving plate 72 during movement, ensuring that the moving plate 72 always slides smoothly in the horizontal direction. This ensures the linearity and accuracy of the movement of the pin 71, preventing the pin 71 from failing to accurately insert into the slot 6 or detaching from the mounting ear 4 due to misalignment of the moving plate 72. At the same time, the stabilizing rod 76 can distribute the tension and elastic force on the moving plate 72, reducing deformation and damage caused by uneven force on the moving plate 72, extending the service life of the moving plate 72 and the pin 71, ensuring the long-term stable operation of the fixing mechanism, and improving the structural reliability and durability of the entire storage device.

[0028] Please see Figure 3 A limiting plate 77 is fixedly connected to the inner side of the stabilizer bar 76, and the limiting plate 77 is located inside the movable plate 72.

[0029] Furthermore, the setting of the limiting plate 77 can effectively prevent the moving plate 72 from moving beyond its limit due to excessive pulling of the pull rope 74 or excessive elasticity of the tension spring 73: when the moving plate 72 moves inward to contact the limiting plate 77, the limiting plate 77 will block its continued movement, avoiding the tension spring 73 from being overstretched and losing its elasticity, or the moving plate 72 from violently colliding with the inner wall of the structural cavity 5 and causing damage to the components; at the same time, the limiting plate 77 can ensure that the pin 71 is kept in a reasonable position when it is open, avoiding the pin 71 from completely detaching from the structural cavity 5 or getting stuck with other components, ensuring the operational stability and safety of the fixing mechanism, and extending the service life of the device.

[0030] Please see Figure 1 A knob 78 is fixedly connected to the front side of the reel 75, and the knob 78 is located on the front side of the storage box 1.

[0031] Furthermore, the knob 78 increases the grip area and friction of the winding reel 75, allowing staff to rotate it more easily and stably, preventing slippage and improving the feel and precision of operation. The visual design of the knob 78 makes the operation position more prominent, facilitating quick location of the operating parts. Especially when operating in low-temperature environments while wearing gloves, the rotation of the winding reel 75 can still be completed efficiently, further optimizing the operating experience and reducing the risk of sample storage and retrieval delays due to inconvenient operation.

[0032] Please see Figure 3 A reinforcing block 79 is fixedly connected to the surface of the pull rope 74, and the surface of the reinforcing block 79 is fixedly connected to the surface of the movable plate 72.

[0033] Furthermore, by setting up the reinforcing block 79, the connection between the pull rope 74 and the moving plate 72 is prone to wear and breakage due to concentrated tension during long-term extension and retraction and stress. The reinforcing block 79 increases the contact area, disperses the tensile load, and reduces stress concentration at the connection between the pull rope 74 and the moving plate 72, effectively preventing the pull rope 74 from falling off or breaking, and ensuring the stability and continuity of tensile force transmission. At the same time, the reinforcing block 79 can also protect the connection part of the moving plate 72, avoid friction of the pull rope 74 causing wear on the surface of the moving plate 72, extend the service life of the moving plate 72 and the pull rope 74, improve the overall reliability of the fixing mechanism, and ensure the long-term stable operation of the device.

[0034] The specific implementation process of this utility model is as follows: In use... Figure 1When the storage box 1 and the sealing plate 3 are in a fixed and closed state, and test tubes need to be placed inside the storage box 1, turn the knob 78. The knob 78 drives the pull rope 74 to rewind. The pull rope 74 drives the moving plate 72 to move. The moving plate 72 stretches the tension spring 73. The moving plate 72 drives the pin 71 to move inward. The pin 71 is dislodged from the slot 6 and the mounting ear 4. After the mounting ear 4 is no longer fixed, the sealing plate 3 can be flipped over to expose the inside of the storage box 1.

[0035] The user then places the test tube inside the storage rack 2, closes the sealing plate 3, resets the mounting ear 4, releases the knob 78, and through the tension of the tension spring 73, moves the moving plate 72 inward. The moving plate 72 drives the pin 71 to insert into the mounting ear 4 and the slot 6, and the sealing plate 3 is fixedly closed to the top of the storage box 1 again.

[0036] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. An induced pluripotent stem cell preservation device, comprising a preservation box (1), characterized in that: The storage box (1) is fixedly installed with a storage rack (2). The top of the storage box (1) is movably connected with a sealing plate (3). The sealing plate (3) has mounting ears (4) fixedly connected to both sides of the bottom front side. The storage box (1) has a structural cavity (5) on the front side. The bottom of the mounting ears (4) extends through the interior of the structural cavity (5). The inner walls of the structural cavity (5) have slots (6) on both sides. The structural cavity (5) has a fixing mechanism inside.

2. The induced pluripotent stem cell preservation device according to claim 1, characterized in that: The fixing mechanism includes a pin (71) located inside the slot (6), a movable plate (72) fixedly connected to the other side of the pin (71), a tension spring (73) fixedly connected to the inner side of the movable plate (72), and the other side of the tension spring (73) fixedly connected to the inner wall of the structural cavity (5). The mounting ear (4) is located on the surface of the pin (71).

3. The induced pluripotent stem cell preservation device according to claim 2, characterized in that: A pull rope (74) is fixedly connected to the inner side of the movable plate (72), and a winding reel (75) is fixedly connected to the inner side of the pull rope (74). The front side of the winding reel (75) extends to the front side of the storage box (1).

4. The induced pluripotent stem cell preservation device according to claim 2, characterized in that: The bottom of the movable plate (72) is provided with a stabilizing rod (76), and the surface of the stabilizing rod (76) is fixedly connected to the inner wall of the structural cavity (5).

5. The induced pluripotent stem cell preservation device according to claim 4, characterized in that: A limiting plate (77) is fixedly connected to the inner side of the stabilizer (76), and the limiting plate (77) is located inside the movable plate (72).

6. The induced pluripotent stem cell preservation device according to claim 3, characterized in that: A knob (78) is fixedly connected to the front side of the winding reel (75), and the knob (78) is located on the front side of the storage box (1).

7. The induced pluripotent stem cell preservation device according to claim 3, characterized in that: A reinforcing block (79) is fixedly connected to the surface of the pull rope (74), and the surface of the reinforcing block (79) is fixedly connected to the surface of the movable plate (72).

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