A dissolving kettle for crude heparin sodium
Patent Information
- Application Number
- CN202522416236.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-11-14
- Publication Date
- 2026-10-09
- Estimated Expiration
- 2035-11-14
AI Technical Summary
[0003]用于肝素钠粗品的溶解釜一般设置有两个进料口，一个用于溶液进料（比较常用和最有效的溶剂是氯化钠溶液），另一个用于肝素钠粗品粉末的进料，如果肝素钠粗品粉末没有完全分散或者过于集中投入，容易出现反应不均匀、不完全的情况，因此，亟待一种改进的技术来解决现有技术中所存在的这一问题
甘素钠末进料口延伸至釜盖内侧并且底部连接有粉末分散机构，粉末分散机构通过锥形板使肝素钠粗品粉末在投料时分散的落入釜体中的溶液中，大大提高反应效果及效率，同时，锥形板外围设置有限位罩，通过限位罩防止甘素钠出品粉末通过锥形板分散后飞到釜体内壁，避免粘附在釜体内壁过高的位置导致浪费。
Smart Images
Figure CN224822191U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of dissolving kettle technology, specifically a dissolving kettle for crude heparin sodium. Background Technology
[0002] A dissolving vessel is an industrial container used to dissolve solid, liquid, or gaseous materials in a liquid solvent through stirring, heating, or other methods, forming a homogeneous solution. It is a very common mixing and reaction device in industries such as chemical, pharmaceutical, food, and coatings. Crude heparin sodium (usually an extract from the small intestinal mucosa of pigs or sheep, containing a large amount of impurities such as proteins, nucleic acids, salts, and others) is completely dissolved in a suitable solvent to form a homogeneous solution, preparing it for subsequent purification steps such as precipitation, filtration, and chromatography.
[0003] Dissolving vessels for crude heparin sodium typically have two inlets: one for feeding the solution (sodium chloride solution is the most commonly used and effective solvent) and the other for feeding the crude heparin sodium powder. If the crude heparin sodium powder is not completely dispersed or is fed in too concentrated a concentration, uneven or incomplete reactions can easily occur. Therefore, an improved technology is urgently needed to solve this problem in the existing technology. Summary of the Invention
[0004] The purpose of this invention is to provide a dissolving vessel for crude heparin sodium to solve the problems mentioned in the background art.
[0005] To achieve the above objectives, this utility model provides the following technical solution: a dissolving vessel for crude heparin sodium, comprising a vessel body, a vessel cover, a motor, a main shaft, a stirring paddle, and a powder dispersion mechanism. The vessel cover is provided on the upper surface of the vessel body. A motor is mounted on the center of the upper surface of the vessel cover via a motor mount. The output shaft of the motor is connected to the top of the main shaft via a coupling. A stirring paddle is provided at the bottom of the main shaft and is rotatably mounted inside the vessel body. A solution inlet and a heparin sodium inlet are provided on the upper surface of the vessel cover. The bottom of the heparin sodium inlet extends into the interior of the vessel cover and is connected to the powder dispersion mechanism. A discharge valve is provided at the bottom of the vessel body. The vessel body is covered with a jacket. The powder dispersion mechanism includes a connecting sleeve, connecting rods, a conical plate, and a limiting cover. Several connecting rods are connected to the bottom of the connecting sleeve, and the bottom of the connecting rods is connected to the conical plate. The limiting cover is connected to the outer periphery of the bottom of the connecting sleeve and is located on the outer periphery of the conical plate. The connecting sleeve is inserted into the bottom of the heparin sodium inlet and fastened with bolts.
[0006] Preferably, the present invention provides a dissolving vessel for crude heparin sodium, wherein the outer surface of the jacket is provided with a plurality of support seats.
[0007] Preferably, the present invention provides a dissolving vessel for crude heparin sodium, wherein the bottom of the jacket is provided with a heat exchange medium inlet, and the upper side of the jacket is provided with a heat exchange medium outlet.
[0008] Preferably, the present invention provides a dissolving vessel for crude heparin sodium, wherein a fixing seat is provided on the upper surface of the vessel cover, and the motor seat is fastened to the fixing seat by bolts.
[0009] Preferably, the present invention provides a dissolving vessel for crude heparin sodium, wherein the upper surface of the vessel lid is further provided with a thermometer port and a pressure gauge port.
