A composite magnetic field generating device for experiments

Abstract

The utility model relates to nanometer medical technology field discloses an experimental composite magnetic field generating device, include: low -frequency rotating magnetic field part includes: two bearings, two groups of feeding assembly and two static magnets, the inner ring of two bearings is connected in first base through fixed support respectively, the outer ring is connected through the multiple first connecting rod of symmetrical setting, the outer ring is connected with motor and is driven to rotate, two groups of feeding assembly are connected on two first connecting rod respectively, two static magnets are connected in feeding assembly one -to -one corresponding symmetry, and feeding assembly drives two static magnets to be close to each other or to be far away from each other, thereby adjusting the magnetic field intensity of experimental area, high -frequency alternating magnetic field part includes: two opposite setting helmholtz coils and high -frequency heating control subsystem connected with it, and helmholtz coil is fixed with the inner ring through second connecting rod. The device can be used for cell experiment and animal experiment simultaneously, and can produce the composite magnetic field of low -frequency rotating magnetic field and high -frequency alternating magnetic field simultaneously.

Description

Technical Field

[0001] This utility model relates to the field of nanomedicine technology, and in particular to an experimental composite magnetic field generating device. Background Technology

[0002] Magnetothermothermal therapy and magnetomechanical therapy based on iron-based magnetic nanoparticles are emerging directions in tumor physical therapy. Their core advantage lies in their precise and controllable in vitro action: by remotely controlling the mechanical or thermal effects of magnetic nanoparticles through an external magnetic field, they selectively kill tumor cells, avoiding damage to normal tissues caused by traditional chemotherapy or radiotherapy, and significantly reducing systemic adverse reactions.

[0003] However, research on Mechanical-Thermal Induction Therapy (MTIT) is still in its early stages. Although some related devices have emerged, some problems still exist. For example, Chinese Patent CN111773545A discloses a magnetic-thermal integrated device, which combines a high-frequency alternating magnetic field and a low-frequency rotating magnetic field generating unit into a composite magnetic field device for research on magnetic nanomaterial magnetothermal therapy and mechanical therapy. However, this technology has the following drawbacks: ① The rotating magnetic field frequency range of this device is 0Hz-40Hz. Existing research shows that excessively high rotating magnetic field frequencies do not produce good tumor-killing effects from magnetic nanomaterials. The excessively large magnetic field frequency range in this device is not conducive to fine-tuning for different tumor tissues / cells; ② The rotating magnetic field strength of this device is not adjustable, being fixed at 40mT, which is not conducive to studying the therapeutic effects of different magnetic field strengths on tumors on the same device. Similarly, Chinese patent CN219440437U discloses a dual-frequency magnetic response nanotherapy platform, a three-dimensional composite magnetic field generator with an appearance similar to CT / MRI that can simultaneously generate high-frequency alternating magnetic fields and low-frequency rotating magnetic fields. This is also used for research on magnetothermal and mechanical therapy of magnetic nanomaterials. However, this technology has the following drawbacks: ① The rotating magnetic field frequency range of this device is 0Hz-100Hz, which also results in an excessively large magnetic field frequency adjustment range, making it unsuitable for fine-tuning for different tumor tissues / cells; ② "Cutting" the coil generates induced current, causing interference between the rotating and alternating magnetic fields, which is not conducive to studying the synergistic effect of the composite magnetic field on tumor cells. Utility Model Content

[0004] To solve the above-mentioned technical problems, this utility model provides an experimental composite magnetic field generator that can be used for both cell experiments and animal experiments, and can simultaneously generate a composite magnetic field of low-frequency rotating magnetic field and high-frequency alternating magnetic field.

[0005] This invention provides an experimental composite magnetic field generating device, comprising: a first base and a low-frequency rotating magnetic field component and a high-frequency alternating magnetic field component connected thereto; the low-frequency rotating magnetic field component includes: two bearings, two sets of feed components, and two stationary magnets. The inner rings of the two bearings are each connected to the first base via fixed brackets, and the outer rings of the bearings are connected via a plurality of symmetrically arranged first connecting rods. A motor is connected to the outer rings to drive their rotation. The two sets of feed components are symmetrically connected to the two first connecting rods, and the two stationary magnets are symmetrically connected to the feed components one-to-one. The feed components drive the two stationary magnets to move closer to or further away from each other; the high-frequency alternating magnetic field component includes: two opposing Helmholtz coils and a high-frequency heating control subsystem connected thereto. The Helmholtz coils are fixed to the inner rings via second connecting rods, and the Helmholtz coils and stationary magnets form an enclosure. A stage is located between the Helmholtz coils and the stationary magnets; the frequency of the rotating magnetic field is changed by controlling the speed of the motor, and the frequency and intensity of the high-frequency alternating magnetic field generated by the Helmholtz coils are adjusted by changing the frequency and magnitude of the current output of the high-frequency heating control subsystem.

