A solid phase extraction device for low molecular weight heparin sodium degradation impurities

Abstract

The utility model relates to solid phase extraction technical field provides a kind of solid phase extraction device of low molecular weight heparin sodium degradation impurity, including extraction structure;Auxiliary structure: the auxiliary structure is coaxially installed in the top of extraction structure;Extraction structure: the extraction structure includes liquid collection pool, control panel, solid phase extraction column and fixed frame;The control panel is fixedly connected to the outer wall one side of liquid collection pool, solid phase extraction column is fixedly connected to the outer wall other side of liquid collection pool, and fixed frame is fixedly connected to the rear portion of liquid collection pool.The utility model is through the setting auxiliary structure, through the auxiliary cooperation between guide frame and motor, when motor works, can make screw block guide slide inside guide frame, so that convex block can be extruded to piston rod, and make piston rod slide inside syringe, can automatically transport low molecular weight heparin sodium solution, while, realize real-time monitoring and control to liquid level.

Description

Technical Field

[0001] This utility model relates to the field of solid phase extraction technology, and in particular to a solid phase extraction device for degrading impurities with low molecular weight heparin sodium. Background Technology

[0002] The solid-phase extraction device for degrading impurities in low molecular weight heparin sodium is a device used to separate and remove degradation impurities from low molecular weight heparin sodium. It utilizes solid-phase extraction technology to selectively adsorb and separate target substances and impurities in the sample through a solid adsorbent.

[0003] Most current solid-phase extraction devices have significant shortcomings. The sample introduction process relies excessively on manual operation, requiring the injection of low molecular weight heparin sodium samples into the solid-phase extraction column manually using a syringe. This operation method is not only inefficient and difficult to adapt to the batch processing requirements of large-scale production, but also prone to insufficient contact between the sample and the packing material due to unstable manually controlled injection rates and inconsistent operating force, which affects the adsorption effect of degraded impurities and reduces separation accuracy. Utility Model Content

[0004] The purpose of this invention is to provide a solid-phase extraction device for degrading impurities with low molecular weight heparin sodium, in order to solve the problem that existing solid-phase extraction devices for degrading impurities with low molecular weight heparin sodium require operators to manually add samples using a syringe, which is prone to errors during operation.

[0005] To solve the above-mentioned technical problems, this utility model provides the following technical solution: a solid-phase extraction device for degrading impurities with low molecular weight heparin sodium, comprising an extraction structure;

[0006] Auxiliary structure: The auxiliary structure is coaxially mounted on the top of the extraction structure;

[0007] Extraction structure: The extraction structure includes a collection tank, a control panel, a solid-phase extraction column, and a fixing frame;

[0008] The control panel is fixedly connected to one side of the outer wall of the collection tank, the solid phase extraction column is fixedly connected to the other side of the outer wall of the collection tank, and the fixing frame is fixedly connected to the rear of the collection tank.

[0009] Auxiliary structure: The auxiliary structure includes a guide frame, a motor, a liquid level sensor, a syringe, and a piston rod;

[0010] The guide frame is fixedly connected to the top of the fixed frame, the motor is fixedly connected to the top of the guide frame, the syringe is fixedly connected to the inside of the fixed frame, the liquid level sensor is fixedly connected to the outside of the syringe, and the piston rod is slidably connected to the inside of the syringe.

[0011] Preferably, the auxiliary structure further includes a screw block, a pressure sensor, a threaded rod, and a protrusion;

[0012] The threaded rod is fixedly connected to the output shaft of the motor, the screw block is threadedly connected to the outside of the threaded rod, the pressure sensor is fixedly connected to the top of the piston rod, and the protrusion is fixedly connected to one end of the screw block.

[0013] Preferably, one end of the screw block is slidably connected to the inside of the guide frame, and the protrusion is horizontally and vertically arranged above the pressure sensor.

[0014] Preferably, the liquid level sensor and the motor are electrically connected, and the motor and the pressure sensor are electrically connected.

[0015] Preferably, the extraction structure further includes a liquid outlet, a collection tank, and a liquid delivery pump;

[0016] The outlet is fixedly connected to the front end of the collection tank, the collection trough is opened inside the collection tank, and the delivery pump is fixedly connected to the outside of the top of the syringe.