[0010] Compared with the prior art, the beneficial effects of this utility model are: The sodium heparin powder feed inlet extends to the inside of the vessel lid and is connected to a powder dispersion mechanism at the bottom. The powder dispersion mechanism uses a conical plate to disperse the crude sodium heparin powder into the solution in the vessel body during feeding, which greatly improves the reaction effect and efficiency. At the same time, a limit cover is set around the conical plate to prevent the sodium heparin powder from flying onto the inner wall of the vessel after being dispersed by the conical plate, thus avoiding waste caused by it adhering too high on the inner wall of the vessel body. Attached Figure Description
[0011] Figure 1 This is a schematic diagram of the structure of this utility model.
[0012] In the diagram: 1. Vessel body; 2. Vessel cover; 3. Motor; 4. Main shaft; 5. Stirring paddle; 6. Motor base; 7. Solution inlet; 8. Sodium heparin inlet; 9. Discharge valve; 10. Jacket; 11. Connecting sleeve; 12. Connecting rod; 13. Conical plate; 14. Limiting cover; 15. Support base; 16. Heat exchange medium inlet; 17. Heat exchange medium outlet; 18. Fixed base; 19. Thermometer port; 20. Pressure gauge port. Detailed Implementation
[0013] The technical solution of this utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model. It should be noted that in the description of this utility model, the terms "inner", "outer", "upper", "lower", "both sides", "one end", "the other end", "left", "right", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.
[0014] Please see Figure 1 This utility model provides a technical solution: a dissolving vessel for crude heparin sodium, comprising a vessel body 1, a vessel cover 2, a motor 3, a main shaft 4, a stirring paddle 5, and a powder dispersion mechanism. The vessel cover 2 is mounted on the upper surface of the vessel body 1. A motor 3 is mounted on the center of the upper surface of the vessel cover 2 via a motor mount 6. A fixing seat 18 is mounted on the upper surface of the vessel cover 2. The motor mount 6 is fastened to the fixing seat 18 with bolts to connect the motor mount 6 and the vessel cover 2. The output shaft of the motor 3 is connected to the top of the main shaft 4 via a coupling. A stirring paddle 5 is mounted at the bottom of the main shaft 4 and rotatably mounted inside the vessel body 1. A solution inlet 7 and a heparin sodium inlet are provided on the upper surface of the vessel cover 2. 8. The bottom of the heparin sodium inlet 8 extends into the interior of the vessel cover 2 and is connected to a powder dispersion mechanism. The bottom of the vessel body 1 is provided with a discharge valve 9. The vessel body 1 is wrapped with a jacket 10. Several support seats 15 are provided on the outer surface of the jacket 10 to achieve overall support and fixation. The bottom of the jacket 10 is provided with a heat exchange medium inlet 16, and the upper side of the jacket 10 is provided with a heat exchange medium outlet 17. Hot water / oil can enter and leave the jacket 10 through the heat exchange medium inlet 16 and the heat exchange medium outlet 17. The upper surface of the vessel cover 2 is also provided with a thermometer port 19 and a pressure gauge port 20 for installing thermometers and pressure gauges respectively, so as to realize the monitoring of temperature and pressure inside the vessel body 1. The powder dispersion mechanism includes a connecting sleeve 11, a connecting rod 12, a conical plate 13, and a limiting cover 14. Several connecting rods 12 are connected to the bottom of the connecting sleeve 11. The bottom of the connecting rods 12 is connected to the conical plate 13. The outer periphery of the bottom of the connecting sleeve 11 is connected to the limiting cover 14. The limiting cover 14 is located on the outer periphery of the conical plate 13. The connecting sleeve 11 is inserted into the bottom of the heparin sodium inlet 8 and fastened with bolts.