[0006] Optionally, the feed assembly includes a support frame and an adjusting screw. The first connecting rod is configured as two sets, with the two sets of first connecting rods arranged opposite each other. The outer side of each set of first connecting rods is fixed to the support frame. The adjusting screw passes through the support frame and is threadedly connected to it. The portion of the adjusting screw located inside the support frame is screwed to a stationary magnet, and the stationary magnet slides in conjunction with the support frame.

[0007] Optionally, a speed sensor is connected to the first base to monitor the rotational speed of the outer ring, and a gaussmeter is placed between the two stationary magnets to monitor the magnetic field strength. The speed sensor, gaussmeter and motor are all connected to the speed control system.

[0008] Optionally, a counterweight is connected to the bottom of the first base.

[0009] Optionally, the Helmholtz coil is fixed inside a sealed container, which is connected to the two inner coils by a connecting rod. The sealed container is filled with cooling water and is connected to a circulating cooling subsystem.

[0010] Optionally, it also includes an infrared thermometer for monitoring the temperature of the experimental area in the high-frequency alternating magnetic field, with the high-frequency heating control subsystem electrically connected to the infrared thermometer.

[0011] Optionally, the stage is connected to a position adjustment component, which adjusts the position of the stage.

[0012] Optionally, the position adjustment component includes: a second base, a lifting assembly, and a slide rail. The second base is located around the first base, the lifting assembly is connected to the first base, and the slide rail is connected to the lifting end of the lifting assembly. The lifting assembly drives the slide rail to move radially along the Helmholtz coil, and the slide rail slides in cooperation with the stage, driving the stage to move axially along the Helmholtz coil.

[0013] Optionally, reinforcing rods are connected between the first connecting rods in the same group to form an I-shaped structure, and the second connecting rod passes through both Helmholtz coils simultaneously.

[0014] Optionally, the top of the first base has a clearance groove through which the stationary magnet passes when it rotates.

[0015] The technical solution provided by this utility model has the following advantages compared with the prior art: The present invention provides an experimental composite magnetic field generator that controls the rotation speed of a motor to drive the outer ring of a bearing to rotate, thereby driving the rotation of symmetrically distributed static magnets to form a rotating magnetic field. By adjusting the rotation speed of the motor, the frequency of the rotating magnetic field can be changed. The frequency adjustment range is 0Hz-20Hz, and each adjustment is made by adding or subtracting 1Hz. By adjusting the distance between the N and S poles of the two static magnets using the feeding assembly, the magnetic field strength of the rotating magnetic field in the experimental area is changed, thereby adjusting the magnetic field strength in the experimental area within the range of 0T-0.4T. The high-frequency heating control subsystem generates a high-frequency alternating current, which, through a Helmholtz coil as the output, produces a high-frequency alternating magnetic field. The magnetic field strength and frequency of the high-frequency alternating magnetic field generated by the Helmholtz coil are adjusted by changing the current output frequency and magnitude of the high-frequency heating control subsystem. The frequency adjustment range is 100kHz-500kHz, and the maximum magnetic field strength is 30kA / m, ultimately achieving a relatively constant temperature in the experimental area. This invention can simultaneously generate a low-frequency rotating magnetic field and a high-frequency alternating magnetic field, making it suitable for research on the synergistic effect of force and heat in tumor treatment. It is applicable to both cell and animal experiments. The vertically distributed static magnets and Helmholtz coil achieve uniform coverage of the magnetic field in the three-dimensional target area, providing a prototype basis for the development of subsequent clinical-grade equipment. Simultaneously, by adjusting the magnetic pole positions of the two symmetrically placed static magnets (NN poles or SS poles opposite each other) to form a field-free region, the heating area can be effectively confined to a specified small area. Meanwhile, the positional distribution of the static magnet and the Helmholtz coil can reduce the generation of induced current when the rotating magnetic field is working, and can effectively reduce the interference between the composite magnetic fields. Attached Figure Description

[0016] Figure 1 A schematic diagram of the overall structure of an experimental composite magnetic field generating device provided for an embodiment of this utility model; Figure 2A front sectional view of an experimental composite magnetic field generating device provided for an embodiment of this utility model; Figure 3 A top sectional view of an experimental composite magnetic field generating device provided for an embodiment of this utility model; Figure 4 This is a schematic diagram of the structure of the high-frequency heating system provided in an embodiment of the present invention; Figure 5 A side view of the bearing provided in an embodiment of this utility model; Figure 6 A cross-sectional view of a sealed container provided in an embodiment of this utility model; Figure 7 A top view of the stage provided in an embodiment of this utility model; Figure 8 A schematic diagram of the speed control system provided in an embodiment of this utility model.