[0017] Preferably, it also includes an anti-detachment structure;

[0018] The anti-fall-off structure includes an auxiliary cylinder, a rotating ring, a through groove, and a spring retaining plate;

[0019] The auxiliary cylinder is fixedly connected to one end of the liquid outlet, the rotating ring is rotatably connected to the outside of the auxiliary cylinder, the through groove is opened on the inner wall of the auxiliary cylinder, and the spring clamp is rotatably connected to the inside of the auxiliary cylinder.

[0020] Preferably, the anti-detachment structure further includes a locking block and a fixing block;

[0021] The card block is fixedly connected to one end of the spring card plate, and the fixing block is fixedly connected to the inner wall of the rotating ring.

[0022] The solid-phase extraction device for degrading impurities with low molecular weight heparin sodium provided by this utility model has the following advantages:

[0023] This invention, through the setting of an auxiliary structure and the auxiliary cooperation between the guide frame and the motor, allows the screw block to slide down inside the guide frame while the motor is working. This causes the protrusion to squeeze the piston rod, and the piston rod to slide down inside the syringe. This allows for the automatic delivery of low molecular weight heparin sodium solution while simultaneously enabling real-time monitoring and control of the liquid level.

[0024] Based on the above-mentioned beneficial effects, an anti-detachment structure is provided. Through the auxiliary cooperation between the auxiliary cylinder and the rotating ring, when the rotating ring is rotated, the fixed block can squeeze the locking block, thereby allowing the spring locking plate to rotate inside the auxiliary cylinder. This can increase the connection stability between the liquid outlet pipe and the liquid outlet, thus preventing leakage. Attached Figure Description

[0025] Figure 1 This is an axonometric view of the present invention;

[0026] Figure 2 This is another isometric view of the present invention;

[0027] Figure 3 For the present utility model Figure 2 Enlarged view of point A in the middle;

[0028] Figure 4 This is a three-dimensional schematic diagram of the auxiliary structure of this utility model;

[0029] Figure 5 This is a three-dimensional sectional view of the auxiliary cylinder of this utility model.

[0030] Explanation of the reference numerals in the figure:

[0031] 11. Collection tank; 12. Control panel; 13. Liquid outlet; 14. Solid phase extraction column; 15. Collection tank; 16. Fixing frame; 17. Liquid delivery pump;

[0032] 21. Guide frame; 22. Motor; 23. Liquid level sensor; 24. Syringe; 25. Piston rod; 26. Screw block; 27. Pressure sensor; 28. Threaded rod; 29. ​​Protrusion;

[0033] 31. Auxiliary cylinder; 32. Rotary ring; 33. Through groove; 34. Spring clamping plate; 35. Clamping block; 36. Fixing block. Detailed Implementation

[0034] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0035] Please see Figures 1-5 This utility model provides a solid-phase extraction device for degrading impurities with low molecular weight heparin sodium, including an extraction structure;

[0036] Auxiliary structure: The auxiliary structure is coaxially mounted at the top of the extraction structure;

[0037] Extraction structure: The extraction structure includes a collection tank 11, a control panel 12, a solid phase extraction column 14, and a fixing frame 16;

[0038] The control panel 12 is fixedly connected to one side of the outer wall of the collection tank 11, the solid phase extraction column 14 is fixedly connected to the other side of the outer wall of the collection tank 11, and the fixing frame 16 is fixedly connected to the rear of the collection tank 11.

[0039] The extraction structure also includes a liquid outlet 13, a collection tank 15, and a liquid delivery pump 17;

[0040] The outlet 13 is fixedly connected to the front end of the collection tank 11, the collection trough 15 is opened inside the collection tank 11, and the delivery pump 17 is fixedly connected to the outside of the top of the syringe 24.

[0041] The solid-phase extraction column 14 is filled with solid adsorbent materials, such as reversed-phase packing, ion exchange packing, or hydrophilic-lipophilic balanced packing. Different packing materials are selected according to the properties of low molecular weight heparin sodium and its degradation impurities to achieve selective adsorption and separation of target analytes and impurities. A pumping device is fixedly connected to the bottom of the solid-phase extraction column 14. The pumping device is responsible for controlling the flow rate of the sample, solvent, or eluent in the solid-phase extraction column 14. Its stability and accuracy are crucial to the solid-phase extraction process. A suitable flow rate helps to improve extraction efficiency and recovery rate. The collection tank 15 is used to collect the target analyte solution after elution for subsequent analysis and detection.