[0015] Installation method and operating principle: First, assemble the powder dispersion mechanism. Weld multiple connecting rods 12 to the bottom of the connecting sleeve 11, then weld the bottom of the connecting rods 12 to the upper surface of the conical plate 13. Next, fit the limiting cover 14 from top to bottom around the connecting sleeve 11 and the conical plate 13, and weld the upper end of the limiting cover 14 to the bottom of the connecting sleeve 11 to complete the assembly of the powder dispersion mechanism. Insert the connecting sleeve 11 of the powder dispersion mechanism into the bottom of the heparin sodium inlet 8 and fasten it with bolts. Connect the top of the main shaft 4 with the stirring paddle 5 to the output shaft of the motor 3 through a coupling. After lifting the vessel cover 2, place the stirring paddle 5 into the vessel body 1, support the vessel cover 2 on the vessel body 1, and connect the vessel cover 2 to the vessel body 1 using flanges and bolts and nuts to complete the installation. In operation, NaCl solution is first pumped into vessel 1 through solution inlet 7. Motor 3 is then started, driving the main shaft 4 and stirring paddle 5 to rotate. While stirring, crude heparin sodium powder is slowly and evenly added through sodium heparin inlet 8. The powder first falls onto conical plate 13 through connecting sleeve 11, where it is dispersed. Slightly clumps of powder are broken up upon impact. The powder then slides down from all directions onto the conical plate 13, dispersing into the stirred NaCl solution for dissolution. The dissolution reaction is typically carried out at room temperature. If the temperature is too low, hot water below 40°C can be pumped into jacket 10 to appropriately raise the temperature and improve the reaction efficiency. Crude heparin sodium powder can be fed via a screw conveyor connected to both the storage tank and sodium heparin inlet 8. This utility model has a reasonable structure. The feed port of sodium heparin extends to the inside of the kettle cover 2 and is connected to the bottom of the powder dispersion mechanism. The powder dispersion mechanism disperses the crude sodium heparin powder into the NaCl solution in the kettle body 1 during feeding through the conical plate 13, which greatly improves the reaction effect and efficiency. At the same time, a limiting cover 14 is set around the conical plate 13 to prevent the sodium heparin powder from flying to the inner wall of the kettle body 1 after being dispersed by the conical plate 13, thus avoiding waste caused by it adhering to the inner wall of the kettle body 1 at too high a position.
[0016] Any aspects of this utility model not described in detail are well-known technologies to those skilled in the art.
[0017] Finally, it should be noted that the above specific embodiments are only used to illustrate the technical solution of this utility model and not to limit it. Although this utility model has been described in detail with reference to the embodiments, those skilled in the art should understand that modifications and equivalent substitutions can be made to the technical solution of this utility model without departing from the spirit and scope of the technical solution of this utility model, and all such modifications and substitutions should be covered within the scope of the claims of this utility model.
Claims
1. A dissolving vessel for crude heparin sodium, characterized in that: The apparatus includes a vessel body (1), a vessel cover (2), a motor (3), a main shaft (4), a stirring paddle (5), and a powder dispersion mechanism. The vessel body (1) is provided with a vessel cover (2) on its upper surface. A motor (3) is provided at the center of the upper surface of the vessel cover (2) via a motor mount (6). The output shaft of the motor (3) is connected to the top of the main shaft (4) via a coupling. A stirring paddle (5) is provided at the bottom of the main shaft (4). The stirring paddle (5) is rotatably disposed inside the vessel body (1). A solution inlet (7) and a heparin sodium inlet (8) are provided on the upper surface of the vessel cover (2). The bottom of the heparin sodium inlet (8) extends into the interior of the vessel cover (2) and is connected to the powder dispersion mechanism. A discharge valve (9) is provided at the bottom of the vessel body (1). The vessel body (1) is wrapped with a jacket (10). The powder dispersion mechanism includes a connecting sleeve (11), a connecting rod (12), a conical plate (13), and a limiting cover (14). The bottom of the connecting sleeve (11) is connected to several connecting rods (12). The bottom of the connecting rods (12) is connected to the conical plate (13). The outer periphery of the bottom of the connecting sleeve (11) is connected to the limiting cover (14). The limiting cover (14) is located on the outer periphery of the conical plate (13). The connecting sleeve (11) is inserted into the bottom of the heparin sodium inlet (8) and fastened with bolts.
2. The dissolving vessel for crude heparin sodium according to claim 1, characterized in that: The outer surface of the jacket (10) is provided with several support seats (15).
3. The dissolving vessel for crude heparin sodium according to claim 1, characterized in that: The jacket (10) has a heat exchange medium inlet (16) at the bottom and a heat exchange medium outlet (17) on one side of the upper part of the jacket (10).
4. The dissolving vessel for crude heparin sodium according to claim 1, characterized in that: The upper surface of the lid (2) is provided with a fixing seat (18), and the motor seat (6) is fastened to the fixing seat (18) by bolts.
5. A dissolving vessel for crude heparin sodium according to claim 1, characterized in that: The upper surface of the lid (2) is also provided with a thermometer port (19) and a pressure gauge port (20).