[0017] Explanation of reference numerals in the attached figures: 1. Static magnet; 2. Bearing; 2-1. Outer ring; 2-2. Inner ring; 3. First connecting rod; 4. Support frame; 5. Fixed bracket; 6. Helmholtz coil; 7. Second connecting rod; 8. Sealed container; 9. Circulating cooling water pipe; 10. Slide rail; 11. Infrared thermometer; 12. Infrared thermometer base; 13. Lifting assembly; 14. Second base; 15. Motor; 16. Speed ​​sensor; 17. First base; 18. Adjusting screw; 19. Stage; 20. Gaussmeter; 21. Speed ​​control system; 22. High-frequency heating system; 22-1. High-frequency heating control subsystem; 22-2. Circulating cooling subsystem. Detailed Implementation

[0018] The following describes a specific embodiment of the present invention in detail with reference to the accompanying drawings. However, it should be understood that the scope of protection of the present invention is not limited to the specific embodiment.

[0019] In the description of this utility model, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "axial", "radial", "circumferential", etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing the technical solution of this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0020] The present invention will be described below through several specific embodiments. To keep the following description of the embodiments of the present invention clear and concise, detailed descriptions of known functions and components may be omitted. When any component of an embodiment of the present invention appears in more than one drawing, the component may be represented by the same reference numerals in each drawing.

[0021] refer to Figure 1 , Figure 2 and Figure 3 , Figure 1 This is a schematic diagram of the overall structure of an experimental composite magnetic field generator provided in an embodiment of the present invention. Figure 2 This is a front sectional view of an experimental composite magnetic field generating device provided in an embodiment of the present invention. Figure 3 A top sectional view of an experimental composite magnetic field generating device provided for an embodiment of this utility model, as shown below. Figure 1 , Figure 2 and Figure 3As shown, this utility model embodiment provides an experimental composite magnetic field generating device, including: a first base 17 and a low-frequency rotating magnetic field component and a high-frequency alternating magnetic field component connected thereto; the low-frequency rotating magnetic field component includes: two bearings 2, two sets of feed components and two static magnets 1, the inner rings 2-2 of the two bearings 2 are each connected to the first base 17 through a fixed bracket 5, the outer rings 2-1 of the bearings 2 are connected through a plurality of symmetrically arranged first connecting rods 3, and the outer rings 2-1 are connected to a motor 15 to drive them to rotate, and the two sets of feed components are each symmetrically connected to the two first connecting rods 3. The first base 17 serves as the support platform for the entire device. The inner rings 2-2 of the two bearings 2 are directly mounted on the first base 17 through a sturdy fixed bracket 5, ensuring the stability and coaxiality of the core rotating component. The outer rings 2-1 of the bearings constitute the motion core of the component. Multiple first connecting rods 3 symmetrically connect the two outer rings 2-1 to form a rigid rotating frame. The motor 15 directly drives the frame through a transmission mechanism (either a gear structure or a pulley structure), allowing it to rotate around the bearing axis. Two stationary magnets 1 are symmetrically connected to the feed assembly, which drives the two stationary magnets 1 to move closer or further away from each other. By controlling the feed assembly, the positions of the two stationary magnets 1 in the radial direction can be adjusted synchronously with high precision, allowing them to move closer or further away from each other, thereby changing the magnetic field strength of the rotating magnetic field in the experimental area. The high-frequency alternating magnetic field component includes two Helmholtz coils 6 arranged opposite each other and a high-frequency heating control subsystem 22-1 connected to them. The high-frequency heating control subsystem 22-1 is connected to the Helmholtz coils 6 through wires, providing them with a controllable high-frequency alternating current. The Helmholtz coil 6 and the inner coil 2-2 are fixed together by the second connecting rod 7. The Helmholtz coil 6 and the stationary magnet 1 form an enclosed structure. The stage 19 is located between the Helmholtz coil 6 and the stationary magnet 1. The two Helmholtz coils 6 are placed strictly coaxially opposite each other, and the distance between the two coils is half the diameter of the coil. They are fixed to the inner coil 2-2 by the second connecting rod 7. Since the inner coil 2-2 is statically connected to the base by the fixed bracket 5, the Helmholtz coil 6 is fixed in space. The Helmholtz coil 6 and the movable stationary magnet 1 together form an enclosed structure in space, placing the stage 19 in its central region to ensure that the sample is in a uniform area after the superposition of the magnetic fields. The frequency of the rotating magnetic field is changed by controlling the rotation speed of the motor 15, and the frequency and intensity of the high-frequency alternating magnetic field generated by the Helmholtz coil 6 are adjusted by changing the frequency and magnitude of the current output of the high-frequency heating control subsystem 22-1. Specifically, the Helmholtz coil 6 can be either ring-shaped or square. In this embodiment, the Helmholtz coil 6 is ring-shaped. This allows for a longer wire length for the same coil diameter, which is beneficial for the coil to output greater power. The internal space of the ring is also larger, which makes it easier to place experimental animals inside the cavity for experiments later.