[0042] Auxiliary structure: The auxiliary structure includes a guide frame 21, a motor 22, a liquid level sensor 23, a syringe 24, and a piston rod 25;

[0043] The guide frame 21 is fixedly connected to the top of the fixed frame 16, the motor 22 is fixedly connected to the top of the guide frame 21, the syringe 24 is fixedly connected to the inside of the fixed frame 16, the liquid level sensor 23 is fixedly connected to the outside of the syringe 24, and the piston rod 25 is slidably connected to the inside of the syringe 24.

[0044] The auxiliary structure also includes a screw block 26, a pressure sensor 27, a threaded rod 28, and a protrusion 29;

[0045] The threaded rod 28 is fixedly connected to the output shaft of the motor 22, the screw block 26 is threadedly connected to the outside of the threaded rod 28, the pressure sensor 27 is fixedly connected to the top of the piston rod 25, and the protrusion 29 is fixedly connected to one end of the screw block 26.

[0046] One end of the screw block 26 is slidably connected to the inside of the guide frame 21. The protrusion 29 is horizontally and vertically arranged above the pressure sensor 27. The liquid level sensor 23 and the motor 22 are electrically connected. The motor 22 and the pressure sensor 27 are electrically connected. The syringe 24 and the piston rod 25 are used to introduce the low molecular weight heparin sodium sample to be processed into the solid phase extraction column 14 to ensure that the sample can enter the solid phase extraction column 14 uniformly and stably, and avoid the extraction effect being affected by the flow rate problem.

[0047] With the auxiliary cooperation between the guide frame 21 and the motor 22, when the motor 22 is working, the screw block 26 can be guided to slide down inside the guide frame 21, so that the protrusion 29 can squeeze the piston rod 25 and make the piston rod 25 slide down inside the syringe 24.

[0048] Working principle: During solid-phase extraction of impurities degraded by low molecular weight heparin sodium;

[0049] First, by starting the liquid delivery pump 17, the solution can be delivered into the syringe 24. The liquid level sensor 23 detects the contact state between the liquid and the sensor probe, changes in physical properties, or differences in signal feedback, and converts the physical quantity of the liquid level height inside the syringe 24 into a readable electrical signal, and controls the motor 22 to work. This allows the output shaft of the motor 22 to drive the threaded rod 28 to rotate through the coupling, and causes one end of the screw block 26 to slide down along the threaded trajectory outside the threaded rod 28 inside the guide frame 21.

[0050] Next, the protrusion 29 fixedly connected to one end of the screw block 26 can squeeze the piston rod 25, so that the bottom end of the piston rod 25 is pressed down inside the syringe 24, and the solution inside the liquid level sensor 23 is delivered to the solid phase extraction column 14. When the piston rod 25 slides down to a certain position, after the pressure inside the syringe 24 reaches the expected value, the pressure sensor 27 can send an electrical signal and control the motor 22 to reverse, so that the screw block 26 releases the squeeze on the piston rod 25, and the piston rod 25 is reset under the action of air pressure.

[0051] This step allows for the automatic delivery of low molecular weight heparin sodium solution while simultaneously enabling real-time monitoring and control of the liquid level.

[0052] Please see Figure 3-5 As shown, this embodiment, based on the above embodiment, also includes an anti-detachment structure;

[0053] The anti-fall-off structure includes an auxiliary cylinder 31, a rotating ring 32, a through groove 33, and a spring retaining plate 34;

[0054] The auxiliary cylinder 31 is fixedly connected to one end of the liquid outlet 13, the rotating ring 32 is rotatably connected to the outside of the auxiliary cylinder 31, the through groove 33 is opened on the inner wall of the auxiliary cylinder 31, and the spring plate 34 is rotatably connected to the inside of the auxiliary cylinder 31.

[0055] The anti-detachment structure also includes a locking block 35 and a fixing block 36;

[0056] The locking block 35 is fixedly connected to one end of the spring locking plate 34, and the fixing block 36 is fixedly connected to the inner wall of the rotating ring 32;

[0057] The auxiliary cylinder 31 is used to open the through groove 33, and one end of the fixing block 36 is attached to one side of the locking block 35;

[0058] With the auxiliary cooperation between the auxiliary cylinder 31 and the rotating ring 32, when the rotating ring 32 is rotated, the fixed block 36 can press the locking block 35, thereby allowing the spring locking plate 34 to rotate inside the auxiliary cylinder 31.