[0022] The present invention provides an experimental composite magnetic field generator that controls the rotation speed of a motor to drive the outer ring of a bearing to rotate, thereby driving the rotation of symmetrically distributed static magnets to form a rotating magnetic field. By adjusting the rotation speed of the motor, the frequency of the rotating magnetic field can be changed. The frequency adjustment range is 0Hz-20Hz, and each adjustment is made by adding or subtracting 1Hz. By adjusting the distance between the N and S poles of the two static magnets using the feeding assembly, the magnetic field strength of the rotating magnetic field in the experimental area is changed, thereby adjusting the magnetic field strength in the experimental area within the range of 0T-0.4T. The high-frequency heating control subsystem generates a high-frequency alternating current, which, through a Helmholtz coil as the output, produces a high-frequency alternating magnetic field. The magnetic field strength and frequency of the high-frequency alternating magnetic field generated by the Helmholtz coil are adjusted by changing the current output frequency and magnitude of the high-frequency heating control subsystem. The frequency adjustment range is 100kHz-500kHz, and the maximum magnetic field strength is 30kA / m, ultimately achieving a relatively constant temperature in the experimental area. This invention can simultaneously generate a low-frequency rotating magnetic field and a high-frequency alternating magnetic field, making it suitable for research on the synergistic effect of force and heat in tumor treatment. It is applicable to both cell and animal experiments. The vertically distributed static magnets and Helmholtz coil achieve uniform coverage of the magnetic field in the three-dimensional target area, providing a prototype basis for the development of subsequent clinical-grade equipment. Simultaneously, by adjusting the magnetic pole positions of the two symmetrically placed static magnets (NN poles or SS poles opposite each other) to form a field-free region, the heating area can be effectively confined to a specified small area. Meanwhile, the positional distribution of the static magnet and the Helmholtz coil can reduce the generation of induced current when the rotating magnetic field is working, and can effectively reduce the interference between the composite magnetic fields.

[0023] Refer again Figure 3 The feed assembly includes a support frame 4 and an adjusting screw 18. Two sets of first connecting rods 3 are arranged opposite each other. Each set of first connecting rods 3 is fixedly connected to the support frame 4 on its outer side, providing a stable support base for the entire feed assembly. The adjusting screw 18 passes through the support frame 4 and is threadedly connected to it. The portion of the adjusting screw 18 located inside the support frame 4 is threaded to a stationary magnet 1. The adjusting screw 18 and the support frame 4 form a core transmission pair. The adjusting screw 18 passes through a precision-machined threaded through-hole on the support frame 4, and the two form a reliable transmission connection through threaded engagement. The mounting base of the stationary magnet 1 is machined with a mounting hole for the adjusting screw. The internal thread of rod 18 is engaged with the mounting base and the adjusting screw 18. The stationary magnet 1 is slidably engaged with the support frame 4 to ensure that the rotational motion can be smoothly converted into linear displacement. To ensure that the stationary magnet 1 can only move linearly and will not rotate with the adjusting screw 18, the stationary magnet 1 (through its mounting base) and the support frame 4 are slidably engaged. Specifically, this can be achieved by setting a linear guide rail or guide groove in the support frame 4 and installing a linear bearing or slider on the mounting base of the stationary magnet 1. This guiding mechanism effectively constrains the degree of freedom of the stationary magnet 1, so that its movement trajectory is strictly limited to the axis of the adjusting screw 18.

[0024] When the adjusting screw 18 is rotated via a handwheel or motor, the rotational motion of the adjusting screw 18 is converted into a smooth and precise linear motion of the static magnet 1 along the screw axis due to the threaded engagement between the adjusting screw 18 and the support frame 4, and the restriction of the rotation of the static magnet 1. By symmetrically adjusting the feed components on both sides, the two static magnets 1 can be synchronously controlled to move closer or further apart, thereby continuously and precisely adjusting the static magnetic field gap, field strength, and magnetic field gradient generated between the two static magnets 1. This adjustment capability is crucial for optimizing the magnetic field uniformity, intensity, and spatial distribution of the sample area under different experimental conditions.

[0025] refer to Figure 5 , Figure 6 , Figure 7 and Figure 8 , Figure 5 This is a side view of the bearing provided in an embodiment of the present utility model. Figure 6 This is a cross-sectional view of a sealed container provided in an embodiment of the present invention. Figure 7 This is a top view of the stage provided in an embodiment of the present invention. Figure 8 A schematic diagram of the speed control system provided in the embodiment of this utility model is shown below. Figure 5 , Figure 6 , Figure 7 and Figure 8 As shown, a speed sensor 16 (such as a Hall effect sensor or an inductive proximity switch) is connected to the first base 17. The probe of this sensor is precisely aligned with the marker (such as an inductive magnet, keyway, or protrusion) installed on the rotating outer ring 2-1 to monitor the actual rotational angular velocity of the outer ring 2-1 in real time and non-contactly, thereby directly obtaining the frequency of the low-frequency rotating magnetic field. The speed sensor 16 is used to monitor the rotational speed of the outer ring 2-1. A gaussmeter 20 is set between the two stationary magnets 1 to monitor the magnetic field strength. The probe is fixed on the stage 19, and its core can be a Hall probe to measure the instantaneous strength (magnetic induction intensity) of the synthetic magnetic field at that position in real time and in situ. The unit can be millitalas (mT) or gauss (G). The speed sensor 16, the gaussmeter 20, and the motor 15 are all connected to the speed control system 21.

[0026] The speed control system 21 controls the speed of the motor 15, which in turn drives the outer ring 2-1 of the bearing 2 to rotate via a pulley. This, in turn, drives the symmetrically distributed stationary magnets 1 to rotate, thus forming a rotating magnetic field. The frequency of the rotating magnetic field is monitored by the speed sensor 16, and the signal is fed back to the speed control system 21. The speed control system 21 adjusts the speed of the motor 15, thereby ultimately changing the frequency of the rotating magnetic field. By rotating the adjusting screw 18, the distance between the two stationary magnets 1 is adjusted, thereby changing the magnetic field strength in the experimental area. This magnetic field strength is ultimately monitored by the gaussmeter 20. The aforementioned monitoring unit and the actuator are connected to a central speed control system 21 (implemented based on a PLC or microcontroller), forming an integrated intelligent control closed loop. The system receives speed pulse signals from speed sensor 16 and analog / digital magnetic field strength signals from gaussmeter 20, and compares them with preset theoretical values ​​in real time. For speed control: the system processes the calculated speed error value through control algorithms such as PID to generate adjustment commands, which are fed back to the driver of motor 15 (a servo motor or stepper motor) to dynamically adjust the torque and speed of motor 15, thereby stabilizing the frequency of the rotating magnetic field at the set value and effectively offsetting the speed deviation caused by load changes or voltage fluctuations. For magnetic field control: the magnetic field strength fed back by gaussmeter 20 is displayed on the display screen of speed control system 21. By rotating the adjusting screw 18, the distance between the two stationary magnets 1 is further adjusted, thereby adjusting the magnetic field strength of the experimental area.

[0027] To ensure the stability and safety of the entire composite magnetic field generator during operation and to suppress harmful vibrations, a counterweight is connected to the bottom of the first base 17 to reduce the vibration generated by the motor 15 during operation. The counterweight is a block or set of high-density materials (such as cast iron or lead blocks) that is firmly fixed to the bottom platform of the first base 17 by bolting, welding or embedding, with the aim of lowering the overall center of gravity of the entire device as much as possible.