[0059] Working principle: When the liquid outlet tube and the liquid outlet 13 are connected;

[0060] First, by rotating the rotating ring 32 clockwise, the fixing block 36 fixedly connected to the inner side of the rotating ring 32 can rotate accordingly, and the fixing block 36 can press against the locking block 35.

[0061] Next, the spring plate 34, which is fixedly connected to the locking block 35 at one end, can rotate inside the auxiliary cylinder 31, and one end of the spring plate 34 can be put into the auxiliary cylinder 31 through the through groove 33. After inserting one end of the liquid outlet pipe into the liquid outlet 13 through the auxiliary cylinder 31, the rotation formed on the rotating ring 32 can be released, so that multiple sets of spring plates 34 can be reset under the influence of elastic force, and form a clamping and positioning outside the connection end of the liquid outlet pipe.

[0062] This step can increase the stability of the connection between the liquid outlet pipe and the liquid outlet 13, thereby preventing leakage.

[0063] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A solid-phase extraction device for degrading impurities with low molecular weight heparin sodium, comprising an extraction structure, characterized in that: Auxiliary structure: The auxiliary structure is coaxially mounted on the top of the extraction structure; Extraction structure: The extraction structure includes a collection tank (11), a control panel (12), a solid phase extraction column (14), and a fixing frame (16); The control panel (12) is fixedly connected to one side of the outer wall of the collection tank (11), the solid phase extraction column (14) is fixedly connected to the other side of the outer wall of the collection tank (11), and the fixing frame (16) is fixedly connected to the rear of the collection tank (11). Auxiliary structure: The auxiliary structure includes a guide frame (21), a motor (22), a liquid level sensor (23), a syringe (24), and a piston rod (25); The guide frame (21) is fixedly connected to the top of the fixed frame (16), the motor (22) is fixedly connected to the top of the guide frame (21), the syringe (24) is fixedly connected to the inside of the fixed frame (16), the liquid level sensor (23) is fixedly connected to the outside of the syringe (24), and the piston rod (25) is slidably connected to the inside of the syringe (24).

2. The solid-phase extraction apparatus for degrading impurities with low molecular weight heparin sodium according to claim 1, characterized in that, The auxiliary structure also includes a screw block (26), a pressure sensor (27), a threaded rod (28), and a protrusion (29); The threaded rod (28) is fixedly connected to the output shaft of the motor (22), the screw block (26) is threadedly connected to the outside of the threaded rod (28), the pressure sensor (27) is fixedly connected to the top of the piston rod (25), and the protrusion (29) is fixedly connected to one end of the screw block (26).

3. The solid-phase extraction apparatus for degrading impurities with low molecular weight heparin sodium according to claim 2, characterized in that, One end of the screw block (26) is slidably connected to the inside of the guide frame (21), and the protrusion (29) is horizontally and vertically arranged above the pressure sensor (27).

4. The solid-phase extraction apparatus for degrading impurities with low molecular weight heparin sodium according to claim 2, characterized in that, The liquid level sensor (23) and the motor (22) are electrically connected, and the motor (22) and the pressure sensor (27) are electrically connected.

5. The solid-phase extraction apparatus for degrading impurities with low molecular weight heparin sodium according to claim 1, characterized in that, The extraction structure also includes a liquid outlet (13), a collection tank (15), and a liquid delivery pump (17); The outlet (13) is fixedly connected to the front end of the collection tank (11), the collection trough (15) is opened inside the collection tank (11), and the delivery pump (17) is fixedly connected to the outside of the top of the syringe (24).

6. The solid-phase extraction apparatus for degrading impurities with low molecular weight heparin sodium according to claim 1, characterized in that, It also includes an anti-detachment structure; The anti-fall-off structure includes an auxiliary cylinder (31), a rotating ring (32), a through groove (33), and a spring retaining plate (34); The auxiliary cylinder (31) is fixedly connected to one end of the liquid outlet (13), the rotating ring (32) is rotatably connected to the outside of the auxiliary cylinder (31), the through groove (33) is opened on the inner wall of the auxiliary cylinder (31), and the spring plate (34) is rotatably connected to the inside of the auxiliary cylinder (31).

7. The solid-phase extraction apparatus for degrading impurities with low molecular weight heparin sodium according to claim 6, characterized in that, The anti-detachment structure also includes a locking block (35) and a fixing block (36); The card block (35) is fixedly connected to one end of the spring card plate (34), and the fixing block (36) is fixedly connected to the inner wall of the rotating ring (32).

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