[0028] When the low-frequency rotating magnetic field component starts, changes speed, and rotates, especially when it drives the stationary magnet 1 and the substantial support frame 4, it generates periodic gyroscopic torque and centrifugal force. The extra mass provided by the counterweight and its low center of gravity generate a strong stabilizing torque, effectively resisting these dynamic forces and preventing the entire device from swaying, tilting, or even overturning, thus ensuring experimental safety. The operation of the motor 15, the unbalanced mass of the rotating components, and the minute clearances of the bearing 2 can all become sources of vibration. These vibrations are transmitted to the entire device and even the experimental environment through the first base 17. The heavy counterweight, acting as an inertial mass block, significantly increases the inertia of the base, absorbing and attenuating these vibration energies. This not only reduces vibration noise but also prevents micro-vibrations from interfering with the experimental area within the Helmholtz coil 6 or affecting the measurement accuracy of sensors such as the gaussmeter 20, which is a key guarantee for obtaining stable and reliable experimental data. A robust and heavy base provides an extremely stable support reference for the rotating components, which ensures the positioning accuracy of the bearing 2, reduces the drift of the rotation axis caused by the flexible deformation of the first base 17, and thus ensures the smoothness and concentricity of the rotational motion of the outer ring 2-1, making the generated rotating magnetic field more uniform and stable.

[0029] Optionally, the Helmholtz coil 6 is fixed inside the sealed container 8, which is connected to the two inner rings 2-2 by the connecting rod 7. The sealed container 8 is filled with cooling water, and the sealed container 8 is connected to the circulating cooling subsystem 22-2 by the circulating cooling water pipe 9.

[0030] The high-frequency heating control subsystem 22 consists of two parts: the high-frequency heating control subsystem 22-1 and the circulating cooling subsystem 22-2. The high-frequency heating control subsystem 22-1 generates a high-frequency alternating current, which is output through the Helmholtz coil 6 to generate a high-frequency alternating magnetic field. Since the Helmholtz coil 6 will generate heat during long-term operation, an external water cooling method is used to avoid coil loss and the impact on the temperature of the experimental area: the Helmholtz coil 6 is immersed in a sealed container 8, and the circulating cooling subsystem 22-2 provides circulating cooling water to the sealed container 8 through the circulating cooling water pipe 9, thereby achieving the purpose of cooling and ensuring that the device can work continuously.

[0031] Studies have shown that excessively high temperatures in magnetic induction hyperthermia can cause a series of adverse reactions in the human body. Therefore, a temperature control system is essential for better simulating human trials and for the subsequent clinical translation of the equipment. (Reference) Figure 4The experimental composite magnetic field generating device provided in this embodiment of the invention also includes an infrared thermometer 11 for monitoring the temperature of the experimental area in the high-frequency alternating magnetic field. The high-frequency heating control subsystem 22-1 is electrically connected to the infrared thermometer 11. The infrared thermometer 11 monitors the real-time temperature of the experimental area in a non-contact manner. After the temperature signal is fed back to the high-frequency heating control subsystem 22-1, the frequency of the high-frequency alternating magnetic field generated by the Helmholtz coil 6 is adjusted by adjusting the output current, so that the temperature of the experimental area reaches a relatively constant temperature (maintained in the range of 42-46℃), the maximum magnetic field strength is 30 kA / m, and the frequency adjustment range is 100 kHz-500 kHz. The high-frequency heating control subsystem 22 and the speed control system 21 can work together to generate alternating / rotating magnetic fields simultaneously or sequentially (the high-frequency heating control subsystem and the speed control system are equipped with a unified high-precision clock source, and the start time and duration of the two control systems are precisely controlled by a time regulator to achieve collaborative work for generating alternating / rotating magnetic fields simultaneously or sequentially).

[0032] The output of the infrared thermometer 11 is electrically connected to the control unit of the high-frequency heating control subsystem 22-1, forming a crucial temperature feedback closed loop. The display screen of the high-frequency heating control subsystem 22-1 can show the temperature readings fed back by the infrared thermometer 11 in real time, allowing operators to intuitively understand the real-time temperature of the experimental area. The control program of the high-frequency heating control subsystem 22-1 has two modes: 1. Manual mode: The high-frequency heating control subsystem 22-1 can be set to a fixed output power; in this mode, the infrared thermometer 11 is only used to measure the temperature of the experimental area. 2. Automatic mode: The high-frequency heating control subsystem 22-1 presets a temperature range (42-46℃). After the signal from the infrared thermometer 11 is transmitted to the high-frequency heating control subsystem 22-1, the high-frequency heating control subsystem 22-1 automatically adjusts the output power according to the preset temperature range to achieve a relatively constant temperature in the experimental area.

[0033] While existing equipment is adequate for cell-level experiments, it cannot meet the requirements of the three-dimensional structure of tumors in animal experiments. In cell experiments, the magnetic field has a short operating distance (usually <15mm) and uniform magnetic field strength; however, in animal experiments, tumors are distributed in three dimensions, and the magnetic field strength decreases with depth, leading to greater differences between experimental groups.

[0034] To accurately position the experimental sample at the core of the uniform region of the composite magnetic field or at a specific gradient position to meet the stringent requirements of different experiments, the stage 19 is connected to a position adjustment component, which adjusts the position of the stage 19.

[0035] Specifically, the position adjustment components include: a second base 14, a lifting assembly 13, and a slide rail 10. The second base 14 is located around the first base 17. As an independent and stable auxiliary frame, the second base 14 is installed on the periphery or side of the first base 17. This split design avoids directly transmitting the load and vibration of the adjustment components to the core magnetic field generating unit, ensuring the stability of the rotating magnetic field components and high-frequency coils on the first base 17. The lifting assembly 13 is connected to the first base 17. The fixed end of the lifting assembly 13 is installed on the second base 14 by bolt connection or integrated design. The slide rail 10 is connected to the lifting end of the lifting assembly 13. The lifting assembly 13 drives the slide rail 10 to move radially along the Helmholtz coil 6. The lifting assembly 13 is the core actuator for realizing radial movement (i.e., moving closer to or away from the central axis of the device). This assembly can be a precision linear lifting mechanism, which can use a screw and nut pair, gear rack, or linear motor as the driving method. The lifting end (i.e., the output end) of the lifting assembly 13 is directly connected to the base of the slide rail 10. Therefore, when the lifting assembly 13 is activated, its lifting end extends or retracts, thereby driving the entire slide rail 10 and its stage 19 to move linearly along the radial direction of the Helmholtz coil 6 (as shown in the Y-axis direction in the figure). This adjustment is used to precisely control the radial distance between the sample and the rotating magnet, which is a key operation for adjusting the magnetic field strength in the sample area. The slide rail 10 and the stage 19 slide in a sliding fit, driving the stage 19 to move along the axial direction of the Helmholtz coil 6. The slide rail 10 itself is a high-precision linear guide mechanism. The stage 19 forms a sliding fit with the slide rail 10 through a slider or sliding sleeve. By manually or by motor driving the slider mechanism on the slide rail 10, the stage 19 can be driven to move smoothly and precisely in a linear direction along the guide direction of the slide rail 10, that is, along the axial direction of the Helmholtz coil 6 (as shown in the X-axis direction in the figure). This adjustment is used to accurately position the sample in the region where the magnetic field generated by the coil pair is most uniform (i.e., the central region of the Helmholtz coil 6). The pre-drilled holes on the surface of the stage 19 are used to fix cell culture dishes, well plates and animal fixation devices. There is a detachable gaussmeter probe 20 at the center of the bottom of the stage 19 for monitoring the magnetic field strength of the experimental area.

[0036] During operation, the radial position of the sample is first adjusted by the lifting component 13, and then its axial position is adjusted by the stage 19 on the drive slide rail 10, so as to find the optimal point of uniform magnetic field under a specific field strength.

[0037] Optionally, reinforcing rods are connected between the first connecting rods 3 in the same group to form an I-shaped structure. This design is an important rigidity reinforcement and vibration suppression solution for rotating frame structures.

[0038] Optionally, the top of the first base 17 has a clearance groove (i.e., the side facing the rotating stationary magnet 1). Each stationary magnet 1 has a precision-machined clearance groove (movement clearance opening) in its movement trajectory area. This groove is a recessed area precisely designed according to the motion envelope of the lower end of the stationary magnet 1. Its core purpose is to allow the bottom of the stationary magnet 1 to pass smoothly through the space where the clearance groove is located without interference when it rotates with the outer ring 2-1 driven by the motor 15. Without this clearance groove, when the support frame 4 drives the stationary magnet 1 to rotate to the lowest point, its bottom will violently collide and interfere with the solid first base 17. The existence of the clearance groove physically provides the necessary rotational movement space for the stationary magnet 1, allowing the user to select a larger magnet with a stronger magnetic field within a limited overall volume without sacrificing magnet performance or increasing the overall size of the device to avoid interference, thus achieving a compact and high-performance device structure.

[0039] This invention utilizes a gaussmeter and an infrared thermometer to rigorously monitor the magnetic field strength and temperature changes in the experimental area, achieving constant magnetic field and temperature, which significantly reduces differences between experimental groups. By synchronously adjusting the dual magnetic field parameters through control equipment, rotating / alternating magnetic fields can be generated simultaneously or sequentially, facilitating the study of the effects of different force-thermal synergistic effects on tumor treatment. Adjustment of the experimental area adjustment component ensures precise control of the experimental area at the center of the magnetic field. The output coil of the high-frequency alternating magnetic field is a Helmholtz coil capable of generating a highly uniform magnetic field; this coil is arranged longitudinally to avoid magnetic field interference when outputting simultaneously with the rotating magnetic field. The temperature of the experimental area is monitored by an infrared thermometer, and the temperature signal is fed back to the high-frequency heating control subsystem. By adjusting the output frequency, the temperature of the experimental area is controlled to remain constant, preventing excessive heat from damaging surrounding tissues.

[0040] The above-described embodiments are merely a few specific examples of this utility model. However, the embodiments of this utility model are not limited thereto, and any variations that can be conceived by those skilled in the art should fall within the protection scope of this utility model.

Claims

1. An experimental composite magnetic field generating device, characterized in that, include: The first base (17) and the low-frequency rotating magnetic field component and the high-frequency alternating magnetic field component connected thereto; The low-frequency rotating magnetic field component includes: two bearings (2), two sets of feed components and two stationary magnets (1). The inner rings (2-2) of the two bearings (2) are each connected to the first base (17) through a fixed bracket (5). The outer rings (2-1) of the bearings (2) are connected through a plurality of symmetrically arranged first connecting rods (3). The outer rings (2-1) are connected to a motor (15) to drive them to rotate. The two sets of feed components are symmetrically connected to the two first connecting rods (3). The two stationary magnets (1) are symmetrically connected to the feed components one by one. The feed components drive the two stationary magnets (1) to move closer to or further away from each other. The high-frequency alternating magnetic field component includes: two opposing Helmholtz coils (6) and a high-frequency heating control subsystem (22-1) connected thereto. The Helmholtz coils (6) and the inner ring (2-2) are fixed by a second connecting rod (7). The Helmholtz coils (6) and the stationary magnet (1) form an enclosed shape. The stage (19) is located between the Helmholtz coils (6) and the stationary magnet (1).

2. The experimental composite magnetic field generating device as described in claim 1, characterized in that, The feeding assembly includes a support frame (4) and an adjusting screw (18). The first connecting rod (3) is set in two sets, with the two sets of first connecting rods (3) arranged opposite to each other. The support frame (4) is fixed to the outside of each set of first connecting rods (3). The adjusting screw (18) passes through the support frame (4) and is threadedly connected to it. The portion of the adjusting screw (18) located inside the support frame (4) is screwed with a stationary magnet (1). The stationary magnet (1) slides with the support frame (4).

3. The experimental composite magnetic field generating device as described in claim 1, characterized in that, A speed sensor (16) is connected to the first base (17). The speed sensor (16) is used to monitor the rotation speed of the outer ring (2-1). A gaussmeter (20) is set between the two stationary magnets (1) to monitor the magnetic field strength. The speed sensor (16), the gaussmeter (20) and the motor (15) are all connected to the speed control system (21).

4. The experimental composite magnetic field generating device as described in claim 1, characterized in that, The bottom of the first base (17) is connected to a counterweight.

5. The experimental composite magnetic field generating device as described in claim 1, characterized in that, The Helmholtz coil (6) is fixed inside a sealed container (8), which is connected to two inner rings (2-2) by a connecting rod (7). The sealed container (8) is filled with cooling water and is connected to a circulating cooling subsystem (22-2).

6. The experimental composite magnetic field generating device as described in claim 5, characterized in that, It also includes an infrared thermometer (11) for monitoring the temperature of the experimental area in the high-frequency alternating magnetic field, and the high-frequency heating control subsystem (22-1) is electrically connected to the infrared thermometer (11).

7. The experimental composite magnetic field generating device as described in claim 1, characterized in that, The stage (19) is connected to a position adjustment component, which adjusts the position of the stage (19).

8. The experimental composite magnetic field generating device as described in claim 7, characterized in that, The position adjustment component includes: a second base (14), a lifting assembly (13), and a slide rail (10). The second base (14) is located around the first base (17). The lifting assembly (13) is connected to the first base (17). The slide rail (10) is connected to the lifting end of the lifting assembly (13). The lifting assembly (13) drives the slide rail (10) to move radially along the Helmholtz coil (6). The slide rail (10) slides with the platform (19), driving the platform (19) to move axially along the Helmholtz coil (6).

9. The experimental composite magnetic field generating device as described in claim 1, characterized in that, A reinforcing rod is connected between the first connecting rods (3) in the same group to form an I-shaped structure, and the second connecting rod (7) passes through two Helmholtz coils (6) at the same time.

10. The experimental composite magnetic field generating device as described in claim 1, characterized in that, The first base (17) has a clearance groove on its top, through which the stationary magnet (1) passes when it rotates.

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